Article
Oncology
Simona Giglio, Cosimo De Nunzio, Roberto Cirombella, Antonella Stoppacciaro, Omar Faruq, Stefano Volinia, Gustavo Baldassarre, Andrea Tubaro, Hideshi Ishii, Carlo M. Croce, Andrea Vecchione
Summary: The study found that plasma miRs can serve as a noninvasive diagnostic tool for prostate cancer, and the model composed of miR-26b-5p and miR-98-5p can effectively distinguish prostate cancer from non-cancer conditions. For high-grade prostate cancer patients, the combination of miR-4732-3p and miR-26b-5p has the highest diagnostic accuracy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Bisheng Cheng, Chen Tang, Junjia Xie, Qianghua Zhou, Tianlong Luo, Qiong Wang, Hai Huang
Summary: This study established a novel predictive model for prostate cancer based on cuproptosis-related genes, providing insights into patient prognosis and highlighting the importance of PDHA1 in cancer progression. High expression of PDHA1 was associated with disease progression, drug sensitivity, and therapeutic response in prostate cancer patients.
Review
Biochemistry & Molecular Biology
Ming-Yue Li, Li-Zhong Liu, Ming Dong
Summary: Lung cancer is often diagnosed late with poor prognosis, and conventional treatments are ineffective for metastatic lung cancer. Lung cancer cell-derived exosomes are receiving attention for their potential in carcinogenesis, diagnosis, therapy, and prognosis of lung cancer, with studies looking into their use as drug delivery vehicles and potential clinical applications.
Article
Cell Biology
Penghui Yuan, Le Ling, Xintao Gao, Taotao Sun, Jianping Miao, Xianglin Yuan, Jihong Liu, Zhihua Wang, Bo Liu
Summary: The study identified SNRPA1 as a prognostic hub RNA-binding protein in prostate cancer, with its expression positively correlated with Gleason score and pathological TNM stage. Molecular experiments confirmed the proliferative role of SNRPA1 in prostate cancer cells, providing evidence for the relationship between RNA-binding proteins and prostate cancer prognosis.
Review
Immunology
Chenming Zhong, Zijun Xie, Ling-hui Zeng, Chunhui Yuan, Shiwei Duan
Summary: This article provides a comprehensive overview of the expression regulation, signaling pathways, and diagnostic and prognostic value of MIR4435-2HG in tumors. It also highlights the potential directions for future research on MIR4435-2HG.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Adriano Basso Dias, Sangeet Ghai
Summary: Prostate cancer (PCa) is the second most common cancer in men and is a leading cause of cancer death. Magnetic resonance imaging (MRI) is recommended as the initial test for men at risk for PCa, but it requires additional resources and cost. Micro-ultrasound (microUS) is a new high resolution ultrasound technology that can be used for prostate imaging and biopsy. Studies have shown that microUS and MRI have comparable detection rates for clinically significant PCa.
Article
Multidisciplinary Sciences
Zeng-Hong Wu, Yun Tang, Yue Zhou
Summary: Alternative splicing (AS) is a critical post-transcriptional regulatory mechanism that increases protein diversity by expanding gene expression patterns. In this study, an all-around AS profile of thyroid cancer cells was drawn based on RNA-seq data, revealing that ASEs are common in TC. Additionally, 1819 AS signatures were significantly associated with the overall survival of TC patients, with seven types of ASEs linked to poor prognosis of TC.
SCIENTIFIC REPORTS
(2021)
Article
Biophysics
Raquel Sanchez-Salcedo, Rebeca Miranda-Castro, Noemi de-los-Santos-Alvarez, Maria Jesus Lobo-Castanon
Summary: A sandwich-type hybridization assay has been developed for detecting prostate cancer by simultaneously measuring prostate cancer antigen 3 and PSA mRNA. This method improves the sensitivity of long noncoding RNA detection and shows good performance in PCa diagnosis without significant cross-talk in the dual configuration.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medicine, General & Internal
Jiahua Gan, Xing Zeng, Xiong Wang, Ya Wu, Ping Lei, Zhihua Wang, Chunguang Yang, Zhiquan Hu
Summary: This study evaluated the diagnostic value of candidate genes (ERG, PCA3, ARV7, PSMA, CK19, and EpCAM) in urinary exosomes. The results showed that the expression of these genes in urinary exosomes was significantly increased in patients with prostate cancer and was closely correlated with the Gleason score. Receiver operating characteristic curves demonstrated that these genes in urinary exosomes could distinguish patients with prostate cancer from healthy individuals.
