Article
Oncology
Yang Yu, Wenfeng Wang, Zuquan Xiong, Zhenyu Yang, Jun Li, Yifan Shen, Bin Gu
Summary: This study compared the perioperative outcomes and complications of open partial nephrectomy (OPN) and laparoscopic partial nephrectomy (LPN). The results showed that LPN had shorter postoperative length of stay and estimated blood loss in patients with low complexity tumors, but longer operative time and renal artery clamp time compared to OPN. LPN and OPN had similar outcomes in patients with moderate and high complexity tumors.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Urology & Nephrology
Fabrizio Gallo, Simone Sforza, Lorenzo Luciani, Daniele Mattevi, Paolo Barzaghi, Andrea Mari, Fabrizio Di Maida, Alessandro Antonelli, Luca Cindolo, Antonio Galfano, Giovannalberto Pini, Guglielmo Mantica, Maurizio Schenone, Luigi Schips, Filippo Annino, Carlo Terrone, Aldo Massimo Bocciardi, Franco Gaboardi, Andrea Minervini
Summary: Our data indicate that simultaneous bilateral RAPNs could be a safe and feasible procedure with promising results for the treatment of bilateral synchronous renal masses in selected patients and expert hands.
WORLD JOURNAL OF UROLOGY
(2022)
Article
Surgery
Zeqi Liu, Xuanyu Zhang, Peng Lv, Bin Wu, Song Bai
Summary: This study compared the outcomes and safety of laparoscopic partial nephrectomy (LPN) and open partial nephrectomy (OPN) in patients with highly anatomical complexity of localized renal cell carcinoma (RCC). The results showed that OPN resulted in better renal function preservation than LPN, and the oncological and safety outcomes were comparable between the two procedures.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Urology & Nephrology
Martin Lorette, Jean-Christophe Bernhard, Charles-Karim Bensalah, Pierre Bigot, Arnauld Villers, Marie Lou Letouche, Nicolas Doumerc, Philippe Paparel, Francois Audenet, Francois-Xavier Nouhaud, Bastien Parier, Thibault Tricard, Cecile Champy, Martin Brenier, Geraldine Pignot, Jean-Alexandre Long, Matthieu Durand, Maxime Vallee, Thibaut Waeckel, Romain Boissier, Ricky Tambwe, Idir Ouzaid, Jonathan Olivier, Zine-Eddine Khene
Summary: The use of nephrometry scores for predicting oncological outcomes after partial nephrectomy is of limited clinical value.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Oncology
Kenichi Nishimura, Yuichiro Sawada, Naoya Sugihara, Keisuke Funaki, Kanae Koyama, Terutaka Noda, Tetsuya Fukumoto, Noriyoshi Miura, Yuki Miyauchi, Tadahiko Kikugawa, Takashi Saika
Summary: This study retrospectively analyzed factors associated with intraoperative urinary collecting system entry (CSE) in robot-assisted partial nephrectomy (RAPN) and explored the indications for intraoperative ureteral catheter placement in RAPN. Results showed that patients in the CSE group had significantly longer operative time, console time, ischemic time, and hospital stay compared to the non-CSE group.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xu Hu, Yaohui Wang, Yanxiang Shao, Kang Wu, Yaxiong Tang, Shangqing Ren, Xiang Li
Summary: This study compared the outcomes of radical nephrectomy (RN) versus partial nephrectomy (PN) in patients with non-clear cell renal cell carcinoma (nccRCC). The results showed that PN was associated with better overall survival (OS) and cancer-specific survival (CSS) compared to RN. For patients with T1 nccRCC, PN may be the preferred option.
Article
Urology & Nephrology
Samuel Weprin, Ugo Falagario, Alessandro Veccia, Naveen Nandanan, Dow Emerson, Christopher Ovanez, Emanuel Albuquerque, Eduardo B. Zukovski, Ryan Clayton, Lance Hampton, Riccardo Autorino
Summary: The study validates the reproducibility and ease of use of the SPARE nephrometry scoring system, showing its accuracy in predicting surgical complications. With high interobserver agreement, this tool can effectively assist physicians in evaluating the complexity of renal surgeries.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Urology & Nephrology
Hidekazu Tachibana, Tsunenori Kondo, Yudai Ishiyama, Maki Yoshino, Kazuhiko Yoshida, Junpei Iizuka, Kazunari Tanabe, Toshio Takagi
Summary: The study aimed to assess the impact of a newly defined longitudinal component on the operative complexity of transperitoneal robot-assisted partial nephrectomy. The study found that the longitudinal location of renal tumors was associated with prolonged console time. This assessment may be helpful in preoperative evaluation of operative complexity.
