Article
Obstetrics & Gynecology
Nicole Ho, Cathy Liu, Anh Nguyen, Christoph Lehner, Akwasi Amoako, Renuka Sekar
Summary: Using transvaginal sonographic cervical length measurement can accurately predict the time of delivery in women at risk of preterm labor.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
I. Sapantzoglou, V. Pergialiotis, I. Prokopakis, A. Douligeris, S. Stavros, P. Panagopoulos, M. Theodora, P. Antsaklis, G. Daskalakis
Summary: The purpose of this study was to evaluate the impact of antibiotic therapy on preterm birth rates in women diagnosed with amniotic fluid sludge. Four retrospective cohort studies were included, involving a total of 369 women. The results showed that there was no significant difference in preterm birth rates between women who received antibiotics and those who did not, regardless of gestational age. However, the included studies had high statistical heterogeneity, indicating a need for larger sample sizes and more well-designed studies.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Acoustics
K. N. Rennert, S. H. Breuking, E. Schuit, M. N. Bekker, M. Woiski, M. A. De Boer, M. Sueters, H. C. J. Scheepers, M. T. M. Franssen, E. Pajkrt, B. W. J. Mol, M. Kok, F. J. R. Hermans
Summary: The study suggests that women whose cervical length increases after arrested preterm labor have a lower risk of preterm birth before 34 weeks compared to women whose cervical length does not change or decreases.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Matthew M. Finneran, Colleen Waickman, Cynthia Shellhaas, Michael Cackovic, Heather A. Frey
Summary: The study found that women with a previous preterm birth who received antenatal corticosteroids for an asymptomatic short cervical length were less likely to have optimal exposure compared to those receiving antenatal corticosteroids for symptoms of preterm labor. Additionally, women with a short cervical length were less likely to receive antenatal corticosteroids within 7 days of a preterm delivery compared to those with preterm labor symptoms.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Obstetrics & Gynecology
Viola Seravalli, Isabella Abati, Noemi Strambi, Lorenzo Tofani, Claudia Tucci, Enrico Tartarotti, Mariarosaria Di Tommaso
Summary: The predictive value of cervical length after 24(+0) weeks of gestation is low in asymptomatic women with singleton pregnancy at low risk for spontaneous preterm birth, suggesting that cervical length screening should be discouraged in these women.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Qian-Qi Liu, Shi Chen, Ming-Hui Liu, Yu Sun, Jun-Ya Chen
Summary: This study compared the value of transvaginal ultrasound (TVU) and Bishop score (BS) in predicting the outcomes of labor induction. The results showed that TVU parameters, including cervical length and E-Cervix, had better predictive values for successful induction compared to the BS.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Aude Figarella, Cecile Chau, Anderson Loundou, Claude d'Ercole, Florence Bretelle
Summary: This study found that women with short cervix detected during midtrimester ultrasound had a higher rate of preterm birth. The study aimed to evaluate the impact of implementing universal transvaginal cervical length screening on preterm birth rate. The results showed a significant decrease in preterm birth rate after the implementation of universal cervical length screening.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
P. Kuusela, B. Jacobsson, H. Hagberg, H. Fadl, P. Lindgren, J. Wesstrom, U-B Wennerholm, L. Valentin
Summary: The study indicates that second-trimester sonographic cervical length can identify women at high risk of spontaneous preterm birth. However, in a population of mainly white women with a low prevalence of preterm birth, its diagnostic performance is at best moderate.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Acoustics
Yingmin Huang, Xiaowen Liang, Jianyi Liao, Yingtao Li, Zhiyi Chen
Summary: This study aims to determine the relationship between amniotic fluid sludge (AFS) and/or short cervical length (<= 25 mm) with the rate of preterm birth in women after cervical cerclage. The study found that AFS and short cervical length were independent risk factors for preterm birth after cervical cerclage. Additionally, mid-trimester AFS can be used as a supplementary ultrasound index for detecting preterm birth in pregnant women with a short cervix.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Rasha E. Khamees, Basma M. Khattab, Amal M. Elshahat, Omima T. Taha, Ahmed A. Aboelroose
Summary: The study evaluated the predictive role of the uterocervical angle and cervical length in preterm birth, finding that a uterocervical angle greater than 105 degrees poses a higher risk for preterm deliveries and provides better diagnostic performance in high-risk patients.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Ahmed Alanwar, Sherif H. Hussein, Heba A. Allam, Ahmed M. Hussein, Ibrahim A. Abdelazim, Ahmed M. Abbas, Mortada Elsayed
