Article
Medicine, General & Internal
Victor Nitti, Cornelia Haag-Molkenteller, Michael Kennelly, Michael Chancellor, Brenda Jenkins, Brigitte Schurch
Summary: Neurogenic detrusor overactivity (NDO) is a complication of various conditions, such as multiple sclerosis and spinal cord injury, which leads to high bladder pressure and urinary incontinence. OnabotulinumtoxinA has been proven to be an effective treatment option for both NDO and non-neurogenic overactive bladder (OAB), significantly improving quality of life in patients. Clinical trials have shown positive results in terms of reduced incontinence episodes, improved urodynamic parameters, and better quality of life for patients with NDO and OAB.
Article
Obstetrics & Gynecology
Matteo Frigerio, Marta Barba, Alice Cola, Federico Spelzini, Rodolfo Milani, Stefano Manodoro
Summary: This study aimed to evaluate the relationship between COUB and POP surgery, and to identify possible risk factors for postoperative COUB. The results showed that patients with more severe anterior compartment prolapse and more frequent overactive bladder were more likely to have COUB preoperatively. However, COUB symptoms decreased significantly after POP repair. In addition, preoperative opening detrusor pressure was identified as the only independent predictor for postoperative COUB.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Biophysics
David P. Rosen, Douglas A. Husmann, Lance A. Mynderse, Troy F. Kelly, Azra Alizad, Mostafa Fatemi
Summary: This study investigated the feasibility of using ultrasound bladder vibrometry (UBV) for detecting detrusor overactivity (DO) and developed a processing approach to identify transient peaks in data series. By applying a DO index as a classifier, sensitivities and specificities of 0.70 and 0.75 were achieved for detecting DO using UBV measurements. The results show promising potential for noninvasive detection of DO with further refinement of the UBV measurement process.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Obstetrics & Gynecology
Ting-Xuan Huang, Tsia-Shu Lo, Hsiao-Jung Tseng, Yi-Hao Lin, Ching-Chung Liang, Wu-Chiao Hsieh
Summary: The primary objective of this study was to determine the prevalence of overactive bladder (OAB) and detrusor overactivity (DO) in female patients referred for urodynamic study (UDS) due to lower urinary tract symptoms (LUTS). The study found that patients with DO were associated with older age, increased parity, greater urine leakage, and worse storage and micturition functions on UDS.
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2023)
Article
Medicine, General & Internal
Jessica Jay Fang, Ming-Ping Wu, Yu-Chun Yen, Jeng-Cheng Wu, Hung-Yen Chin
Summary: The study found that nulliparous women with OAB had a significantly higher prevalence of abnormal voiding patterns, DO, and MUCP compared to parous women. Especially in nulliparous women, abnormal voiding patterns were significantly associated with DO and MUCP.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Biology
Aida Javan Balegh Marand, Cleo Baars, John Heesakkers, Ellen van den Munckhof, Morteza Ghojazadeh, Mohammad Sajjad Rahnama'i, Dick Janssen
Summary: Through the study, it was found that there are significant differences in the urinary microbiome between patients with OAB and those without OAB, with OAB patients having fewer and less diverse microbiomes, as well as a higher proportion of Lactobacillus, particularly Lactobacillus iners. These results suggest that the urinary microbiome may be involved in the pathogenesis of a specific phenotype of OAB and provide a new starting point for studying the causes and treatments of OAB.
Article
Urology & Nephrology
Elisabeth Lapointe, Narcisse Singbo, Elizabeth Naud, Stephane Bolduc
Summary: Propiverine has shown to be an efficient and safe option for treating OAB in children, with an increase in bladder capacity and expected bladder capacity observed in patients on the medication. The drug offered comparable efficacy and tolerability when compared to other molecules used in historical cohorts.
