Article
Biochemistry & Molecular Biology
Christopher Mendoza, Dario Mizrachi
Summary: Decades of evidence suggest that alterations in cell adhesion properties contribute to the invasive and migratory phenotype of neoplastic cells. The role of tight junction proteins in the tumor microenvironment is crucial. Reprogramming immune cells using CAR-T cells to target and eliminate tumors has been approved as a therapy. Researchers have developed a new biologic that specifically targets cancer cells and reduces proliferation and metastasis.
Article
Oncology
Xiang Shu, Qin Zhou, Xiaohui Sun, Michelle Flesaker, Xingyi Guo, Jirong Long, Mark E. Robson, Xiao-Ou Shu, Wei Zheng, Jonine L. Bernstein
Summary: This study identified 98 proteins that may have potential causal associations with the risk of breast cancer subtypes. The associations of ICAM1, PLA2R1, and TXNDC12 varied significantly across the subtypes. These findings contribute to understanding the heterogeneity in the etiology of different subtypes of breast cancer and may aid in personalized risk assessment of the disease.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Xinning Wang, Aditi Shirke, Ethan Walker, Rongcan Sun, Gopolakrishnan Ramamurthy, Jing Wang, Lingpeng Shan, Joey Mangadlao, Zhipeng Dong, Jing Li, Ziying Wang, Mark Schluchter, Dong Luo, Yu Wang, Shaun Stauffer, Susann Brady-Kalnay, Christopher Hoimes, Zhenghong Lee, James P. Basilion
Summary: Researchers have developed a new PSMA-targeting drug conjugate with potent and selective antitumor activity, showing potential to impact therapeutic management of lethal prostate cancers.
Article
Cell Biology
Xu Hou, Hong-Jun Du, Jian Zhou, Dan Hu, Yu-Sheng Wang, Xuri Li
Summary: The study found that JAM-C, highly expressed in retinal capillary endothelial cells, translocated from the cytoplasm to the cytomembrane upon treatment with VEGF or PDGF-C. Modulating JAM-C activity in RCECs affected the adhesion and transmigration of macrophages from wet age-related macular degeneration patients, potentially suggesting a therapeutic target for related ocular diseases. Additionally, elevated serum soluble JAM-C levels may serve as a molecular marker for wAMD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hao Li, Dong Luo, Chaonan Yuan, Xinning Wang, Jing Wang, James P. Basilion, Thomas J. Meade
Summary: PSMA is a transmembrane protein highly expressed in aggressive prostate cancer, utilized in various imaging modalities as a biomarker. MR imaging provides detailed information but requires development of molecular contrast agents for improved sensitivity. In this study, targeted and activatable MR contrast agents were successfully used to differentiate between PSMA+ and PSMA- prostate cancer cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Immunology
Mate Kiss, Els Lebegge, Aleksandar Murgaski, Helena Van Damme, Daliya Kancheva, Jan Brughmans, Isabelle Scheyltjens, Ali Talebi, Robin Maximilian Awad, Yvon Elkrim, Pauline M. R. Bardet, Sana M. Arnouk, Cleo Goyvaerts, Johan Swinnen, Frank Aboubakar Nana, Jo A. Van Ginderachter, Damya Laoui
Summary: This study found that cancer-associated inflammation can enhance the expression of JAM-A on circulating monocytes, but the function of JAM-A in tumor-infiltrating myeloid cells is little understood. Through gene knockout mouse experiments and RNA sequencing, we found that JAM-A is dispensable for the recruitment and transcriptional reprogramming of myeloid cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Danielle S. Bitterman, Ming-Hui Chen, Jing Wu, Andrew A. Renshaw, Marian Loffredo, Philip W. Kantoff, Eric J. Small, Anthony V. D'Amico
Summary: This study found that low testosterone level at PSA failure in high-risk patients with PC treated with RT is associated with increased PCSM and ACM risk, and that higher PSAn is also associated with worse PCSM and ACM risk, especially in men with normal testosterone levels at PSA failure.
