Article
Acoustics
F. Ciccarone, A. Biscione, F. Moro, D. Fischerova, L. Savelli, M. Munaretto, L. Jokubkiene, P. Sladkevicius, V Chiappa, R. Fruscio, D. Franchi, E. Epstein, D. Timmerman, W. Froyman, L. Valentin, G. Scambia, A. C. Testa
Summary: Ovarian carcinosarcoma is typically diagnosed in postmenopausal women and at an advanced stage. The most common ultrasound appearance is a large solid tumor with irregular margins, inhomogeneous echogenicity of the solid tissue, and cystic areas.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Acoustics
Yixin Zhang, Yuli Zhao, Li Feng
Summary: The study externally validated the good performance of the ADNEX model in a tertiary center in China, showing a good distinction between tumor subtypes. The ADNEX model is a valuable tool in clinical practice and may help in managing patients with adnexal masses.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
So Yeong Jeong, Sae Rom Chung, Jung Hwan Baek, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee
Summary: Sonographic features of posterior capsular abutment are sensitive and reliable for the diagnosis of posterior minor extrathyroidal extension (ETE) and are associated with lymphovascular invasion and lateral neck lymph node metastasis in papillary thyroid microcarcinoma (PTMC) patients. The assessment of posterior minor ETE is important for considering candidates for active surveillance among PTMC patients.
EUROPEAN RADIOLOGY
(2022)
Article
Acoustics
C. Landolfo, T. Bourne, W. Froyman, B. Van Calster, J. Ceusters, A. C. Testa, L. Wynants, P. Sladkevicius, C. Van Holsbeke, E. Domali, R. Fruscio, E. Epstein, D. Franchi, M. J. Kudla, V. Chiappa, J. L. Alcazar, F. P. G. Leone, F. Buonomo, M. E. Coccia, S. Guerriero, N. Deo, L. Jokubkiene, L. Savelli, D. Fischerova, A. Czekierdowski, J. Kaijser, A. Coosemans, G. Scambia, I. Vergote, D. Timmerman, L. Valentin
Summary: This study validated the use of modified benign simple descriptors (BDs) to exclude malignancy in most women with adnexal masses, and proposed a two-step strategy using the ADNEX model to estimate the risk of malignancy. The modified BDs were applicable to 37% of tumors, 99.3% of which were benign. The two-step strategy showed an AUC of 0.94.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
JianHong Shang, Ting Lei, LiHong Wu, MeiFang Lin, HongNing Xie
Summary: This study describes the clinical and sonographic features of ovarian benign Brenner tumor (BBT) and malignant Brenner tumor (MBT) and compares the diagnostic performance of four different models in differentiating them. The results show that BBT is often a small solid tumor with sparse color Doppler signals, containing calcifications with posterior acoustic shadowing. The most common pattern of MBT is a large multilocular-solid or solid mass with irregular tumor borders, and it is mostly moderately or richly vascularized at color Doppler. These four models have excellent performance in distinguishing them.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pyeong Hwa Kim, Hee Mang Yoon, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee, Jin Seong Lee, Ah Young Jung, Young Ah Cho, Boram Bak, Dong Gyu Na
Summary: This study evaluated the diagnostic performance of the 2021 K-TIRADS biopsy criteria for detecting malignant thyroid nodules in a pediatric population and compared it with the 2016 K-TIRADS. The results showed that the 2021 K-TIRADS had superior diagnostic accuracy to the 2016 K-TIRADS, especially with a biopsy cut-off of 0.5 cm for K-TIRADS 5 and 1.0-1.5 cm for K-TIRADS 4.
