Article
Biochemistry & Molecular Biology
Sergey S. Lebedev, Mikhail M. Tavobilov, Alexey A. Karpov, Kirill A. Abramov, Pavel O. Bochkov, Roman V. Shevchenko, Natalia P. Denisenko, Alexey Shabunin, Dmitri A. Sychev
Summary: In this study, we investigated the correlation between urinary 6β-OHC/C ratio and liver function, as well as the effects of CYP3A4*22 and CYP3A5*3 polymorphisms on liver failure in patients with obstructive jaundice. Our results showed that 6β-OHC concentration and 6β-OHC/cortisol ratio can serve as significant predictors of liver failure in patients with moderate and severe obstructive jaundice. Additionally, we found that the CC genotype of CYP3A4*22 and the GA genotype of CYP3A5*3 polymorphism may be associated with liver failure.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Panpan Li, Yanjun Liu, Juan Zhao, Wenjie Pan, Yuan He, Shunzhe Fu, Yuanfa Liu, Yong-Jiang Xu
Summary: Salecan, a natural beta-glucan, has been approved as a novel food ingredient in China. It has the potential to alleviate liver injury through regulating oxidative stress, activating the Nrf2 signaling pathway, and modulating the composition of the gut microbiota. Microbiota-derived metabolites of Salecan also contribute to its hepatoprotective effect against liver injury.
Article
Chemistry, Applied
Yanjun Liu, Panpan Li, Wenjie Pan, Juan Zhao, Chen Guang Olnood, Yuanfa Liu, Yong-Jiang Xu
Summary: This study investigated the anti-inflammatory effects and underlying mechanism of Salecan supplementation in CCl4-induced liver injury. The results showed that Salecan alleviated liver injury through regulating inflammatory response and M2 macrophage polarization. Moreover, Salecan modulated gut microbiota composition and its metabolites played a part in the hepatoprotective and anti-inflammatory effects against liver injury. These findings supported the potential of Salecan intervention for attenuating liver injury.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Daisuke Yamanaka, Suzuka Kurita, Yuka Hanayama, Yoshiyuki Adachi
Summary: Beta-glucan, consisting of beta-1,3-linked D-glucose units, is present in various plants and microorganisms with diverse structures and bioactivities. A split-luciferase complementation assay was developed for the structural analysis of long-chain beta-1,6-branched beta-1,3-glucan, demonstrating the potential for real-time monitoring and differentiation of beta-glucans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Mayuka Inukai, Naoya Kobayashi, Hirotoshi Endo, Koki Asakawa, Keisuke Amano, Yuki Yasuda, Ugo Cenci, Christophe Colleoni, Steven Ball, Shoko Fujiwara
Summary: Haptophytes synthesize unique beta-glucans with more beta-1,6-linkages than beta-1,3-linkages as storage polysaccharides. The study found that PhTGS, a homolog of yeast 1,6-beta-transglycosylase, is involved in beta-glucan synthesis in the haptophyte Pleurochrysis haptonemofera. Knockdown of PhTGS repressed beta-glucan accumulation and induced lipid production, suggesting its role in carbon metabolic flow. Furthermore, PhTGS was expressed more in light, indicating its specific function in beta-glucan synthesis during photosynthesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Fan Yang, Shang Shang, Mengfei Qi, Yajinjing Xiang, Lingmin Wang, Xinyi Wang, Tao Lin, Doudou Hao, Jiajia Chen, Jia Liu, Qing Wu
Summary: This review summarizes the recent advances in the application of yeast glucan particles (YGPs) in oral targeted delivery systems, including their structure, preparation methods, drug encapsulation, and characterization. It highlights the mechanism and validation of the target recognition interaction between YGPs and macrophages, and presents inspiring cases to demonstrate the promising applications of yeast cells. The future opportunities and challenges that YGPs may face are also emphasized in this article.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pediatrics
Rupali Jain, Amit Gupta, Devasenathipathy Kandasamy, Manisha Jana
