Article
Medicine, Research & Experimental
Merve Denizalti, Irfan Anjum, Gul Simsek, Sevgen Celik Onder, Nezahat Tugba Durlu-Kandilci
Summary: This study investigates the expression and effects of protease activated receptors (PARs) in interstitial cystitis/bladder pain syndrome (IC/BPS). Results show that PAR1 and PAR2 are expressed in rat bladder, and trypsin-induced contractions are potentiated in CYP-induced cystitis. PAR2 is identified as the main PAR subtype involved in IC/BPS. IP3 and Ca2+ sensitization are found to play important roles in cystitis pathology.
Article
Urology & Nephrology
Rehab Sabri Abdelrahman, Eman Mohamad El Nashar, Mansour Abdullah Alghamdi, Khulood Mohammed Al-Khater, Reham Ismail Taha
Summary: This study aimed to investigate the effect of Vinpocetine on cyclophosphamide-induced cystitis and found that Vinpocetine could alleviate inflammation and protect the bladder.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhimin Mao, Kun Zhong, Xiaojun Liu, Xuhui Zeng
Summary: This study revealed that ferroptosis is an important mechanism underlying CYP-induced cystitis. The use of ferroptosis inhibitors can improve ferroptosis and prevent bladder damage caused by CYP.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Tsubasa Ochiai, Yuka Sasaki, Chieko Yokoyama, Hiroshi Kuwata, Shuntaro Hara
Summary: The study revealed that PTGIS-derived PGI(2)-IP signaling exacerbated CP-induced bladder inflammatory reactions, while Ptgis deficiency or treatment with an IP selective antagonist could suppress CP-induced bladder inflammation and hemorrhagic cystitis, thus relieving nociceptive behavior.
Article
Medicine, Research & Experimental
Rania A. Elrashidy, Rehab A. Hasan
Summary: The study demonstrated that montelukast has a superior protective effect against CPA-induced HC compared to MESNA. Montelukast protects the bladder from damage by inhibiting inflammatory responses and promoting cellular autophagy.
Article
Pharmacology & Pharmacy
Shiori Kawasaki, Masahiko Soga, Yusuke Sakurai, Isamu Nanchi, Miyuki Yamamoto, Sunao Imai, Tatsuya Takahashi, Naoki Tsuno, Toshiyuki Asaki, Yasuhide Morioka, Masahide Fujita
Summary: The study suggests the involvement of TRPV4 in bladder pain in a mouse cystitis model, indicating that a TRPV4 antagonist may be useful for patients with irritable bladder pain such as those with interstitial cystitis/painful bladder syndrome.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Yuan-Hsiang Hsu, Hann-Chorng Kuo
Summary: This study investigated the usefulness of urinary biomarkers in assessing bladder condition and histopathology in IC/BPS patients. The results show that urinary biomarker levels are associated with symptoms and pathological manifestations, helpful in identifying HIC and NHIC subtypes, but most biomarkers are not strongly correlated with specific bladder histopathological findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Maryam Fatima, Irfan Anjum, Aamir Abdullah, Shaun Zshaan Abid, Muhammad Nasir Hayat Malik
Summary: The study demonstrates the protective effect of boswellic acids on cyclophosphamide-induced cystitis in rats, indicating their potential as therapeutic alternatives for cystitis. Boswellic acids exhibit antioxidant and anti-inflammatory properties, reducing urothelial damage and inflammation.
Article
Immunology
Sonia Kiran, Ahmed Rakib, Udai P. Singh
Summary: This study found that the NLRP3 inhibitor dapansutrile (Dap) can improve bladder inflammation and suppress interstitial cystitis (IC) by reducing the number of CXCR3(+)T cells, mast cells, and neutrophils, and inducing the production of dendritic cells (DCs) as a protective measure.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andrzej Wrobel, Lukasz Zapala, Tomasz Kluz, Artur Rogowski, Marcin Misiek, Kajetan Juszczak, Jacek Sienko, Daniela Gold, Klaudia Stangel-Wojcikiewicz, Ewa Poleszak, Piotr Radziszewski
Summary: Administration of asiatic acid in rats with CYP-induced cystitis resulted in improved bladder function, decreased inflammation, and modulation of various biomarkers in both bladder urothelium and detrusor muscle. Asiatic acid demonstrated efficacy as a potential treatment for CYP-induced cystitis in rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Murat Demir, Fikret Altindag
Summary: This study aimed to investigate the effects of berberine and curcumin on cyclophosphamide-induced cystitis. The results showed that treatment with berberine and curcumin could reduce pathological changes, apoptosis, and inflammation in cystitis.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhenglin Chang, Lingyue An, Zhican He, Yuyan Zhang, Shujue Li, Min Lei, Peng Xu, Yongchang Lai, Zheng Jiang, Yapeng Huang, Xiaolu Duan, Wenqi Wu
Summary: The study revealed that allicin in garlic is a key active component in treating UTIs through modulation of immune and inflammatory responses mainly via the AKT/NF-kappa B pathway.
Article
Multidisciplinary Sciences
Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash, Jau-Song Yu
Summary: Chronic ketamine abuse is found to be associated with bladder dysfunction and cystitis, with significant changes in urinary protein profiles, particularly an increase in APOA1 levels. Furthermore, urinary ketamine and metabolites are positively correlated with symptoms of overactive bladder syndrome, urinary RBC/WBC, and pain rating scale in ketamine abusers, providing potential insights for new molecular tools to manage ketamine-induced bladder dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Lucas Solyano Almeida de Oliveira, Sara Raquel de Moura Bandeira, Rodrigo Lopes Gomes Goncalves, Benedito Pereira de Sousa Neto, Diana Carvalho de Rezende, Antonio Carlos dos Reis-Filho, Ian Jhemes Oliveira Sousa, Flaviano Ribeiro Pinheiro-Neto, Boris Timah Acha, Gabriela do Nascimento Caldas Trindade, Lazaro Gomes do Nascimento, Damiao Pergentino de Sousa, Fernanda Regina de Castro Almeida, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Francisco de Assis Oliveira
Summary: The study found that isopropyl gallate (IPG) can alleviate ifosfamide (IFOS)-induced hemorrhagic cystitis by enhancing antioxidant activity and anti-inflammatory mechanisms. This suggests that IPG may be a promising adjuvant therapy for oxazaphosphorine-based chemotherapy treatments.
Article
Medicine, Research & Experimental
Seckin Engin, Elif Nur Barut, Yesim Kaya Yasar, Aysun Celik Soysal, Tugba Arici, Gokcen Kerimoglu, Mine Kadioglu, Sena F. Sezen
Summary: Trimetazidine (TMZ) exerts protective effects in cyclophosphamide (CP)-induced cystitis through inhibiting TLR4/ NF Kappa B signaling. TMZ improves histological disturbances and contraction abnormalities in the bladder by enhancing antioxidant capacity and suppressing inflammation, as indicated by decreased TNF-alpha and IL-1 beta levels. However, TMZ also enhances the cytotoxicity of CP when combined.