Article
Obstetrics & Gynecology
Erika Bonacina, Pablo Garcia-Manau, Monica Lopez, Sara Caamina, Angels Vives, Eva Lopez-Quesada, Marta Ricart, Anna Maroto, Laura de Mingo, Elena Pintado, Laura Castillo-Ribelles, Lourdes Martin, Alicia Rodriguez-Zurita, Esperanza Garcia, Mar Pallarols, Laia Vidal-Sagnier, Mireia Teixidor, Carmen Orizales-Lago, Adela Perez-Gomez, Vanesa Ocana, Linda Puerto, Pilar Millan, Merce Alsius, Sonia Diaz, Nerea Maiz, Elena Carreras, Anna Suy, Manel Mendoza
Summary: The study aimed to assess whether aspirin treatment could be discontinued in pregnancies with a normal uterine artery pulsatility index (≤90th percentile) at 24-28 weeks. The results showed that discontinuing aspirin treatment was non-inferior to continuing aspirin treatment for preventing preterm pre-eclampsia in women with a uterine artery pulsatility index ≥90th percentile at 24-28 weeks.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Sonali S. Dash, Pramila Jena, Swetaparna Khuntia, Mona Pathak, Sudhanshu K. Rath
Summary: Combining UAPI values from the first and second trimesters improves the predictive diagnosis of pregnancy-induced hypertension (PIH), with no extra cost to the patient.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Anna Meroni, Margaret Mascherpa, Monica Minopoli, Benjamin Lambton, Rawan Elkalaawy, Alexander Frick, Basky Thilaganathan
Summary: Routine mid-gestational uterine artery Doppler can modify the risk for preterm pre-eclampsia after first-trimester combined pre-eclampsia screening. Women at low risk in the first trimester but with high mid-gestational uterine artery Doppler resistance had a higher prevalence of preterm pre-eclampsia. This suggests that pregnancy care should not be de-escalated for women at high risk in the first trimester with low mid-gestational uterine artery Doppler resistance, and escalation of care may be justified for women at low risk but with high mid-gestational uterine artery Doppler resistance.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Medicine, General & Internal
Nadia Shahid, Mehar Masood, Zakia Bano, Urooj Naz, Syeda Fariha Hussain, Adnan Anwar, Atif A. Hashmi
Summary: This study aimed to determine the role of Doppler U/S in predicting PE among high-risk women. The overall sensitivity of Doppler U/S in predicting PE was found to be 71.4%, with notching of uterine arteries showing better specificity compared to high RI.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed at evaluating the hypothesis that 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment; it was observed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 infection compared to those without COVID-19, suggesting that Doppler Ultrasound measurement may be a potential method for the management of high-risk pregnancies after asymptomatic/mild COVID-19 infection.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Z. Avul, C. M. Guven, B. S. Feyzioglu, S. O. Sancar
Summary: This study aimed to evaluate whether 6-14 months pregnant women diagnosed with COVID-19 may have abnormal placental function detectable by increased uterine artery Doppler indices in the second trimester and whether these women could benefit from treatment. A total of 63 women diagnosed with COVID-19 during the first trimester of their pregnancy and 68 healthy women were involved in the study. The results showed that uterine artery Doppler indices were significantly increased in second trimester women with COVID-19 compared to those without COVID-19, indicating potential high-risk pregnancies.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Medicine, General & Internal
Eran Ashwal, Jasmine Ali-Gami, Amir Aviram, Stefania Ronzoni, Elad Mei-Dan, John Kingdom, Nir Melamed
Summary: This study aimed to investigate the association of second-trimester sonographic placental morphology markers with placenta-mediated complications and determine whether these markers are predictive of placental dysfunction independent of uterine artery Doppler. The results showed that placental area is independently associated with the risk of placenta-mediated complications, but when combined with uterine artery Doppler, it did not significantly improve the prediction of such complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Suchada Erjongmanee, Vorapong Phupong
Summary: This study aimed to determine the predictive value of first-trimester serum SHARP1 level and second-trimester uterine artery Doppler in singleton pregnancy for the prediction of preeclampsia. The study demonstrated that combining the first-trimester serum SHARP1 level with the second-trimester uterine artery PI had good sensitivity to predict preeclampsia.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Michelle Jie, Shireen Jaufuraully, James Lambert, Raffaele Napolitano, Dimitrios Siassakos
Summary: The study aimed to explore the association between abnormal uterine artery Dopplers and normal PAPP-A with adverse obstetric/neonatal outcomes. The results showed that pregnancies with abnormal uterine artery Dopplers and normal PAPP-A are at increased risk of pre-eclampsia, small for gestational age fetuses, emergency cesarean section, neonatal unit admission, and neonatal hypoglycemia. This highlights the importance of routine measurement of uterine artery Dopplers in all pregnancies for antenatal management and counseling.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Jiang-Nan Wu, Ming-Qing Li, Feng Xie, Bin Zhang
Summary: The study found that the second-trimester measured UtA indices had a satisfactory performance at the 9th week in predicting subsequent preeclampsia. The right UtA-RI was the first choice in ruling out preeclampsia, while the left UtA-PI showed the best authenticity of the prediction.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
G. P. Guy, K. Leslie, D. Diaz Gomez, K. Forenc, E. Buck, A. Khalil, B. Thilaganathan