Article
Chemistry, Medicinal
Aleksei E. Machulkin, Anastasia A. Uspenskaya, Nikolay U. Zyk, Ekaterina A. Nimenko, Anton P. Ber, Stanislav A. Petrov, Vladimir Polshakov, Radik R. Shafikov, Dmitry A. Skvortsov, Ekaterina A. Plotnikova, Andrei A. Pankratov, Galina B. Smirnova, Yulia A. Borisova, Vadim S. Pokrovsky, Vasilii S. Kolmogorov, Alexander N. Vaneev, Alexander D. Khudyakov, Olga E. Chepikova, Sergey Kovalev, Andrey A. Zamyatnin, Alexander Erofeev, Petr Gorelkin, Elena K. Beloglazkina, Nikolay Zyk, Elena S. Khazanova, Alexander G. Majouga
Summary: The synthesized PSMA-targeted conjugate shows promising potential for prostate cancer chemotherapy, with high tumor growth inhibition levels and therapeutic index on PSMA(+) xenografts compared to PSMA(-) xenografts. Acute, chronic, and subchronic toxicities studies, as well as pharmacokinetics, support the potential of this conjugate as a therapeutic agent.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Qian Wu, Yong-bin Wang, Xiao-wen Che, Hui Wang, Wei Wang
Summary: JAML protein is an oncogenic protein in lung adenocarcinoma (LUAD) and may serve as a novel therapeutic target. The flavonoid kaempferol inhibits JAML, leading to suppression of proliferation, migration, and invasion of LUAD cells, and partially inhibits epithelial-mesenchymal transition (EMT) through the PI3K/AKT/mTOR pathway. These findings suggest that JAML is a new target for kaempferol in LUAD cells.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Article
Endocrinology & Metabolism
Terri C. Thayer, Joanne Davies, James A. Pearson, Stephanie J. Hanna, Li Wen, F. Susan Wong
Summary: Our results suggest that a loss of NOD-LNSC MHC-independent suppressive mechanisms may contribute to diabetes development. In contrast, non-MHC-matched, control C57BL/6 mouse LNSC suppressed T-cell receptor engagement by anti-CD3/CD28 via MHC-independent mechanisms, modifying antigen sensitivity and effector function.
Article
Cell Biology
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee
Summary: ICAM-1 is a potential therapeutic target for colorectal cancer (CRC) that enhances treatment effectiveness by promoting the c-MET-SRC signaling axis. Treatment with antibodies targeting ICAM-1 can reduce metastasis and angiogenesis in CRC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Miki Yamaguchi, Sachie Hirai, Masashi Idogawa, Toshiyuki Sumi, Hiroaki Uchida, Naoki Fujitani, Motoko Takahashi, Yuji Sakuma
Summary: There is a need for novel and effective treatments for small cell lung carcinoma (SCLC). This study investigated the use of an antibody-drug conjugate (ADC) targeting junctional adhesion molecule 3 (JAM3) as a potential therapy for SCLC. The results showed that JAM3 mRNA was expressed at higher levels in SCLC cell lines and tissues compared to lung adenocarcinoma. The ADC specifically targeting JAM3 exhibited dose- and time-dependent antitumor effects on SCLC cells. Silencing JAM3 alone suppressed the growth of SCLC cells. These findings suggest that targeting JAM3 with an ADC could be a promising approach for treating SCLC.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Jonathon J. Graham, Sujit Mukherjee, Muhammad Yuksel, Rebeca Sanabria Mateos, Tengfei Si, Zhenlin Huang, Xiahong Huang, Hadil Abu Arqoub, Vishal Patel, Mark McPhail, Yoh Zen, Nigel Heaton, Maria Serena Longhi, Michael A. Heneghan, Rodrigo Liberal, Diego Vergani, Giorgina Mieli-Vergani, Yun Ma, Bu'Hussain Hayee
Summary: The study found that the gut homing hypothesis is not the primary driver of PSC, and aberrant recruitment of gut-derived T cells to the liver is also seen in other chronic liver diseases. This finding provides a new understanding of the pathogenesis of PSC and CLD.
Article
Gastroenterology & Hepatology
Miguel S. Marques, Ana C. Costa, Hugo Osorio, Marta L. Pinto, Sandra Relvas, Mario Dinis-Ribeiro, Fatima Carneiro, Marina Leite, Ceu Figueiredo
Summary: Helicobacter pylori infects approximately half of the world's population and is a major risk factor for peptic ulcer disease and gastric cancer. It disrupts epithelial integrity by targeting the junctional adhesion molecule-A (JAM-A) and uses a unique strategy to do so. This study identified PqqE (HP1012) as the virulence factor responsible for cleaving JAM-A, providing new insights into the pathogenesis of this infection.
