Article
Biochemistry & Molecular Biology
Wei-Chun Chen, Chao-Min Cheng, Wan-Ting Liao, Ting-Chang Chang
Summary: Clinical endometriosis/adenomyosis can be diagnosed by serum CA125, as well as urinary markers such as VDBP and A1AT creatinine ratios. The combination of these biomarkers provides good diagnostic performance. The development of non-invasive point-of-care tests using these markers is of great importance.
Review
Immunology
Ankur Kaushal, Narinder Kaur, Surbhi Sharma, Anil K. K. Sharma, Deepak Kala, Hridayesh Prakash, Shagun Gupta
Summary: Early and effective diagnosis of cancer is crucial for proper management. Biomarker-based cancer diagnosis, which integrates biosensing devices with nanoparticles, shows potential for early detection, disease monitoring, and therapy. This study comprehensively analyzes recent designs and fabrication methods of electrochemical biosensors for early cancer detection, while also discussing the role of biomarkers in cancer therapeutics.
Review
Obstetrics & Gynecology
Diana Encalada Soto, Sarah Rassier, Isabel C. Green, Tatnai Burnett, Zaraq Khan, Adela Cope
Summary: Endometriosis is a complex benign gynecologic condition that has a significant impact on the global healthcare system and the quality of life for millions of women. Noninvasive diagnostic testing options, such as miRNA, proteomics, metabolomics, genomics, and the microbiome, show promise and advancement in the diagnosis of endometriosis.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuanmeng Liu, Jianzhang Wang, Xinmei Zhang
Summary: This review discusses the role of NF-KB signaling in endometriosis and its regulation by various factors. It provides an update on the effects of NF-KB on endometriotic cells, peritoneal macrophages, and endometriosis-related symptoms, and summarizes potential drugs for targeting NF-KB.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Critical Care Medicine
Rafael Paez, Michael N. Kammer, Nicole T. Tanner, Samira Shojaee, Brent E. Heideman, Tobias Peikert, Meridith L. Balbach, Wade T. Iams, Boting Ning, Marc E. Lenburg, Christopher Mallow, Lonny Yarmus, Kwun M. Fong, Stephen Deppen, Eric L. Grogan, Fabien Maldonado
Summary: Lung cancer is a leading cause of cancer-related deaths and early detection is crucial. Current stratification approaches for nodules are suboptimal, leading to unnecessary invasive procedures. Noninvasive strategies, such as biomarkers, are urgently needed. However, further studies are required to validate the clinical utility of these biomarkers.
Article
Medical Laboratory Technology
Anuja Pant, Kareena Moar, Taruna K. Arora, Pawan Kumar Maurya
Summary: Endometriosis is a severe reproductive disorder affecting a significant percentage of women. The current diagnostic approaches are invasive, leading to delayed treatment. Finding sensitive and specific biomarkers for early diagnosis is a research priority. Non-invasive detection of biomarkers may provide early diagnosis, and future advancements in science and technology may result in a potent remedy for endometriosis.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Suyog Basnet, Evan Michael Vallenari, Urusha Maharjan, Sunita Sharma, Olaf Schreurs, Dipak Sapkota
Summary: S100A16 is a member of the S100 protein family and is expressed in various human tissues, particularly those rich in epithelial cells. It is differentially expressed in the majority of human cancers and has been implicated in tumorigenesis, including cell proliferation, differentiation, migration, invasion, and epithelial-mesenchymal transition. Additionally, S100A16 expression has prognostic potential in various cancer types.
Review
Biochemistry & Molecular Biology
Sean W. D. Carter, Samantha Neubronner, Lin Lin Su, Pradip Dashraath, Citra Mattar, Sebastian E. Illanes, Mahesh A. Choolani, Matthew W. Kemp
Summary: This review highlights the importance of sterile inflammation in chorioamnionitis and the lack of accuracy in current diagnostic tests. Further validation of current tests and development of new detection methods are urgently needed.