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2022)
Article
Pharmacology & Pharmacy
A. Elif Muderrisoglu, Ayse A. Sakul, Sandra Murgas, Jean J. M. C. H. de la Rosette, Martin C. Michel
Summary: This study explored the impact of comorbidities of diabetes and hypertension, which are known risk factors of atherosclerosis, on the symptoms and treatment response of overactive bladder syndrome (OAB) patients. The results showed that OAB patients with both comorbidities had more severe symptoms compared to those with either comorbidity alone. However, the impact of comorbidities on baseline symptoms such as incontinence intensity, frequency or nocturia, and patient perception of bladder condition was inconsistent or absent. Having either comorbidity alone was associated with a smaller improvement of symptoms, while the combination of both comorbidities had a greater effect, although the overall attenuation associated with comorbidity was small.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Urology & Nephrology
Taras Ptashnyk, Martin Hatzinger, Federico L. Zeller, Ruth Kirschner-Hermanns
Summary: In patients with overactive bladder (OAB), differences were found between those with detrusor overactivity and those without in terms of age, disease duration, frequency of urination, nocturia episodes, urgency episodes, incontinence episodes, and impact on quality of life. Patients with detrusor overactivity displayed more severe OAB symptoms and lower quality of life impact.
SCANDINAVIAN JOURNAL OF UROLOGY
(2021)
Review
Urology & Nephrology
Si-hong Shen, Xue Jia, Liao Peng, Xiao Zeng, Hong Shen, De-yi Luo
Summary: Intravesical oxybutynin therapy is effective and safe for both adults and children with neurogenic detrusor overactivity, as it increases bladder capacity and improves detrusor pressure and bladder compliance.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Peng Sun, Zheng Wang, Tong Wu, Shishuai Zuo, Xiaoyu Huang, Zilian Cui, Dong Zhang
Summary: This study developed injectable, adhesive, and self-healing composite hydrogels loaded with oxybutynin hydrochloride, which provided relief to overactive bladder by decreasing the expression of Orail and STIM1 in rats.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan-Hong Jiang, Jia-Fong Jhang, Ya-Hui Wu, Hann-Chorng Kuo
Summary: This study investigated the levels of urine inflammatory and oxidative stress biomarkers in patients with detrusor underactivity (DU) and detrusor overactivity with DU (DO-DU). The results showed that DU and DO-DU patients had different urine biomarker profiles compared to controls. Multivariate logistic-regression models revealed that 8-OHdG, PGE2, EGF, IL-5, IL-8, IL-10, and TAC were significant biomarkers for diagnosing DU.
Article
Food Science & Technology
Chung-Cheng Wang, Eric Chieh-Lung Chou, Yao-Chi Chuang, Chih-Chieh Lin, Yu-Chao Hsu, Chun-Hou Liao, Hann-Chorng Kuo
Summary: The results indicated that intradetrusor onabotulinumtoxinA injections were safe and significantly improved subjective measures related to neurogenic detrusor overactivity (NDO) or overactive bladder (OAB) in patients. The study showed positive outcomes in terms of efficacy and safety for both NDO and OAB patients, suggesting the potential benefits of onabotulinumtoxinA injection in treating these conditions.
Article
Pharmacology & Pharmacy
Yuze Sheng, Shuang Zhang, Jiawei Ling, Chenlu Hu, Zhenhai Zhang, Huixia Lv
Summary: In this study, oxybutynin nanosuspension and gel preparation were developed to enhance the transdermal permeation of oxybutynin and improve its bioavailability. Compared to commercial transdermal products, the new formulations showed no skin irritation and facilitated drug delivery through hair follicles.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Rui Xu, Tong-Xin Yang, Ke-Wei Fang, Guang Wang, Pei Li
Summary: This study conducted a literature search to analyze the urodynamic outcomes of oral antimuscarinic drugs and OnabotulinumtoxinA in treating neurogenic detrusor overactivity (NDO). It found that OnabotulinumtoxinA was more effective in improving certain urodynamic endpoints compared to other drugs. Additionally, the study showed that select medications such as oxybutynin, solifenacin, and tolterodine also had positive effects on urodynamic results in NDO.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Sanjay Sinha, Enrico Finazzi-Agro, Roger Roman Dmochowski, Hashim Hashim, Valerio Iacovelli
Summary: This study aimed to examine the utility, accuracy, and categorization of BCI and BOOI indices and related evidence. Results showed general agreement among experts regarding the utility and accuracy of the indices, as well as the clinical value of BCI. However, there is a significant knowledge gap in evaluating the discriminant power of existing cutoffs and exploring new ones.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Sanjay Sinha, Hashim Hashim, Enrico Finazzi-Agro, Roger Roman Dmochowski, Valerio Iacovelli
