Article
Biochemistry & Molecular Biology
Ya-Ning Shi, Le-Ping Liu, Chang-Feng Deng, Tan-Jun Zhao, Zhe Shi, Jian-Ye Yan, Yong-Zhen Gong, Duan-Fang Liao, Li Qin
Summary: The study found that celastrol effectively inhibited intimal hyperplasia and hyperproliferation of VSMCs by inducing autophagy, suggesting it may be a novel drug with great potential to prevent restenosis. The mechanism behind this effect involves lysosomal degradation of c-MYC and the Wnt5a/PKC/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Kathleen Zohorsky, Shigang Lin, Kibret Mequanint
Summary: The study demonstrated that utilizing bead-bound Jagged1 was effective in activating Notch3 and promoting SMC differentiation/maturation, while magnetic pulling forces did not activate Notch3 but instead provided necessary clustering or traction forces for Notch activation. The findings suggest that manipulation of Jagged1 presentation strategy can improve biomaterial-driven control of SMC behavior.
Article
Cell Biology
Huajun Zheng, Weicheng Zhai, Chongbin Zhong, Qingqing Hong, Hekai Li, Bowen Rui, Xingxing Zhu, Dongdong Que, Liyun Feng, Bin Yu, Guanlin Huang, Jianlong Yin, Jiacheng Li, Jing Yan, Pingzhen Yang
Summary: This study demonstrated that Nkx2-3 inhibited VSMCs proliferation and migration through enhancing autophagy levels, which in turn suppressed the occurrence of vascular restenosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Yarong Liu, Aiwei Song, Hongfei Wu, Yin Sun, Min Dai
Summary: Paeonol induces autophagy in VSMCs by activating the III class PI3K/Beclin-1 signaling pathway, ultimately inhibiting VSMCs apoptosis.
Article
Cell Biology
Cansu Karakaya, Mark C. C. van Turnhout, Valery L. L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. M. Sahlgren, Sandra Loerakker
Summary: Mechanical stimuli and Notch signaling play important roles in regulating vascular growth and remodeling. This study reveals that cyclic strain decreases Notch signaling and leads to the loss of contractile features in vascular smooth muscle cells. Activation of Notch signaling partially rescues the contractile features of these cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Francesca Del Gaudio, Dongli Liu, Urban Lendahl
Summary: Notch signalling is a highly conserved mechanism that plays important roles in differentiation and homeostasis in various tissues. This review focuses on the recent advances in understanding the roles of Notch signalling in the vasculature. It discusses the regulation of blood vessel generation and remodelling, as well as the contribution of dysregulated Notch signalling to vascular diseases. Furthermore, it highlights the current gaps in knowledge and challenges in understanding the role of Notch in the vasculature.
Article
Hematology
Yung-Chun Wang, Dunpeng Cai, Xiao-Bing Cui, Ya-Hui Chuang, William P. Fay, Shi-You Chen
Summary: JAK3 plays a crucial role in reendothelialization after vascular injury, with JAK3 deficiency attenuating intimal hyperplasia and enhancing the rate of reendothelialization. Knockdown of JAK3 restores smooth muscle cell expression and promotes endothelial cell proliferation in the injured area.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Seul Gi Kim, Jin Young Sung, Young Jin Kang, Hyoung Chul Choi
Summary: This study reveals the anti-aging mechanism of PPAR-γ and the role of Fisetin in inhibiting cellular senescence through the activation of PPAR-γ and inhibition of mTORC2. The mTORC2 signaling pathway is considered a significant target for regulating autophagy and cellular senescence.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Gabriel Hoi-Huen Chan, Enoch Chan, Carsten Tsun-Ka Kwok, George Pak-Heng Leung, Simon Ming-Yuen Lee, Sai-Wang Seto
Summary: Ageing is a risk factor for degenerative diseases, including cardiovascular diseases. The tumor suppressor gene p53 may play a regulatory role in vascular remodeling, atherosclerosis, and pulmonary hypertension. Further studies are needed to fully understand the effects of p53 in cardiovascular function and its therapeutic potential.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Ting Wen, Yanyan Duan, Dan Gao, Xinxin Zhang, Xiaoyan Zhang, Liang Liang, Ziyan Yang, Peiran Zhang, Jiayulin Zhang, Jiaxing Sun, Yixuan Feng, Qijun Zheng, Hua Han, Xianchun Yan
Summary: This study aims to elucidate the regulation of Notch signaling in vascular smooth muscle cell phenotypic transition. The researchers found that miR-342-5p promotes vSMC-PT through a negative-feedback regulation of Notch signaling by downregulating FOXO3. In a simulated tumor microenvironment, miR-342-5p was upregulated by tumor cell-derived conditional medium and its blockade abrogated vSMC-PT induced by the medium. These findings suggest that miR-342-5p could be a potential target for cancer therapy.
