Article
Infectious Diseases
Laurent Coudeville, Amine Amiche, Ashrafur Rahman, Julien Arino, Biao Tang, Ombeline Jollivet, Alp Dogu, Edward Thommes, Jianhong Wu
Summary: The study found that the Hajj pilgrimage has a significant impact on the transmission of invasive meningococcal disease (IMD), affecting both pilgrims and the local population. Quadrivalent ACWY vaccination was found to be highly effective in reducing the risk of outbreaks during Hajj.
BMC INFECTIOUS DISEASES
(2022)
Review
Biotechnology & Applied Microbiology
Anand P. Dubey, Rashna Dass Hazarika, Veronique Abitbol, Shafi Kolhapure, Someya Agrawal
Summary: The risk of meningococcal transmission is increased by crowding and prolonged close contact. India faces a unique situation with significant IMD-related complications despite a low reported incidence. Preventive measures may require broader meningococcal vaccination and enhanced disease surveillance.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Kailey Hughes, Donald B. Middleton, Mary Patricia Nowalk, Goundappa K. Balasubramani, Emily T. Martin, Manjusha Gaglani, H. Keipp Talbot, Manish M. Patel, Jill M. Ferdinands, Richard K. Zimmerman, Fernanda P. Silveira
Summary: This study evaluated the vaccine effectiveness against influenza hospitalization among immunocompromised adults during the 2017-2018 influenza season. The results showed that while immunocompromised adults had a higher vaccination rate, their protection against influenza was lower, with a vaccine effectiveness of 33% in the overall adult population. Further research is needed to assess vaccine effectiveness among different immunocompromising conditions and explore ways to improve effectiveness for immunocompromised individuals.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Bruno Lewin, Lei Qian, Runxin Huang, Lina S. Sy, Kristin Goddard, Allison L. Naleway, Malini DeSilva, Matthew F. Daley, Michael M. McNeil, Lisa A. Jackson, Steven J. Jacobsen
Summary: By studying EHR data of nearly a million travelers, it was found that travelers who received travel vaccines were generally younger, healthier, and had lower Hispanic representation compared to those who did not receive travel vaccines. Healthcare utilization significantly decreased during travel, with outpatient visits dropping from 294.8 visits per 10,000 person-days before travel to 24.2 visits per 10,000 person-days during reported travel dates.
Article
Immunology
Constantina Boikos, Lauren Fischer, Dan O'Brien, Joe Vasey, Gregg C. Sylvester, James A. Mansi
Summary: This study estimated the relative vaccine effectiveness (rVE) of cell-propagated inactivated quadrivalent influenza vaccine (ccIIV4) versus egg-derived inactivated quadrivalent influenza vaccine (eIIV4) in preventing influenza-related medical encounters in the 2018-2019 US season. The results showed a statistically significantly greater reduction in influenza-related medical encounters in individuals vaccinated with ccIIV4 compared to eIIV4, supporting ccIIV4 as a potentially more effective public health measure against influenza.
CLINICAL INFECTIOUS DISEASES
(2021)
Editorial Material
Public, Environmental & Occupational Health
Ramadan A. Farahat, Sheharyar H. Khan, Frew Benson, David L. Heymann, Ziad A. Memish
Summary: With ongoing cholera outbreaks in many countries, the risk to MG events cannot be ignored. Cholera vaccine should be used to vaccinate high-risk populations in affected countries, but the lack of supply calls for an increase in vaccine availability.
JOURNAL OF TRAVEL MEDICINE
(2023)
Review
Immunology
Rina Fajri Nuwarda, Abdulsalam Abdullah Alharbi, Veysel Kayser
Summary: Influenza is a major public health concern, and vaccines are an effective method for prevention and control. New vaccine platforms and advancements in vaccine manufacturing processes are being explored to improve effectiveness and stability.
