Review
Pharmacology & Pharmacy
Yujie Zhang, Yuanru Zhao, Yuanyuan Zhang, Qingguang Liu, Mingzhen Zhang, Kangsheng Tu
Summary: Sonodynamic therapy (SDT) is a noninvasive treatment approach for cancer and other diseases that has attracted extensive attention. Nanoparticles have been developed and used as sonosensitizers or as carriers for sonosensitizers to target tissues or tumor cells with high specificity and accuracy. Recent studies have shown that both apoptosis and autophagy occur after SDT, and this review summarizes the progress in autophagy activation by SDT through multiple mechanisms in tumor therapies.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Peng Chen, Ping Zhang, Navid Hussain Shah, Yanyan Cui, Yaling Wang
Summary: Sonodynamic therapy (SDT) is an emerging non-invasive cancer treatment method with deep penetration, good therapeutic efficacy, and minimal damage to normal tissues. Inorganic sonosensitizers play a crucial role in SDT and show great potential due to their high stability and longer circulation time. This review discusses the possible mechanisms of SDT, summarizes the latest research progress on inorganic sonosensitizers, and introduces strategies for optimizing treatment efficacy. The challenges and future prospects of sonodynamic therapy are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Lin Song, Xuandi Hou, Kin Fung Wong, Yaoheng Yang, Zhihai Qiu, Yong Wu, Shang Hou, Chunlong Fei, Jinghui Guo, Lei Sun
Summary: Sonodynamic therapy (SDT) utilizing gas vesicles (GVs) as stable nuclei enhances cavitation effects, increases cell toxicity, and exhibits specific targeting towards CD44(+) cells.
ACTA BIOMATERIALIA
(2021)
Review
Clinical Neurology
Neel H. Mehta, Harshal A. Shah, Randy S. D'Amico
Summary: Sonodynamic therapy (SDT) is a promising noninvasive technique that uses ultrasound to activate targeted agents for glioma treatment. The comprehensive overview of preclinical data on SDT efficacy is needed, considering the variations in sonosensitizers, sonication protocols, and model systems. Coupling sonosensitizers with focused ultrasound induces cytotoxic activity in tumor cells through oxidative stress, apoptotic signaling, and intracellular calcium overload. Further research and ongoing trials are necessary to understand the biochemical and mechanistic properties of SDT and evaluate its clinical feasibility for glioma treatment.
WORLD NEUROSURGERY
(2023)
Article
Chemistry, Physical
Sen Jiang, Congcong Liu, Qijia He, Kun Dang, Weiwei Zhang, Yang Tian
Summary: Immune therapy based on PD-L1 is commonly used for treating tumors. However, strategies to enhance immune checkpoint blockade therapy fail to address the issue of increased PD-L1 expression in tumors. Here, we synthesized Dy-TCPP MOF nanocrystals that effectively reduce PD-L1 expression in tumor cells both in vitro and in vivo, providing a promising approach for tumor treatment through immune therapy without immune checkpoint inhibitor drugs. Additionally, the Dy-TCPP nanocrystals can be used for sonodynamic therapy and obtain T2-weight MRI of tumor sites, making it a potential diagnostic and therapeutic platform for combined tumor treatment.
