Article
Oncology
Naoki Fujita, Shingo Hatakeyama, Kazutaka Okita, Masaki Momota, Yuki Tobisawa, Tohru Yoneyama, Hayato Yamamoto, Atsushi Imai, Hiroyuki Ito, Takahiro Yoneyama, Yasuhiro Hashimoto, Kazuaki Yoshikawa, Chikara Ohyama
Summary: This study evaluated the impact and utility of intraoperative upper urinary tract cytology examination in patients with NMIBC who had undergone TURBT. The results showed a low positive predictive value for the intraoperative examination, leading to the conclusion that it may not be recommended for use in this patient population.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Anders Vikerfors, Sabina Davidsson, Janusz Frey, Tomas Jerlstrom, Jessica Carlsson
Summary: The study found that high serum PD-L1 levels are associated with aggressive disease and development of metastatic disease in BC patients, but no significant difference was found in urine sPD-L1 levels in BC patients.
Article
Oncology
Aleksander Slusarczyk, Piotr Zapala, Tomasz Piecha, Lukasz Zapala, Tomasz Borkowski, Piotr Radziszewski
Summary: The study found that patients who underwent radical nephroureterectomy for upper urinary tract urothelial cancer after radical cystectomy experienced poor overall survival and cancer-specific survival, with most surgeries being performed for locally advanced tumors. Independent risk factors for worse survival included UTUC T stage, presence of metastasis, and male gender.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Uwe Bieri, Benedikt Kranzbuehler, Burkhardt Seifert, Birgit Maria Helmchen, Alexander Gu, Basil Kaufmann, Dejan Lavrek, Thomas Scherer, Marian S. Wettstein, Cedric Poyet, Thomas Hermanns
Summary: Patients with non-muscle invasive urothelial bladder cancer are at increased risk for a secondary upper-urinary-tract urothelial carcinoma. Routine upper-tract imaging surveillance during bladder cancer follow-up may not be useful in detecting these secondary cancers. Risk-adjusted follow-up strategies should be explored in the future.
Article
Biology
Periklis Koukourikis, Maria Papaioannou, Petros Georgopoulos, Ioannis Apostolidis, Stavroula Pervana, Apostolos Apostolidis
Summary: Neurogenic bladder patients are at higher risk for advanced-stage bladder cancer, so it's important to develop non-invasive screening methods. A study found that changes in certain tumor-suppressing genes associated with bladder cancer were significantly more frequent in neurogenic bladder patients, especially in males. Biopsies showed a high percentage of chronic inflammation. Larger long-term studies are needed to establish the value of this non-invasive method in screening and diagnosis, as well as possible associations between gene changes, chronic inflammation, and bladder cancer in the neurogenic population.
Article
Oncology
Wei Ouyang, Lufeng Luo, Junjie Zhang, Ran Xu, Qiang Lu, Zhenzhou Xu, Jianye Liu, Pei Li, Yaqun Zhang, Chuanchi Zhou, Wei Tang, Zhenting Wang, Manman Cao, Genming Xu, Long Wang
Summary: A novel diagnostic model combining NRN1 methylation and gene mutation (FGFR3 and TERT) with age was developed and validated for analyzing the risk of upper tract urothelial carcinoma in hematuria patients, leading to a reduction in the need for invasive examinations.