Summary: This Delphi study aimed to examine global expert consensus on the utility, accuracy, and categorization of Bladder Contractility Index (BCI), Bladder Outlet Obstruction Index (BOOI), and the related evidence. The study found little data supporting the use of BCI and BOOI indices in children, but establishing urodynamic indices in children may help improve the treatment of functional urological disorders in children.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Sanjay Sinha, Roger Roman Dmochowski, Hashim Hashim, Enrico Finazzi-Agro, Valerio Iacovelli
Summary: This study examined global expert consensus on the utility, accuracy, and categorization of bladder contractility index (BCI), bladder outlet obstruction index (BOOI), and the related evidence. The results showed that experts had concerns regarding the utility and accuracy of BCI and BOOI, and there was only partial support for the utility of bladder contractility and bladder outflow obstruction. Additionally, there was a lack of evidence in this regard.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Urology & Nephrology
Stephanie A. Stalder, Oliver Gross, Collene E. Anderson, Lucas M. Bachmann, Sarah Baumann, Veronika Birkhauser, Mirjam Bywater, Giulio del Popolo, Daniel S. Engeler, Enrico Finazzi Agro, Susanne Friedl, Nuno Grilo, Stephan Kiss, Miriam Koschorke, Lorenz Leitner, Martina D. Liechti, Ulrich Mehnert, Stefania Musco, Helen Sadri, Lara Stachele, Jure Tornic, Stephanie van Der Lely, Stephen Wyler, Thomas M. Kessler
Summary: This study protocol describes a randomized controlled trial investigating the efficacy and safety of transcutaneous tibial nerve stimulation (TTNS) for refractory neurogenic lower urinary tract dysfunction (NLUTD). The primary outcome is improvement in bladder diary variables at study end compared to baseline values. Secondary outcomes include urodynamic, neurophysiological, and bowel function measures, as well as safety assessments.
Article
Biochemistry & Molecular Biology
Manuela Montanaro, Massimiliano Agostini, Lucia Anemona, Elena Bonanno, Francesca Servadei, Enrico Finazzi Agro, Anastasios D. D. Asimakopoulos, Carlo Ganini, Chiara Cipriani, Marta Signoretti, Pierluigi Bove, Francesco Rugolo, Benedetta Imperiali, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: Prostate cancer is a common and deadly cancer in men, and the current clinical tools for prognosis are insufficient. This study found that ZNF750 protein levels are reduced in prostate cancer samples, especially in metastatic samples. It also showed that nuclear expression of ZNF750 is significantly reduced in patients with metastatic cancer. The bioinformatics analysis suggests that ZNF750 expression is positively correlated with better prognosis, indicating its potential as a reliable biomarker for metastatic prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Luca Orecchia, Matteo Ricci, Simona Ippoliti, Anastasios D. Asimakopoulos, Eleonora Rosato, Angelica Fasano, Diego Manfrin, Stefano Germani, Enrico Finazzi Agro, Alessandra Nardi, Roberto Miano
Summary: This study validates the effectiveness of 3D printed models of the upper urinary tract and synthetic training stones for high-fidelity simulation of retrograde intrarenal surgery (RIRS). The results support the usage of these models in simulation courses and evaluate their potential role in standardized training curricula.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Surgery
Carlo Giulioni, Anastasios D. D. Asimakopoulos, Filippo Annino, Giulia Garelli, Julien Riviere, Julie Piechaud-Kressmann, Nam-Son Vuong, Laurent Hugo Lopez, Jean-Baptiste Roche, Jean Rouffilange, Jean-Luc Hoepffner, Andrea Benedetto Galosi, Richard Pierre Gaston, Thierry Piechaud, Gregory Pierquet
Summary: Objective: To present and report the outcomes of robot-assisted pudendal nerve release (RPNR) in the treatment of chronic pelvic pain caused by pudendal nerve entrapment (PNE). Methods: 32 patients were recruited and underwent RPNR. Significant pain reduction was observed at 3 and 6 months post-surgery. The study concluded that RPNR is a safe and effective approach for resolving pain caused by PNE, and timely nerve decompression can enhance outcomes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Computer Science, Cybernetics
Tommaso Bagneschi, Domenico Chiaradia, Gabriele Righi, Giulio Del Popolo, Antonio Frisoli, Daniele Leonardis
Summary: We propose a new soft exoskeleton that actively supports hand closure and opening by using a unique tendon routing system. The design enhances stability, reduces slippage and detachment, and provides comfortable clenching effect. Additionally, the use of a single actuator and modular design improves adaptability to different hand sizes. Experimental evaluations have demonstrated positive results in terms of stability, deformation, inter-finger compliance, and grasping force. Initial evaluations with Spinal Cord Injury patients have provided valuable insights into the device's strengths and limitations in real-life scenarios.
