Article
Chemistry, Analytical
Yuwei Lan, Yang Zhou, Man Wu, Chunping Jia, Jianlong Zhao
Summary: The isolation of single cells or droplets is a crucial step in single-cell analysis, particularly important for cancer research and diagnostic methods. This review provides an overview of current and developing technologies for achieving this isolation. Microfluidic-based manipulation, with its advantages of miniaturization and low cost, has gained extensive attention recently. Five microfluidic strategies including trapping, discrete manipulation, bioprinting, capillary, and inertial force, are discussed in terms of their principles, features, modified approaches, applications, advantages, drawbacks, and future trends.
Article
Nanoscience & Nanotechnology
Paul Wrede, Amirreza Aghakhani, Ugur Bozuyuk, Erdost Yildiz, Metin Sitti
Summary: Microparticle manipulation and trapping are crucial in biotechnology. This study proposes the use of hollow borosilicate microparticles and a single-lens focused ultrasound (FUS) transducer for effective manipulation. The method proves effective under realistic flow rates and ultrasound amplitudes and has potential biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Analytical
Yupan Wu, Yingqi Meng
Summary: This paper reviews emerging tools enabled by microfluidic technologies for cell manipulation, including sorting and single cell trapping, and even single cell characterization. The focus is on electric field, mechanical, and fluorescence-based methods for single cell analysis and characterization, as well as the integrated microfluidic devices. The authors further discuss future commercialization and research prospects, highlight current bottlenecks, and provide their perspective on the prospects for microfluidic cell manipulation.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Mechanics
Takayuki Suzuki, Srivathsan Kalyan, Cynthia Berlinicke, Samantha Yoseph, Donald J. Zack, Soojung Claire Hur
Summary: Viscoelastic focusing is a promising method for manipulating micro and nanoscale bioparticles. This study investigates the mechanisms and applications of viscoelastic focusing in rectangular microchannels. By varying the fluid elasticity and inertia, the flow characteristics driving cell focusing are revealed. The findings provide guidance for the application of viscoelastic focusing in flow cytometry and particle sorting, as well as valuable insights for device design.
Article
Chemistry, Multidisciplinary
Iuliia P. Novoselova, Andreas Neusch, Julia-Sarita Brand, Marius Otten, Mohammad Reza Safari, Nina Bartels, Matthias Karg, Michael Farle, Ulf Wiedwald, Cornelia Monzel
Summary: The properties of two different types of magnetic nanoparticles were investigated and their potential for biomedical applications was assessed. The study confirmed their biocompatibility in a living cell environment and found that magnetoferritin exhibited a higher magnetic force response inside cells compared to 'nanoflower' nanoparticles.
Article
Optics
Zijie Zhao, Jianping Xia, Tony Jun Huang, Jun Zou
Summary: This Letter presents a ring-shaped photoacoustic tweezers capable of manipulating micron-sized particles. By illuminating an absorptive liquid medium with a pulsed laser beam, acoustic radiation force and vaporization repulsion are generated, enabling continuous and versatile movement of single or multiple particles. The tweezers demonstrate interactions between particles, including separation, attachment, and grouping, combining the advantages of optical and acoustic tweezers.
Article
Materials Science, Multidisciplinary
Xingyi Wan, Xiaodi Zhang, Zhirong Liu, Jiaming Zhang, Zhou Li, Zhong Lin Wang, Linlin Li
Summary: Cell sheet harvesting is a promising strategy for scaffold-free cell transplantation and tissue engineering, which requires modulating cell adhesion behavior. Recent research demonstrates a noninvasive and highly efficient cell harvesting method based on the piezoelectric effect, which shows great application prospects in cell sheet engineering.