Article
Oncology
Yansheng Xu, Xin Ma, Xing Ai, Jiangping Gao, Yiming Liang, Qin Zhang, Tonghui Ma, Kaisheng Mao, Qiaosong Zheng, Sizhen Wang, Yuchen Jiao, Xu Zhang, Hongzhao Li
Summary: This study utilized the epigenetic biomarker ONECUT2 for the first time in the detection of UTUC and combined it with high-throughput sequencing to improve sensitivity. The logistic regression model developed showed high accuracy in predicting UTUC risk and outperformed other existing panels. Additionally, the high negative predictive value of the model helps to exclude patients without UTUC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Eva Castellano, Celia Samba, Gloria Esteso, Laura Simpson, Elena Vendrame, Eva M. Garcia-Cuesta, Sheila Lopez-Cobo, Mario Alvarez-Maestro, Ana Linares, Asier Leibar, Thanmayi Ranganath, Hugh T. Reyburn, Luis Martinez-Pineiro, Catherine Blish, Mar Vales-Gomez
Summary: In this study, the phenotype of cells released into the urine of bladder cancer patients 3-7 days after BCG instillations was analyzed using mass cytometry. Informative markers associated with treatment response were identified. Further studies should evaluate cells and soluble factors in urine in larger cohorts of patients to characterize the immune response and identify the risk of complications from BCG treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Bo Fan, Yuanbin Huang, Shuang Wen, Qiliang Teng, Xinrui Yang, Man Sun, Tingyu Chen, Yan Huang, Yumei Wang, Zhiyu Liu
Summary: Preoperative urine cytology has been validated as a potential predictor of intravesical recurrence in UUT-UC patients after RNU, with significant improvement in predictive efficacy and accuracy when combined with other factors. Preoperative positive urine cytology is associated with an increased risk of IVR and malignant biological behavior.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Thomas van Doeveren, Jose A. Nakauma-Gonzalez, Andrew S. Mason, Geert J. L. H. van Leenders, Tahlita C. M. Zuiverloon, Ellen C. Zwarthoff, Isabelle C. Meijssen, Angelique C. van der Made, Antoine G. van Der Heijden, Kees Hendricksen, Bas W. G. van Rhijn, Charlotte S. Voskuilen, Job van Riet, Winand N. M. Dinjens, Hendrikus J. Dubbink, Harmen J. G. van de Werken, Joost L. Boormans
Summary: By sequencing genes in 15 UTUC patients treated by RNU, it was found that the majority of patients had a clonal relationship between UTUC and subsequent UCB, supporting the idea that UCBs following UTUC surgery are primarily clonally derived recurrences.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Cell Biology
Simon Walz, Paul Pollehne, Philipp Vollmer, Wilhelm K. Aicher, Arnulf Stenzl, Niklas Harland, Bastian Amend
Summary: Different scaffolds have different effects on cell growth and protein expression in bladder cancer cells. BME is more effective in promoting organoid growth and protein expression.
Article
Chemistry, Analytical
Xiaowei Wei, Lijun Cai, Hanxu Chen, Luoran Shang, Yuanjin Zhao, Weijian Sun
Summary: This study proposes a novel system for multiplexed analysis of bladder cancer-derived urine exosomes using magnetic microspheres as barcoded microcarriers. The unique structure of the microcarriers allows for controllable movement and high sensitivity detection of exosomes. The noninvasive nature of the platform, combined with its good sensitivity, specificity, low sample consumption, and ease of use, indicates its great potential for bladder cancer diagnosis in clinical applications.
ANALYTICAL CHEMISTRY
(2022)
Article
Urology & Nephrology
David D'Andrea, Surena Matin, Peter C. Black, Firas G. Petros, Homayoun Zargar, Colin P. Dinney, Michael S. Cookson, Wassim Kassouf, Marc A. Dall'Era, John S. McGrath, Jonathan L. Wright, Andrew C. Thorpe, Todd M. Morgan, Jeffrey M. Holzbeierlein, Trinity J. Bivalacqua, Srikala S. Sridhar, Scott North, Daniel A. Barocas, Yair Lotan, Andrew J. Stephenson, Bas W. van Rhijn, Philippe E. Spiess, Siamak Daneshmand, Shahrokh F. Shariat
Summary: The study found that patients with UTUC had a lower rate of pathological complete response but a higher rate of pathological objective response after NAC treatment. Cox regression analysis revealed that UTUC patients had better overall survival and cancer-specific survival outcomes.
