期刊
BIOTECHNOLOGY JOURNAL
卷 10, 期 9, 页码 1329-1344出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201400387
关键词
Cell lines; Cell substrates; Chimeric vaccines; Viral vaccines; Virus-like particles
资金
- Fundacao Para a Ciencia e a Tecnologia (FCT), Portugal [PTDC/EBB-BIO/118621/2010, PTDC/EBB-BIO/118615/2010, EXPL/BBB-BIO/1129/2013]
- FCT [SFRH/BD/81598/2011, SFRH/BD/90685/2012]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/81598/2011, PTDC/EBB-BIO/118615/2010, SFRH/BD/90685/2012, EXPL/BBB-BIO/1129/2013] Funding Source: FCT
Vaccination is one of the most effective interventions in global health. The worldwide vaccination programs significantly reduced the number of deaths caused by infectious agents. A successful example was the eradication of smallpox in 1979 after two centuries of vaccination campaigns. Since the first variolation administrations until today, the knowledge on immunology has increased substantially. This knowledge combined with the introduction of cell culture and DNA recombinant technologies revolutionized vaccine design. This review will focus on vaccines against human viral pathogens, recent developments on vaccine design and cell substrates used for their manufacture. While the production of attenuated and inactivated vaccines requires the use of the respective permissible cell substrates, the production of recombinant antigens, virus-like particles, vectored vaccines and chimeric vaccines requires the use - and often the development - of specific cell lines. Indeed, the development of novel modern viral vaccine designs combined with, the stringent safety requirements for manufacture, and the better understanding on animal cell metabolism and physiology are increasing the awareness on the importance of cell line development and engineering areas. A new era of modern vaccinology is arriving, offering an extensive toolbox to materialize novel and creative ideas in vaccine design and its manufacture.
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