EUROPEAN RADIOLOGY
(2023)
Article
Acoustics
K. Palsdottir, S. Fridsten, L. Blomqvist, Z. Alagic, D. Fischerova, A. Gaurilcikas, K. Hasselrot, F. Jaderling, A. C. Testa, A. Sundin, E. Epstein
Summary: Experienced and less experienced observers showed moderate interobserver agreement for assessing local tumor extension in cervical cancer patients using transvaginal ultrasound (TVS) while MRI observers had moderate-to-good agreement. The level of interobserver agreement was associated with experience among TVS observers only for parametrial invasion.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Acoustics
L. S. E. Eriksson, D. Nastic, P. G. Lindqvist, S. Imboden, H. Jarnbert-Pettersson, J. W. Carlson, E. Epstein
Summary: The study evaluated the predictive ability of demographic and sonographic variables and ProMisE classification for preoperatively predicting tumor recurrence in women with endometrial cancer. Results showed that the combination of these factors had better predictive ability than the ESMO classification, indicating their potential use for preoperative risk stratification of endometrial cancer patients.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Pyeong Hwa Kim, Chong Hyun Suh, Jung Hwan Baek, Sae Rom Chung, Young Jun Choi, Jeong Hyun Lee
Summary: This study compared unnecessary biopsy rates and diagnostic performance in examining thyroid nodules using four US-based risk stratification systems. The ACR-TIRADS system showed a significantly lower unnecessary biopsy rate compared to other systems, indicating potential for reducing unnecessary biopsies.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan Zhang, Xia Zhang, Jie Li, Qian Cai, Zhi Qiao, Yu kun Luo
Summary: CEUS is a more valuable and non-invasive imaging modality compared to conventional US in detecting extracapsular extension in papillary thyroid carcinoma. Single capsular invasion was a poor predictor of cervical lymph node metastasis, while extracapsular extension assessments were clinically significant for predicting cervical lymph node metastasis. Among the thyroid papillary carcinoma nodules with differential enhancement, hyper-enhanced nodules had the highest incidence of single capsule invasion (41.9%), while hypo-enhanced ones had a higher incidence of ECE (47.4%).
EUROPEAN RADIOLOGY
(2021)
Article
Acoustics
John S. Pulvino, Elena Resnick, Joseph R. Wax
Summary: Acute urinary retention in women is rare and is seldom caused by a pelvic mass. This case study presented a unique instance where a large ovarian mucinous cystadenoma led to acute urinary retention, which was successfully resolved through laparoscopic surgery.
JOURNAL OF CLINICAL ULTRASOUND
(2021)
Article
Acoustics
D. Fischerova, P. Pinto, A. Burgetova, M. Masek, J. Slama, R. Kocian, F. Fruhauf, M. Zikan, L. Dusek, P. Dundr, D. Cibula
Summary: This study compared transvaginal and transabdominal ultrasound with contrast-enhanced computed tomography (CT) and whole-body magnetic resonance imaging with diffusion-weighted sequence (WB-DWI/MRI) in the assessment of ovarian cancer. The results suggest that ultrasound may be an alternative method for ovarian cancer staging, with good evaluation of peritoneal and lymph-node involvement and prediction of non-resectability based on abdominal markers.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Review
Oncology
Patricia Pinto, Andrea Burgetova, David Cibula, Ingfrid S. Haldorsen, Tereza Indrielle-Kelly, Daniela Fischerova
Summary: For advanced-stage ovarian cancer, maximal-effort debulking surgery is recommended. The role of imaging is to provide a systematic and structured preoperative report on tumor dissemination, with special emphasis on key sites affecting resectability in ovarian cancer surgery. While imaging methods cannot reliably detect small volume carcinomatosis, they are highly effective in detecting bulky disease at critical sites for cytoreduction, making them useful in avoiding unnecessary explorations.
Article
Hematology
Marcello Di Nisio, Matteo Candeloro, Nicola Potere, Camilla Federici, Anne W. S. Rutjes, Maria Domenica Guglielmi, Ettore Porreca
Summary: This study compared the performance of age- and CPTP-adjusted D-dimer approaches among cancer outpatients with suspected DVT, and derived a cancer-specific CPTP rule.