APPLIED MATERIALS TODAY
(2021)
Article
Chemistry, Physical
Siyu Kang, Muhammad Shemyal Nisar, Yu Lu, Ning Chang, Yan Huang, Haibin Ni, Sergey M. M. Novikov, Yi Wang, Qiannan Cui, Xiangwei Zhao
Summary: This study introduces a new 3D biocompatible plasmonic tweezer for single living cell manipulation in solution. The key design involves a tapered tip with a three-layer surface structure, which enables reversible binding between functionalized surface and cell membrane through surface plasmon polaritons and thermally driven phase transition of the thermosensitive hydrogel. The 3D biocompatible plasmonic tweezer achieves selective capture, 3D pathway free transport, and position-controlled release of target cells, with excellent biocompatibility, low energy consumption, and high operational flexibility.
Article
Chemistry, Multidisciplinary
Qi Zhang, Yunlong Shao, Boye Li, Yuanyuan Wu, Jingying Dong, Dongtang Zhang, Yanan Wang, Yong Yan, Xiayan Wang, Qiaosheng Pu, Guangsheng Guo
Summary: A novel system is developed for single-cell spatial manipulation, which corrects aberrations through simultaneous bright-field triple-view imaging, enabling precise manipulation and spatial positioning of single cells. This system has higher spatial resolution and accuracy for subcellular content extraction and drug delivery.
Article
Chemistry, Multidisciplinary
Ayoola T. Brimmo, Anoop Menachery, Pavithra Sukumar, Mohammad A. Qasaimeh
Summary: The study introduces a multifunctional noncontact scanning probe that allows precise manipulation of living single cells within their physiological tissue environment. The technology showcases adjustable spatial ability by transfecting adjacent single cells with different DNA plasmid vectors.
Article
Nanoscience & Nanotechnology
Yang Yang, Wei Pang, Hongxiang Zhang, Weiwei Cui, Ke Jin, Chongling Sun, Yanyan Wang, Lin Zhang, Xiubao Ren, Xuexin Duan
Summary: The article introduces a versatile microsystem for observing and analyzing single cells, which can perform various tasks such as observation, pretreatment, and analysis through methods like sound wave triggering and microchannel limitation. The reliability and robustness of this technology in complex biological samples have been demonstrated, indicating its broad potential in various fields.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Chemistry, Analytical
Ru-Jia Yu, Yong-Xu Hu, Ke-Le Chen, Zhen Gu, Yi-Lun Ying, Yi-Tao Long
Summary: This technical note presents a nanopipet-based method for precise manipulation of single cells, allowing the extraction of femtoliter volumes of cytoplasm for analysis. It can identify unusual single cell behavior and enable multi-imaging in single living cells through the injection of exogenous components.
ANALYTICAL CHEMISTRY
(2022)
Article
Acoustics
Yushun Zeng, Jia Hao, Junhang Zhang, Laiming Jiang, Sangyeon Youn, Gengxi Lu, Dongliang Yan, Haochen Kang, Yizhe Sun, K. Kirk Shung, Keyue Shen, Qifa Zhou
Summary: This article introduces an ultrasound single-beam acoustic tweezer system, which can manipulate and characterize leukemia cells through high-frequency ultrasound without contacting the cells. The results demonstrate that this system can be applied in studying and understanding the deformability of leukemia cells.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Physics, Applied
Lu Shen, Junfei Tai, Alexandru Crivoi, Junfei Li, Steven Cummer, Zheng Fan
Summary: This paper investigates the mechanism of self-stabilizing, three-dimensional Mie particle manipulation in water via an acoustic tweezer with a single transducer. A carefully designed acoustic lens is attached to the transducer to form an acoustic vortex, which provides angular momentum on the trapped polymer sphere and leads to a fast-spinning motion. The spinning motion of the trapped sphere links the acoustic radiation force and hydrodynamic forces together, so that the sphere can spontaneously achieve new force balance and follow the translational motion of the acoustic tweezer. Non-spherical objects can also be manipulated by this acoustic tweezer.