Summary: Cholestatic jaundice with elevated conjugated bilirubin can have various causes in neonates and children. In neonates, common causes include extrahepatic biliary atresia, choledochal cyst, neonatal hepatitis, cytomegalovirus infection, and biliary plug. In late infancy and childhood, viral hepatitis, choledochal cyst, cholelithiasis, worm infestation, and biliary compression due to external causes are common. Early diagnosis is important for treatable causes, and modern diagnostic modalities can aid in rapid diagnosis and surgical treatment.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Food Science & Technology
Qinhui Liu, Qin Tang, Xinchun Liu, Min Tian, Xiandan Jing, Zongyun Feng, Xuping Yang
Summary: Studies have demonstrated the positive effect of highland barley ss-glucan (HBBG) on various liver diseases, including acute liver injury and liver regeneration. In this study, the researchers investigated the beneficial impact of HBBG on liver regeneration following partial hepatectomy (PH) using mouse models. They found that HBBG promoted hepatocyte proliferation and liver regeneration after PH by activating the STAT3-CyclinD1 signaling pathway. Furthermore, the intervention of HBBG decreased hepatocyte apoptosis in a liver injury model induced by CCl4.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Agriculture, Multidisciplinary
Huicui Liu, Tao Chen, Xiaoqing Xie, Xinlei Wang, Yiwen Luo, Nan Xu, Zhen Sa, Min Zhang, Zhifei Chen, Xinzhong Hu, Juxiu Li
Summary: The study demonstrates that BG from highland barley can significantly alleviate liver steatosis induced by NAFLD, by altering lipid metabolic patterns and regulating lipid metabolism-related genes. Additionally, the research also identified 13 differentially regulated lipid species that may serve as lipid biomarkers.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Biochemistry & Molecular Biology
Yanmin Cui, Xuedong Han, Xiaopei Hu, Tuoping Li, Suhong Li
Summary: In this study, the structural and physicochemical properties of beta-glucans from Lentinula edodes, yeast, and oat were compared using HPLC and FT-IR analysis. Different micro surfaces and structures were observed for beta-glucans from different species. Additionally, the antioxidant activities and alpha-glucosidase inhibitory activity varied among the beta-glucans.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Gastroenterology & Hepatology
Matthias Egger, Angela Horvath, Florian Prueller, Peter Fickert, Malcolm Finkelman, Lisa Kriegl, Henning Gronbaek, Holger Jon Moller, Juergen Prattes, Robert Krause, Martin Hoenigl, Vanessa Stadlbauer
Summary: Liver cirrhosis, a systemic disease causing 1 million deaths per year, is associated with fungal translocation and its effects on gut integrity, inflammation, and liver disease severity/outcome. This study found a correlation between fungal translocation and markers of gut inflammation, as well as a significant difference in mortality between patients with positive versus negative fungal translocation. Further research is needed to understand the complex interactions and potential therapeutic interventions.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Jun-Jian Liu, Yan Xu, Shuai Chen, Cheng-Fei Hao, Jing Liang, Zhong-Lian Li
Summary: The study revealed that YCHD's protective effects against OJ are related to various biological processes and signaling pathways, including Nrf2 signaling. YCHD alleviated liver injury and oxidative damage by upregulating the Nrf2 pathway, reducing levels of TBIL, DBIL, ALT, and AST, as well as promoting translocation of Nrf2 into the nucleus.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fengmin Yang, Lu Meng, Sisi Lin, Feng Wu, Jinyao Liu
Summary: By encapsulating antigen-carrying pseudoviruses inside positively charged polyethyleneimine-modified yeast capsules, a robust oral delivery system has been developed, providing a versatile platform for the development of various oral vaccines.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Dominik Rotrekl, Petra Salamunova, Lenka Parakova, Ondrej Bado, Ivan Salon, Frantisek Stepanek, Jaroslav Hanus, Jan Hosek
Summary: The study assessed the usability of yeast glucan particles as carriers for curcumin and the beneficial effect of curcumin in the particles on colitis in rats. The composites showed promising results in reducing colitis symptoms and decreasing pro-inflammatory cytokines, with a greater anti-inflammatory effect compared to pure particles or curcumin alone.
CARBOHYDRATE POLYMERS
(2021)
