Article
Plant Sciences
Hyo-Jung Kim, Bo -Ram Jin, Hyo-Jin An
Summary: This study confirmed the efficacy of Psoralea corylifolia L. seed against BPH by regulating prostate cell proliferation and apoptosis, showing therapeutic potential in both in vitro cell lines and in vivo rat models.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Jaekwon Seok, Hee Jeong Kwak, Yeonjoo Kwak, Moonjung Lee, Kyoung Sik Park, Aram Kim, Ssang-Goo Cho
Summary: This study investigates the effects of androgen suppression therapy on bladder cancer progression and identifies potential therapeutic targets. It is found that dutasteride, a 5 alpha-reductase inhibitor, can inhibit cell proliferation and migration of bladder cancer cells by regulating the expression of cancer progression proteins. Additionally, the study reveals the role of the target gene SRD5A1 in bladder cancer and its correlation with patient survival.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Agriculture, Multidisciplinary
Hyo-Jung Kim, Byung-Hak Kim, Bo-Ram Jin, Sang Jae Park, Hyo-Jin An
Summary: Purple corn extract (PCE) has ameliorative effects on benign prostatic hyperplasia (BPH) by reducing androgen receptor (AR) expression and inhibiting the PI3K/AKT signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Review
Biochemistry & Molecular Biology
Junya Hata, Yuki Harigane, Kanako Matsuoka, Hidenori Akaihata, Kei Yaginuma, Satoru Meguro, Seiji Hoshi, Yuichi Sato, Soichiro Ogawa, Motohide Uemura, Yoshiyuki Kojima
Summary: Benign prostatic hyperplasia (BPH) is a chronic proliferative disease mainly characterized by stromal proliferation. Although aging and androgen have been considered risk factors, recent studies suggest the involvement of androgen-independent factors, such as inflammation, in BPH development. In this study, whole-genome gene expression analysis using a stromal-dominant BPH rat model revealed activated immune response-related pathways and complement classical pathways. Moreover, the autoimmune reaction triggered complement pathway activation in the proliferative process of BPH. Understanding the role of androgen-independent factors, like immune responses, contributes to unraveling the pathogenesis of BPH and may lead to new therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xueni Wang, Junjie Zhu, Huimin Yan, Mengyao Shi, Qiaoqi Zheng, Yu Wang, Yan Zhu, Lin Miao, Xiumei Gao
Summary: Kaempferol has been identified as a natural compound that inhibits tumor development in androgenic related prostate cancer and suppresses testosterone-induced benign prostatic hyperplasia (BPH) via modulation of the androgen receptor function.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kai-Yen Tsai, Deng-Chyang Wu, Wen-Jeng Wu, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Hsiang-Ying Lee
Summary: This study investigates the potential relationship between human microbiota and prostatic disease by analyzing stool and urine samples from patients. The results suggest that the microbiota composition in urine samples is different among different patient populations, indicating a potential link between microbiota and prostatic disease.
Review
Biochemistry & Molecular Biology
Weronika Ratajczak, Michal Lubkowski, Anna Lubkowska
Summary: This review article discusses the role of heat shock proteins (HSPs) in prostate diseases and their potential as therapeutic targets. HSPs are overexpressed in benign prostatic hyperplasia (BPH) and prostate cancer (PCa), and play roles in maintaining cell homeostasis, protein folding and repair, as well as immune response and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Tiziana Genovese, Marika Cordaro, Rosalba Siracusa, Enrico Gugliandolo, Alessio Filippo Peritore, Livia Interdonato, Rosalia Crupi, Salvatore Cuzzocrea, Rosanna Di Paola, Roberta Fusco, Daniela Impellizzeri
Summary: The study revealed that ultra-micronized um-PEA/Baic can reduce prostate weight and DHT production in BPH-induced rats, while modulating apoptotic and inflammatory pathways as well as oxidative stress.