JOURNAL OF ENDOUROLOGY
(2022)
Review
Surgery
Yu-Li Jiang, Dong-dong Yu, Yang Xu, Ming-Hua Zhang, Fu-Sheng Peng, Peng Li
Summary: This study compared the perioperative outcomes of robotic partial nephrectomy (RPN) vs. laparoscopic partial nephrectomy (LPN) for complex renal tumors with a RENAL nephrometry score >= 7. The study found no significant differences in estimated blood loss, hospital stay, positive surgical margin, major postoperative complications, and transfusion between the two groups. However, RPN showed better outcomes in the operating time, postoperative renal function, warm ischemia time, conversion rate to radical nephrectomy, and intraoperative complications.
FRONTIERS IN SURGERY
(2023)
Letter
Medicine, General & Internal
Aparna Sharma, Ranjit K. Sahoo, Atul Batra, Archie Bleyer, Toni K. Choueiri, Thomas Powles
Summary: Adding adjuvant pembrolizumab after nephrectomy can significantly improve disease-free survival in patients with renal-cell carcinoma, but there are concerns regarding the arbitrary duration of 12 months of adjuvant treatment. Many patients discontinued treatment due to adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Wenhao Lin, Zhenggang Yang, Ling Yan, Jun Dai, Chen Fang, Yining Hao, Danfeng Xu, Jin Zhang, Juping Zhao
Summary: This study compared radical nephrectomy (RN) with partial nephrectomy (PN) in patients with cystic renal cell carcinoma (cRCC) using data from the SEER database and a Chinese retrospective cohort. The results showed that, after propensity score-matching (PSM), RN was associated with worse overall survival and cancer-specific survival compared to PN in cRCC patients.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao Wu, Johannes Uhlig, Brian M. Shuch, Annemarie Uhlig, Hyun S. Kim
Summary: In this study, a cost-effectiveness analysis was performed to assess the benefits of partial nephrectomy (PN) and percutaneous cryoablation (PCA) for patients with cT1a renal cell carcinoma (RCC). The results suggest that PCA is more cost-effective than PN in the majority of scenarios, although the currently available evidence is of limited quality.
EUROPEAN RADIOLOGY
(2023)
Article
Urology & Nephrology
Xinfei Li, Dapeng Wu, Xuepei Zhang, Xiang Wang, Yangyang Xu, Shubo Fan, Zhihua Li, Kunlin Yang, Xiaoteng Yu, Zhongyuan Zhang, Lin Cai, Zheng Zhang, Cheng Shen, Jin Tao, Hailong Hu, Liqun Zhou, Xuesong Li
Summary: This study developed a 3D scoring system to assess the surgical complexity and outcomes of robot-assisted partial nephrectomy. The ADDD scoring system was found to be effective in predicting perioperative complications, trifecta outcomes, and postoperative renal function preservation. This scoring system can guide surgical decision-making and optimize surgical outcomes.
WORLD JOURNAL OF UROLOGY
(2023)
Article
Urology & Nephrology
Sandeep Gurram, Nicholas A. Friedberg, Chirag Gordhan, Winston Li, Michael A. Ahdoot, Jillian Egan, Nitin K. Yerram, Gennady Bratslavsky, Adam R. Metwalli, W. Marston Linehan, Mark W. Ball
Summary: A retrospective study on patients undergoing reoperative partial nephrectomy found that the robotic approach was associated with fewer major complications, lower blood transfusion rates, and overall complications compared to open surgical cohorts. Prior surgical approaches were not predictive of major complications, indicating their lesser importance in perioperative outcomes.
JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vinson Wai-Shun Chan, Filzah Hanis Osman, Jon Cartledge, Walter Gregory, Michael Kimuli, Naveen S. Vasudev, Christy Ralph, Satinder Jagdev, Selina Bhattarai, Jonathan Smith, James Lenton, Tze Min Wah
Summary: A retrospective study compared the long-term and peri-operative outcomes of image-guided ablation (IGA) and laparoscopic partial nephrectomy (LPN) in localized RCC patients. The study found that IGA had better local recurrence-free survival (LRFS) and metastasis-free survival compared to LPN, and also preserved kidney function better post-operatively.
EUROPEAN RADIOLOGY
(2022)
Article
Urology & Nephrology
R. Bertolo, M. Vittori, C. Cipriani, F. Mariorino, V Iacovelli, F. Petta, N. Toschi, M. Ferro, M. Panei, S. Travaglia, P. Bove
Summary: The study evaluated the safety and effectiveness of ThuVEP in elderly patients compared to younger patients and found that it was a safe and effective treatment option for elderly patients with BPH. Postoperatively, significant improvements were observed in the younger group at 30 days, but differences between the groups disappeared by the 90-day follow-up with no significant differences in readmission rates or need for reinterventions.
ACTAS UROLOGICAS ESPANOLAS
(2021)
Editorial Material
Urology & Nephrology
Riccardo Campi, Riccardo Bertolo, Andrea Minervini
Letter
Urology & Nephrology
Riccardo Bertolo, Pierluigi Bove
Letter
Urology & Nephrology
Jeremy Yuen-Chun Teoh, Marcelo Langer Wroclawski, Steffi Yuen, Bryan Cheng, Riccardo Bertolo, Daniele Castellani, Vineet Gauhar, Thomas Herrmann
WORLD JOURNAL OF UROLOGY
(2022)
Letter
Urology & Nephrology
Riccardo Campi, Riccardo Bertolo, Andrea Minervini
Article
Urology & Nephrology
Riccardo Bertolo, Pierluigi Bove, Andrea Minervini, Alessandro Antonelli
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Riccardo Bertolo, Chiara Cipriani, Matteo Vittori, Marco Carilli, Francesco Maiorino, Valerio Iacovelli, Carlo Ganini, Michele Antonucci, Marta Signoretti, Filomena Petta, Massimo Panei, Pierluigi Bove
Summary: This study evaluated the efficacy of Mictalase (R) suppositories in controlling irritative symptoms and preventing lower urinary tract infections in patients undergoing ThuLEP through a randomized trial. The results showed that patients who received Mictalase (R) treatment had significantly improved IPSS scores at 30 days postoperation, and a lower rate of positive urine cultures at 15 days postoperatively.
Review
Medicine, General & Internal
Eduard Roussel, Riccardo Campi, Daniele Amparore, Riccardo Bertolo, Umberto Carbonara, Selcuk Erdem, Alexandre Ingels, Onder Kara, Laura Marandino, Michele Marchioni, Stijn Muselaers, Nicola Pavan, Angela Pecoraro, Benoit Beuselinck, Ivan Pedrosa, David Fetzer, Maarten Albersen
Summary: The incidental detection of renal masses has increased in recent years, resulting in the need for better presurgical characterization of these masses. Novel ultrasound-based techniques, such as contrast-enhanced ultrasound, ultrasound molecular imaging, elastography, and micro-Doppler imaging, have shown potential in non-invasively characterizing renal masses, but further validation and research are needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Riccardo Bertolo, Orietta Dalpiaz, Giorgio Bozzini, Chiara Cipriani, Matteo Vittori, Thomas Alber, Francesco Maiorino, Marco Carilli, Robin Zeder, Valerio Lacovelli, Michele Antonucci, Marco Sandri, Pierluigi Bove
Summary: This study compared the efficacy and safety of thulium laser enucleation of prostate (ThuLEP) and laparoscopic trans-vesical simple prostatectomy (LSP) in the treatment of benign prostatic hyperplasia (BPH). The results showed that ThuLEP and LSP had comparable effects in relieving symptoms and improving patient-reported outcomes, but LSP was more invasive.