Article
Chemistry, Multidisciplinary
Long Xi, Yunfeng Han, Chang Liu, Yihan Liu, Zhenping Wang, Ruibing Wang, Ying Zheng
Summary: This study demonstrates a new strategy for inhibiting keratinocyte hyperproliferation in psoriasis management through the use of ultrasound-triggered phase-transition nanodroplets, which enhance skin penetration and induce reactive oxygen species (ROS) to induce keratinocyte apoptosis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Ting Wang, Wangrui Peng, Meng Du, Zhiyi Chen
Summary: Immunotherapy is a promising treatment for cancer, but its application is limited due to the suppression of tumor microenvironment and immune-related adverse events. Sonodynamic therapy (SDT) has been shown to effectively activate antitumor immunity and kill tumor cells. Various SDT therapies alone or in combination with other treatments have been developed to induce immunogenic cell death (ICD) and enhance immunotherapy. This paper provides an overview of the research progress in SDT and nanotechnology, discusses the strategies involving SDT alone, SDT-based synergistic induction of antitumor immunity, and SDT-based immunotherapy for multimodal immunotherapy. The prospects and challenges of SDT-based therapies in cancer immunotherapy are also discussed.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Jinsheng Huang, Zecong Xiao, Yongcheng An, Shisong Han, Wei Wu, Yong Wang, Yu Guo, Xintao Shuai
Summary: A novel nanocarrier was developed for tumor-targeted delivery in melanoma to activate anti-tumor immunity and reduce adverse effects. Additionally, combining sonodynamic therapy with immunotherapy effectively promotes anti-cancer immunity and suppresses melanoma growth.
Review
Biochemistry & Molecular Biology
Suhui Sun, Ping Wang, Sujuan Sun, Xiaolong Liang
Summary: Ultrasound is widely used in biomedicine for tumor diagnosis and therapy, especially with recent advances in micro/nanotechnology promoting ultrasound-based applications. By activating nano-sized drug delivery systems, ultrasound can achieve targeted drug release at tumor sites through various mechanisms.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Luca Raspagliesi, Antonio D'Ammando, Matteo Gionso, Natasha D. Sheybani, Maria-Beatriz Lopes, David Moore, Steven Allen, Jeremy Gatesman, Edoardo Porto, Kelsie Timbie, Andrea Franzini, Francesco Di Meco, Jason Sheehan, Zhiyuan Xu, Francesco Prada
Summary: This study demonstrated the safety of low-intensity ultrasound irradiation of healthy brain tissue using FDA-approved sonosensitizers in a large animal model. The results support the clinical translation of sonodynamic therapy for intracranial gliomas and other brain tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Acoustics
Lihua Fan, Aliyu Idris Muhammad, Balarabe Bilyaminu Ismail, Donghong Liu
Summary: Sonodynamic antimicrobial chemotherapy (SACT) combines low-intensity ultrasound with chemotherapeutic agents to effectively combat microbial burden. With its superior penetration ability and high target specificity, SACT has emerged as a promising alternative for microbial inactivation. This treatment method has attracted increasing attention in recent years.
ULTRASONICS SONOCHEMISTRY
(2021)
Review
Nanoscience & Nanotechnology
Chunyue Wang, Yuhang Tian, Bolin Wu, Wen Cheng
Summary: Sonodynamic therapy (SDT) is a rapidly developing non-surgical therapy that uses ultrasound to initiate sensitizers' catalytic reaction, showing great potential for safe and non-invasive cancer treatment. Sonosensitizers, as essential components of SDT, have been extensively explored to optimize their functions and integrate multiple medical fields. Combining imaging and SDT has been found to lead to better anticancer outcomes.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Jing Liang, Xiaohui Qiao, Luping Qiu, Huning Xu, Huijing Xiang, Hong Ding, Yu Chen
Summary: This comprehensive review summarizes the immunological effects induced by different therapeutic ultrasound technologies, including ultrasound-mediated microbubble destruction (UTMD), sonodynamic therapy (SDT), and focused ultrasound (FUS), as well as the main underlying mechanisms involved. It also discusses the recent research progress of engineering intelligent nanoplatform for improving the antitumor efficiency of therapeutic ultrasound technologies, and presents the key issues and challenges currently faced in clinical translation as well as the prospects for future clinical translation of these emerging nanomaterials and ultrasonic immunotherapy.
