Dynamic metabolic engineering: New strategies for developing responsive cell factories

Multivariate modular metabolic engineering for pathway and strain optimization

(2014) Bradley Walters Biggs et al.   CURRENT OPINION IN BIOTECHNOLOGY

Looking for the pick of the bunch: high-throughput screening of producing microorganisms with biosensors

(2014) Marcus Schallmey et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic flux redirection from a central metabolic pathway toward a synthetic pathway using a metabolic toggle switch

(2014) Yuki Soma et al.   METABOLIC ENGINEERING

Functional optimization of gene clusters by combinatorial design and assembly

(2014) Michael J Smanski et al.   NATURE BIOTECHNOLOGY

Tunable protein degradation in bacteria

(2014) D Ewen Cameron et al.   NATURE BIOTECHNOLOGY

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control

(2014) P. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Designing RNA-Based Genetic Control Systems for Efficient Production from Engineered Metabolic Pathways

(2014) Jason T. Stevens et al.   ACS Synthetic Biology

Near-infrared Light Responsive Synthetic c-di-GMP Module for Optogenetic Applications

(2014) Min-Hyung Ryu et al.   ACS Synthetic Biology

Optimizing Metabolite Production Using Periodic Oscillations

(2014) Steven W. Sowa et al.   PLoS Computational Biology

Directed Evolution of the Quorum-Sensing Regulator EsaR for Increased Signal Sensitivity

(2013) Jasmine Shong et al.   ACS Chemical Biology

Design and Kinetic Analysis of a Hybrid Promoter–Regulator System for Malonyl-CoA Sensing in Escherichia coli

(2013) Peng Xu et al.   ACS Chemical Biology

Protein design in systems metabolic engineering for industrial strain development

(2013) Zhen Chen et al.   Biotechnology Journal

Dynamic gene expression for metabolic engineering of mammalian cells in culture

(2013) Huong Le et al.   METABOLIC ENGINEERING

Engineering dynamic pathway regulation using stress-response promoters

(2013) Robert H Dahl et al.   NATURE BIOTECHNOLOGY

Precise and reliable gene expression via standard transcription and translation initiation elements

(2013) Vivek K Mutalik et al.   NATURE METHODS

Design and use of synthetic regulatory small RNAs to control gene expression in Escherichia coli

(2013) Seung Min Yoo et al.   Nature Protocols

Tailored fatty acid synthesis via dynamic control of fatty acid elongation

(2013) J. P. Torella et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis and Design of a Genetic Circuit for Dynamic Metabolic Engineering

(2013) Nikolaos Anesiadis et al.   ACS Synthetic Biology

Metabolite Recognition Principles and Molecular Mechanisms Underlying Riboswitch Function

(2012) Alexander Serganov et al.   Annual Review of Biophysics

Synthetic biology devices as tools for metabolic engineering

(2012) Eric Shiue et al.   BIOCHEMICAL ENGINEERING JOURNAL

Redirecting carbon flux into malonyl-CoA to improve resveratrol titers: Proof of concept for genetic interventions predicted by OptForce computational framework

(2012) Namita Bhan et al.   CHEMICAL ENGINEERING SCIENCE

Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene α-santalene in a fed-batch mode

(2012) Gionata Scalcinati et al.   METABOLIC ENGINEERING

An integrated computational and experimental study for overproducing fatty acids in Escherichia coli

(2012) Sridhar Ranganathan et al.   METABOLIC ENGINEERING

A dynamic metabolite valve for the control of central carbon metabolism

(2012) Kevin V. Solomon et al.   METABOLIC ENGINEERING

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Genome-scale promoter engineering by coselection MAGE

(2012) Harris H Wang et al.   NATURE METHODS

Genetic switchboard for synthetic biology applications

(2012) J. M. Callura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Circuit Performance under Conditions Relevant for Industrial Bioreactors

(2012) Felix Moser et al.   ACS Synthetic Biology

Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron

(2011) Marc Jungbluth et al.   BMC Systems Biology

Introduction and expression of genes for metabolic engineering applications in Saccharomyces cerevisiae

(2011) Nancy A. Da Silva et al.   FEMS YEAST RESEARCH

From zero to hero—Design-based systems metabolic engineering of Corynebacterium glutamicum for l-lysine production

(2011) Judith Becker et al.   METABOLIC ENGINEERING

Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways

(2011) Joshua K. Michener et al.   METABOLIC ENGINEERING

Engineering microbes to sense and eradicate Pseudomonas aeruginosa, a human pathogen

(2011) N. Saeidi et al.   Molecular Systems Biology

Optimal regulatory strategies for metabolic pathways in Escherichia coli depending on protein costs

(2011) F. Wessely et al.   Molecular Systems Biology

In silico feedback for in vivo regulation of a gene expression circuit

(2011) Andreas Milias-Argeitis et al.   NATURE BIOTECHNOLOGY

Versatile RNA-sensing transcriptional regulators for engineering genetic networks

(2011) J. B. Lucks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Synthetic Optogenetic Transcription Device Enhances Blood-Glucose Homeostasis in Mice

(2011) H. Ye et al.   SCIENCE

Biosensors and their applications in microbial metabolic engineering

(2011) Fuzhong Zhang et al.   TRENDS IN MICROBIOLOGY

Regulation of β-Lactamase Activity by Remote Binding of Heme: Functional Coupling of Unrelated Proteins through Domain Insertion

(2010) Wayne R. Edwards et al.   BIOCHEMISTRY

Engineering Static and Dynamic Control of Synthetic Pathways

(2010) William J. Holtz et al.   CELL

Scale-down simulators for metabolic analysis of large-scale bioprocesses

(2010) Peter Neubauer et al.   CURRENT OPINION IN BIOTECHNOLOGY

Autonomous induction of recombinant proteins by minimally rewiring native quorum sensing regulon of E. coli

(2010) Chen-Yu Tsao et al.   METABOLIC ENGINEERING

Microbial production of fatty-acid-derived fuels and chemicals from plant biomass

(2010) Eric J. Steen et al.   NATURE

OptForce: An Optimization Procedure for Identifying All Genetic Manipulations Leading to Targeted Overproductions

(2010) Sridhar Ranganathan et al.   PLoS Computational Biology

Redirection of flux through the FPP branch-point inSaccharomyces cerevisiaeby down-regulating squalene synthase

(2008) Eric M. Paradise et al.   BIOTECHNOLOGY AND BIOENGINEERING

Engineering Complex Riboswitch Regulation by Dual Genetic Selection

(2008) Vandana Sharma et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic metabolic engineering for increasing bioprocess productivity

(2008) Nikolaos Anesiadis et al.   METABOLIC ENGINEERING

A flow cytometry-based screen for synthetic riboswitches

(2008) Sean A. Lynch et al.   NUCLEIC ACIDS RESEARCH

Promoter library designed for fine-tuned gene expression in Pichia pastoris

(2008) Franz S. Hartner et al.   NUCLEIC ACIDS RESEARCH

Surface Sites for Engineering Allosteric Control in Proteins

(2008) J. Lee et al.   SCIENCE