Article
Immunology
Tor Kristian Andersen, Johanna Bodin, Fredrik Oftung, Bjarne Bogen, Siri Mjaaland, Gunnveig Grodeland
Summary: The 2009 swine flu pandemic exposed the limitations of egg-based vaccines in terms of global supply, prompting the urgent need for efficient new vaccine platforms; DNA vaccines have since been developed as a temperature stable, cost-effective option for pandemic responses, capable of inducing rapid protective immune responses without the need for adjuvants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tanja Becker, Husni Elbahesh, Leslie A. Reperant, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus
Summary: Influenza vaccines have been available for over 80 years and have contributed significantly to reducing morbidity and mortality. However, limitations in their effectiveness persist due to antigenic evolution and production methods. Alternative approaches are being pursued to design and produce vaccines with broader and longer-lasting immune responses.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biotechnology & Applied Microbiology
Laura J. Fischer, Robert C. Rains, Sherry M. Brett-Major, Mikiko Senga, Debra Holden, David M. Brett-Major
Summary: With the recent COVID-19 pandemic, the importance of vaccine development, distribution, and uptake has gained significant attention. This review discusses the emergency setting and vaccine product design in relation to fielding vaccines, providing a concise source of expert knowledge that can aid future vaccine ventures and increase general awareness of the process and barriers in various settings.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Nathaniel M. Lewis, Jessie R. Chung, Timothy M. Uyeki, Lisa Grohskopf, Jill M. Ferdinands, Manish M. Patel
Summary: This study analyzes the comparability of relative vaccine effectiveness across different studies and suggests that this comparability is dependent on the absolute vaccine effectiveness of the comparator vaccine. These findings have implications for the design of influenza vaccine studies and data reporting.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Tracy A. Becerra-Culqui, Darios Getahun, Vicki Chiu, Lina S. Sy, Hung Fu Tseng
Summary: This study investigated the association between prenatal influenza vaccination or infection and autism spectrum disorder (ASD) in offspring. The findings showed no association between prenatal influenza vaccination or infection and ASD risk in children.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Constantina Boikos, Ian McGovern, Deborah Molrine, Justin R. Ortiz, Joan Puig-Barbera, Mendel Haag
Summary: This study summarizes the relative vaccine effectiveness (rVE) of the cell-based quadrivalent inactivated influenza vaccine (IIV4c) versus the egg-based quadrivalent influenza vaccines (IIV4e) in preventing influenza-related medical encounters (IRMEs). The results show that IIV4c consistently has higher relative effectiveness than IIV4e, regardless of the circulating strains and antigenic drift or egg adaptation.
Article
Immunology
Minjin Kim, Yucheol Cheong, Jinhee Lee, Jongkwan Lim, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: This study demonstrated that caspase-triggered live attenuated influenza vaccine induced broad reactive antibody response and provided heterosubtypic protection against diverse influenza viruses in mice model. The protection relied on non-neutralizing antibodies-mediated ADCC activities and robust mucosal secretion of sIgA, which highlight the potential of this vaccine as a promising option for developing a universal influenza vaccine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Ivan Martinez-Baz, Miguel Fernandez-Huerta, Ana Navascues, Francisco Pozo, Camino Trobajo-Sanmartin, Itziar Casado, Aitziber Echeverria, Carmen Ezpeleta, Jesus Castilla
Summary: This study estimated the effectiveness of the influenza vaccine in preventing outpatient and hospitalized cases in the 2022-2023 season. The results showed that the vaccine was effective against influenza B, moderately effective against A(H3N2), and ineffective against A(H1N1). The effectiveness of the vaccine was lower in hospitalized patients compared to outpatients, possibly due to a lower proportion of influenza B cases. The null effectiveness against A(H1N1) was consistent with antigenic drift and supported the use of a new composition for the 2023-2024 influenza vaccine.
