期刊
ULTRASTRUCTURAL PATHOLOGY
卷 36, 期 1, 页码 40-47出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/01913123.2011.629770
关键词
Alcohol; electron microscopy; myelin sheath; prefrontal cortex; striatum; substantia nigra; synapses
Alcohol-induced damage causes dysfunction of selected brain regions. Multidisciplinary studies have provided an extensive description of changes observed in neurons and glia following alcohol consumption. In this study the authors have elucidated preferential cellular vulnerability in three different brain regions. Autopsy material of the prefrontal cortex, striatum, and substantia nigra obtained from the brain tissue of alcoholic subjects was used in this study. We found that dendritic tree and astroglial damage is irreversible, while neuronal somata and most axons do not display irreversible changes.
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