Review
Microbiology
Yew Wai Leong, Bruce Russell, Benoit Malleret, Laurent Renia
Summary: This review explores the erythrocyte tropism of malarial parasites, focusing on their preference for invading reticulocytes. Possible mechanisms mediating erythrocyte tropism and the implications of specific tropisms to disease pathophysiology are also discussed.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Genetics & Heredity
Jiao Li, Lingyun Lu, Yi Liu, Xijie Yu
Summary: Bone marrow is a heterogeneous environment containing various cells, with changes in osteoblast and adipocyte numbers being critical factors in bone marrow adipose tissue (BMAT) production. Targeting the formation of BMAT could be a more effective approach in treating osteoporosis than blocking bone-destroying molecules produced by BMAT. Understanding the molecular basis of increased BM adiposity during pathologic bone loss is essential for developing therapeutic strategies.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Biochemistry & Molecular Biology
Antonio G. Solimando, Carmen Palumbo, Mary Victoria Pragnell, Max Bittrich, Antonella Argentiero, Markus Krebs
Summary: In recent years, it has become evident that bone marrow failures and myeloid malignancy predisposition syndromes have a wide range of phenotypes. Diagnosis of these diseases should be considered in patients with unexplained hematopoiesis defects. Treatment of hypocellular bone marrow failure remains challenging. Exogenous stressors, immune defects, and constitutional genetic defects contribute to disease progression. Understanding the diverse phenotypes of inherited and acquired bone marrow failures and predispositions to myeloid malignancies is crucial. Exploring the pathomechanisms of bone marrow failure may lead to the discovery of new therapeutic and diagnostic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Jeremy Epah, Gabriele Spohn, Kathrin Preiss, Markus M. Mueller, Johanna Doerr, Rainer Bauer, Shabnam Daqiq-Mirdad, Joachim Schwaeble, Stefanie N. Bernas, Alexander H. Schmidt, Erhard Seifried, Richard Schaefer
Summary: This study found that the collection efficiency of bone marrow (BM) samples varies greatly worldwide. The implementation of a small volume aspirate policy improved the total nucleated cell yields in BM products. The impact of the BM collection technique on the quality of hematopoietic progenitor cell-manufacture was assessed.
Article
Biochemistry & Molecular Biology
Yali Li, Huayuan Tang, Fengling Chen, Jiewen Chen, Hong Wang, Zee Chen, Yaoyun Duan, Xinru Wang, Li Li, Kunfu Ouyang
Summary: SET domain-containing 2 (SETD2), the primary methyltransferase for histone 3 lysine-36 trimethylation (H3K36me3), is essential for fetal erythropoiesis. Loss of Setd2 leads to anemia and impairs erythroblast differentiation. Several embryonic erythropoiesis-related genes are identified as likely downstream targets of SETD2 regulation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Meijuan Bai, Peijuan Cao, Yijun Lin, Pengcheng Yu, Shuo Song, Lingling Chen, Lan Wang, Yan Chen
Summary: Short-term caloric restriction (CR) promotes erythropoiesis and ameliorates phenylhydrazine-induced acute anemia.
FRONTIERS IN NUTRITION
(2022)
Review
Pharmacology & Pharmacy
Andre F. Rodrigues, Michael Bader
Summary: This review summarizes the evidence showing that angiotensin II (Ang II) modulates physiological and pathological erythropoiesis processes through the AT1 receptor, including stimulation of renal erythropoietin synthesis, direct action on bone marrow precursor cells, and modulation of sympathetic nerve activity to the bone marrow.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Olga Perik-Zavodskaia, Roman Perik-Zavodskii, Kirill Nazarov, Marina Volynets, Saleh Alrhmoun, Julia Shevchenko, Sergey Sennikov
Summary: This study comprehensively characterized mouse erythroid cells using transcriptomic and proteomic approaches, revealing functional differences and gene expression profiles. It highlights the importance of investigating specific markers and subpopulations of erythroid cells in future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Valentina Giudice, Chiara Cardamone, Massimo Triggiani, Carmine Selleri
Summary: Bone marrow failure (BMF) syndromes are non-malignant hematologic diseases characterized by cytopenias, with immune system dysfunction playing a central role in the pathogenesis. Pro-inflammatory cytokines are crucial in shaping immune responses and sustaining inflammation during BMF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lismeri Wuicik Merfort, Mateus de Oliveira Lisboa, Luciane Regina Cavalli, Carmem Maria Sales Bonfim
Summary: Fanconi Anemia is a genomic instability disease characterized by sensitivity to DNA cross-linking agents and chromosomal abnormalities. Diagnosis relies on cytogenetic analysis, which reveals chromosomal breaks induced by cross-linking agents. Understanding the genetic abnormalities and monitoring patients' prognosis is important for clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Nicole Vogel, Markus Schmugge, Raffaele Renella, Nicolas Waespe, Heinz Hengartner
Summary: Diamond-Blackfan anemia (DBA) is a rare genetic disorder caused by mutations in ribosomal subunit genes, leading to macrocytic anemia and congenital malformations. A retrospective study of 17 pediatric DBA patients in Switzerland revealed a wide range of clinical presentations and treatment needs, with patients carrying RPL mutations showing more physical malformations and milder anemia compared to RPS mutation carriers.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Hematology
Mengying Chen, Yuhan Zhang, Kailun Jiang, Weixi Wang, He Feng, Ru Zhen, Chingyee Moo, Zhuonan Zhang, Jiahai Shi, Caiyong Chen
Summary: This study reveals the importance of the guanine nucleotide exchange factor Grab in regulating iron metabolism during erythropoiesis. Grab activates the GTPase Rab8 to regulate the exocytosis of transferrin receptor, thereby impacting iron uptake and erythroblast hemoglobinization.
Article
Oncology
Harry Lesmana, Timothy Jacobs, Michelle Boals, Nathan Gray, Sara Lewis, Juan Ding, Guolian Kang, Melvanique Hale, Mitchell Weiss, Ulrike Reiss, Winfred Wang, Marcin Wlodarski
Summary: This study evaluated the efficacy and safety of standard immunosuppressive therapy and combination therapy with eltrombopag in pediatric severe aplastic anemia patients. The results showed a higher objective response rate in the treatment group with eltrombopag added, and no significant differences in infections between the two therapies.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Biophysics
Gaurav Kharya, Atish Bakane, Shirali Agarwal, Archana Rauthan
Summary: The T-cell-replete haploidentical transplant with PTIS, augmented John Hopkins conditioning and plerixafor-based mobilization is a safe and effective way of treating patients suffering from SCD, with minimal or no risk of graft failure and acceptable GvHD rates.
BONE MARROW TRANSPLANTATION
(2021)
Article
Hematology
Moonjung Jung, Parinda A. Mehta, Caroline S. Jiang, Rasim O. Rosti, Gabriel Usleaman, Joel M. Correa da Rosa, Francis P. Lach, Erica Goodridge, Arleen D. Auerbach, Stella M. Davies, Agata Smogorzewska, Farid Boulad
Summary: Among siblings with Fanconi anaemia, there is significant correlation in hematological progression, while constitutional abnormalities do not show strong concordance except for kidney abnormalities and microcephaly.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