Summary: The study evaluates the clinical effectiveness of implementing a first-trimester combined pre-eclampsia screening program in a public healthcare setting. The results show a significant reduction in screen-positive rate, increased aspirin use, and effective identification of preterm pre-eclampsia.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Acoustics
N. Gana, M. Sarno, N. Vieira, A. Wright, M. Charakida, K. H. Nicolaides
Summary: This study aimed to evaluate the potential value of ophthalmic artery Doppler at 11-13 weeks' gestation as a predictive marker for pre-eclampsia (PE) and compare it with other first-trimester biomarkers. The results showed that ophthalmic artery PSV ratio may be helpful in predicting the development of preterm PE. However, larger studies are still needed to validate this finding.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Medicine, General & Internal
Serena Resta, Gaia Scandella, Ilenia Mappa, Maria Elena Pietrolucci, Pavjola Maqina, Giuseppe Rizzo
Summary: The number of pregnancies achieved through IVF is increasing globally, with improved chances of success due to technological advances. However, pregnancies conceived through IVF have a higher risk of adverse maternal and perinatal outcomes, mainly related to hypertensive diseases, pre-eclampsia, and fetal growth restriction. Advances in ultrasound technology allow for the evaluation of placental volume and hemodynamics, with differences observed between fresh and frozen-thawed embryos.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Acoustics
M. Mendoza, P. Garcia-Manau, S. Arevalo, M. Aviles, B. Serrano, M. A. Sanchez-Duran, I Garcia-Ruiz, E. Bonacina, E. Carreras
Summary: This study compared the prediction of early-onset and preterm PE when serum biomarkers were assessed before vs after 11 weeks of gestation, finding similar predictive abilities in both scenarios. This suggests that a two-step approach for PE risk assessment can be used, allowing for immediate risk calculation at the time of the first-trimester scan.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Acoustics
I Sapantzoglou, A. Wright, M. Gallardo Arozena, R. Vallenas Campos, M. Charakida, K. H. Nicolaides
Summary: The study showed that the ophthalmic artery PSV ratio at 19-23 weeks' gestation could be used to predict the development of PE, especially preterm PE. Combining the PSV ratio with other biomarkers improved the accuracy of predicting PE, but larger studies are needed to validate these findings.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Peripheral Vascular Disease
Veronica Giorgione, Gwyneth Jansen, Jamie Kitt, Chahinda Ghossein-Doha, Paul Leeson, Basky Thilaganathan
Summary: There is an increased occurrence of cardiovascular diseases in women within 1 to 2 decades after a preeclamptic pregnancy. Recent evidence suggests that the abnormal biochemical and echocardiographic findings in preeclamptic women do not resolve after giving birth. Many women remain hypertensive in the immediate postnatal period, with some showing signs of cardiac dysfunction. Close monitoring and effective blood pressure control in the immediate postnatal period may lead to persistently lower blood pressures in women years after stopping medication. This review emphasizes the importance of delivering effective medical care in the fourth trimester of pregnancy to improve long-term cardiovascular health after a preeclamptic birth.
Review
Peripheral Vascular Disease
Isabelle Malhame, Susan Dong, Ambreen Syeda, Rizwana Ashraf, Jonathan Zipursky, Daphne Horn, Stella S. Daskalopoulou, Rohan D'Souza
Summary: This study conducted a systematic review to summarize the evidence on the use of loop diuretics in the context of hypertensive disorders during pregnancy and the postpartum period. The results showed that the antepartum use of loop diuretics was associated with lower diastolic blood pressure and cardiac output, while the postpartum use reduced the need for additional antihypertensive medications.
JOURNAL OF HYPERTENSION
(2023)
Article
Acoustics
E. Jauniaux, F. D'Antonio, A. Bhide, F. Prefumo, R. M. Silver, A. M. Hussein, S. A. Shainker, F. Chantraine, Z. Alfirevic
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
B. Liu, B. Thilaganathan, A. Bhide
Summary: This study compared the short-term variation (STV) outputs of a novel self-applied non-invasive fetal electrocardiography (NIFECG) device with those obtained from computerized cardiotocography (cCTG). The study found that, after appropriate filtering, removal of poor-quality traces, and correction for signal loss, NIFECG was able to produce STV values strongly correlated with those of cCTG.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
B. Liu, B. Thilaganathan, A. Bhide
Summary: The study found that there is a correlation between phase-rectified signal averaging (PRSA) and computerized cardiotocography (cCTG), as well as a relationship between PRSA and short-term variation (STV). PRSA may be an equivalent method of fetal assessment to STV and can generate interpretable non-invasive fetal electrocardiography (NIFECG) traces with high accuracy. These findings raise the possibility of self-applied at-home or remote fetal heart-rate monitoring, increasing surveillance in high-risk women without impacting service demand.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Editorial Material
Acoustics
T. Stampalija, A. Bhide, A. E. P. Heazell, A. Sharp, C. Lees
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Medicine, General & Internal
Susan E. O'Rinn, Jon F. R. Barrett, Janet A. Parsons, John C. Kingdom, Rohan D'Souza
Summary: Placenta accreta spectrum disorder is a life-threatening condition that can lead to serious maternal complications. Current research on outcomes of this disorder lacks consistency, making it difficult to inform practice. This study protocol aims to develop a core outcome set (COS) for PAS disorder to standardize outcomes and improve management practices.