Article
Biotechnology & Applied Microbiology
Lina Zhang, Pengfeng Zhu, Ting Wan, Huaiyan Wang, Zhilei Mao
Summary: In this study, an oxygen-deficient TiO2-x coated with glutamine layer was designed for targeted delivery. The TiO2-x showed high photothermal and sonodynamic efficiency. The combination of SDT and PTT achieved optimized therapeutic effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Oncology
Jia-Rui Du, Yang Wang, Zong-Hua Yue, Han-Yu Zhang, Hui Wang, Guo-Qing Sui, Zhi-Xia Sun
Summary: Tumor immunotherapy, which enhances the immune response and activates immune cells, has become an important approach in tumor therapy. Sonodynamic therapy, which produces cytotoxic substances to tumor tissue, induces apoptosis, and enhances immunity, combined with immunotherapy, shows promise as a strategy for cancer treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Dermatology
Mohadese Estaji, Manijhe Mokhtari-Dizaji, Mansoureh Movahedin, Arash Padash, Sahar Ghaffari Khaligh
Summary: Fullerene nanoemulsion significantly reduced epidermis and dermis thickness, Young modulus, and shear modulus, leading to decreased skin stiffness and effective wrinkle repair. Histological studies confirmed the therapeutic effect of fullerene nanoemulsion on skin wrinkles.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Article
Biology
Somayeh Moradi, Manijhe Mokhtari-Dizaji, Fariba Ghassemi, Shahab Sheibani, Fahimeh Asadi Amoli
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2020)
Article
Acoustics
Zeinab Hormozi Moghaddam, Manijhe Mokhtari-Dizaji, Mansoureh Movahedin
Summary: This study found that low-intensity ultrasound at 40 kHz with a mechanical index of 0.40 can effectively increase the proliferation and colonization of spermatogonial stem cells.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Dermatology
Mohadese Estaji, Manijhe Mokhtari-Dizaji, Mansoureh Movahedin, Sahar Ghaffari Khaligh
Summary: The study introduced a new non-invasive imaging method for evaluating the physical and mechanical parameters of skin during photoaging. Results showed that the thickness, Young modulus, and shear modulus of skin layers increased significantly during UVB damage, indicating an improvement in skin elasticity.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Article
Dermatology
Akbar Adelnia, Manijhe Mokhtari-Dizaji, Saman Hoseinkhani, Mohsen Bakhshandeh
Summary: The study showed that dual-frequency sonication enhances the induction of inertial cavitation, leading to increased sonochemical processes and drug release from nanocarriers.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Article
Physics, Multidisciplinary
Neda Goharpey, Manijhe Mokhtari-Dizaji, Mohsen Bakhshandeh
JOURNAL OF THE KOREAN PHYSICAL SOCIETY
(2020)
Article
Engineering, Multidisciplinary
Zeinab Hormozi-Moghaddam, Manijhe Mokhtari-Dizaji, Mohammad-Ali Nilforoshzadeh, Mohsen Bakhshandeh
Summary: This study found that a mechanical index of 0.20 promoted collagen I expression and cell proliferation through low-intensity ultrasound stimulation.
Article
Multidisciplinary Sciences
Zeinab Hormozi Moghaddam, Manijhe Mokhtari-Dizaji, Mohammad Ali Nilforoshzadeh, Mohsen Bakhshandeh, Sahar Ghaffari Khaligh
SCIENTIFIC REPORTS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Effat Soleimani, Manijhe Mokhtari-Dizaji, Nasser Fatouraee, Hazhir Saberi
Summary: This study reconstructed models from ultrasound image processing to assess differences in stresses on plaques with mild and severe stenosis. The radial displacement waveforms of the model closely correlated with image processing, and as stenosis increased, stresses at different positions of the plaques significantly increased.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alireza Mohammadkarim, Manijhe Mokhtari-Dizaji, Ali Kazemian, Hazhir Saberi, Niloofar Ayoobi Yazdi, Mahbod Esfehani
Summary: This study investigated the incidence of short-term atherosclerosis in the common carotid arteries following radiotherapy and proposed the arterial shear modulus as a new biomarker for radiation induced atherosclerosis.