FRONTIERS IN MEDICINE
(2022)
Review
Oncology
Milena Matuszczak, Jack A. Schalken, Maciej Salagierski
Summary: In prostate cancer, overdiagnosis and overtreatment are common problems. New liquid biopsy biomarker tests have been developed to improve diagnosis, prognosis, and decision-making. The current gold standard for diagnosing prostate cancer relies on digital rectal examination and elevated prostate-specific antigen levels before biopsy.
Article
Oncology
Weigang Liu, Mengqian Yu, Sheng Cheng, Xiaoxu Zhou, Jia Li, Yan Lu, Pengyuan Liu, Shiping Ding
Summary: This study reveals the clinical significance of 5'-tRFs in prostate adenocarcinoma (PRAD). The upregulation of 5'-tRFs in PRAD tumor samples suggests their potential as biomarkers for diagnosis and prognosis, as well as for molecular subtyping. The findings highlight the added and improved prognostic information provided by 5'-tRFs for PRAD patients.
Article
Oncology
Leihuan Huang, Xin Zeng, Haijing Ma, Yu Yang, Yoshie Akimoto, Gang Wei, Ting Ni
Summary: This study investigates the role of intron retention (IR) in tumorigenesis at a pan-cancer level and identifies IR events associated with tumor and patient survival. These IR events may modulate the expression of host genes, including those involved in cancer biology.
Review
Biochemistry & Molecular Biology
Ping Yang, Mei Meng, Quansheng Zhou
Summary: The study reveals that oncogenic CTAs are overexpressed in various cancers, promoting carcinogenesis, metastasis, and drug resistance. However, challenges in CTA-targeted cancer immunotherapy include deficient MHC-I antigen presentation, immunosuppressive cells in tumor tissues, and the tumor microenvironment reducing therapy efficacy. New strategies are proposed to overcome these barriers and develop potent immune therapeutics against cancer, as oncogenic CTAs show high tumor specificity and immunogenicity. Future breakthroughs in cancer therapy are expected with CTAs-targeted immunotherapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Genetics & Heredity
Xu Cheng, Xuanzi Yi
Summary: This study describes 26 RNA writers that mediate gene expression and genetic mutation in prostate cancer and evaluates their expression patterns in 948 prostate cancer samples. The RM Score, developed using principal component analysis algorithms, quantifies the RNA modification patterns of specific tumors. Analysis shows significant differences in prognosis between two categories determined by unsupervised clustering methods. The study also examines the relationship between the RM Score and clinical characteristics, immune infiltration level, drug response, and efficacy of chemotherapy and immunotherapy.
FRONTIERS IN GENETICS
(2023)
Review
Biotechnology & Applied Microbiology
Haotian Chen, Bairen Pang, Cheng Zhou, Meng Han, Jie Gong, Yong Li, Junhui Jiang
Summary: Current diagnostic tools for prostate cancer (PCa) diagnosis and risk stratification are inadequate. Traditional therapies have poor efficacy against metastatic PCa, making it a significant burden on global men's health. Prostate cancer-derived extracellular vesicles (PCDEVs) have gained attention for their role in communication within the tumor microenvironment. Recent advancements have shown that PCDEVs proteins play a crucial role in PCa invasion, progression, metastasis, therapeutic resistance, and immune evasion. This review discusses the applications of sEV proteins in PCa diagnosis and prognosis through liquid biopsy, focuses on the roles of PCa-derived small EVs (sEVs) proteins in the tumor microenvironment associated with cancer progression, and explores the therapeutic potential of sEV proteins for future metastatic PCa therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Obstetrics & Gynecology
Stephanno G. P. Sarmento, Antonio F. Moron, Larry J. Forney, Alan R. Hatanaka, Francisco H. C. Carvalho, Marcelo S. Franca, Tatiana K. Hamamoto, Rosiane Mattar, Iara M. Linhares, Evelyn Minis, Adriana Sanudo, Ester Sabino, Marilza V. C. Rudge, Steven S. Witkin
Summary: In this study, elevation of TIMP-1 and L-lactic acid levels in vaginal secretions, as well as dominance of L. iners in the vaginal microbiome, are associated with an increased risk of spontaneous preterm birth in primigravid women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Andrology
Amaro N. Duarte-Neto, Thiago A. Teixeira, Elia G. Caldini, Cristina T. Kanamura, Michele S. Gomes-Gouvea, Angela B. G. dos Santos, Renata A. A. Monteiro, Joao R. R. Pinho, Thais Mauad, Luiz F. F. da Silva, Paulo H. N. Saldiva, Marisa Dolhnikoff, Katia R. M. Leite, Jorge Hallak
Summary: Pathological findings in testes from fatal COVID-19 cases showed a combination of orchitis, vascular changes, basal membrane thickening, Leydig and Sertoli cell scarcity, and reduced spermatogenesis associated with local SARS-CoV-2 infection, which may impair hormonal function and fertility in men.