Article
Pharmacology & Pharmacy
Wei Gu, Xing Wang, Huanfen Zhao, Jianlin Geng, Xiaolong Li, Kunjie Zheng, Yunpeng Guan, Xiaoyu Hou, Chao Wang, Guangyao Song
Summary: Diabetic kidney disease is a common complication of diabetes, and lipid deposits in the kidneys contribute to kidney damage. This study found that abnormal lipid metabolism is closely related to diabetic kidney disease in patients. Additionally, the administration of resveratrol in mice with high-fat diet-induced renal abnormalities reduced lipid deposition, improved renal function, and regulated lipid synthesis pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Yanfei Cui, Jing Fan, Wenbo Shi, Zuozhi Zhou
Summary: This study elucidated the crucial role of circ_0001667 in breast cancer, affecting tumor cell proliferation, migration, invasion, and chemoresistance by regulating the expression of miR-4458 and NCOA3.
DRUG DEVELOPMENT RESEARCH
(2022)
Article
Engineering, Electrical & Electronic
Chenglin Zhang, Qunfei Zhang, Wentao Shi, Weidong Wang, Jiajie Xu, Feifei Pang
Summary: The study proposes a recursive scheme relying on mobile bistatic sonar to estimate target location and clock bias accurately by acquiring measurement information at multiple time steps. Orthogonal transformation ensures computational efficiency and numerical reliability, while the CRLB is derived as a lower bound on estimating errors under Gaussian noise.
IET RADAR SONAR AND NAVIGATION
(2022)
Article
Mathematics, Interdisciplinary Applications
Hongyan Jia, Zhonggao Chen, Wenxin Shi, Guoyuan Qi
Summary: The paper introduces a new generalized Hamiltonian chaotic system with transient quasi-periodic flows and intermittent chaos, which exhibits conservative characteristics and various coexisting flows. The Hamiltonian energy of the system meets certain conditions and is only related to initial points.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2022)
Article
Chemistry, Physical
Bing Zhang, Heli Tang, Jinyu Chen, Bing Zhang, Yu Shen, Wenxin Shi
Summary: Understanding the effect of cations on membrane fouling is important, with higher ionic strength leading to increased membrane fouling and decreased flux recovery rate. Ca2+ was found to be more effective than Na+ in mitigating membrane fouling.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Microbiology
Marcia Dinis, Melissa Agnello, Lujia Cen, Bhumika Shokeen, Xuesong He, Wenyuan Shi, David T. W. Wong, Renate Lux, Nini Chaichanasakul Tran
Summary: Dental caries is the most common chronic disease in children, and the role of Streptococcus mutans in its development is still not fully understood. This study explored the correlation between S. mutans levels and other microorganisms in the saliva of caries-concordant and discordant populations. The results showed that the salivary microbial communities clustered based on S. mutans levels and were independent of caries experience. Disease-associated species were increased in populations with high S. mutans levels, while health-associated species were more abundant in populations with low S. mutans levels. The study highlights the importance of considering additional microbial markers in conjunction with S. mutans for the diagnosis and management of dental caries in the discordant population.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Physical
Haoyue Zhang, Guangwei She, Jing Xu, Shengyang Li, Yun Liu, Jun Luo, Wensheng Shi
Summary: In this study, a Ptx(x=2,3)Si/PtSi/p-Si photocathode was designed and fabricated to improve the photovoltage and enhance the hydrogen evolution reaction kinetics for efficient H-2 generation via PEC. The use of dopant segregation elevated the Schottky barrier height, leading to a high photovoltage, while in situ formation of a high catalytic activity Ptx(x=2,3)Si layer on the photocathode significantly enhanced the HER kinetics. The photocathode achieved a favorable onset potential for HER and a high saturated photocurrent density, with a maximum ABPE of 5.8% and excellent stability in long-term PEC H-2 generation testing.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Multidisciplinary Sciences
Yang Shen, Miou Zhou, Denise Cai, Daniel Almeida Filho, Giselle Fernandes, Ying Cai, Andre F. de Sousa, Min Tian, Nury Kim, Jinsu Lee, Deanna Necula, Chengbin Zhou, Shuoyi Li, Shelbi Salinas, Andy Liu, Xiaoman Kang, Masakazu Kamata, Ayal Lavi, Shan Huang, Tawnie Silva, Won Do Heo, Alcino J. Silva
Summary: This study reveals that delayed expression of CCR5 after memory formation determines the duration of the temporal window for memory linking. It lowers neuronal excitability and regulates memory allocation, reducing memory overlap. Age-related increase in CCR5 expression impairs memory linking, which can be reversed with genetic knockout and a specific drug.