THROMBOSIS RESEARCH
(2023)
Article
Oncology
Lucas W. Thornblade, Ernest Han, Yuman Fong
Summary: Patients with colorectal cancer ovarian metastasis have favorable long-term survival. Survival rates are higher if the tumor is isolated to the ovary or if metachronous to the primary cancer.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Acoustics
C. Landolfo, T. Bourne, W. Froyman, B. Van Calster, J. Ceusters, A. C. Testa, L. Wynants, P. Sladkevicius, C. Van Holsbeke, E. Domali, R. Fruscio, E. Epstein, D. Franchi, M. J. Kudla, V. Chiappa, J. L. Alcazar, F. P. G. Leone, F. Buonomo, M. E. Coccia, S. Guerriero, N. Deo, L. Jokubkiene, L. Savelli, D. Fischerova, A. Czekierdowski, J. Kaijser, A. Coosemans, G. Scambia, I. Vergote, D. Timmerman, L. Valentin
Summary: This study validated the use of modified benign simple descriptors (BDs) to exclude malignancy in most women with adnexal masses, and proposed a two-step strategy using the ADNEX model to estimate the risk of malignancy. The modified BDs were applicable to 37% of tumors, 99.3% of which were benign. The two-step strategy showed an AUC of 0.94.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
A. Romiti, F. Moro, L. Ricci, C. Codeca, F. Pozzati, M. Viggiano, R. Vicario, I. Fabietti, G. Scambia, P. Bagolan, A. C. Testa, L. Caforio
Summary: This retrospective study examined 51 fetal ovarian cysts in 48 fetuses and reclassified the cysts using IOTA terminology. The results showed that anechoic cysts and cysts with low-level content often resolved spontaneously, while cysts with ground-glass, hemorrhagic, mixed, or undefined content were frequently associated with postoperative necrosis.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
E. A. F. Dancet, L. Ameye, W. Sermeus, M. Welkenhuysen, K. T. Zondervan, C. De Cicco, V Mijatovic, A. Schreurs, D. Timmerman, T. M. D'Hooghe
Summary: European patients seek more patient-centred healthcare by crossing borders. This study validated the ENDOCARE questionnaire in nine different languages and demonstrated its benchmark potential. Significant between-country variance in case-mix-adjusted overall and dimensional patient-centredness scores explained 3-9% of the total variance in patient-centredness across 10 European countries. Compared to the least patient-centred country, endometriosis care in Denmark, Italy, and Belgium was more patient-centred.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Oncology
Floriana Mascilini, Lorena Quagliozzi, Mariateresa Mirandola, Francesca Moro, Nicoletta D'Alessandris, Francesca De Felice, Antonia Carla Testa, Giovanni Scambia, Anna Fagotti
Summary: This study aimed to evaluate the accuracy of pathological diagnosis by transvaginal ultrasound-guided biopsy versus surgery in patients with suspicious primary advanced tubo-ovarian carcinoma. The results showed that ultrasound-guided biopsy is a feasible, safe, and accurate method to provide histological diagnosis in these patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Oncology
Stefan Timmerman, Lil Valentin, Jolien Ceusters, Antonia C. Testa, Chiara Landolfo, Povilas Sladkevicius, Caroline Van Holsbeke, Ekaterini Domali, Robert Fruscio, Elisabeth Epstein, Dorella Franchi, Marek J. Kudla, Valentina Chiappa, Juan L. Alcazar, Francesco P. G. Leone, Francesca Buonomo, Maria Elisabetta Coccia, Stefano Guerriero, Nandita Deo, Ligita Jokubkiene, Jeroen Kaijser, Giovanni Scambia, Rochelle Andreotti, Dirk Timmerman, Tom Bourne, Ben Van Calster, Wouter Froyman
Summary: Correct diagnosis of ovarian cancer is important for better prognosis. The O-RADS lexicon and the IOTA 2-step strategy can be used to stratify patients into risk groups. However, the observed malignancy rate in O-RADS 2 was not clearly below 1%.