Article
Urology & Nephrology
Yi Lu, Shujun Fan, Yuxuan Song, Kang Liu, Kechong Zhou, Jiaqi Kang, Shangren Wang, Yongjiao Yang, Xiaoqiang Liu
Summary: The study found that a longer anogenital distance is associated with more severe BPH-related symptoms. It is recommended to consider anogenital distance as a marker for BPH-LUTS. Further research is needed to explore this interesting issue.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Andrology
Sung Han Kim, Whi An Kwon, Jae Young Joung
Summary: This study evaluated the impact of BPH and prostatitis on the risk of prostate cancer in Korean men and found that patients with BPH and prostatitis had a significantly increased risk of developing prostate cancer. In particular, the risk was highest for patients with both BPH and prostatitis.
WORLD JOURNAL OF MENS HEALTH
(2021)
Review
Biology
Che-Hsueh Yang, Yen-Chuan Ou, Chi-Chien Lin, Yi-Sheng Lin, Min-Che Tung, Chia-Cheng Yu, Jen-Tai Lin, Chen-Yueh Wen
Summary: Phloretin, a potent anti-inflammatory and anti-oxidative flavonoid, shows promising effects in treating BPH and PCa, based on animal and in-vitro studies. Further research is needed regarding its safety and effective dosages in human clinical trials.
Article
Biochemistry & Molecular Biology
Bassel Mansour, Adam Monyok, Mario Gajdacs, Balazs Stercz, Nora Makra, Kinga Penzes, Istvan Vadnay, Dora Szabo, Eszter Ostorhazi
Summary: The balance between the microbiome associated with bladder mucosa and human beta defensin (HBD) levels in urine is a dynamic and host-specific relationship. In bladder cancer patients, the levels of antibacterial and antitumor defensin (HBD1) decrease, while other defensins (HBD2 and HBD3) increase significantly. The composition of microbiome in tumor samples is also related to the levels of these defensins.
Article
Oncology
Ritaparna Ahmed, Leyder Elena Lozano, Amandine Anastasio, Sebastien Lofek, Beatris Mastelic-Gavillet, Blanca Navarro Rodrigo, Sylvain Nguyen, Florence Dartiguenave, Sonia-Cristina Rodrigues-Dias, Valerie Cesson, Massimo Valerio, Beat Roth, Lana Elias Kandalaft, Irina Redchenko, Adrian Vivian Sinton Hill, Alexandre Harari, Pedro Romero, Laurent Derre, Selena Vigano
Summary: Lymphocytes expanded from BPH tissue samples can recognize tumor antigens and autologous tissue independently from the presence of tumor lesions. These findings support the connection between BPH and prostate cancer and may lead to personalized preventive vaccination strategies for patients with BPH.
Article
Endocrinology & Metabolism
Jordan J. Kramer, Lin Gu, Daniel Moreira, Gerald Andriole, Stephen J. Freedland, Ilona Csizmadi
Summary: In older men, smoking does not increase the risk of developing lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) in asymptomatic men, nor does it affect the progression of LUTS in symptomatic men.
Article
Anesthesiology
Robert G. Hahn, Dan Drobin
Summary: This study found that during spinal anesthesia, as mean arterial pressure decreased, the capillary filtration of fluid decreased. Venous blood sampled from nonanesthetized body regions had about twice the reduction effect compared to blood sampled from anesthetized body regions.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2021)
Article
Anesthesiology
Robert G. Hahn
Summary: Induction of anesthesia causes a decrease in mean arterial pressure, leading to a slowed distribution and elimination of infused crystalloid fluid. Factors such as age, gender, type of anesthesia, and use of ephedrine do not have a significant impact on plasma volume expansion, except for their possible influence on mean arterial pressure.
