期刊
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
卷 36, 期 2, 页码 159-165出版社
WILEY
DOI: 10.1002/uog.7724
关键词
diffusion weighted imaging; DWI; growth restriction; inositol; magnetic resonance spectroscopy; MRS; SGA; small-for-gestational-age
资金
- Fondo de Investigacion Sanitaria (Spain) [PI/060347]
- Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK)
- Thrasher Research Fund (Salt Lake City, USA)
- Marie Curie Host Fellowships for Early Stage Researchers [FETAL-MED-019707-2]
- Marie Curie IAPP Fellowship for Experienced Researchers [PIAP-GA-2008-217911]
Objectives To assess microstructural and metabolic brain differences between small-for-gestational age (SGA) and appropriate-for-gestational age (AGA) fetuses at 37 weeks' gestation by magnetic resonance imaging (MRI) spectroscopy and diffusion weighted imaging. Methods Eight SGA and five matched AGA singleton fetuses, all with normal umbilical artery Doppler, were evaluated using MRI at 37 weeks to measure markers of brain microstructure and metabolism. The metabolic spectrum of N-acetyl-aspartate/choline, choline/creatine, inositol/choline and creatine/choline ratios in the left frontal lobe and the apparent diffusion coefficient from the right and left basal ganglia and frontal and occipital lobes, pyramidal tract and corpus callosum were analyzed and compared. Results As compared with controls, SGA fetuses showed a significant increase in inositol/choline ratio (SGA, 0.57 vs. AGA, 0.25; P = 0.04) and significantly higher ADC values in the pyramidal tract (SGA, 119.87 x 10(-5) mm(2)/s vs. AGA, 105.11 x 10(-5) mm(2)/s; P = 0.04). Conclusions SGA fetuses with normal umbilical artery Doppler present microstructural and metabolic brain changes, suggesting the existence of an abnormal in-utero brain development in fetuses with this condition. Copyright (C) 2010 ISUOG. Published by John Wiley e. Sons, Ltd.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据