Review
Biochemistry & Molecular Biology
Justyna Suwara, Ewa Radzikowska-Cieciura, Arkadiusz Chworos, Roza Pawlowska
Summary: ATP is a crucial molecule for nucleic acids biosynthesis and intracellular energy storage, but it also functions as a signaling molecule. This article summarizes the latest data on the role of ATP in intra- and extracellular signaling pathways, including purinergic signaling, MAP kinase pathway, mTOR, and calcium signaling. The importance of ATP-dependent processes in maintaining the proper functioning of various systems and the potential pathological consequences of ATP imbalance are discussed, including neurodegenerative diseases, cardiovascular diseases, diabetes, obesity, cancers, and immune pathogenesis.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Nicholas Dale
Summary: This review emphasizes the importance of real-time measurements of extracellular ATP and adenosine concentrations, provides additional mechanistic insights, and outlines current techniques available for spatially localized measurements. The examples of CO2 and nutrient sensing highlight the impact of direct real-time measurements, demonstrating the role of purinergic signaling in breathing control, weight regulation, and sleep-wake state. Additionally, the complex mechanisms of activity-dependent adenosine release in different brain regions are discussed, underscoring the potential of whole blood purine measurements in clinical practice.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Duo Wang, Zirui Zeng, Mengyue Shen, Ryuji Okazaki, Hironori Miyata, Tomo Yonezawa, Yasuhiro Yoshida
Summary: Neutrophil endocytosis is closely related to ATP-centered energy metabolism. Inhibition of dynamin inhibits ATP consumption triggered by neutrophil endocytosis, while inhibition of ATP synthase and nicotinamide adenine dinucleotide phosphate oxidase suppresses neutrophil endocytosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Valentina Carotti, Juan P. Rigalli, Jenny van Asbeck-van der Wijst, Joost G. J. Hoenderop
Summary: Purinergic signalling is a process mediated by purinergic receptors, where extracellular nucleotides and nucleosides bind to the receptors, resulting in changes in cell physiology. This signalling is involved in important physiological processes and pathophysiological situations such as cancer and inflammation. Extracellular vesicles (EVs) play a crucial role in modulating purinergic signalling and can affect target cells and tissues located at distant locations. The regulation of extracellular ATP levels and adenosine by EVs has significant impact on processes like inflammation, immune response, and cancer pathogenesis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Julia Leao Batista Simoes, Helena Fornari Basso, Greicy Cristine Kosvoski, Jullye Gavioli, Filomena Marafon, Charles Elias Assmann, Fabiano Barbosa Carvalho, Margarete Dulce Bagatini
Summary: COVID-19 is caused by a new member of the Coronaviridae family, the SARS-CoV-2 virus, which infects the respiratory tract by binding to ACE2 receptors. The infection triggers immune responses and cytokine storm, leading to severe respiratory symptoms and potential organ failure. Modulating purinergic receptors may offer a promising therapeutic approach to mitigate the severity of the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Fisheries
Shuo Li, Tongtong Zhang, Yu Feng, Jinsheng Sun
Summary: Extracellular nucleotides, such as ATP and ADP, released during inflammation or infection, play a crucial role in regulating immune responses in fish by activating specific purinergic receptors on immune cells.