APPLIED PHYSICS LETTERS
(2023)
Review
Chemistry, Analytical
Qi Zhang, Caiwei Zhou, Wanting Yu, Yujie Sun, Guangsheng Guo, Xiayan Wang
Summary: Isotropic imaging of single cells plays a crucial role in cellular research. This article provides an overview of various contactless manipulation methods for single-cell isotropic imaging and discusses their advantages, disadvantages, and application scenarios, aiming to assist researchers in selecting the optimal imaging method.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Seungmin Noh, Sungwoong Jeon, Eunhee Kim, Untaek Oh, Danbi Park, Sun Hwa Park, Sung Won Kim, Salvador Pane, Bradley J. Nelson, Jin-young Kim, Hongsoo Choi
Summary: This study introduces a biodegradable GelMA microrobot that can be mass-produced in a microfluidic channel. The microrobot shows precise rolling motion in response to an external rotating magnetic field and can release loaded stem cells for proliferation and differentiation after enzymatic degradation.
Article
Materials Science, Multidisciplinary
Fajer Mushtaq, Xiang-zhong Chen, Andrea Veciana, Marcus Hoop, Bradley J. Nelson, Salvador Pane
Summary: Toxic heavy-metal pollution poses a significant threat to the environment and human health. Conventional removal methods are not practical, leading to a growing interest in reduction treatments. Researchers have discovered that wireless magnetic fields can induce the reduction of toxic heavy metals, proposing a catalytic reduction mechanism based on the magnetoelectric effect.
APPLIED MATERIALS TODAY
(2022)
Article
Multidisciplinary Sciences
Wai Hoe Chin, Ciaren Kett, Oren Cooper, Deike Museler, Yaqi Zhang, Rebecca S. Bamert, Ruzeen Patwa, Laura C. Woods, Citsabehsan Devendran, Denis Korneev, Joe Tiralongo, Trevor Lithgow, Michael J. McDonald, Adrian Neild, Jeremy J. Barr
Summary: The majority of viruses in the gut are bacterial viruses known as bacteriophages, which coevolve with gut bacteria. This study investigated the evolutionary interactions between bacteriophages, bacterial hosts, and the mammalian gut mucosa. The researchers found that bacteriophages can evolve in response to a mammalian-derived mucosal environment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Electrical & Electronic
Cedric Fischer, Thomas Quirin, Christophe Chautems, Quentin Boehler, Joris Pascal, Bradley J. Nelson
Summary: Remote magnetic navigation (RMN) allows for precise and accurate wireless steering of magnetic catheters through complex structures. This study proposes a localization method that uses multiple Hall sensors to measure the magnetic fields produced by the magnetic navigation systems (MNSs) and estimate the full sensor pose. The results provide insights into the minimal requirements for an MNS in terms of localization accuracy.
IEEE TRANSACTIONS ON MAGNETICS
(2023)
Article
Biochemical Research Methods
Bryan Ang, Ankush Sookram, Citsabehsan Devendran, Vincent He, Kellie Tuck, Victor Cadarso, Adrian Neild
Summary: Surface acoustic wave (SAW) driven devices often use polymeric microfluidic channels with low acoustic impedance mismatch to the fluid in contact for precise control of the wave field. This work demonstrates the successful implementation of integrating a glass insert at the ceiling of the PDMS microfluidic channel in a SAW activated nanosieve, resulting in a significant increase in flow rate and maintenance of high capture efficiencies. The glass-inserted device allows for processing larger volume samples, overcoming a main limitation of these devices.
Article
Mechanics
Alen Pavlic, Cooper Lars Harshbarger, Luca Rosenthaler, Jess Gerrit Snedeker, Juerg Dual
Summary: This study presents a technique utilizing acoustically excited sharp edges to generate strong mixing flow in a microfluidic chip. The chip is capable of precise manipulation of fluids and objects on the microscale, making it crucial for various applications in life sciences and chemical engineering.
