Article
Radiology, Nuclear Medicine & Medical Imaging
Rongbiao Tang, Yongfang Li, Le Qin, Fuhua Yan, Guo-Yuan Yang, Ke-Min Chen
Summary: This study evaluated the feasibility of using PR-based PCCT with microbubble contrast agent for vascular imaging. Results showed that microbubbles provided weaker contrast enhancement compared to iodine, but still sufficient for imaging rat aortas. The imaging modality can currently be used as a complement or alternative to absorption-based microCT for imaging vessels in biological samples.
Article
Engineering, Mechanical
Hossein Azizi Sormoli, Afsaneh Mojra, Ghassem Heidarinejad
Summary: High-intensity focused ultrasound (HIFU) has great potential in cancer treatment, but there are challenges in using acoustic energy to treat vascularized tumors, such as reduced treatment efficiency due to blood flow cooling. A novel strategy is proposed by injecting Levovist contrast agent solution in the vascularized tumor, which improves cancer treatment by considering the interaction between Levovist microbubbles and ultrasonic waves. The results show that MB oscillation increases temperature rise, advances irreversible damage, and expands the necrotic area, indicating the effectiveness of injecting Levovist contrast agent solution in reducing treatment time and avoiding multiple sonication.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Lei Chen, Bingwan Dong, Liu Jiang, Jixin Zhang, Luzeng Chen, Tiancheng Li, Yuhong Shao, Xiuming Sun
Summary: SonoVue effectively demonstrated the lymphatic drainage region for all enrolled thyroid malignancies, with a sentinel lymph node detection rate of 96.77% and a diagnostic accuracy for lymph node metastasis of 86.67% and 91.67% in the central and lateral compartments, respectively.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Enrica Chiesa, Antonietta Greco, Rossella Dorati, Bice Conti, Giovanna Bruni, Dimitrios Lamprou, Ida Genta
Summary: The study successfully synthesized new multifunctional polymeric nanoparticles for blood pool contrast agents using microfluidic technology. By co-encapsulating iodinated contrast agents and antioxidants into the nanoparticles, the protective effect on human kidney cells was preliminarily assessed, showing promising potential for further applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biotechnology & Applied Microbiology
Yading Zhao, Dandan Shi, Lu Guo, Mengmeng Shang, Xiao Sun, Dong Meng, Shan Xiao, Xiaoxuan Wang, Jie Li
Summary: This study developed a novel acidity-responsive nanoscale ultrasound contrast agent, L-Arg@PTX nanodroplets, for co-delivery of paclitaxel and L-arginine. These nanodroplets exhibited uniform size and high drug loading efficiency, enabling good ultrasound diagnostic imaging capability and improved tumor aggregation. Combined with ultrasound targeted microbubble destruction (UTMD), the nanodroplets increased cellular reactive oxygen species, alleviating hypoxia and increasing cytotoxic T lymphocytes infiltration, and synergistically enhancing immunotherapy with PTX-induced immunogenic cell death.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Acoustics
Bin-Bin Jin, Yan Ma, Xiu-Hua Zhao, Yi-Ling Teng, Shang-Yong Zhu
Summary: This retrospective study analyzed the data of 299 infertile women who underwent hysterosalpingo-contrast sonography (HyCoSy) and found that secondary infertility, history of intrauterine surgery, thin endometrial thickness, and tubal obstruction were risk factors for the occurrence of intravasation. Sonographers and gynecologists should be aware of these risk factors and select the appropriate timing of HyCoSy to reduce the occurrence of intravasation and other complications after thorough explanation and communication with the patients.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Shaobo Jin, Guoyong Ye, Na Cao, Xuling Liu, Liguo Dai, Pengpeng Wang, Tong Wang, Xueyong Wei
Summary: This study demonstrates a method of surface acoustic wave-controlled fusion of microdroplets, which shows good arrangement effect of different sizes of microdroplets without any modification.
