期刊
UPSALA JOURNAL OF MEDICAL SCIENCES
卷 117, 期 2, 页码 99-112出版社
UPSALA MED SOC
DOI: 10.3109/03009734.2012.665097
关键词
Animal tumor model; brain tumor; cancer stem cell; glioma; neural stem cell; platelet-derived growth factor (PDGF); PDGF receptor
资金
- Swedish Cancer Society
- Swedish Childhood Cancer Foundation
- Swedish Research Council
- Cancer Society in Stockholm
- King Gustaf V Jubilee Fund
- Karolinska Institutet
- Stockholm County Council
- Karolinska Healthcare Research Biobank (KHRBB)
The family of platelet-derived growth factors (PDGFs) plays a number of critical roles in normal embryonic development, cellular differentiation, and response to tissue damage. Not surprisingly, as it is a multi-faceted regulatory system, numerous pathological conditions are associated with aberrant activity of the PDGFs and their receptors. As we and others have shown, human gliomas, especially glioblastoma, express all PDGF ligands and both the two cell surface receptors, PDGFR-alpha and -beta. The cellular distribution of these proteins in tumors indicates that glial tumor cells are stimulated via PDGF/PDGFR-alpha autocrine and paracrine loops, while tumor vessels are stimulated via the PDGFR-beta. Here we summarize the initial discoveries on the role of PDGF and PDGF receptors in gliomas and provide a brief overview of what is known in this field.
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