Novel sulfonamides were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, (HNMR)-H-1, and (CNMR)-C-13). In vitro, developed compounds were screened for their antibacterial activities against medically important gram (+) and gram (-) bacterial strains, namely, S. aureus, B. subtilis, E. coli, and K. pneumoniae. The antibacterial activities have been determined by measuring MIC values (mu g/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 5a and 9a have most potent activity against E. coli with zone of inhibition: 31 +/- 0.12 mm (MIC: 7.81 mu g/mL) and 30 +/- 0.12 mm (MIC: 7.81 mu g/mL), respectively, nearly as active as ciprofloxacin (zone of inhibition: 32 +/- 0.12 mm). In contrast, all the compounds were totally inactive against the gram (+) B. subtilis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据