Article
Acoustics
David Q. Le, Virginie Papadopoulou, Paul A. Dayton
Summary: The study found that under certain parameters in therapeutic ultrasound, microbubble coalescence is likely to occur, generating bubbles much larger than those found in commercial contrast agents; however, in diagnostic contrast-enhanced ultrasound imaging, coalescence is unlikely to happen.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ngoc Ton, Una Goncin, Arash Panahifar, M. Adam Webb, Dean Chapman, Sheldon Wiebe, Steven Machtaler
Summary: The study aimed to find a contrast agent for multiple-image radiography (MIR). After evaluating the size, shell material, and concentration of microbubbles through experiments, it was found that lipid microbubbles of 6-10 μm are viable contrast agents, with a minimum concentration of 5x10^7 microbubbles/ml needed to generate a detectable signal.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Eitan Edri, Nina Armon, Ehud Greenberg, Shlomit Moshe-Tsurel, Danielle Lubotzky, Tommaso Salzillo, Ilana Perelshtein, Maria Tkachev, Olga Girshevitz, Hagay Shpaisman
Summary: Production of multilayered microstructures composed of conducting platinum and insulating silicon oxide layers is demonstrated using laser printing. The height of the insulating layer and resistivity of the silicon oxide layer were controlled by varying the laser power and number of iterations. Microfluidics was also shown to enhance multilayered laser microprinting by quickly switching between precursors.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Li Wei, Qianhui Liang, Wei Zhou, Haiyang Han, Zuyi Mao
Summary: This study focused on exploring the application value of microbubble contrast agents in the diagnosis of prostate cancer. By preparing targeted nano-microbubbles, the study demonstrated a strong targeting performance and enhancement effect in vitro and in vivo experiments. Compared with routine trans-rectal ultrasound (TRUS) diagnosis, the targeted nano-bubbles showed marked advantages in terms of sensitivity, specificity, and accuracy in diagnosing prostate cancer.
SCIENCE OF ADVANCED MATERIALS
(2021)
Letter
Nanoscience & Nanotechnology
Amirabas Bakhtiari, Christian J. Kaehler
Summary: We propose an advanced single-particle positioning technique using two microbubbles-induced ultrasound-driven microstreaming to position microparticles in a microchannel or direct them to desired exits of a Y-shaped microchannel. An open-loop control algorithm is developed for automatic detection, tracking, and precise positioning of microparticles in the presence of two microbubbles. The accuracy enhancement of particle positioning using two microbubbles is evaluated compared to the system's results with one microbubble.
MICROFLUIDICS AND NANOFLUIDICS
(2023)
Article
Biotechnology & Applied Microbiology
Oliver McRae, Peter L. L. Walls, Venkatesh Natarajan, Chris Antoniou, James C. Bird
Summary: This study develops a predictive model for sparger-induced cell viability reduction, supported by microfluidic experiments and fluid dynamic simulations. It provides critical insights into the relationship between bubble-induced fluid stressors and mammalian cell viability.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Engineering, Electrical & Electronic
Gabriele Frigenti, Lucia Cavigli, Fulvio Ratto, Sonia Centi, Tupak Garcia-Fernandez, Daniele Farnesi, Stefano Pelli, Silvia Soria, Gualtiero Nunzi Conti
Summary: Optical microresonators based on Whispering Gallery Modes have been extensively studied for fundamental research and various applications. Microbubbles resonators made from glass capillaries combine high optical and mechanical Q-factors with microfluidics. In this study, they were used as platforms for photoacoustic detection and photothermal spectroscopy, demonstrating their unique capabilities.
JOURNAL OF LIGHTWAVE TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Amirabas Bakhtiari, Christian J. Kahler
Summary: We have presented a novel technique that uses ultrasound-driven microbubble streaming to automatically position single microparticles of any size and physical properties in microchannels. This technique is universally applicable in microfluidics and provides high positioning accuracy without the need for flow preconditioning.
MICROFLUIDICS AND NANOFLUIDICS
(2022)
Article
Acoustics
Ting Luo, Zhen Wang, Xiaoling Yu, Zhiyu Han, Zhigang Cheng, Fangyi Liu, Jie Yu, Ping Liang
Summary: This study aimed to investigate the contribution of subtotal ultrasound-guided percutaneous microwave ablation (MWA) to the inhibition of programmed cell death protein-1 (PD-1) in advanced hepatocellular carcinoma (HCC). The results showed that MWA >50% AR could enhance immune-related gene expression, activate CD8+ T cells, and thereby boost the immunomodulatory effect of PD-1 inhibitors.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Letter
Acoustics
Bernard Cosyns, Sharon L. Mulvagh
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Keith Barron, Michael Blaivas, Laura Blaivas, John Sadler, Isadora Deal
Summary: Researchers investigated whether quantitative ultrasound assessment of hyoid bone movement during induced swallowing would predict the failure of traditional assessment methods in stroke patients. They found that manual ultrasound measurement was not accurate in predicting the assessment outcome, but a machine learning algorithm showed substantial agreement with the results, suggesting its potential for improving dysphagia assessment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sheng Chen, Yi-Jie Qiu, Qi Zhang, Xiu-Yun Lu, Yun-Lin Huang, Yi Dong, Wen-Ping Wang