Article
Chemistry, Analytical
Bryan Ang, Ruhollah Habibi, Ciaren Kett, Wai Hoe Chin, Kellie L. Tuck, Adrian Neild, Victor J. Cadarso
Summary: Microfluidic concentration technology can detect low concentrations of bacteria in samples, making it suitable for time-sensitive situations such as clinical settings and food quality control. By using a packed bed of micro-particles activated by surface acoustic waves, bacteria can be efficiently captured and recovered for further analysis.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Robotics
Quentin Boehler, Simone Gervasoni, Samuel L. Charreyron, Christophe Chautems, Bradley J. Nelson
Summary: This article discusses the use of magnetic navigation systems in remote magnetic navigation to steer magnetic objects. The design, workspace definition, measurement methodology, and evaluation metrics of these systems are explored and illustrated with examples.
IEEE TRANSACTIONS ON ROBOTICS
(2023)
Article
Multidisciplinary Sciences
Donghoon Kim, Minsoo Kim, Steffen Reidt, Hyeon Han, Ali Baghizadeh, Peng Zeng, Hongsoo Choi, Josep Puigmarti-Luis, Morgan Trassin, Bradley J. Nelson, Xiang-Zhong Chen, Salvador Pane
Summary: By designing twisted architectures, we have developed freestanding nanoscale ferroic oxide structures that exhibit a giant recoverable strain (>8%) and shape-memory effect. This breakthrough overcomes the size limitations in traditional shape-memory alloys and paves the way for engineering small-scale actuating devices such as nanorobots and artificial muscle fibrils.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Hongri Gu, Marino Moeckli, Claas Ehmke, Minsoo Kim, Matthias Wieland, Simon Moser, Clemens Bechinger, Quentin Boehler, Bradley J. Nelson
Summary: Magnetic continuum soft robots can actively control their tip and navigate in complex in vivo environments. MaSoChains are a type of magnetic soft-robotic chains that can self-fold into large assemblies with stable configurations and programmable shapes and functions. They provide many desirable features and functions that are difficult to achieve with existing surgical tools.
NATURE COMMUNICATIONS
(2023)
Article
Computer Science, Information Systems
Jiaen Wu, Barna Becsek, Alessandro Schaer, Henrik Maurenbrecher, George Chatzipirpiridis, Olgac Ergeneman, Salvador Pane, Hamdi Torun, Bradley J. Nelson
Summary: A novel algorithm based on reduced support vector machine (RSVM) and finite state machine (FSM) is developed for real-time and reliable detection of gait phases. The algorithm is implemented on a microcontroller of a wearable device and evaluates its performance with healthy subjects, showing promising real-time performance and robustness.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Chemistry, Physical
Vincent He, Victor J. Cadarso, Susanne Seibt, Ben J. Boyd, Adrian Neild
Summary: In this study, a microfluidic approach was used to prepare different aqueous and lipid droplets and induce phase transformations in the liquid medium. The results showed that when the lipid droplets and aqueous droplets coalesced, distinct structures with different compositions formed on the two sides of the merged droplet. Through diffusion limited interface, water molecules gradually hydrated the lipid portion, leading to a series of phase transformations. This study provides a new approach for studying the kinetics of phase transformations and identifying non-equilibrium phases in droplet-based lyotropic liquid systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Editorial Material
Robotics
Bradley J. Nelson
Article
Chemistry, Multidisciplinary
Joaquin Llacer-Wintle, Jan Renz, Lukas Hertle, Andrea Veciana, Denis von Arx, Jiang Wu, Pere Bruna, Marija Vukomanovic, Josep Puigmarti-Luis, Bradley J. Nelson, Xiang-Zhong Chen, Salvador Pane
Summary: Magnetoelectricity allows solid-state materials to generate electricity under magnetic fields. A new magnetopyroelectric (MPE) effect is demonstrated in nanostructured composites of magnetic and pyroelectric materials. The composites consist of magnetic iron oxide nanoparticles dispersed in a ferroelectric poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) matrix. This new approach provides an opportunity to develop magnetoelectric materials for various applications.