Review
Neurosciences
Edward Beamer, Manvitha Kuchukulla, Detlev Boison, Tobias Engel
Summary: Despite progress in understanding the pathogenesis of hyperexcitable networks and lowered seizure thresholds, treating epilepsy remains challenging. Many patients are resistant to current medications, which only provide symptomatic relief. Efforts are focused on finding new treatments with novel mechanisms of action to modify disease progression. Purines like ATP and adenosine play key roles in the epileptogenic process, with potential as targets for therapeutic strategies.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Yunshuo Zhao, Xiaotong Chen, Zhe Ding, Chuanjie He, Guanfei Gao, Sifan Lyu, Yanfeng Gao, Jiangfeng Du
Summary: This study successfully identified a CD39 inhibitor through a combination of methods, demonstrating its effectiveness in inhibiting CD39 enzyme activity and suppressing tumor cell proliferation. Understanding the binding mode and mechanism of action of the inhibitor can potentially lead to further optimization and exploration of its anticancer activity in vivo.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Pharmacology & Pharmacy
Waldemar Schaefer, Tobias Staehler, Carolina Pinto Espinoza, Welbeck Danquah, Jan Hendrik Knop, Bjoern Rissiek, Friedrich Haag, Friedrich Koch-Nolte
Summary: P2X7, an ion channel gated by extracellular ATP, plays important roles in inflammation and apoptosis. Polymorphisms in the P2X7 gene are common, and their frequencies vary among different human populations. Considering P2X7 variants of participants is important in designing clinical trials targeting P2X7.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
R. O. Leite, P. O. de Souza, C. B. Haas, F. da Silveira, K. R. Mohr, A. P. S. Bertoni, M. S. Soares, J. H. Azambuja, M. Dal Pra, L. L. P. da Cruz, N. E. Gelsleichter, K. Begnini, G. Hasko, M. R. Wink, R. M. Spanevello, E. Braganhol
Summary: Sepsis is a life-threatening organ dysfunction caused by a dysregulated inflammatory response to infection. Purinergic signaling, mediated by purines such as ATP and adenosine, plays a crucial role in the immune and inflammatory responses during sepsis. Sepsis disrupts the balance of ATP and adenosine levels, leading to dysregulation of immune responses. The measurement of serum levels and activities of purinergic pathway markers may serve as potential biomarkers for sepsis diagnosis and treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Physiology
Mafalda S. L. Aresta Branco, Alejandro Gutierrez Cruz, Jacob Dayton, Brian A. Perrino, Violeta N. Mutafova-Yambolieva
Summary: Prior studies indicate that ATP released by the urothelium plays an important role in bladder mechanotransduction and undergoes hydrolysis during bladder filling. Experimental results show that the hydrolysis of ATP and ADP is significantly greater in distended bladders compared to non-distended bladders, while the hydrolysis of AMP remains unchanged. Furthermore, the activity of nucleotidases is also higher in the extraluminal solution from distended bladders. These findings suggest that the hydrolysis reaction during bladder filling is mechanosensitive.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Microbiology
Catherine S. Nation, Akram A. Da'dara, Manal Elzoheiry, Patrick J. Skelly
Summary: Schistosomes promote Treg survival by cleaving NAD and ATP, creating a less hostile immune environment for the parasites.
Review
Medicine, Research & Experimental
Karine Paula Reichert, Milagros Fanny Vera Castro, Charles Elias Assmann, Nathieli Bianchin Bottari, Vanessa Valeria Miron, Andreia Cardoso, Naiara Stefanello, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
Summary: This review focuses on the role of the purinergic system in diabetes and hypertension, highlighting changes in the expression of P1 and P2 receptors, as well as the activities of CD39, CD73, and ADA. It suggests that manipulating the purinergic axis at various levels could potentially prevent or exacerbate the development of diabetes and hypertension as a compensatory mechanism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Takahiro Kumagawa, Nobuhiro Moro, Takeshi Maeda, Masato Kobayashi, Yuto Furukawa, Katsunori Shijo, Atsuo Yoshino
Summary: The aim of this study was to investigate the effects of P2Y1 receptor blockers on postinjury inflammatory responses in cerebral contusion injury. The results showed that the administration of P2Y1 receptor blockers successfully suppressed microglial activation but did not improve behavioral outcomes.
