Review
Oncology
Chunyu Zhang, Jiao Hu, Huihuang Li, Hongzhi Ma, Belaydi Othmane, Wenbiao Ren, Zhenglin Yi, Dongxu Qiu, Zhenyu Ou, Jinbo Chen, Xiongbing Zu
Summary: Early detection of lymph node metastasis is crucial for improving prognosis and overall survival in bladder cancer patients, but current diagnostic methods are limited. Non-coding RNA and m6A have been reported to be abnormally expressed in bladder cancer related to lymph node metastasis, offering potential for more accurate diagnostic methods in future clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andreja Erman, Urska Kamensek, Urska Dragin Jerman, Mojca Pavlin, Maja Cemazar, Peter Veranic, Rok Romih
Summary: The study investigated the fate of cancer cells applied intravesically after transurethral resection of bladder tumors, revealing that these cells initially adhere to and migrate through the traumatized epithelium before reaching the basal lamina; E-cadherin and desmoplakin 1/2 were identified as potential immunohistochemical markers of tumor margins based on the labeling of various junctional proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Guofeng Ma, Wen Xue, Jie Ni, Ran Tao
Summary: The research reveals that miR-522-3p can suppress the malignancy and cisplatin resistance of gastric cancer cells by targeting TCF4. This study may provide a potential biomarker for gastric cancer diagnosis and a novel direction for gastric cancer chemotherapy.
JOURNAL OF ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Geoffrey Brown
Summary: This review investigates how oncogenes contribute to the development of malignant tumors, with the cancer stem cell theory suggesting that cancer is a hierarchical structure of cells derived from transformed stem cells. It examines the loss of intrinsic versatility in stem cells, the role of proto-oncogenes in cell lineage determination, and the impact of epigenetic events in regulating cell fate and tumor development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ting Xu, Hongmei Ding, Jie Chen, Jiahui Lei, Meng Zhao, Bingyu Ji, Youguo Chen, Songbing Qin, Qinqin Gao
Summary: This article provides an update on the roles of aberrant DNA methylation in endometrial carcinogenesis and discusses the opportunities and challenges of utilizing DNA methylation in the management and prevention of endometrial cancer.
Article
Cell Biology
Daniela Eletto, Francesca Reppucci, Agostino Ronga, Vincenzo Altieri, Sergio Brongo, Rosanna Martinelli, Margot De Marco, Liberato Marzullo
Summary: Diuron, a substituted urea herbicide, may induce bladder carcinogenesis by involving the BAG3 protein, which could potentially serve as an early biomarker for damage caused by chronic exposure to Diuron.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Roopak Murali, Vaishnavi Balasubramaniam, Satish Srinivas, Sandhya Sundaram, Ganesh Venkatraman, Sudha Warrier, Arun Dharmarajan, Rajesh Kumar Gandhirajan
Summary: Ovarian cancers are a type of tumor that originates from different cells of the ovary and account for around 4% of all cancers in women worldwide. There are more than 30 identified tumor types based on cellular origins, with epithelial ovarian cancer (EOC) being the most common and deadly type. EOC can be further categorized into different subtypes. The development of ovarian cancer has long been associated with endometriosis, a chronic inflammation leading to the accumulation of mutations. Recent studies have elucidated the role of somatic mutations and their impact on altered tumor metabolism. Several oncogenes and tumor suppressor genes have been implicated in ovarian cancer progression. This review highlights the genetic alterations and their impact on metabolic networks in ovarian cancer, providing insights into potential personalized therapies.
Article
Biochemistry & Molecular Biology
Eve Pellerin, Felix-Antoine Pellerin, Stephane Chabaud, Frederic Pouliot, Martin Pelletier, Stephane Bolduc
Summary: The study reveals that glucuronidated BPs have different effects on normal urothelial cells and bladder cancer cells. They decrease the activity of normal cells but increase the bioenergetics and activity of cancer cells. This suggests that the ubiquitous presence of BP metabolites in urine could promote the progression of bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Shuangmei Tian, Jing Wang, Fangyuan Zhang, Degeng Wang
Summary: This study compares the regulation of oncogenes and tumor suppressor genes (TSG) by miRNA. The results show that cancer gene mRNAs have more miRNA binding sites and are more repressed by miRNA than the overall protein-coding gene population. Importantly, TSG mRNAs are more highly targeted and regulated by miRNA than oncogene mRNAs.
Article
Hematology
Shuo Yang, Xiao-Na Zhu, Hui-Lin Zhang, Qian Yang, Yu-Sheng Wei, Di Zhu, Meng-Di Liu, Shao-Ming Shen, Li Xia, Ping He, Meng-Kai Ge, Yi-Lian Pan, Meng Zhao, Ying-Li Wu, Jun-Ke Zheng, Guo-Qiang Chen, Yun Yu
Summary: The study revealed that ANP32B forms a repressive complex with p53 in hematopoietic cells, inhibiting p53's transcriptional activity, while deleting ANP32B enhances p53 activity and impairs the function of LSCs in CML. Therefore, inhibiting ANP32B may be a potential strategy for treating CML.