Article
Medicine, General & Internal
Sarah C. J. Jorgensen, Alejandro Hernandez, Deshayne B. Fell, Peter C. Austin, Rohan D'Souza, Astrid Guttmann, Kevin A. Brown, Sarah A. Buchan, Jonathan B. Gubbay, Sharifa Nasreen, Kevin L. Schwartz, Mina Tadrous, Kumanan Wilson, Jeffrey C. Kwong
Summary: This study aimed to assess the effectiveness of maternal mRNA covid-19 vaccination during pregnancy against Delta and Omicron SARS-CoV-2 infection and hospital admission in infants. The results showed that maternal vaccination with two doses during pregnancy provided high protection against Delta and moderate protection against Omicron infection and hospital admission in infants, with the third trimester and third dose being the most effective. The effectiveness of two doses decreased as infants age beyond eight weeks.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Cell Biology
Clara Apicella, Camino S. M. Ruano, Basky Thilaganathan, Asma Khalil, Veronica Giorgione, Geraldine Gascoin, Louis Marcellin, Cassandra Gaspar, Sebastien Jacques, Colin E. Murdoch, Francisco Miralles, Celine Mehats, Daniel Vaiman
Summary: In this study, we aimed to identify genetic variants affecting gene expression in the human placenta, specifically in normal and pathological situations. The analysis was constrained by the fact that placental tissue samples from diseased individuals are typically obtained at an earlier gestational age compared to control samples, leading to confounding factors in transcriptome regulation. To address this issue, we implemented a novel approach that accounted for gestational age and identified disease-specific cis-eQTLs. Through statistical correction and analysis, we identified a list of e-genes that significantly influenced expression levels, demonstrating the validity of our methodology for future research purposes.
Review
Cardiac & Cardiovascular Systems
Veronica Giorgione, Matthew Cauldwell, Basky Thilaganathan
Summary: Hypertensive disorders of pregnancy (HDP) occur in approximately 10% of pregnancies and are associated with multiorgan manifestations related to endothelial dysfunction. Women with HDP have an increased risk of cardiovascular disease during delivery hospitalisation and are more likely to develop cardiovascular risk factors and major cardiovascular disease in the long term. Chronic hypertension, obesity, hypercholesterolaemia, and diabetes are the main mediators of cardiovascular disease in women with a history of HDP. Optimising blood pressure levels in the immediate postpartum period can improve long-term cardiovascular health. Peripartum screening based on maternal demographics and clinical and echocardiographic data can help identify high-risk HDP women who would benefit from targeted cardiovascular prevention.
EUROPEAN CARDIOLOGY REVIEW
(2023)
Article
Immunology
E. Mcclymont, A. Atkinson, A. Albert, G. Av-Gay, J. Andrade, J. Barrett, T. Bogler, I. Boucoiran, E. Castillo, R. D'Souza, D. El-Chaar, S. Fadel, D. B. Fell, I. Korchinski, V. Kuret, G. Ogilvie, V. Poliquin, M. Sadarangani, H. Scott, J. W. Snelgrove, M. Tunde-Byass, D. Money
Summary: This prospective cohort study aimed to describe self-reported reactogenicity, pregnancy outcomes, and SARS-CoV-2 infection following COVID-19 vaccination during pregnancy. The study found no significant differences in adverse pregnancy or infant outcomes between vaccinated and unvaccinated pregnant individuals, except for a higher risk of NICU admission among the unvaccinated group. Vaccinated participants also reported lower rates of SARS-CoV-2 infection compared to the unvaccinated group.
Article
Obstetrics & Gynecology
Dylan Young, Bita Houshmand, Chunyi Christie Tan, Abirami Kirubarajan, Ashna Parbhakar, Jazleen Dada, Wendy Whittle, Mara L. L. Sobel, Luis M. M. Gomez, Mario Ruediger, Ulrich Pecks, Peter Oppelt, Joel G. G. Ray, Sebastian R. R. Hobson, John W. W. Snelgrove, Rohan D'Souza, Rasha Kashef, Dafna Sussman
Summary: This study established an international database of 1501 SARS-CoV-2-positive cases in pregnancy and used machine learning models to predict adverse maternal and perinatal outcomes. A subset of 25 features was selected for prediction, including patient characteristics, symptoms, and laboratory markers. The Random Forest model achieved an accuracy of 89.0% and can assist clinicians in making decisions for hospital admission and early treatment of pregnant individuals with COVID-19.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Meeting Abstract
Obstetrics & Gynecology
Genevieve Pinnington, Kristin Horsley, Rohan D'Souza
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Dylan Herman, Christina Salmon, Janet Parsons, Clara Juando-Prats, Patricia O'Campo, Rohan D'Souza
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)