Article
Pediatrics
Qi Li, Miao Cai, Qingsong Pu, Shengde Wu, Xing Liu, Tao Lin, Dawei He, Jianguo Wen, Guanghui Wei
Summary: The study aimed to establish a predictive model for upper urinary tract damage (UUTD) in children with neurogenic bladder (NB) and verify its efficacy. Recurrent urinary tract infection, bladder compliance, detrusor leak point pressure, overactive bladder, and clean intermittent catheterization were identified as predictors. The nomogram showed good discrimination and clinical applicability in assessing the risk of progressing to UUTD in NB children.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Zhi-Cheng Gong, Zhi-Liang Wu, Yao-An Wen, Jie-Peng Zou, Xisheng Wang, Xiaoyan Leng, Anthony J. Bleyer, Chunhua Deng, Michael P. Feloney, Yuanyuan Zhang, Shan-Chao Zhao
Summary: Male patients with bladder stones often experience sexual dysfunction and lower urinary tract symptoms, which can be significantly improved by surgical removal of the stones. Patients with BPH are more likely to have sexual dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Cell & Tissue Engineering
Dae Hwan Kim, So Young Chun, EunHye Lee, Bomi Kim, BoHyun Yoon, Haejung Gil, Man-Hoon Han, Yun-Sok Ha, Jun Nyung Lee, Tae Gyun Kwon, Bum Soo Kim, Byung Ik Jang
Summary: IL-10 deficiency exacerbates renal inflammation, fibrosis, and functional failure in high-fat diet-induced obese mice, suggesting that IL-10 therapy may be applicable to obesity-related chronic renal failure.
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
Article
Urology & Nephrology
Hwanik Kim, Byong Chang Jeong, Sangchul Lee, Ja Hyeon Ku, Tae Gyun Kwon, Tae-Hwan Kim, Seung Hyun Jeon, Sang Hyub Lee, Jong Kil Nam, Wansuk Kim, Ji Youl Lee, Sung Hoo Hong, Koon Ho Rha, Woong Kyu Han, Won Sik Ham, Young Goo Lee, Yong Seong Lee, Sung Yul Park, Young Eun Yoon, Sung Gu Kang, Seok Ho Kang, Jong Jin Oh
Summary: The study aimed to evaluate postoperative complications in patients with bladder cancer who underwent robot-assisted radical cystectomy and identify predictors for these complications. The results showed that patients with diabetes mellitus, chronic kidney disease, dyslipidemia, or a larger intraoperative fluid volume were more likely to develop postoperative complications. Additionally, patients with postoperative complications had a possibility of lower cancer-specific survival rate.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Eun Hye Lee, So Young Chun, Bo Hyun Yoon, Hyun Tae Kim, Jae-Wook Chung, Jun Nyung Lee, Yun-Sok Ha, Tae Gyun Kwon, Kyeong-Hyeon Byeon, Bum Soo Kim
Summary: This study found that renal extracellular matrix can be a suitable material for the culture and usage of renal proximal tubular epithelial (RPTE) cells. By using renal extracellular matrix as coating, hydrogel, and scaffold materials, it can promote the proliferation of RPTE cells and maintain their cellular properties.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Andrology
Gyoohwan Jung, Jung Kwon Kim, Seong Soo Jeon, Jae Hoon Chung, Cheol Kwak, Chang Wook Jeong, Hanjong Ahn, Jae Young Joung, Tae Gyun Kwon, Sung Woo Park, Seok-Soo Byun
Summary: The Korean Urological Oncology Society (KUOS) established a prospective registry for the active surveillance (AS) of prostate cancer (PC) using their database and presented interim analysis. From May 2019 to June 2021, a total of 296 patients were enrolled in the registry, and 284 patients were analyzed.