Article
Immunology
Rowa Y. Alhabbab, Abdullah Algaissi, Ahmed Bakr Mahmoud, Almohanad A. Alkayyal, Sawsan Al-Amri, Mohamed A. Alfaleh, Mohammad Basabrain, Roua Abdullah Alsubki, Ibrahim S. Almarshad, Abdulelah M. Alhudaithi, Omar A. Al Gafari, Yasser A. Alshamlan, Hassan M. Aldossari, Mohammed M. Alsafi, Abdullah Bukhari, Wael Bajhmom, Ziad A. Memish, Waleed S. Al Salem, Anwar M. Hashem
Summary: In this study, the immune responses in MERS survivors were characterized and detectable and persistent MERS-CoV-specific humoral and cellular memory responses were found for up to 6.9 years.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Public, Environmental & Occupational Health
Ramadan A. Farahat, Sheharyar H. Khan, Frew Benson, David L. Heymann, Ziad A. Memish
Summary: With ongoing cholera outbreaks in many countries, the risk to MG events cannot be ignored. Cholera vaccine should be used to vaccinate high-risk populations in affected countries, but the lack of supply calls for an increase in vaccine availability.
JOURNAL OF TRAVEL MEDICINE
(2023)
Editorial Material
Public, Environmental & Occupational Health
Jaffar A. Al-Tawfiq, Rana F. Kattan, Saleh Abdullah S. Almoallem, Kauthar J. Altawfiq, Ezzeddine Mohsni, Ziad A. Memish
Summary: Polio is the longest-lasting Public Health Emergency of International Concern (PHEIC), and the ongoing outbreaks of cVDPV pose additional risks globally. The binary nature of PHEIC declarations does not support the continuation of the polio PHEIC due to the need for tiered or graded strategies to combat such diseases.
JOURNAL OF TRAVEL MEDICINE
(2023)
Editorial Material
Public, Environmental & Occupational Health
D. Katterine Bonilla-Aldana, Julian Ruiz-Saenz, Marlen Martinez-Gutierrez, Wilmer Villamil-Gomez, Hugo Mantilla-Meluk, German Arrieta, Darwin A. Leon-Figueroa, Vicente Benites-Zapata, Joshuan J. Barboza, Agueda Munoz-Del-Carpio-Toia, Oscar H. Franco, Maritza Cabrera, Ranjit Sah, Jaffar A. Al-Tawfiq, Ziad A. Memish, Fatma A. Amer, Jose Antonio Suarez, Andres F. Henao-Martinez, Carlos Franco-Paredes, Alimuddin Zumla, Alfonso J. Rodriguez-Morales
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Green & Sustainable Science & Technology
Najim Z. Z. Alshahrani, Iman Ridda, Harunor Rashid, Faris Alzahrani, Lujain Mohammed Bin Othman, Hassan Ali Alzaydani
Summary: This study investigated the willingness of the Saudi public to receive a COVID-19 vaccine booster dose and identified the factors that influenced their willingness. The results showed that 86.8% of the respondents were willing to receive a COVID-19 vaccine booster dose. Age, marital status, and prior receipt of an influenza vaccine were significantly associated with the willingness to receive the booster dose, while having a bachelor's degree or above and not following COVID-19 news were associated with a lower intention to receive the boosters.