Summary: This study compared the predictive value of cervical length and Bishop score for cesarean delivery during labor induction in full-term pregnancies. The results indicated that both cervical length and Bishop score had poor predictive value for cesarean delivery after labor induction.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Julie A. Romero, Katheryne Downes, Hope Pappas, Michal A. Elovitz, Lisa Danielle Levine
Summary: In women presenting with preterm labor symptoms, a cervical length that shortens by more than 10 mm from anatomic ultrasound is associated with an increased risk of spontaneous preterm birth. Using this cervical length shortening of >10 mm as a screening test shows a moderate sensitivity and specificity in predicting spontaneous preterm birth.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Obstetrics & Gynecology
Dereje W. Gudicha, Roberto Romero, Doron Kabiri, Edgar Hernandez-Andrade, Percy Pacora, Offer Erez, Juan Pedro Kusanovic, Eunjung Jung, Carmen Paredes, Stanley M. Berry, Lami Yeo, Sonia S. Hassan, Chaur-Dong Hsu, Adi L. Tarca
Summary: The study showed that using a customized cervical length assessment for screening spontaneous preterm birth can better identify at-risk women and improve the distinction between patients at risk for impending preterm birth in those who have an episode of preterm labor.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Heather R. Masters, Carri Warshak, Samantha Sinclair, Sara Rountree, Emily DeFranco
Summary: This study aims to quantify the time requirement for transvaginal cervical length (TVCL) screening with the implementation of universal TVCL screening. The results show that the average duration of TVCL screening is 9.8 minutes, and the majority of ultrasounds require less than 15 minutes to complete. Ultrasounds performed in private practice sites require less time compared to those at teaching sites. Implementation of a universal TVCL program adds an average of 10 minutes to each ultrasound exam, but this additional time diminishes with increasing experience.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Omer Weitzner, Yael Yagur, Tal Biron-Shental, Keren Tzadikevitch-Geffen, Shiran Bookstein, Ofer Markovitch
Summary: This study found that the difference in cervical length measurements between 14-16 weeks and 21-24 weeks of gestation in women with twin pregnancies is not a reliable predictor of preterm birth.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Editorial Material
Obstetrics & Gynecology
Piya Chaemsaithong, Roberto Romero, Waranyu Lertrut, Arunee Singsaneh, Pisut Pongchaikul
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Marcia Arenas-Hernandez, Eunjung Jung, Manaphat Suksai, Francesca Gotsch, Offer Erez, Adi L. Tarca
Summary: The study found that pregnant women with severe PPH had higher median maternal plasma concentrations of IL-16, IL-6, IL-12/IL-23p40, MCP-1, and IL-1 beta than patients without PPH. These cytokines could serve as biomarkers or therapeutic targets.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Doron Kabiri, Dror Raif Nesher, Danielle Luxenbourg, Amihai Rottenstreich, Joshua Rosenbloom, Yosef Ezra, Simcha Yagel, Shay Porat, Roberto Romero
Summary: Vaginal progesterone treatment in women with threatened preterm labor and a short cervix after 24 weeks of pregnancy is associated with lower rates of preterm birth. The treatment also prolongs the time interval from diagnosis to delivery and reduces the frequency of neonatal intensive care unit admission.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Maria Teresa Gervasi, Roberto Romero, Elisa Cainelli, Paola Veronese, Maria Rosa Tran, Eunjung Jung, Manaphat Suksai, Mariachiara Bosco, Francesca Gotsch
Summary: This study suggests that asymptomatic intra-amniotic inflammation in the mid-trimester of pregnancy can increase the risk of neurodevelopmental disorders in children. Early recognition and treatment of maternal immune activation may be a strategy for preventing such disorders in offspring.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Tinnakorn Chaiworapongsa, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Dahiana M. Gallo, Eunjung Jung, Arthur Krieger, Piya Chaemsaithong, Offer Erez, Adi L. Tarca
Summary: This study aimed to determine the prevalence, characteristics, and clinical significance of angiogenic/antiangiogenic factor abnormalities in women with preeclampsia stratified according to gestational age at delivery. The results showed that patients with early preeclampsia had an abnormal angiogenic profile in virtually all cases, whereas only 50% of women with preeclampsia at term had such abnormalities. These findings have implications for future clinical care and research.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Letter
Obstetrics & Gynecology
Bo Hyun Yoon, Roberto Romero, Kyung Joon Oh, Hyeon Ji Kim, Eunjung Jung, Francesca Gotsch
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Roberto Romero