Article
Urology & Nephrology
Vinicius Genuino dos Santos, Gabriel Arantes dos Santos, Cristovao Barbosa Neto, Nayara Izabel Viana, Ruan Pimenta, Vanessa Ribeiro Guimaraes, Patricia Candido, Poliana Romao, Juliana A. de Camargo, Katia Ramos Moreira Leite, Miguel Srougi, Jose Cury, William C. Nahas, Sabrina Thalita Reis
Summary: This study found that the expression of miR-29b is downregulated in the fibrous plaque, tunica albuginea, and corpus cavernosum of patients with PD compared to the control group. This provides evidence for the association between miR-29b and PD.
Article
Urology & Nephrology
P. Romao, I. de Campos Souza, I Silva, V. Ribeiro Guimaraes, J. Alves de Camargo, G. A. dos Santos, N. Izabel Viana, M. Srougi, K. R. Moreira Leite, S. T. Reis, R. Pimenta
Summary: The study found that the AR gene was downregulated in the PC3 cell line, and X chromosome polysomy was present in both PC3 and LNCaP cell lines. HUMARA-Q assay revealed that both X chromosomes in PC3 cells exhibited AR activity, while only one AR gene was methylated in LNCaP cells.
ACTAS UROLOGICAS ESPANOLAS
(2022)
Article
Nutrition & Dietetics
Vanessa Cristina de Castro Rodrigues, Patricia da Graca Leite Speridiao, Adriana Sanudo, Mauro Batista Morais
Summary: A cross-sectional study compared feeding difficulties in children aged 2-5 years on a cows' milk elimination diet due to food allergy with a control group on an unrestricted diet. The study found that children on the elimination diet had higher frequency of picky eating and feeding problems. Picky eating was associated with lower weight-for-age z-scores. Food refusal and/or inappetence as manifestations of food allergy were linked to feeding difficulties, while current constipation and anticipatory gagging were associated with picky eating, avoidant eating, and feeding problems in both groups.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Dermatology
Juliana L. M. Soares, Vanessa A. Rocha, Adriana Sanudo, Helio Amante Miot, Edileia Bagatin
Summary: Gynoid lipodystrophy is a common chronic disorder with a high prevalence among adolescent girls. The onset of the disorder is associated with familial occurrence, body composition, diet habits, exercise, and hormonal factors.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Article
Clinical Neurology
Alexandre Kim Sangalan Sasaoka, Antonio Fernandes Moron, Edward Araujo, Adriana Sanudo, Mauricio Mendes Barbosa, Herbene Jose Figuinha Milani, Stephanno Gomes Pereira Sarmento, Sergio Cavalheiro
Summary: This study aimed to analyze the evolution of uterine scar thickness after open fetal surgery for myelomeningocele and establish a cut-off point for uterine scar thickness associated with high risk of uterine rupture. The results showed that thinner uterine scars were significantly associated with increased likelihood of thinning during pregnancy follow-up. A cut-off point of ≤3.0 mm in scar thickness may be useful for decision-making regarding the risk of uterine rupture and indication of caesarean section.
CHILDS NERVOUS SYSTEM
(2023)
Article
Urology & Nephrology
Victor Srougi, Rodolfo Anisio Santana de Torres Bandeira, Sabrina Thalita Reis, Gabriel Arantes dos Santos, Hiury da Silva Andrade, Katia Ramos Moreira Leite, David Hamilton-Cho, Anuar Ibrahim Mitre, Marco Antonio Arap, Miguel Srougi, Ricardo Jordao Duarte
Summary: Patients with high ICC density experience significant improvement in hydronephrosis following pyeloplasty, but ICC density is not associated with functional outcomes.
Article
Cell Biology
Lars Egevad, Brett Delahunt, Kenneth A. Iczkowski, Theo van der Kwast, Geert J. L. H. van Leenders, Katia R. M. Leite, Chin-Chen Pan, Hemamali Samaratunga, Toyonori Tsuzuki, Nita Mulliqi, Xiaoyi Ji, Henrik Olsson, Masi Valkonen, Pekka Ruusuvuori, Martin Eklund, Kimmo Kartasalo
Summary: There is evidence that cribriform morphology is associated with a worse prognosis for prostatic adenocarcinoma. This study aimed to investigate the reproducibility of cribriform cancer diagnosis in prostate needle biopsies. A panel of nine prostate pathology experts independently reviewed 304 digitised biopsies and achieved a 2/3 consensus diagnosis of cribriform and noncribriform cancer in 90% of the cases. Strict diagnostic criteria were used to identify cribriform patterns and generate a set of consensus cases for standardization.