MATERIALS HORIZONS
(2023)
Article
Geosciences, Multidisciplinary
Bastian Bergfeld, Alec van Herwijnen, Gregoire Bobillier, Philipp L. Rosendahl, Philipp Weissgraeber, Valentin Adam, Juerg Dual, Juerg Schweizer
Summary: The study investigated the crack speed, touchdown distance, and energy dissipation during dynamic crack propagation. Key data such as elastic modulus and specific fracture energy were obtained. Based on these findings, an index for self-sustained crack propagation is proposed.
NATURAL HAZARDS AND EARTH SYSTEM SCIENCES
(2023)
Article
Acoustics
Maxwell J. Kiernan, Rashid Al Mukaddim, Carol C. Mitchell, Jenna Maybock, Stephanie M. Wilbrand, Robert J. Dempsey, Tomy Varghese
Summary: In this study, a method for automatically determining bounding boxes and lumen segmentation using a Mask R-CNN network trained on sonographer assisted groundtruth carotid lumen segmentations is presented. This method is of great importance for analyzing ultrasound images that require time and labor, and it also lays the foundation for developing accurate plaque segmentation and wall thickness measurement methods.
Article
Acoustics
Junzhen Wang, Jianmin Qu
Summary: This article presents the solution to guided wave fields in a double-layer plate and proposes a nonlinear spring-interface model for the bonding between the two sublayers. The study finds that the nonlinearity of the spring-interface can generate resonant guided waves in the double-layer plate, providing a theoretical foundation for the development of nondestructive evaluation techniques using nonlinear guided waves.
Article
Acoustics
Shuyuan Ye, Tianyu Peng, Zhili Long, Zhiming Jiang, Xiangqing Li, Zhonghua Cao
Summary: In this study, a novel approach based on beating vibration model is proposed for frequency tracking, which accurately determines the resonant frequency of the transducer in a short time.
Article
Acoustics
Shuling Gao, Rui Zhang, Zheng Fan, Ning Li, Yanan Yue, Lili Xie
Summary: In this study, a novel method is proposed to monitor fatigue damage in welded joints by computing the energy density in the diffuse ultrasonic signal. The results indicate that the correlation coefficient of the energy density exhibits a significant decreasing trend when crack initiation occurs, providing a unique signal to indicate crack initiation in welded joints.
Article
Acoustics
Ata Jafarzadeh, Peter D. Folkow, Anders Bostrom
Summary: This study investigates the scattering of elastic waves by an anisotropic sphere with orthorhombic symmetry inside an isotropic medium, and applies it to the characterization of polycrystalline materials with anisotropic grains. The expansion coefficients of the wave and displacement field are determined inside the sphere using recursion relations and boundary conditions. The T matrix elements are then obtained and used to analyze the attenuation and phase velocity of polycrystalline materials, particularly at low frequencies. The proposed approach shows good agreement with previous results and finite element method for strongly anisotropic materials.
Article
Acoustics
F. R. Akhmedzhanov, M. I. Elboeva, S. Z. Mirzaev
Summary: The dependence of elastic and acousto-optic properties on the direction of wave vector and polarization of acoustic and optical waves in lead molybdate crystals has been investigated. Effective photoelastic constants were determined using the Dixon method for different geometries of Bragg light diffraction. The study of the acousto-optic quality factor dependence on the direction of the wave vector of longitudinal acoustic waves in the symmetry plane revealed that the maximum and minimum values are observed when light is diffracted by pure longitudinal waves in this plane. Additionally, it was found that the acousto-optic quality factor in lead molybdate crystals is practically the same as in paratellurite crystals.
Article
Acoustics
H. Franklin
Summary: This paper investigates the interaction between double porosity distributed cylindrical bodies and the surrounding fluid using a generalized self consistent method. The study reveals that there is a correlation between the propagating waves and the effective quantities at low frequencies, which is influenced by the volume fraction of scatterers and the porosity.