Article
Oncology
Teng Li, Yin-Ping Zhang, Jun-Juan Kong, Min Kong, Ge Meng, Wen-Xin Shi
Summary: The study evaluated the effectiveness of timing it right (TIR) applications in patients undergoing radiotherapy for head and neck cancer. The TIR intervention program significantly improved the unmet needs and psychological pain of these patients. The TIR group showed significant improvements in various aspects, including information needs, health and psychological problems, healthcare staff, physical symptoms, health facilities and services, religious/spiritual support, and psychological pain.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Multidisciplinary Sciences
Yan Guo, Qixin Zhou, Jun Nan, Wenxin Shi, Fuyi Cui, Yongfa Zhu
Summary: This study synthesized perylenetetracarboxylic acid nanosheets with a thickness of approximately 1.5 nm and demonstrated their activity as highly efficient hydrogen evolution photocatalysts. The introduction of carboxyl groups increased the internal electric fields, promoting charge-carrier separation, and weakened charge-carrier recombination by migrating photogenerated electrons and holes to the edge and plane, respectively. Furthermore, the reduction potential and hydrophilic sites of perylenetetracarboxylic acid were enhanced. This work provides a strategy for designing future efficient photocatalysts.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Qiang Li, Zhaogang Teng, Jun Tao, Wenhui Shi, Guangwen Yang, Yu Zhang, Xiaodan Su, Lin Chen, Weijun Xiu, Lihui Yuwen, Heng Dong, Yongbin Mou
Summary: The elasticity-dependent effect of the nanovaccine on dendritic cell-mediated immune responses is studied. The prepared soft mesoporous organosilica-based nanovaccine (SMONV) shows enhanced internalization by dendritic cells and induces effective antigen delivery, leading to immune response activation. Moreover, SMONV also enhances lymphatic drainage of antigens, stimulating robust humoral and cellular immunity.
Article
Chemistry, Multidisciplinary
Fangfang Wu, Yuchao Chen, Yulong Chen, Ruilian Yin, Yancong Feng, Dong Zheng, Xilian Xu, Wenhui Shi, Wenxian Liu, Xiehong Cao
Summary: Optimization of electrolyte composition is a practical way to improve the performance of aqueous zinc-ion batteries (ZIBs). In this study, a mixture electrolyte containing 10 vol% of N,N-Dimethylacetamide (DMA) and ZnSO4 was used to enhance the reversibility of Zn plating/stripping. It was found that DMA has the ability to reconstruct the solvation structure of Zn2+ and inhibit dendrite growth on Zn anode.
Article
Multidisciplinary Sciences
Benjamin K. Estep, Charles J. Kuhlmann, Satoru Osuka, Gajendra W. Suryavanshi, Yoshiko Nagaoka-Kamata, Ciearria N. Samuel, Madison T. Blucas, Chloe E. Jepson, Paul A. Goepfert, Masakazu Kamata
Summary: SARS-CoV-2 infection and COVID-19 vaccination can decrease the numbers and functionality of hematopoietic stem progenitor cells in umbilical cord blood, raising concerns for HSPC-based therapies.
Article
Oncology
Tracy R. Daniels-Wells, Pierre V. Candelaria, Emiko Kranz, Jing Wen, Lan Wang, Masakazu Kamata, Juan C. Almagro, Otoniel Martinez-Maza, Manuel L. Penichet
Summary: Individuals infected with HIV have an increased risk of developing certain cancers, including non-Hodgkin lymphoma. This study demonstrates that antibodies targeting the transferrin receptor 1 (TfR1) can prolong survival in mouse models of AIDS-NHL. Targeting TfR1 with these antibodies may be a potential therapy for AIDS-NHL.
Article
Business, Finance
Wen Shi, Xiaogang Bi
Summary: This research examines the impact of Buddhism on mergers & acquisitions (M&As) performance using data from 4622 M&A transactions of Chinese public firms between 2004 and 2018. The findings provide ample evidence that acquirers located in regions with a higher intensity of Buddhism achieve better short-term and long-term performance after the merger. Furthermore, the study reveals that state ownership plays a crucial role in mitigating this effect, and the value creation is driven by higher deal completion rates and fewer violation cases for acquiring firms. Finally, the study addresses the issue of endogeneity, and the results remain unchanged.
ACCOUNTING AND FINANCE
(2023)
Article
Green & Sustainable Science & Technology
Dong Zheng, Wenxian Liu, Xiaojing Dai, Jinxiu Feng, Xilian Xu, Ruilian Yin, Wenbin Que, Wenhui Shi, Fangfang Wu, Huaping Wu, Xiehong Cao
Summary: This study develops a novel cathode material for flexible zinc-air batteries and demonstrates its potential application in flexible electronics. The material exhibits excellent battery performance and sensing sensitivity, which is crucial for achieving high-performance and integrated power sources.
ADVANCED ENERGY AND SUSTAINABILITY RESEARCH
(2022)