INTERNATIONAL BRAZ J UROL
(2022)
Review
Medicine, General & Internal
Stijn Muselaers, Selcuk Erdem, Riccardo Bertolo, Alexandre Ingels, Onder Kara, Nicola Pavan, Eduard Roussel, Angela Pecoraro, Michele Marchioni, Umberto Carbonara, Laura Marandino, Daniele Amparore, Riccardo Campi
Summary: PSMA PET/Computed Tomography has the potential to be an important imaging tool for staging and monitoring renal cell carcinoma, as it is highly expressed in the microvasculature of solid tumors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Aldo Brassetti, Giovanni E. Cacciamani, Andrea Mari, Juan D. Garisto, Riccardo Bertolo, Chandru P. Sundaram, Ithaar Derweesh, Ahmet Bindayi, Prokar Dasgupta, James Porter, Alexander Mottrie, Luigi Schips, Koon Ho Rah, David Y. T. Chen, Chao Zhang, Kenneth Jacobsohn, Umberto Anceschi, Alfredo M. Bove, Manuela Costantini, Mariaconsiglia Ferriero, Riccardo Mastroianni, Leonardo Misuraca, Gabriele Tuderti, Alexander Kutikov, Wesley M. White, Stephen T. Ryan, Francesco Porpiglia, Jihad Kaouk, Andrea Minervini, Inderbir Gill, Riccardo Autorino, Giuseppe Simone
Summary: Robot-assisted partial nephrectomy is a viable option for treating tumors larger than 7 cm, but the risk of postoperative renal function deterioration should be considered. Off-clamp robotic partial nephrectomy has shorter operation times and may improve perioperative outcomes.
Article
Medicine, General & Internal
Riccardo Bertolo, Chiara Cipriani, Matteo Vittori, Riccardo Campi, Juan Garisto, Michele Di Dio, Filippo Annino, Pierluigi Bove
Summary: Robotic technology allows beginner surgeons to perform minimally-invasive partial nephrectomy with a shorter learning curve compared to pure laparoscopy. This video-article presents the surgical technique and outcomes of the first 11 cases performed by a young surgeon using robotic PN. The off-clamp approach and simple enucleation technique were successfully employed, yielding comparable results to existing literature.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Alfredo Distante, Laura Marandino, Riccardo Bertolo, Alexandre Ingels, Nicola Pavan, Angela Pecoraro, Michele Marchioni, Umberto Carbonara, Selcuk Erdem, Daniele Amparore, Riccardo Campi, Eduard Roussel, Anna Calio, Zhenjie Wu, Carlotta Palumbo, Leonardo D. D. Borregales, Peter Mulders, Constantijn H. J. Muselaers
Summary: Renal cell carcinoma (RCC) presents histopathological challenges for accurate diagnosis and prognosis. This literature review explores recent advancements in AI applications in RCC pathology, with the aim of improving precision, efficiency, and objectivity in histopathological analysis. AI-powered approaches demonstrate effective identification and classification abilities, enabling accurate diagnosis, grading, and prognosis prediction. Challenges include standardization, generalizability, performance benchmarking, and data integration into clinical workflows. Accurate interpretation of AI decisions by pathologists and robust validation workflows are crucial for enhancing patient care.
Article
Urology & Nephrology
Riccardo Bertolo, Pierluigi Bove, Marco Sandri, Luca Cindolo, Filippo Annino, Costantino Leonardo, Paolo Parma, Roberto Nucciotti, Angelo Porreca, Mario Falsaperla, Domenico Veneziano, Antonio Celia, Luigi Schips, Claudio Simeone, Marco Carini, Andrea Minervini, Alessandro Antonelli
MINERVA UROLOGY AND NEPHROLOGY
(2022)
Review
Oncology
Carlo Ganini, Ivano Amelio, Riccardo Bertolo, Eleonora Candi, Angela Cappello, Chiara Cipriani, Alessandro Mauriello, Carla Marani, Gerry Melino, Manuela Montanaro, Maria Emanuela Natale, Giuseppe Tisone, Yufang Shi, Ying Wang, Pierluigi Bove
Summary: Serine and one-carbon unit metabolisms play essential roles in cellular functions such as proliferation and biosynthesis, especially in cancer. Experimental evidence suggests that genes and enzymes involved in one-carbon metabolism may play critical roles in prostate cancer.