WORLD JOURNAL OF MENS HEALTH
(2023)
Article
Urology & Nephrology
Hyun Jung Jin, Ji Sung Shim, Tae Gyun Kwon, Tae-Hwan Kim, Seung Hyun Jeon, Sang Hyub Lee, Sung Gu Kang, Jong Kil Nam, Wan Suk Kim, Byung Chang Jeong, Jong Jin Oh, Sang Chul Lee, Ji Youl Lee, Sung-Hoo Hong, Koon Ho Rha, Woong Kyu Han, Won Sik Ham, Young Goo Lee, Yong Seong Lee, Sung Yul Park, Young Eun Yoon, Ja Hyeon Ku, Seok Ho Kang
Summary: This study compared the perioperative and oncologic outcomes of robot-assisted radical cystectomy (RARC) in female and male patients. The results showed that female and male patients had comparable perioperative outcomes and complication rates, but the type of complications differed by sex. The 5-year survival rates were also similar between female and male patients.
INVESTIGATIVE AND CLINICAL UROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Eun Hye Lee, So Young Chun, Jun Nyung Lee, Bo Hyun Yoon, Jae-Wook Chung, Man-Hoon Han, Tae Gyun Kwon, Yun-Sok Ha, Bum Soo Kim
Summary: This study aims to extract high-quality and high-purity human collagen from human perirenal adipose tissue, and develop a extraction process superior to traditional methods to improve yield, cellular compatibility, and physicochemical properties.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Eun Hye Lee, Jae-Wook Chung, Eunji Sung, Bo Hyun Yoon, Minji Jeon, Song Park, So Young Chun, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, Tae Hwan Kim, Seock Hwan Choi, Eun Sang Yoo, Tae Gyun Kwon, Ho Won Kang, Wun-Jae Kim, Seok Joong Yun, Sangkyu Lee, Yun-Sok Ha
Summary: This study evaluated the role of PDK4 in bladder cancer and its related protein changes. It was found that elevated expression of PDK4 was observed in high-grade bladder cancers. Knockdown of PDK4 in bladder cancer cells resulted in reduced cell migration and invasion. Additionally, a PDK4 knockdown xenograft model showed reduced bladder cancer growth. These findings suggest that PDK4 plays a critical role in the metastasis and growth of bladder cancer cells through changes in ERK, SRC, and JNK.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jae-Wook Chung, Jun-Koo Kang, Se Won Jang, Eun Hye Lee, So Young Chun, Seock Hwan Choi, Jun Nyung Lee, Bum Soo Kim, Hyun Tae Kim, See Hyung Kim, Tae-Hwan Kim, Eun Sang Yoo, Tae Gyun Kwon, Dong Jin Park, Yun-Sok Ha
Summary: The study aimed to establish an objective standard for the optimal timing of preoperative chest CT in patients with renal cell carcinoma (RCC). The study found that cT stage (≥ cT1b), Charlson comorbidity index (CCI) ≥ 4, and low albumin/globulin ratio (AGR) were associated with a higher risk of positive chest CT scans. The proposed strategy for chest CT scans had a superior net benefit compared to other strategies. Therefore, the study recommends chest CT in patients with ≥ cT1b disease, CCI ≥ 4, and low AGR.