Article
Geriatrics & Gerontology
Tatiana Karpusenko, Maynara Alfonsi, Nayara Tasse de Oliveira Cirino, Erika Yukie Ishigaki, Adriana Sanudo, Sergio Marcio Pacheco Paschoal, Luiz Eugenio Garcez Leme, Monica Rodrigues Perracini
Summary: This cross-sectional exploratory study investigated factors associated with unrecovered falls among older patients with a history of falls in the previous year. Depressive symptoms, ADL/IADL limitation, mobility limitation, under-nutrition, and outdoor falls were found to be associated with unrecovered falls. Professionals should consider preventive strategies and preparedness procedures for those who are more likely to experience unrecovered falls.
Article
Biochemistry & Molecular Biology
Ruan Pimenta, Carolina Mie Mioshi, Guilherme L. Goncalves, Patricia Candido, Juliana A. Camargo, Vanessa R. Guimaraes, Caroline Chiovatto, Vitoria Ghazarian, Poliana Romao, Karina Serafim da Silva, Gabriel A. dos Santos, Iran A. Silva, Miguel Srougi, William C. Nahas, Katia R. Leite, Nayara I. Viana, Sabrina T. Reis
Summary: This study aimed to evaluate the suppressive effect of miR-137 in prostate cancer, regardless of diet-induced hypercholesterolemia. The results showed that miR-137 could inhibit the transcription and translation of the p160 family, SRC-1, SRC-2, and SRC-3, and indirectly reduce the expression of AR. It also inhibited cell migration and invasion, reduced proliferation, and increased apoptosis rates. In vivo experiments demonstrated that tumor growth was arrested after intratumoral restoration of miR-137, with a more significant response in the hypercholesterolemic group.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Isadora Oliveira Ansaloni Pereira, Glenda Nicioli da Silva, Tamires Cunha Almeida, Ana Paula Braga Lima, Andre Luiz Ventura Savio, Katia Ramos Moreira Leite, Daisy Maria Favero Salvadori
Summary: Long non-coding RNAs are frequently dysregulated and have been associated with carcinogenesis, aggressiveness, and chemoresistance in tumors. In this study, we investigated the combined expression of JHDM1D and JHDM1D-AS1 in bladder tumors, and found that it can distinguish between low-grade and high-grade tumors. We also discovered that silencing JHDM1D-AS1 can reduce the growth and proliferation of high-grade bladder tumor cells and increase their sensitivity to gemcitabine treatment.
Article
Pediatrics
Maria Fernanda B. de Almeida, Adriana Sanudo, Kelsy N. Areco, Rita de Cassia X. Balda, Daniela T. Costa-Nobre, Mandira D. Kawakami, Tulio Konstantyner, Ana Silvia S. Marinonio, Milton H. Miyoshi, Paulo Bandiera-Paiva, Rosa M. V. Freitas, Liliam C. C. Morais, Monica L. P. Teixeira, Bernadette Waldvogel, Carlos Roberto V. Kiffer, Ruth Guinsburg
Summary: This study analyzed the temporal trend, causes, and timing of neonatal mortality of moderate and late preterm infants in Sao Paulo State, Brazil from 2004-2015. The results showed a decrease in neonatal mortality rate over the past decade, but highlighted the need for improvement in perinatal healthcare.
Article
Psychology, Clinical
Vera Salvo, Daniela Fernandez Curado, Adriana Sanudo, Fabiane Aparecida Canaan Rezende, Marcelo Demarzo
Summary: The objective of this study was to validate the Brazilian Mindful Eating Scale (MES-B), which assesses mindfulness in eating behavior. A total of 236 overweight or obese Brazilian women participated in the study. Through confirmatory factor analysis and reliability analysis, the MES-B was found to have 24 items and six domains. The scale was initially validated but further evaluation in different genders is necessary.
Article
Public, Environmental & Occupational Health
Larissa Festa, Marli de Fatima Prado, Amanda Cristina Santos Jesuino, Rita de Cassia Xavier Balda, Angela Tayra, Adriana Sanudo, Mariza Vono Tancredi, Maria Aparecida da Silva, Valdir Monteiro Pinto, Daniela Testoni Costa-Nobre, Carlos Roberto Veiga Kiffer, Carla Gianna Luppi
Summary: The objective of this study was to describe the frequency of underreporting of unfavorable outcomes of congenital syphilis in the state of Sao Paulo, Brazil, from 2007 to 2018. Through probabilistic and deterministic linkage methods, the study analyzed cases of abortion, fetal and non-fetal deaths due to congenital syphilis reported on the Notifiable Health Conditions Information System (SINAN) and on the Mortality Information System (SIM). The results showed an increase in unfavorable outcomes, with a 11.4% increase in infant deaths due to congenital syphilis and a 3.0% increase in fetal deaths.
EPIDEMIOLOGIA E SERVICOS DE SAUDE
(2023)