Review
Medicine, General & Internal
Luca Parodi, Ilda Hoxhaj, Giorgia Dinoi, Mariateresa Mirandola, Federica Pozzati, Ghergana Topouzova, Antonia Carla Testa, Giovanni Scambia, Ursula Catena
Summary: The article reviews the diagnosis and treatment of complete uterine septum, double cervix, and vaginal septum, and describes the associated fertility outcomes. It found that surgical treatment leads to favorable fertility outcomes, including a reduction in miscarriage rate.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Nicolo Bizzarri, Antonella Biscione, Francesca Moro, Luigi Pedone Anchora, Valeria Catinella, Camilla Certelli, Elena Teodorico, Anna Fagotti, Francesco Fanfani, Ali Kucukmetin, Denis Querleu, Gabriella Ferrandina, Giovanni Scambia, Antonia Carla Testa
Summary: The aim of the study was to investigate the prognostic impact of ultrasound tumor parameters and patients' anthropometric parameters on cervical cancer. The study found that low body mass index (BMI) and ultrasound tumor volume were associated with a higher risk of recurrence. Additionally, the study identified a significant relation between ultrasound characteristics and pathological parametrial infiltration. These findings suggest that these parameters can be useful in pre-operative workup for a patient-tailored treatment in early-stage cervical cancer.
Article
Oncology
Simona Maria Fragomeni, Francesca Moro, Fernando Palluzzi, Floriana Mascilini, Vittoria Rufini, Angela Collarino, Frediano Inzani, Luciano Giaco, Giovanni Scambia, Antonia Carla Testa, Giorgia Garganese
Summary: Inguinal node status is crucial for prognosis and treatment strategies in vulvar cancer. Ultrasound examination is becoming the preferred method for preoperative evaluation of inguinofemoral lymph nodes, improving surgical planning accuracy.
Article
Medicine, General & Internal
Saskia J. M. Klein Meuleman, Ally Murji, Thierry van den Bosch, Oliver Donnez, Grigoris Grimbizis, Ertan Saridogan, Frederick Chantraine, Tom Bourne, Dirk Timmerman, Judith A. F. Huirne, Robert A. de Leeuw
Summary: This qualitative study evaluated how experts define and diagnose cesarean scar disorder. Through a modified Delphi procedure, consensus was achieved among 31 international gynecologists on the definition, symptoms, conditions to exclude, and diagnostic criteria of this disorder. Using a standardized definition for the constellation of symptoms resulting from a symptomatic uterine cesarean scar will have important implications for patient care and future niche-related research.
Article
Surgery
Mariateresa Mirandola, Benedetta Gui, Angelica Naldini, Nazario Foschi, Viola Casula, Antonia Carla Testa, Giovanni Scambia, Ursula Catena
Summary: This article reports a case of persistent urogenital sinus (PUGS) in an adult female associated with complex Mullerian malformation. The condition was diagnosed through the integration of gynecological ultrasound and hysteroscopy performed by expert operators. Ultrasound guided endoscopy played a crucial role in achieving a dynamic one-stop diagnosis, avoiding delays and misdiagnosis caused by the separate application of different radiological and endoscopic techniques in preoperative assessment.
FRONTIERS IN SURGERY
(2023)
Letter
Medical Laboratory Technology
Margot van Riel, Yan Zhao, Tatjana Jatsenko, Lore Lannoo, Dirk Timmerman, Joris R. Vermeesch
CLINICAL CHEMISTRY
(2023)
Editorial Material
Acoustics
K. Dewilde, Y. Groszmann, D. Van Schoubroeck, K. Grewal, J. Huirne, R. de Leeuw, T. Bourne, D. Timmerman, T. Van Den Bosch
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Health Care Sciences & Services
Ashleigh Ledger, Jolien Ceusters, Lil Valentin, Antonia Testa, Caroline Van Holsbeke, Dorella Franchi, Tom Bourne, Wouter Froyman, Dirk Timmerman, Ben Van Calster
Summary: Assessing the malignancy risk of ovarian tumors is crucial for selecting appropriate management. In this study, six algorithms were compared to estimate the probabilities of different types of ovarian tumors. The models developed showed good performance, but individual probability estimates varied substantially.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)