Article
Biophysics
Mohammad Javad Khosravanipour, Manijhe Mokhtari-Dizaji, Farshid Farhan, Roya Sattarzadeh-Badkoubeh
Summary: Coronary artery stenosis is a common heart disease affecting myocardial mechanics. This study compared Ghista-Sandler and Mirsky wall stress models, finding that the Ghista-Sandler model had higher specificity and sensitivity in diagnosing patients with stenosis compared to the Mirsky model.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2021)
Article
Biophysics
Sare Mortazavi, Manijhe Mokhtari-Dizaji
Summary: The aim of this study is to extract the acoustic pressure distribution in target tissue layers based on the nonlinear behavior of waves. The effect of high intensity focused ultrasound (HIFU) on the temperature distribution of the tissue was analyzed and compared with linear behavior. The simulations and experimental results showed that there is a significant difference in the pressure and temperature distributions between linear and nonlinear models at high intensity.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2022)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
S. Moradi, S. Sheibani, M. Mokhtari Dizaji, F. Ghassemi, M. Arjmand
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
S. Moradi, S. Sheibani, M. Mokhtari Dizaji, F. Ghassemi, F. Asadi Amoli, M. Arjmand
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Homa Soleimani, Parviz Abdolmaleki, Manijhe Mokhtari-Dizaji, Tayebeh Toliat, Abbas Tavasoly
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2020)
Article
Acoustics
Ting Luo, Zhen Wang, Xiaoling Yu, Zhiyu Han, Zhigang Cheng, Fangyi Liu, Jie Yu, Ping Liang
Summary: This study aimed to investigate the contribution of subtotal ultrasound-guided percutaneous microwave ablation (MWA) to the inhibition of programmed cell death protein-1 (PD-1) in advanced hepatocellular carcinoma (HCC). The results showed that MWA >50% AR could enhance immune-related gene expression, activate CD8+ T cells, and thereby boost the immunomodulatory effect of PD-1 inhibitors.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Letter
Acoustics
Bernard Cosyns, Sharon L. Mulvagh
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Keith Barron, Michael Blaivas, Laura Blaivas, John Sadler, Isadora Deal
Summary: Researchers investigated whether quantitative ultrasound assessment of hyoid bone movement during induced swallowing would predict the failure of traditional assessment methods in stroke patients. They found that manual ultrasound measurement was not accurate in predicting the assessment outcome, but a machine learning algorithm showed substantial agreement with the results, suggesting its potential for improving dysphagia assessment.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sheng Chen, Yi-Jie Qiu, Qi Zhang, Xiu-Yun Lu, Yun-Lin Huang, Yi Dong, Wen-Ping Wang
Summary: The impact of hepatocellular carcinoma (HCC) tumor size on Sonazoid contrast-enhanced ultrasound (CEUS) enhancement features was evaluated. The study found that tumor size had a significant impact on the washout features of HCC lesions, with smaller lesions exhibiting a later occurrence of washout.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Sean Mcgrath, Yu-Jack Shen, Masato Aragaki, Yamato Motooka, Takamasa Koga, Alexander Gregor, Nicholas Bernards, Emmanuel Cherin, Christine E. M. Demore, Kazuhiro Yasufuku, Naomi Matsuura
Summary: This study assessed the imaging ability of CE-EBUS in vitro and in vivo and found that CE-EBUS can produce contrast imaging comparable to commercial pre-clinical and clinical ultrasound systems. CE-EBUS has the potential for clinical characterization of mediastinal lymph nodes in lung cancer patients.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Ahmed M. Al-Jumaily, Hassan Liaquat, Sharad Paul
Summary: This article presents a comprehensive review on the effect of various operational parameters of focused ultrasound (FUS) on the injury zone produced by ultrasound beams for different dermatological applications. The article highlights the efficient operational parameters of FUS to enhance pain relief during surgery and make skin treatment more affordable. Additionally, a prospective future technique for efficient FUS is discussed.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Celine Porte, Thomas Lisson, Matthias Kohlen, Finn von Maltzahn, Stefanie Dencks, Saskia von Stillfried, Marion Piepenbrock, Anne Rix, Anshuman Dasgupta, Patrick Koczera, Peter Boor, Elmar Stickeler, Georg Schmitz, Fabian Kiessling