Article
Developmental Biology
Jennifer Kurz, Anna-Carina Weiss, Hauke Thiesler, Fairouz Qasrawi, Lena Deuper, Jaskiran Kaur, Carsten Rudat, Timo H. Luedtke, Irina Wojahn, Herbert Hildebrandt, Mark-Oliver Trowe, Andreas Kispert
Summary: The Notch signaling pathway plays an important role in regulating the expression of Myocd and a group of late SMC structural genes during visceral SMC differentiation in the ureter.
Article
Pharmacology & Pharmacy
Randa M. Breikaa, Kimberly Denman, Yukie Ueyama, Patricia E. McCallinhart, Aiman Q. Khan, Gunjan Agarwal, Aaron J. Trask, Vidu Garg, Brenda Lilly
Summary: This study reveals the essential role of Jag1 in adult endothelial cells in regulating and maintaining smooth muscle cell function in arterial vessels, partially through autoregulation of Notch signaling and influencing cell matrix/adhesion components in smooth muscle cells.
VASCULAR PHARMACOLOGY
(2022)
Article
Cell Biology
Madhulika Tripathi, Brijesh Kumar Singh, Elisa A. Liehn, Sheau Yng Lim, Keziah Tikno, David Castano-Mayan, Chutima Rattanasopa, Pakhwan Nilcham, Siti Aishah Binte Abdul Ghani, Zihao Wu, Syaza Hazwany Azhar, Jin Zhou, Sauri Hernandez-Resendiz, Gustavo E. Crespo-Avilan, Rohit Anthony Sinha, Benjamin Livingston Farah, Kyaw Thu Moe, Deidre Anne De Silva, Veronique Angeli, Manvendra K. Singh, Roshni R. Singaraja, Derek J. Hausenloy, Paul Michael Yen
Summary: Caffeine reduces vascular smooth muscle cell proliferation and restenosis by stimulating autophagy and inhibiting WNT signaling.
Review
Physiology
Sera Nakisli, Alfonso Lagares, Corinne M. M. Nielsen, Henar Cuervo
Summary: Previously considered passive support cells, mural cells-pericytes and vascular smooth muscle cells-have started to garner more attention in disease research, as more subclassifications, based on morphology, gene expression, and function, have been discovered. Central nervous system (CNS) arteriovenous malformations (AVMs) represent a neurovascular disorder in which mural cells have been shown to be affected, both in animal models and in human patients. In this review, we summarize the observed perturbations to mural cells in human CNS AVM samples and CNS AVM animal models, and we discuss various potential mechanisms relating mural cell pathologies to AVMs.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenjing Yan, Yan Cao, Panpan Zhen, Dengyu Ji, Jiayin Chai, Ke Xue, Hongyan Dai, Wen Wang
Summary: This study established a HHcy rat model and found that HHcy can significantly increase vascular pulse wave velocity and pulse pressure, leading to changes in vascular morphology and structure. HHcy can also induce VSMCs senescence, and the decreased autophagy level is involved in vascular ageing induced by HHcy.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2021)