IEEE TRANSACTIONS ON HAPTICS
(2023)
Review
Chemistry, Multidisciplinary
Luigi Napolitano, Simona Ippoliti, Peter Fletcher, Martina Caruso, Luigi Cirillo, Roberto Miano, Enrico Finazzi Agro, Roberto La Rocca, Ferdinando Fusco, Davide Arcaniolo, Luca Orecchia
Summary: Bladder cancer is a common disease globally, with aggressive features and high relapse rates. A scoring system called 'Vesical Imaging Reporting and Data System' (VI-RADS) has been validated for local staging of bladder cancer. This review discusses the current application and potential future clinical implications of VI-RADS in the diagnosis, management, and follow-up of bladder cancer.
APPLIED SCIENCES-BASEL
(2023)
Article
Urology & Nephrology
Yazan Al Salhi, Andrea Fuschi, Alessia Martoccia, Cosimo de Nunzio, Bozzini Giorgio, Alessandro Sciarra, Martina Maggi, Ester Illiano, Elisabetta Costantini, Asimakopoulos Anastasios, Antonio Carbone, Antonio L. Pastore
Summary: The early introduction of clean intermittent catheterization (CIC) in patients with orthotopic neobladder (ONB) after radical cystectomy (RC) can improve functional outcomes, continence status, and reduce the incidence of urinary tract infections (UTIs).
MINERVA UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Simona Ippoliti, Gaia Colalillo, Gerald Egbury, Luca Orecchia, Peter Fletcher, Thierry Piechaud, Richard Gaston, Enrico Finazzi-Agro, Roberto Miano, Anastasios D. Asimakopoulos
Summary: This study reviewed the evidence on various prostatectomy techniques and found that robot-assisted radical prostatectomy and Retzius-sparing technique have a positive impact on postoperative continence recovery. Standardization of continence outcome reporting is recommended.
JOURNAL OF ENDOUROLOGY
(2023)
Article
Urology & Nephrology
Tufan Tarcan, Enrico Finazzi-Agro, Thomas M. Kessler, Maurizio Serati, Eskinder Solomon, Peter F. W. M. Rosier
Summary: This article discusses the design considerations for evaluating the value of urodynamic studies (UDS) in functional urology, suggesting that assessing the value of diagnostic tests based solely on treatment success is conceptually flawed. The article also provides recommendations for the design of a hypothetical randomized controlled trial, including considerations for study population, clinical endpoints, intervention and control group design, among others.
NEUROUROLOGY AND URODYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Alessia Martoccia, Yazan Al Salhi, Andrea Fuschi, Onofrio Antonio Rera, Paolo Pietro Suraci, Silvio Scalzo, Alice Antonioni, Fabio Maria Valenzi, Manfredi Bruno Sequi, Cosimo De Nunzio, Riccardo Lombardo, Alessandro Sciarra, Giovanni Di Pierro, Giorgio Bozzini, Anastasios D. Asimakopoulos, Enrico Finazzi Agro, Alessandro Zucchi, Marilena Gubiotti, Mauro Cervigni, Antonio Carbone, Antonio Luigi Pastore
Summary: This study compared two different surgical approaches (transvaginal mesh surgery with levatorplasty and robot-assisted sacrocolpopexy) in the treatment of multicompartment prolapse. The results showed that both surgeries were effective in correcting prolapse, but robot-assisted sacrocolpopexy had a greater improvement in bowel symptoms.
Article
Urology & Nephrology
Anastasios D. Asimakopoulos, Marilena Gubbiotti, Enrico Finazzi Agro, Elena Morini, Valentina Giommoni, Thierry Piechaud, Richard Gaston, Filippo Annino
Summary: This study aims to assess the urodynamic features of intracorporeal orthotopic modified-Y Bordeauxneobladder (iYNB) and its impact on incontinence-specific health-related quality of life. The results demonstrate that the volume and pressure characteristics of iYNB are acceptable and can improve patients' quality of life. Larger prospective studies with longer follow-up are needed to further evaluate iYNB.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