PERIOPERATIVE MEDICINE
(2021)
Article
Anesthesiology
Laurence Weinberg, Fumitaka Yanase, Shervin Tosif, Bernhard Riedel, Rinaldo Bellomo, Robert G. Hahn
Summary: This study found that there are different temporal patterns of plasma syndecan-1 concentration after surgery, with the greatest increases observed in patients with greater blood loss, more liver surgery, and longer operations.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Hematology
Robert G. Hahn
Summary: This study aimed to investigate the effect of interstitial washdown on fluid distribution in normovolemic and hypovolemic volunteers. The results showed that lymph containing high levels of albumin flowed into the plasma just after blood withdrawal. Although interstitial washdown reduced the volume of extravascular fluid after fluid loading, it played no major role in determining the distribution of crystalloid fluid after hemorrhage.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2023)
Article
Critical Care Medicine
Robert Svensson, Robert G. Hahn, Joachim H. Zdolsek, Hans Bahlmann
Summary: The hyperchloremic acidosis commonly seen in diabetic ketoacidosis may not be primarily caused by the chloride content of resuscitation fluids but, rather, by the restoration of plasma volume, which reveals the hidden metabolic acidosis caused by a decreased Na-Cl gap.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2022)
Editorial Material
Anesthesiology
Robert G. Hahn
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Nutrition & Dietetics
Robert G. Hahn
Summary: This study investigated the sensitivity and specificity of biomarkers in urine for quantifying daily water intake. It found that biomarkers in morning urine and spot urine samples can distinguish between large and small water intakes, with osmolality performing slightly better than creatinine. However, the accuracy of these indications is lower during days of increased fluid intake.
Article
Anesthesiology
Robert G. Hahn, Lena Nilsson, Hans Bahlmann
Summary: This study investigated the predictive value of hemodynamic indicators provided by esophagus Doppler monitoring and pulse oximetry for fluid responsiveness during goal-directed fluid therapy, and suggested that these indicators could help clinicians avoid unnecessary fluid bolus infusions.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Infectious Diseases
Dennis Nordvall, Dan Drobin, Toomas Timpka, Robert G. G. Hahn
Summary: This study aimed to identify pre-pandemic diagnoses recorded in a middle-aged and elderly population that were associated with the development of severe COVID-19. It found that individuals previously diagnosed with dementia, cerebral palsy, kidney failure, type 2 diabetes mellitus, hypertension, and obesity were at a higher risk of developing severe COVID-19.
BMC INFECTIOUS DISEASES
(2023)
Article
Peripheral Vascular Disease
Joachim H. Zdolsek, Markus Zdolsek, Robert G. Hahn
Summary: By analyzing data from 27 infusions of 20% albumin given to volunteers and patients, it was found that during the infusion of 20% albumin, there was a decrease in the difference between the plasma colloid osmotic pressure and plasma albumin, indicating an enrichment of non-albumin proteins in the plasma. Additionally, the infusion of 20% albumin led to a decrease in the concentration of immunoglobulins in the plasma, supporting the hypothesis that efferent lymph contributes to the protein-containing fluid recruited during the infusion of 20% albumin in humans.
MICROVASCULAR RESEARCH
(2023)
Article
Multidisciplinary Sciences
Robert G. Hahn, Laurence Weinberg, Yuhong Li, Hans Bahlmann, Rinaldo Bellomo, Patrick Y. Wuethrich
Summary: Elevations of plasma creatinine after major surgery are associated with low urine flow, greater blood loss, and concentrated urine before and after the surgery. Renal water conservation-related mechanisms contribute to the development of increased plasma creatinine.
Article
Peripheral Vascular Disease
Robert G. Hahn
Summary: The fast-exchange interstitial fluid compartment is directly connected to the circulating blood, while the slow-exchange compartment is not.
MICROVASCULAR RESEARCH
(2024)
Article
Critical Care Medicine
Markus Zdolsek, Folke Sjoberg, Robert G. Hahn
Summary: This study investigated the difference in plasma volume expansion when administering 20% albumin rapidly compared to slowly. The results showed that the rapid infusion led to a larger plasma volume expansion in the first two hours, but both infusion rates had similar effects afterwards. The intravascular persistence of albumin was longer with rapid infusion, and urine output was three times larger than the infused volume. Atrial natriuretic peptide accelerated albumin leakage and urine flow.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2022)
Article
Critical Care Medicine
Robert G. Hahn, Randal O. Dull
Summary: The study showed that crystalloid fluid accelerates lymphatic flow, increasing plasma albumin concentration and maintaining intravascular volume. However, this effect diminishes after a few hours.
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2021)
Review
Critical Care Medicine
Randal O. Dull, Robert G. Hahn
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)