Article
Infectious Diseases
Rr Suzy Indharty, Budi Sylvana, Liliek Marhaendo Susilo, Tety Rachmawati, Zolaiha Zuchdi, Imron Cahyono, Mohammad Imran Saleh Hamdani, Asep Kusnali, Dede Anwar Musadad, Muhammad Firdaus, Al Asyary, Ziad A. Memish
Summary: This study aimed to evaluate community readiness for performing the Hajj during the ongoing COVID-19 pandemic in Indonesia. The results showed that face-to-face health coaching was low, while online coaching was high. There is an urgent need to establish clear, meaningful, empathetic, consistent, and contextual messages to promote the health improvement of pilgrims.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Victor Daniel Rosenthal, Ruijie Yin, Sheila Nainan Myatra, Ziad A. Memish, Camilla Rodrigues, Mohit Kharbanda, Sandra Liliana Valderrama-Beltran, Yatin Mehta, Majeda Afeef Al-Ruzzieh, Guadalupe Aguirre-Avalos, Ertugrul Guclu, Chin Seng Gan, Luisa Fernanda Jimenez Alvarez, Rajesh Chawla, Sona Hlinkova, Rajalakshmi Arjun, Hala Mounir Agha, Maria Adelia Zuniga Chavarria, Narangarav Davaadagva, Yin Hoong Lai, Katherine Gomez, Daisy Aguilar-de-Moros, Chian-Wern Tai, Alejandro Sassoe Gonzalez, Lina Alejandra Aguilar Moreno, Kavita Sandhu, Jaroslaw Janc, Mary Cruz Aleman Bocanegra, Dincer Yildizdas, Yuliana Andrea Cano Medina, Maria Isabel Villegas Mota, Abeer Aly Omar, Wieslawa Duszynska, Amani Ali El-Kholy, Safaa Abdulaziz Alkhawaja, George Horhat Florin, Eduardo Alexandrino Medeiros, Lili Tao, Nellie Tumu, May Gamar Elanbya, Reshma Dongol, Vesna Mioljevic, Lul Raka, Lourdes Duenas, Nilton Yhuri Carreazo, Tarek Dendane, Aamer Ikram, Tala Kardas, Michael M. Petrov, Asma Bouziri, Nguyen Viet-Hung, Vladislav Belskiy, Naheed Elahi, Estuardo Salgado, Zhilin Jin
Summary: This study aimed to identify the incidence and risk factors of central-line-associated bloodstream infection (CLABSI) in low- and middle-income countries (LMICs). The results showed that the CLABSI rate in LMICs was significantly higher than that reported by CDC NHSN. Independent risk factors for CLABSI included length of stay, number of CL days, surgical hospitalization, tracheostomy use, hospital ownership and type, and ICU type. The study suggested reducing length of stay and CL days, using PICC instead of other types of central lines, and implementing evidence-based CLABSI prevention recommendations.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Infectious Diseases
Faizah Alotaibi, Naif Khalaf B. Alharbi, Lindsey Y. Rosen, Ayed M. Asiri, Abdullah H. Assiri, Hanan Balkhy, Majed Al Jeraisy, Yasser Mandourah, Sameera AlJohani, Shmeylan Al Harbi, Hani A. Aziz M. Jokhdar, Ahmad A. Deeb, Ziad Memish, Jesna Jose, Sameeh Ghazal, Sarah A. Al Faraj, Ghaleb Al Mekhlafi, Nisreen Murad Sherbeeni, Fatehi Elnour M. Elzein, Badriah AlMutairi, Abdulaziz L. Al-Dawood, Mashan Abdullah, Tlili W. Barhoumi, Mohammed Alenazi, Abdulrahman M. Almasood, Steven M. Holland, Yaseen Arabi, Saudi Critical Care Trials Grp
Summary: This study found the presence of autoantibodies to type I interferons (IFNs) in hospitalized MERS patients, especially in critically ill patients, which is associated with worse clinical outcomes.
INFLUENZA AND OTHER RESPIRATORY VIRUSES
(2023)
Article
Pharmacology & Pharmacy
Hatem A. Abuelizz, Ahmed H. Bakheit, Mohamed H. Al-Agamy, Harunor Rashid, Gamal A. E. Mostafa, Rashad Al-Salahi
Summary: Candida albicans is a common fungus that can cause invasive human diseases. Certain synthesized benzo[g]quinazoline compounds have shown good inhibitory effects against C. albicans and could be used as a model for the development of novel antifungal derivatives.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Letter
Surgery
Ismail Dergaa, Karim Chamari, Ramadan Abdelmoez Farahat, Mohamed Romdhani, Morteza Taheri, Ziad A. A. Memish, Samya A. A. Al Abdulla
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Immunology
Abdulkarim Alhetheel, Ahmed Albarrag, Zahid Shakoor, Ali Somily, Mazin Barry, Haifa Altalhi, Muhammed Bakhrebah, Majed Nassar, Mohamed Alfageeh, Ayed Assiri, Sarah Alfaraj, Ziad Memish
Summary: Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with intense pulmonary inflammation and chemokines play a role in leukocyte infiltration. This study found significantly higher levels of IP-10, MIP-1A, MIP-1B, MCP-1, and MIG in symptomatic MERS-CoV-infected patients compared to healthy controls. Asymptomatic patients also had elevated levels of IP-10 and MCP-1. Increased MCP-1 levels were associated with fatal outcomes.