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Tomi Kanninen, Eunjung Jung, Dahiana M. Gallo, Ramiro Diaz-Primera, Roberto Romero, Francesca Gotsch, Manaphat Suksai, Mariachiara Bosco, Tinnakorn Chaiworapongsa
Summary: Preeclampsia and fetal growth disorders are pregnancy-specific conditions that share common pathophysiological mechanisms. This study suggests that the severity of the maternal inflammatory response is highest in patients with preeclampsia, while patients with an SGA fetus also show elevated inflammatory response.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero
Summary: This review examines the efficacy of vaginal progesterone (VP) in preventing preterm birth (PTB) in different subsets of high-risk women. The evidence suggests that VP is effective in reducing the risk of PTB and improving perinatal outcomes in certain groups, such as singleton gestations with a short cervix. However, further research is needed to determine its efficacy in other high-risk groups.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Dahiana M. Gallo, Roberto Romero, Mariachiara Bosco, Francesca Gotsch, Sunil Jaiman, Eunjung Jung, Manaphat Suksai, Carlos Lopez Ramon y Cajal, Bo Hyun Yoon, Tinnakorn Chaiworapongsa
Summary: Green-stained amniotic fluid, also known as meconium-stained amniotic fluid, is a common obstetric hazard. It can be caused by the passage of fetal colonic content or intraamniotic bleeding. Birth with green-stained amniotic fluid is associated with fetal acidemia and potential complications like respiratory distress and seizures. Infection/inflammation inside the amniotic fluid plays a role in the development of meconium-stained amniotic fluid and can lead to clinical chorioamnionitis and neonatal sepsis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Obstetrics & Gynecology
Agustin Conde-Agudelo, Roberto Romero, Anoop Rehal, Maria L. Brizot, Vicente Serra, Eduardo Da Fonseca, Elcin Cetingoz, Argyro Syngelaki, Alfredo Perales, Sonia S. Hassan, Kypros H. Nicolaides
Summary: This study evaluated the efficacy of vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin pregnancies. The results showed that vaginal progesterone did not prevent preterm birth or improve perinatal outcomes in unselected twin pregnancies. However, it appeared to reduce the risk of preterm birth and neonatal morbidity and mortality in twin pregnancies with a sonographic short cervix.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Microbiology
Jonathan J. Panzer, Roberto Romero, Jonathan M. Greenberg, Andrew D. Winters, Jose Galaz, Nardhy Gomez-Lopez, Kevin R. Theis
Summary: The existence of a microbiota in the human placenta is still debated. Recent DNA sequencing investigations reported the presence of a microbiota in typical human term placentas, but it could be background DNA or contamination. Re-analysis of publicly available 16S rRNA gene datasets showed that Lactobacillus, a vaginal bacterium, was highly abundant in placentas but disappeared after applying DNA contaminant removal. Furthermore, bacterial profiles of placental samples clustered primarily by study origin and mode of delivery, suggesting that placentas delivered at term are unlikely to be the original source of observed bacterial DNA signals.
Letter
Obstetrics & Gynecology
Piya Chaemsaithong, Piroon Jenjaroenpun, Pisut Pongchaikul, Arunee Singsaneh, Iyarit Thaipisuttikul, Roberto Romero, Thidathip Wongsurawat
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Priya Prasad, Roberto Romero, Tinnakorn Chaiworapongsa, Nardhy Gomez-Lopez, Anderson Lo, Jose Galaz, Andreea B. B. Taran, Eunjung Jung, Francesca Gotsch, Nandor Gabor Than, Adi L. L. Tarca
Summary: Approximately 47% of women with preterm labor deliver at term, but their infants are at higher risk for being small for gestational age and having neurodevelopmental disorders. This study tested the involvement of components of the insulin-like growth factor system in preterm labor and found higher levels of certain components in women with a history of preterm labor.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Nardhy Gomez-Lopez, Roberto Romero, Maria Fernanda Escobar, Javier Andres Carvajal, Maria Paula Echavarria, Ludwig L. Albornoz, Daniela Nasner, Derek Miller, Dahiana M. Gallo, Jose Galaz, Marcia Arenas-Hernandez, Gaurav Bhatti, Bogdan Done, Maria Andrea Zambrano, Isabella Ramos, Paula Andrea Fernandez, Leandro Posada, Tinnakorn Chaiworapongsa, Eunjung Jung, Valeria Garcia-Flores, Manaphat Suksai, Francesca Gotsch, Mariachiara Bosco, Nandor Gabor Than, Adi L. Tarca
Summary: In this study, the plasma proteome of pregnant and non-pregnant COVID-19 patients and controls was characterized. The findings revealed shared and pregnancy-specific proteomic changes in COVID-19 patients compared to controls, and the plasma proteome accurately identifies COVID-19 patients, even when they are asymptomatic. This study provides insight into the pathogenesis of COVID-19 and explains the more severe outcomes observed in pregnant women.
COMMUNICATIONS MEDICINE
(2023)