Article
Acoustics
Yuchen Liu, Mahshid Hafezi, Andrew Feeney
Summary: This study investigates the use of Nitinol, a shape memory alloy, in a Langevin power ultrasonic transducer to mitigate the influence of temperature on device performance. The results demonstrate that by controlling the microstructure of Nitinol, the nonlinear softening of the piezoelectric stack can be reduced, leading to higher and more stable vibration amplitudes. Furthermore, the use of Nitinol allows for stable resonance frequency and performance even with temperature changes and continuous operation.
Article
Acoustics
Shrutika Sharma, Vishal Gupta, Deepa Mudgal
Summary: Poly Lactic Acid (PLA) based bone plates fabricated using Fused Deposition Modeling can have improved mechanical strength by biocompatible polydopamine (PDM) coating. The effect of ultrasonic assisted coating parameters on tensile strength of coated bone plates was investigated and compared using Response Surface Methodology (RSM) and machine learning (ML) models. The gradient boosting regression (GBReg) model outperformed other models in terms of accuracy and prediction performance for predicting the tensile strength of PDM coated bone plates.
Article
Acoustics
Kirill Kolesnik, Vijay Rajagopal, David J. Collins
Summary: Superstrate-based acoustofluidic devices offer advantages of cost, interchangeability and prevention of contamination between samples. This study analyzes the coupling layers and superstrate dimensions for efficient sound transmission, finding that a superstrate thickness of 0.55 times the acoustic wavelength maximizes acoustic coupling.
Article
Acoustics
Dingpeng Wang, Xiaocen Wang, Shili Chen, Jian Li, Lin Liang, Yang Liu
Summary: This paper proposes an end-to-end ultrasonic guided wave joint learning imaging method for sparse and limited-view transducer arrays, which significantly improves the quality of imaging results by integrating sparse feature reconstruction and deep learning imaging methods.
Article
Acoustics
Zubeir M. Ebrahim Saib, Anthony J. Croxford, Bruce W. Drinkwater
Summary: This paper proposes a numerical model using FDTD scheme to solve the nonlinear elastic bulk wave equations, aiming to better understand nonlinear ultrasonic techniques. The model considers material and geometrical nonlinearities and uses a stress-type boundary condition for excitation. Simulation and experimental results validate the effectiveness of the model.
Article
Acoustics
Sol R. Martinez, Emmanuel Odella, Luis E. Ibarra, Arianna Sosa Lochedino, Ana B. Wendel, Andres M. Durantini, Carlos A. Chesta, Rodrigo E. Palacios
Summary: Sonodynamic inactivation (SDI) has an advantage over optical excitation-based protocols due to the deeper penetration of ultrasound (US) excitation. In this study, we applied conjugated polymer nanoparticles (CPNs) as an efficient sonosensitizer (SS) in SDI of pathogens and characterized the sonoreactor. We found that CPNs have a germicidal effect on planktonic cultures and mature biofilms, highlighting their potential for novel inactivation protocols.
Article
Acoustics
Quentin Baudis, Tony Valier-Brasier, Regis Wunenburger
Summary: In this study, we present a detailed procedure for measuring the rheological properties of soft, highly attenuating, visco-elastic materials at ultrasonic frequencies. We use a crosslinked Polyurethane (PU) elastomer as an example and determine its complex longitudinal modulus M and shear modulus G as a function of frequency and temperature. The results show that M, G, and bulk modulus K obey the time-temperature superposition principle and can be accurately described using a fractional derivative rheological model.
Article
Acoustics
Richard E. Jacob, Matthew S. Prowant, Chris A. Hutchinson
Summary: Ultrasonic inspection of cast austenitic stainless steel (CASS) in the nuclear industry is challenging due to sound field scatter and attenuation caused by the coarse-grained microstructure. Modeling and simulation are important tools for addressing key aspects of inspections, but developing a useful and reliable CASS model is challenging. This study demonstrates a method of creating a realistic CASS model and compares it with laboratory-measured sound fields, showing promising results.