Article
Health Care Sciences & Services
Khalid Alhasan, Malik Sallam, Fadi Aljamaan, Tariq Ali, Ahmed Al-jedai, Ahmed Nazmi, Aziza Ajlan, Hassan Aleid, Enaam Karar, Moheeb Al-Awwami, Hamad Almojalli, Yaser Zahir Shah, Amir Eltayeb Ismail Mohammed, Mazin Barry, Sarah Alsubaie, Abdulrahman Altheaby, Reem S. Almaghrabi, Sumayah Askandarani, Ziad A. Memish, Jaffar A. Al-Tawfiq, Dieter Clemens Broering, Mohamad-Hani Temsah
Summary: This survey aimed to assess the knowledge, perceptions, and advocacy of Mpox vaccines among solid organ transplant healthcare workers (HCWs) in Saudi Arabia. The majority of participants were more concerned about COVID-19 than Mpox, and less than 60% believed that all HCWs should be vaccinated. The results highlight the need for increased education on Mpox among transplant HCWs in Saudi Arabia.
Article
Immunology
Faeza Netfa, Catherine King, Cristyn Davies, Harunor Rashid, Mohamed Tashani, Robert Booy, Rachel Skinner
Summary: Background: Little data exists on whether HPV vaccination coverage varies by parents' cultural or ethnic background in Australia, which has a large immigrant population. This study aimed to identify facilitators and barriers to HPV vaccination among Arabic-speaking mothers in Western Sydney, South Western Sydney, and Wollongong, NSW, Australia. Methods: Interviews were conducted with sixteen mothers of adolescents from Arabic backgrounds, revealing facilitators (e.g., knowledge of HPV, trust in school vaccination program) and barriers (e.g., communication gaps, health system gaps) to HPV vaccination. Mothers suggested involving religious and cultural leadership, encouraging engagement with GPs, and providing school-based education to improve acceptance. Conclusion: Interventions via schools, health professionals, and religious and cultural organizations could assist Arabic-speaking immigrant families in HPV vaccination decision making.
Article
Infectious Diseases
Joanne Jackson, Nicole Sonneveld, Harunor Rashid, Larissa Karpish, Seaneen Wallace, Lisa Whop, Cyra Patel, Julia Brotherton, Han Wang, Alexandra Hendry, Brynley Hull, Katrina Clark, Stephen Lambert, Aditi Dey, Frank Beard
Summary: This report is the fifth comprehensive report by the National Centre for Immunisation Research and Surveillance (NCIRS) on vaccine preventable diseases (VPDs) and vaccination coverage in Aboriginal and Torres Strait Islander people from 2016 to 2019. It analyzes and assesses data on notifications, hospital admissions, deaths, and vaccination coverage to support service delivery, policy development, and further research. The report highlights achievements in improving the health of Aboriginal and Torres Strait Islander people through immunization programs and suggests future directions.
COMMUNICABLE DISEASES INTELLIGENCE
(2023)
Letter
Public, Environmental & Occupational Health
Nadeem Gul Dar, Sarah H. Alfaraj, Khulood N. Alboqmy, Hala Amer, Nazia Khanum, Faleh Alshakrah, Hassan Abdallah, Deva Kumar, Shaimaa H. Alzarzour, Nojoom A. Alzahrani, Jasser Y. Arishy, Suhair A. Ahmed, Vicenta Escorpion, Edna Lopez, Sami Jedeba, Ziad A. Memish
Summary: A cluster of 16 locally acquired monkeypox cases occurred in Riyadh, Saudi Arabia, with 10 cases reporting engaging in sexual behavior within 21 days before symptom onset, all of whom had heterosexual contact with illegal partners within 1 week before symptoms appeared.
JOURNAL OF TRAVEL MEDICINE
(2023)