Review
Oncology
Zuzana Pokorna, Jan Vyslouzil, Vaclav Hrabal, Borivoj Vojtesek, Philip J. Coates
Summary: This review summarizes the regulation of two major protein variants of the p53 family member p63, TAp63 and Delta Np63, highlighting their different functions and pathways in cellular biology. TAp63 is mainly involved in senescence, metabolism, and germ cell genome maintenance, while Delta Np63 primarily maintains stem/progenitor cells in various epithelia.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sydney R. Grant, Li Tang, Lei Wei, Barbara A. Foster, Gyorgy Paragh, Wendy J. Huss
Summary: More than 80,000 new cases of bladder cancer are estimated to be diagnosed in 2023, but the 5-year survival rate has remained unchanged for decades, highlighting the need for prevention. Mutations in cancer-driving genes in normal urothelium have shown a significant correlation with bladder cancer tissue, providing evidence for mutation hotspots in assessing cancer risk. A machine learning model using personal risk factors and mutations within bladder cancer hotspots has shown promising results in predicting high- vs. low-risk normal urothelium.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Dana L. Woodstock, Morgan A. Sammons, Martin Fischer
Summary: p53 and p63, as transcription factors, regulate both shared and unique target genes to exert their tumor suppressive or oncogenic effects. The previous notion of strict competition between the two siblings needs to be reevaluated, as they can also collaborate towards a common goal.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Xuan-Mei Piao, Byungdoo Hwang, Pildu Jeong, Young Joon Byun, Ho Won Kang, Sung Phil Seo, Won Tae Kim, Jong-Young Lee, Yun-Sok Ha, Young-Suk Lee, Isaac Y. Kim, Yung Hyun Choi, Eun-Jong Cha, Sung-Kwon Moon, Seok Joong Yun, Wun-Jae Kim
Summary: COL6A1 and COL6A2 play important roles in the pathogenesis and progression of BCa, inhibiting cell proliferation, inducing G(1) phase cell cycle arrest, regulating signaling pathways, and suppressing the activity of matrix metalloproteinases, ultimately forming a physical barrier to inhibit BCa tumor growth and invasion.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Soumen Bera, Shrinidhi Kadkol, Lenny K. Hong, Waleed Ali, John D. Brockman, Maria Sverdlov, Eileen Brister, Virgilia Macais, Andre Kajdacsy-Balla, Klara Valyi-Nagy, Ziqiao Xu, Irida Kastrati, Li Liu, Alan M. Diamond
Summary: SELENOF selenoprotein levels are decreased in prostate cancer and reducing SELENOF in prostate epithelial cells results in a transformed phenotype. The increase in eiF4a3 translation factor and hypomethylation of its corresponding gene contribute to the lower levels of SELENOF. Ectopic expression of eIF4a3 in prostate cancer cells reduces SELENOF levels.
MOLECULAR CARCINOGENESIS
(2023)
Article
Medicine, Research & Experimental
Ming Chen, Jiangwen Zhang, Alice H. Berger, Moussa S. Diolombi, Christopher Ng, Jacqueline Fung, Roderick T. Bronson, Mireia Castillo-Martin, Tin Htwe Thin, Carlos Cordon-Cardo, Robin Plevin, Pier Paolo Pandolfi
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Oncology
Irfan Nasir, Laura Fernandez, Pedro Vieira, Oriol Pares, Ines Santiago, Mireia Castillo-Martin, Hugo Domingos, Jose F. Cunha, Carlos Carvalho, Richard J. Heald, Geerard L. Beets, Amjad Parvaiz, Nuno Figueiredo
Article
Cell Biology
Jlenia Guarnerio, Yang Zhang, Giulia Cheloni, Riccardo Panella, Jesse Mae Katon, Mark Simpson, Akinobu Matsumoto, Antonella Papa, Cristian Loretelli, Andreas Petri, Sakari Kauppinen, Cassandra Garbutt, Gunnlaugur Petur Nielsen, Vikram Deshpande, Mireia Castillo-Martin, Carlos Cordon-Cardo, Spentzos Dimitrios, John G. Clohessy, Mona Batish, Pier Paolo Pandolfi
Article
Cell Biology
Ling-shiang Chuang, Joshua Morrison, Nai-yun Hsu, Philippe Ronel Labrias, Shikha Nayar, Ernie Chen, Nicole Villaverde, Jody Ann Facey, Gilles Boschetti, Mamta Giri, Mireia Castillo-Martin, Tin Htwe Thin, Yashoda Sharma, Jaime Chu, Judy H. Cho
DISEASE MODELS & MECHANISMS
(2019)
Article
Cell & Tissue Engineering
Mireia Castillo-Martin, Nataliya Gladoun, Dan Han, Adolfo Firpo-Betancourt, Jose M. Silva, Carlos Cordon-Cardo