Review
Medicine, Research & Experimental
Yuqing Wang, Tengteng Shao, Jialin Wang, Xiaoting Huang, Xiaofei Deng, Yemin Cao, Mingmei Zhou, Cheng Zhao
Summary: Diabetic foot ulcer (DFU) is a major chronic complication of diabetes and early risk stratification can reduce hospitalization and mortality rates. In addition to existing inflammatory biomarkers, new biomarkers are needed for predicting and intervening in DFU.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Zhenzhen Lu, Ying Gao
Summary: This study identified potential therapeutic biomarkers for endometriosis by analyzing endometriosis and ovarian cancer datasets, validated key genes associated with recurrence and survival, and screened relevant therapeutic agents and potential therapeutic targets.
ANNALS OF MEDICINE
(2021)
Review
Clinical Neurology
Marwa Kaisey, Ghazal Lashgari, Justyna Fert-Bober, Daniel Ontaneda, Andrew J. Solomon, Nancy L. Sicotte
Summary: This review summarizes recent studies on fluid biomarkers for multiple sclerosis (MS), with a focus on blood biomarkers. The research in this field is still in its early stages and accurate and easily obtainable biomarkers for MS have not yet been identified and validated. Continuing efforts to define laboratory diagnostic biomarkers are likely to play an increasingly important role in defining MS at the earliest stages, leading to better long-term clinical outcomes.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Eun Hae Kwon, Sabrina Tennagels, Ralf Gold, Klaus Gerwert, Leon Beyer, Lars Toenges
Summary: This paper emphasizes the importance of reliable objective markers for identifying individuals at risk of Parkinson's disease. Advances in biomarker discovery, particularly in the cerebrospinal fluid (CSF), have provided promising preliminary results. Potential biomarkers include alpha-synuclein species, markers of amyloid and tau pathology, neurofilament light chain, lysosomal enzymes, and markers of neuroinflammation. Metabolomics approaches have also offered insights into novel biological pathways. Genetic forms of PD can help identify subgroups suitable for targeted treatments. Further validation studies are needed to determine the most valuable CSF biomarkers or combinations for clinical and research purposes.
Review
Biochemistry & Molecular Biology
Nicolas Monnin, Anne Julie Fattet, Isabelle Koscinski
Summary: Endometriosis is caused by ectopic endometrial tissue, and its chronic inflammation is associated with pain and fertility problems. Endometriotic implants produce their own estrogen through aromatase and are dependent on estrogen receptor beta (ESR beta) while being resistant to progesterone. The transcription factor SF1 promotes aromatase synthesis and its expression, along with ESR beta, is enhanced by demethylation. Local estrogen concentrations play a role in implantation and development of endometriotic implants, as well as potentially promoting genital cancer. Certain microbiota components, prenatal exposure to endocrine disruptors, and phthalates are associated with increased estrogen levels, while the impact of dioxin and tobacco on endometriosis is less clear.
Review
Allergy
Margitta Worm, Stefan Vieths, Vera Mahler
Summary: Significant progress has been made in the field of anaphylaxis and urticaria in recent years. Studies have provided insights into the genetic and biomarker aspects of these conditions, as well as their IgE-dependent and non-IgE-dependent mechanisms. The potential triggers of anaphylactic reactions related to COVID-19 vaccination and the impact of the COVID-19 pandemic on chronic urticaria have been reported. Clinical advancements include severity grading and risk factors for anaphylaxis, as well as the distinction of phenotypes and triggers for both conditions. Novel treatment approaches for anaphylaxis and different subtypes of urticaria have been evaluated.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wonchan Park, Seong-Woo Maeng, Jee Won Mok, Minji Choi, Hyung Joon Cha, Choun-Ki Joo, Sei Kwang Hahn
Summary: A facile method for early diagnosis of tumors is developed by extracting exosomes from interstitial fluid using hydrogel microneedles. The hydrogel MNs expand in the skin to absorb the ISF, and the tumor exosomes bind with the glypican-1 antibodies inside the hydrogel. Exosomes are separately purified from the ISF to analyze tumor-related biomarkers, and colorectal cancer can be diagnosed by ELISA for model mice. This noninvasive hydrogel MN system plays an important role in early cancer diagnosis.