BRAIN RESEARCH BULLETIN
(2022)
Review
Immunology
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu
Summary: This review examines the role of purinergic signaling in ischemia-reperfusion injury and rejection after heart transplantation, as well as its clinical applications and prospects.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Urology & Nephrology
Toby C. Chai, Tirsit S. Asfaw, Jan E. Baker, Becky Clarkson, Pamela Coleman, Susan Hoffstetter, Kimberly Konkel, Missy Lavender, Shailaja Nair, Jenna Norton, Leslee Subak, Anthony Visco, Robert A. Star, Tamara Bavendam
JOURNAL OF UROLOGY
(2017)
Article
Cell Biology
Ming Lu, Jian-Ri Li, Lery Alvarez-Lugo, Yan Li, Shan Yu, XuanHao Li, Benkang Shi, Toby C. Chai
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2018)
Article
Urology & Nephrology
Marian Acevedo-Alvarez, Judy Yeh, Lery Alvarez-Lugo, Ming Lu, Nitin Sukumar, Warren G. Hill, Toby C. Chai
NEUROUROLOGY AND URODYNAMICS
(2018)
Article
Multidisciplinary Sciences
Haeyeong Lee, Byoung H. Koh, Lauren E. Peri, Robert D. Corrigan, Hyun-Tai Lee, Nikita E. George, Bhupal P. Bhetwal, Yeming Xie, Brian A. Perrino, Toby C. Chai, Kenton M. Sanders, Sang Don Koh
SCIENTIFIC REPORTS
(2017)
Review
Endocrinology & Metabolism
Benjamin Abelson, Daniel Sun, Lauren Que, Rebecca A. Nebel, Dylan Baker, Patrick Popiel, Cindy L. Amundsen, Toby Chai, Clare Close, Michael DiSanto, Matthew O. Fraser, Stephanie J. Kielb, George Kuchel, Elizabeth R. Mueller, Mary H. Palmer, Candace Parker-Autry, Alan J. Wolfe, Margot S. Damaser
BIOLOGY OF SEX DIFFERENCES
(2018)
Article
Biochemical Research Methods
Ming Lu, Kejia Zhu, Peter G. Schulam, Toby C. Chai
Article
Urology & Nephrology
Jennifer Anger, Una Lee, A. Lenore Ackerman, Roger Chou, Bilal Chughtai, J. Quentin Clemens, Duane Hickling, Anil Kapoor, Kimberly S. Kenton, Melissa R. Kaufman, Mary Ann Rondanina, Ann Stapleton, Lynn Stothers, Toby C. Chai
JOURNAL OF UROLOGY
(2019)
Article
Cell Biology
Zonglong Wu, Yan Li, Qinggang Liu, Yaxiao Liu, Lipeng Chen, Hongda Zhao, Hongda Guo, Kejia Zhu, Nan Zhou, Toby C. Chai, Benkang Shi
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2019)
Article
Environmental Sciences
Deepa R. Camenga, Sonya S. Brady, Cecilia T. Hardacker, Beverly R. Williams, Jeni Hebert-Beirne, Aimee S. James, Kathryn Burgio, Jesse Nodora, Jean F. Wyman, Amanda Berry, Lisa K. Low, Linda Brubaker, Elizabeth R. Mueller, Colleen M. Fitzgerald, Jennifer M. Hebert-Beirne, Missy Lavender, David A. Shoham, Kathryn L. Burgio, Cora E. Lewis, Alayne Markland, Gerald McGwin, Camille Vaughan, Beverly Rosa Williams, Emily S. Lukacz, Sheila Gahagan, D. Yvette LaCoursiere, Jesse N. Nodora, Janis M. Miller, Lawrence Chin- An, Lisa Kane Low, Bernard L. Harlow, Kyle D. Rudser, Haitao Chu, John Connett, Melissa Constantine, Cynthia Fok, Sarah Lindberg, Todd Rockwood, Diane Kaschak Newman, C. Neill Epperson, Kathryn H. Schmitz, Ariana L. Smith, Ann Stapleton, Jean Wyman, Siobhan Sutcliffe, Jerry L. Lowder, Leslie Rickey, Shayna D. Cunningham, Toby Chai, Jessica B. Lewis, Tamara Bavendam, Ziya Kirkali, Chris Mullins, Jenna Norton
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2019)
Article
Urology & Nephrology
Raj Ayyagari, Taylor Powell, Lawrence Staib, Julius Chapiro, Juan-Carlos Perez-Lozada, Shivank Bhatia, Toby Chai, Steven Schoenberger, Ralph Devito
Article
Radiology, Nuclear Medicine & Medical Imaging
Raj Ayyagari, Taylor Powell, Lawrence Staib, Julius Chapiro, Anusha Raja, Shivank Bhatia, Toby Chai, Steven Schoenberger, Ralph Devito
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Article
Urology & Nephrology
Eric Rovner, Toby C. Chai, Sharon Jacobs, George Christ, Karl-Erik Andersson, Mitchell Efros, Victor Nitti, Kelvin Davies, Andrew R. McCullough, Arnold Melman
NEUROUROLOGY AND URODYNAMICS
(2020)
Article
Public, Environmental & Occupational Health
Sonya S. Brady, Linda Brubaker, Cynthia S. Fok, Sheila Gahagan, Cora E. Lewis, Jessica Lewis, Jerry L. Lowder, Jesse Nodora, Ann Stapleton, Mary H. Palmer
HEALTH PROMOTION PRACTICE
(2020)
Article
Urology & Nephrology
A. Lenore Ackerman, Toby C. Chai
CURRENT BLADDER DYSFUNCTION REPORTS
(2019)
Article
Physiology
Judy Yeh, Ming Lu, Lery Alvarez-Lugo, Toby C. Chai
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2019)