Summary: This study aimed to refine ULM for breast cancer patients by optimizing the measurement protocol, identifying translational challenges, and combining ULM with shear wave elastography. The results showed that the settings for microbubble injection strongly influence ULM images, requiring optimized protocols for different indications. Patient and examiner motion were identified as the main translational challenges for ULM.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Review
Acoustics
Jocelyne Rivera, Antonia Digklia, Anna S. Christou, James Anibal, Katherine A. Vallis, Bradford J. Wood, Eleanor Stride
Summary: Immunotherapy is a major modality in cancer medicine, but its efficacy is limited and it has potential side effects. Ultrasound and cavitation agents can enhance the effectiveness of immunotherapy and stimulate immune responses.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Shyamala Guruvare, Shripad Hebbar, Lakshmi Bai, Padmapriya Jaiprakash, Deepa Reddy, Deepa Hc
Summary: This study assessed the accuracy of 3-D surface rendering of 2-D ultrasound images of the uterus using FMRA software for mapping uterine fibroids compared to pathological evaluation. The results showed good correlation between the two methods in terms of fibroid size and location. Inter-observer analysis also demonstrated reproducibility of measurements from two sonologists using the 3-D model.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Yuting Shen, Jiadong Zhang, Daohuai Jiang, Zijian Gao, Yuwei Zheng, Feng Gao, Fei Gao
Summary: This study proposes a straightforward simulation approach based on superposed Wave (s-Wave) to accelerate photoacoustic simulation. By manipulating the phase and amplitude of sensor data, the computation time is significantly reduced. The results show that s-Wave exhibits a speed improvement >2000 times compared with k-Wave in a sparse system configuration, and in terms of optimization-based image reconstruction, the reconstruction time is reduced by approximately 50 times.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jason Voorneveld, Johan G. Bosch
Summary: This study assesses the effect of spatial velocity gradients (SVGs) on block matching, and finds that the sinusoidal flow wavelength and SVG angle have significant impact on the bias and precision of block matching.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Kartini Rahmat, Nazimah Ab Mumin, Wei Lin Ng, Nur Aishah Mohd Taib, Wai Yee Chan, Marlina Tanty Ramli Hamid
Summary: This study demonstrates the value of ABUS as an adjunct to DBT in breast screening and diagnosis, with improved cancer detection rates.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Jieyu Hu, Sindre Hellum Olaisen, Erik Smistad, Havard Dalen, Lasse Lovstakken
Summary: This study introduces a fully automated, real-time method for measuring left atrial volume in echocardiography using a neural network to identify key time points and segmentation techniques. The results show that this method provides comparable accuracy to manual measurements while saving time and reducing operator variability, with an average volume difference of 2.9 mL for 2-D and 7.8 mL for 3-D imaging. The application of pseudo-labeling improves the stability of volume curves and the accuracy of end-systole measurement.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Anam Bhatti, Takuro Ishii, Yoshifumi Saijo
Summary: A new protocol for fabricating a microflow phantom with bifurcated geometry at a superficial region was proposed in this study. Ultrasound imaging confirmed the successful creation of the desired flow tract with bifurcation at a depth of 2-5 mm. The experiments demonstrated the validity of the proposed protocol for creating a microscale intricate flow tract with desired dimensions and depth. This new phantom will facilitate further improvement in ultrasound technologies for precise visualization of superficial complex vasculatures.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)
Article
Acoustics
Nima Mobadersany, Pengcheng Liang, Paul Kemper, Elisa E. Konofagou
Summary: This study describes a technique for manufacturing arterial phantoms using polyvinyl alcohol and evaluates the use of pulse wave imaging (PWI) to assess plaque stiffness. The results show that PWI can distinguish between plaques of different stiffness and composition.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2024)