Summary: The impact of hepatocellular carcinoma (HCC) tumor size on Sonazoid contrast-enhanced ultrasound (CEUS) enhancement features was evaluated. The study found that tumor size had a significant impact on the washout features of HCC lesions, with smaller lesions exhibiting a later occurrence of washout.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Ahmed M. Al-Jumaily, Hassan Liaquat, Sharad Paul
Summary: This article presents a comprehensive review on the effect of various operational parameters of focused ultrasound (FUS) on the injury zone produced by ultrasound beams for different dermatological applications. The article highlights the efficient operational parameters of FUS to enhance pain relief during surgery and make skin treatment more affordable. Additionally, a prospective future technique for efficient FUS is discussed.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Celine Porte, Thomas Lisson, Matthias Kohlen, Finn von Maltzahn, Stefanie Dencks, Saskia von Stillfried, Marion Piepenbrock, Anne Rix, Anshuman Dasgupta, Patrick Koczera, Peter Boor, Elmar Stickeler, Georg Schmitz, Fabian Kiessling
Summary: This study aimed to refine ULM for breast cancer patients by optimizing the measurement protocol, identifying translational challenges, and combining ULM with shear wave elastography. The results showed that the settings for microbubble injection strongly influence ULM images, requiring optimized protocols for different indications. Patient and examiner motion were identified as the main translational challenges for ULM.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Jocelyne Rivera, Antonia Digklia, Anna S. Christou, James Anibal, Katherine A. Vallis, Bradford J. Wood, Eleanor Stride
Summary: Immunotherapy is a major modality in cancer medicine, but its efficacy is limited and it has potential side effects. Ultrasound and cavitation agents can enhance the effectiveness of immunotherapy and stimulate immune responses.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Shyamala Guruvare, Shripad Hebbar, Lakshmi Bai, Padmapriya Jaiprakash, Deepa Reddy, Deepa Hc
Summary: This study assessed the accuracy of 3-D surface rendering of 2-D ultrasound images of the uterus using FMRA software for mapping uterine fibroids compared to pathological evaluation. The results showed good correlation between the two methods in terms of fibroid size and location. Inter-observer analysis also demonstrated reproducibility of measurements from two sonologists using the 3-D model.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Yuting Shen, Jiadong Zhang, Daohuai Jiang, Zijian Gao, Yuwei Zheng, Feng Gao, Fei Gao
Summary: This study proposes a straightforward simulation approach based on superposed Wave (s-Wave) to accelerate photoacoustic simulation. By manipulating the phase and amplitude of sensor data, the computation time is significantly reduced. The results show that s-Wave exhibits a speed improvement >2000 times compared with k-Wave in a sparse system configuration, and in terms of optimization-based image reconstruction, the reconstruction time is reduced by approximately 50 times.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jason Voorneveld, Johan G. Bosch
Summary: This study assesses the effect of spatial velocity gradients (SVGs) on block matching, and finds that the sinusoidal flow wavelength and SVG angle have significant impact on the bias and precision of block matching.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Kartini Rahmat, Nazimah Ab Mumin, Wei Lin Ng, Nur Aishah Mohd Taib, Wai Yee Chan, Marlina Tanty Ramli Hamid
Summary: This study demonstrates the value of ABUS as an adjunct to DBT in breast screening and diagnosis, with improved cancer detection rates.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jieyu Hu, Sindre Hellum Olaisen, Erik Smistad, Havard Dalen, Lasse Lovstakken
Summary: This study introduces a fully automated, real-time method for measuring left atrial volume in echocardiography using a neural network to identify key time points and segmentation techniques. The results show that this method provides comparable accuracy to manual measurements while saving time and reducing operator variability, with an average volume difference of 2.9 mL for 2-D and 7.8 mL for 3-D imaging. The application of pseudo-labeling improves the stability of volume curves and the accuracy of end-systole measurement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Anam Bhatti, Takuro Ishii, Yoshifumi Saijo
Summary: A new protocol for fabricating a microflow phantom with bifurcated geometry at a superficial region was proposed in this study. Ultrasound imaging confirmed the successful creation of the desired flow tract with bifurcation at a depth of 2-5 mm. The experiments demonstrated the validity of the proposed protocol for creating a microscale intricate flow tract with desired dimensions and depth. This new phantom will facilitate further improvement in ultrasound technologies for precise visualization of superficial complex vasculatures.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Nima Mobadersany, Pengcheng Liang, Paul Kemper, Elisa E. Konofagou
Summary: This study describes a technique for manufacturing arterial phantoms using polyvinyl alcohol and evaluates the use of pulse wave imaging (PWI) to assess plaque stiffness. The results show that PWI can distinguish between plaques of different stiffness and composition.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)