Discovery and preclinical development of new antibiotics

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

(2013) Vincent Hernandez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells

(2013) Swen Seeland et al.   TOXICOLOGY IN VITRO

Selection of resistance at lethal and non-lethal antibiotic concentrations

(2012) Diarmaid Hughes et al.   CURRENT OPINION IN MICROBIOLOGY

Evolution of antibiotic resistance at non-lethal drug concentrations

(2012) Dan I. Andersson et al.   DRUG RESISTANCE UPDATES

Intra- and Extracellular Activities of Dicloxacillin and Linezolid against a ClinicalStaphylococcus aureusStrain with a Small-Colony-Variant Phenotype in anIn VitroModel of THP-1 Macrophages and anIn VivoMouse Peritonitis Model

(2011) Anne Sandberg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Challenges of Antibacterial Discovery

(2011) L. L. Silver   CLINICAL MICROBIOLOGY REVIEWS

Assessment of Cytochrome P450 Enzyme Inhibition and Inactivation in Drug Discovery and Development

(2011) David O. Nettleton et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Drug-permeability and transporter assays in Caco-2 and MDCK cell lines

(2011) Donna A Volpe   Future Medicinal Chemistry

Discovery research: the scientific challenge of finding new antibiotics

(2011) D. M. Livermore et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development

(2009) Masato Chiba et al.   AAPS Journal

Intracellular Activity of Antibiotics against Staphylococcus aureus in a Mouse Peritonitis Model

(2009) A. Sandberg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Port-a-Patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology

(2009) Niels Fertig et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Bacterial genotoxicity bioreporters

(2009) Alva Biran et al.   Microbial Biotechnology