STEM CELL RESEARCH
(2019)
Review
Microbiology
Joana R. Lerias, Eric de Sousa, Georgia Paraschoudi, Joao Martins, Carolina Condeco, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Andreia Maia, Mireia Castillo-Martin, Antonio Beltran, Dario Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer
FRONTIERS IN MICROBIOLOGY
(2020)
Review
Cell Biology
Joana R. Lerias, Georgia Paraschoudi, Eric de Sousa, Joao Martins, Carolina Condeco, Nuno Figueiredo, Carlos Carvalho, Ernest Dodoo, Mireia Castillo-Martin, Antonio Beltran, Dario Ligeiro, Martin Rao, Alimuddin Zumla, Markus Maeurer
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Gastroenterology & Hepatology
Laura M. Fernandez, Nuno L. Figueiredo, Angelita Habr-Gama, Guilherme P. Sao Juliao, Pedro Vieira, Bruna B. Vailati, Irfan Nasir, Oriol Pares, Ines Santiago, Mireia Castillo-Martin, Carlos Carvalho, Amjad Parvaiz, Rodrigo Oliva Perez
DISEASES OF THE COLON & RECTUM
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sofia Carrilho Vaz, Angelo Silva, Carla Oliveira, Rita Marques, Antonio Galzerano, Mireia Castillo-Martin
CLINICAL AND TRANSLATIONAL IMAGING
(2020)
Review
Immunology
Eric de Sousa, Joana R. Lerias, Antonio Beltran, Georgia Paraschoudi, Carolina Condeco, Jessica Kamiki, Patricia Alexandra Antonio, Nuno Figueiredo, Carlos Carvalho, Mireia Castillo-Martin, Zhe Wang, Dario Ligeiro, Martin Rao, Markus Maeurer
Summary: This article discusses factors associated with the successful outcome of immune checkpoint blockade in patients with solid cancers, including high tumor mutational burden, T-cell recognition of private neoantigens, and explores immune therapy strategies related to T-cell receptors, IFN-gamma, HLA, and other factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Mariana Tavares Barroso, Bruna Costa, Catia Rebelo de Almeida, Mireia Castillo Martin, Nuno Couto, Tania Carvalho, Rita Fior
Summary: This study successfully developed a zebrafish xenograft model to evaluate the response of pancreatic cancer cells to different chemotherapies, providing more treatment options for clinical decisions.
Article
Oncology
Thanigaivelan Kanagasabai, Guoliang Li, Tian Huai Shen, Nataliya Gladoun, Mireia Castillo-Martin, Sherly I. Celada, Yingqiu Xie, Lakendria K. Brown, Zaniya A. Mark, Josiah Ochieng, Billy R. Ballard, Carlos Cordon-Cardo, Samuel E. Adunyah, Renjie Jin, Robert J. Matusik, Zhenbang Chen
Summary: The study found that miR-21 promotes the progression of prostate cancer by activating the IRS1/SREBP-1 axis, and targeting the miR-21/SREBP-1 signaling pathway may be a novel strategy for controlling the malignancy of prostate cancer.
Article
Medicine, General & Internal
Saba Abdulghani, Angela Afonso, Mireia Castillo, Javier Martin-Fernandez, Ines Franco, Bruna Parreira, Ana Couto, Jacome Bruges-Armas, Ana Maria Rodrigues, Ana Goncalves, Alexandre Dias, Ionela Toader, Andreia Lopes, Claudia Faria, Fernanda Marques, Joao Carlos Sousa, Ricardo Silvestre, Paulo Pereira, Manuel Correia, Luis Maia, Helena Canhao, Sergio Dias
ACTA MEDICA PORTUGUESA
(2022)
Article
Oncology
Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Sonia Fernandez-Ruiz, Cristina Viera, Onintza Carlevaris, Amaia Ercilla, Isabel Mendizabal, Teresa Martin, Alice Macchia, Laura Camacho, Mikel Pujana-Vaquerizo, Pilar Sanchez-Mosquera, Veronica Torrano, Natalia Martin-Martin, Patricia Zuniga-Garcia, Mireia Castillo-Martin, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Miguel Unda, Jose M. Mato, Edurne Berra, Maria L. Martinez-Chantar, Arkaitz Carracedo
Summary: This study investigates the regulation and function of Glycine N-Methyltransferase (GNMT) in prostate cancer and discovers that the enzyme is repressed when the oncogenic PI3K pathway is activated, adding complexity to its dependency on androgen signaling. Additionally, the study demonstrates the requirement of GNMT expression for the onset of invasive prostate cancer in a genetic mouse model.
Article
Gastroenterology & Hepatology
Miguel Bispo, Ricardo Rio-Tinto, Paulo Fidalgo, Mireia Castillo-Martin, Jacques Deviere
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY
(2020)