Article
Computer Science, Interdisciplinary Applications
Bong-Il Song, Jinny Lee, Wonho Jung, Bum Soo Kim
Summary: This study demonstrates that the variant coefficient of stone density measured by a three-dimensional segmentation-based method can be used to differentiate pure uric acid stones from non-pure uric acid stones, providing a prediction model for preoperative pure uric acid stones and reducing invasive procedures.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hyung Jun Kwon, So Young Chun, Eun Hye Lee, BoHyun Yoon, Man-Hoon Han, Jae-Wook Chung, Yun-Sok Ha, Jun Nyung Lee, Hyun Tae Kim, Dae Hwan Kim, Tae Gyun Kwon, Bum Soo Kim, Syng-Ook Lee, Byung Ik Jang
Summary: Ulcerative colitis is characterized by inflammation in the colon, and obesity is closely related to its occurrence and progression. The connection between obesity and colitis is primarily through excessive adipogenesis-related inflammatory responses that cause mucosal dysfunction. Several etiological mechanisms, including excessive adipogenesis, lipotoxicity, pro-inflammatory adipokines/cytokines, macrophage polarization, oxidative stress, endoplasmic reticulum stress, and gut microbiota, link obesity and colitis. The resulting low-grade enteric inflammations lead to mucosal layer damage, especially goblet cell dysfunction, ultimately resulting in colitis. Inhibiting the inflammatory response is the most effective approach for treating obesity-related colitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Do Hae Jung, Joo Yong Lee, Dong Hyuk Kang, Kyungtae Ko, Dong Hoon Koh, Ohseong Kwon, Kyo Chul Koo, Kwang Taek Kim, Myung Soo Kim, Bum Soo Kim, Hyeon Woo Kim, Juhyun Park, Woojin Bang, Kyung-Jin Oh, Young Eun Yoon, Ki Soo Lee, Dong Sup Lee, Sang Hyub Lee, Seungsoo Lee, Hun Joo Lee, Wonho Jung, Dae Sung Cho, Sung Yong Cho, Min Soo Choo, Jae Young Choi, Taesoo Choi, Deok Hyun Han, Byoung Kyu Han, Seung Hyun Jeon, Sunghyun Paick, Ill Young Seo, Hyung Joon Kim
Summary: This article provides evidence-based recommendations and expert opinions to help urologists make optimal decisions in managing urolithiasis. Frequently asked questions by urologists in clinical practice are addressed based on the latest evidence and expert opinions. The authors offer practical guidance for the diagnosis, treatment, and prevention of urolithiasis in various clinical scenarios. It serves as a valuable resource for urologists.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Urology & Nephrology
Dong Jin Park, Bum Soo Kim, Soon Oh Kwon, Jae-Wook Chung, Yun-Sok Ha, Seock Hwan Choi, Hyun Tae Kim, Eun Sang Yoo
Summary: This study compared the characteristics of asymptomatic and symptomatic nephrolithiasis in patients who underwent surgical treatment for kidney stones. The results showed that the asymptomatic group had a significantly higher body mass index (BMI) and a significantly lower urine pH, while the symptomatic group had a significantly higher proportion of calcium oxalate dihydrate stones. The multivariate logistic regression analysis indicated that BMI and urine pH were independent predictive variables for asymptomatic renal stones.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Urology & Nephrology
Seung-hwan Jeong, Sang Eun Yeon, Su Youn Kim, Tae Gyun Kwon, Seong Soo Jeon, Young Deuk Choi, Dongdeuk Kwon, Byung Ha Chung, Sung-Hoo Hong, Byung Hoon Kim, Hyo Jin Lee, Sang Joon Shin, Woo Suk Choi, Sung Woo Park, Taek Won Kang, Seok Joong Yun, Jin Seon Cho, See Min Choi, Na-Ri Lee, Cheol Kwak
Summary: This study evaluated the effectiveness and safety of AAP in patients with metastatic castration-resistant prostate cancer (mCRPC) in pre- and post-chemotherapy settings, using real-world data.
INVESTIGATIVE AND CLINICAL UROLOGY
(2023)
Article
Andrology
Jae Hoon Chung, Tae Gyun Kwon, Cheol Kwak, Gyung Tak Sung, Soo Dong Kim, Jin Seon Cho, Hyung Jin Kim, Hanjong Ahn, Seong Soo Jeon
Summary: This study evaluated the efficacy and safety of udenafil in patients with erectile dysfunction following bilateral nerve-sparing robot-assisted laparoscopic radical prostatectomy. The results showed that udenafil improved erectile function without any severe adverse effects.
WORLD JOURNAL OF MENS HEALTH
(2023)
