Article
Oncology
Junyue Tao, Xiao Li, Chaozhao Liang, Yi Liu, Jun Zhou
Summary: This study investigated the role of basement membrane (BM) genes in clear cell renal cell carcinoma (ccRCC), identifying reliable prognostic biomarkers and establishing a prognostic model based on BM genes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Junwen Shen, Rongjiang Wang, Yu Chen, Zhihai Fang, Jianer Tang, Jianxiang Yao, Jianguo Gao, Xiaonong Chen, Xinli Shi
Summary: This study investigated the clinical significance, biological functions, and underlying mechanisms of CXCL genes in ccRcc. The results showed that CXCL genes were upregulated in renal cancer tissue and significantly impacted patient survival. The study also identified CXCL gene-immune cell interactions and demonstrated that CXCL2 plays a role in neutrophil recruitment and polarization, promoting ccRcc progression.
Article
Pharmacology & Pharmacy
An Liu, Fei Li, Bao Wang, Le Yang, Hai Xing, Chang Su, Li Gao, Minggao Zhao, Lanxin Luo
Summary: This study comprehensively investigated the landscape of Ca2+ channels, pumps and exchangers in KIRC patients. Significant differences were found in prognosis, immune cell infiltration, and targeted drug sensitivities between high and low CRGs-related risk subtypes. TRPM3 was identified as a key CRG associated with poor prognosis in KIRC patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Fiorella L. Roldan, Laura Izquierdo, Mercedes Ingelmo-Torres, Juan Jose Lozano, Raquel Carrasco, Alexandra Cunado, Oscar Reig, Lourdes Mengual, Antonio Alcaraz
Summary: In this study, molecular markers for disease progression in ccRCC were identified and a gene expression-based signature was developed. This signature enhances the prediction of prognosis and could be used for personalized disease management.
Article
Multidisciplinary Sciences
Na Li, Jie Chen, Qiang Liu, Hongyi Qu, Xiaoqing Yang, Peng Gao, Yao Wang, Huayu Gao, Hong Wang, Zuohui Zhao
Summary: Phosphorylated mTOR was identified as an independent predictor of poor survival, and mTOR was associated with tumor immune infiltrates in ccRCC patients, validating the potential involvement of mTOR in the initiation and progression of ccRCC.
Article
Multidisciplinary Sciences
Ziwen Pan, Sheng Chang, Song Chen, Daqiang Zhao, Zhiyu Zou, Linrui Dai, Yibo Hou, Qianqian Zhang, Yuanyuan Yang, Zhishui Chen, Weijie Zhang, Yuanyuan Zhao
Summary: By using bioinformatics analysis, four potential biomarker genes for the prognosis of clear cell renal cell carcinoma (ccRCC) were identified. Immune infiltration can predict the efficacy of immunotherapy.
Article
Oncology
Lishan He, Huiming Jiang, Zhenqiang Lai, Zhixiong Zhong, Zhanqin Huang
Summary: STX4 is constantly up-expressed in kidney renal clear cell carcinoma tissues, associated with a poor prognosis, suggesting it can be an effective biomarker and novel therapeutic target in KIRC.
Article
Medicine, General & Internal
Kai Liu, Yingxue Gao, Quanwu Zhang
Summary: This study reveals the high expression of MALAT1 in ccRCC and its association with poor prognosis. MALAT1 expression is correlated with clinicopathological features, overall survival, and immune cell infiltration. Prognostic models are also established to predict survival.
Article
Multidisciplinary Sciences
Mingrui Li, Minxin He, Fangshi Xu, Yibing Guan, Juanhua Tian, Ziyan Wan, Haibin Zhou, Mei Gao, Tie Chong
Summary: This study investigated the role and significance of AQPs in ccRCC, identifying AQPs that are associated with the prognosis of ccRCC and suggesting their potential as new survival markers for targeted therapy.
Review
Biochemistry & Molecular Biology
Chaston Weaver, Khaled Bin Satter, Katherine P. Richardson, Lynn K. H. Tran, Paul M. H. Tran, Sharad Purohit
Summary: This review focuses on the molecular changes associated with the development of clear cell renal carcinoma (ccRCC) and the gene expression and protein signatures, highlighting the importance of utilizing these molecular profiles in clinical practice. Machine learning and precision medicine may help overcome the barriers in incorporating tumor molecular profiles into the diagnosis and treatment of ccRCC.
Article
Oncology
Xiaomei Sun, Pengfei Liu
Summary: This study investigated the expression and prognostic significance of NEIL3 in KIRC. The results showed that NEIL3 was overexpressed in KIRC and associated with worse outcomes. Functional and immune infiltration analysis revealed that NEIL3 may be involved in multiple signaling pathways and immune cell regulation. Therefore, NEIL3 may serve as a potential independent biomarker for KIRC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Genetics & Heredity
Zhi Liu, Jun Zhang, Deyun Shen, Xuechun Hu, Zongpan Ke, I. Nyoman Ehrich Lister, Bungaran Sihombing
Summary: This study found that cytoskeleton-associated protein 2-like protein is upregulated in clear cell renal cell carcinoma tissues and may promote disease progression through multiple signaling pathways. It can serve as a prognostic marker and a potential treatment target in clear cell renal cell carcinoma.
FRONTIERS IN GENETICS
(2023)
Article
Oncology
Fiorella L. Roldan, Juan J. Lozano, Mercedes Ingelmo-Torres, Raquel Carrasco, Esther Diaz, Miguel Ramirez-Backhaus, Jose Rubio, Oscar Reig, Antonio Alcaraz, Lourdes Mengual, Laura Izquierdo
Summary: In this study, biomarkers for tumor progression in intermediate/high-risk ccRCC were identified from tissue samples and an improved prognostic model was developed. The model could provide better individualized management recommendations based on molecular and clinical data.
Article
Multidisciplinary Sciences
Yanlin Tang, Changzheng Zhang, Chujin Ye, Kaiwen Tian, Jiayi Zeng, Shouyu Cheng, Weinan Zeng, Bowen Yang, Yanjun Liu, Yuming Yu
Summary: In this study, we investigated the role of programmed cell death (PCD) in clear cell renal cell carcinoma (ccRCC) and developed a PCD-based gene classifier for prognosis and therapeutic efficacy differentiation in ccRCC. Through gene set enrichment analysis (GSEA), we identified enriched and prognostic PCD in ccRCC and explored the functional status of ccRCC patients with different PCD risks. We also analyzed the tumor microenvironment, immunogenicity, and therapeutic response in different molecular clusters. Our findings suggest that PCD, specifically apoptosis and pyroptosis, is correlated with prognosis in ccRCC and that high PCD levels are associated with poor prognosis and a suppressive immune microenvironment.
Article
Oncology
Zijian Zhou, Jiajin Wu, Yuanyuan Yang, Peng Gao, Lujia Wang, Zhong Wu
Summary: This study found that hepcidin expression is upregulated in clear cell renal cell carcinoma (ccRCC) and is correlated with patient age, T stage, and pathologic stage. Hepcidin promoter methylation is significantly associated with poor clinical parameters and hepcidin may serve as an independent prognostic factor. Mechanistically, hepcidin is involved in immune-related and metabolism-related pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)