Article
Clinical Neurology
Bernadette Kirzinger, Andrea Stroux, Torsten Rackoll, Matthias Endres, Agnes Floeel, Martin Ebinger, Alexander Heinrich Nave
Summary: Elevated levels of IL-6 and fibrinogen in early subacute stroke were associated with worse outcomes up to 6 months post-stroke. However, exposure to aerobic physical fitness training did not alter the dynamics of inflammatory markers over time.
FRONTIERS IN NEUROLOGY
(2021)
Article
Biology
Quesia Euclides Teixeira, Dennis de Carvalho Ferreira, Alexandre Marques Paes da Silva, Lucio Souza Goncalves, Fabio Ramoa Pires, Florence Carrouel, Denis Bourgeois, Irna Sufiawati, Luciana Armada
Summary: The expression of pro-inflammatory cytokines IL-1 beta, IL-6 and TNF-alpha is higher in chronic apical periodontitis lesions (CAPLs) in elderly individuals compared to adults. Ageing may act as a modifier on periradicular disease, although further research is needed to understand the reasons and consequences of inflammation in the elderly.
Article
Veterinary Sciences
Jessica Maria Abbate, Francesca Arfuso, Kristian Riolo, Elisabetta Giudice, Barbara Brunetti, Giovanni Lanteri
Summary: This study evaluated the gene expression of pro-inflammatory cytokines and miRNAs in canine mammary tumors and their correlation with tumor proliferation index. The results highlighted the important role of IL-6 and TNF-alpha in breast cancer, and suggested that miR-21 may serve as a prognostic biomarker in CMTs.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Immunology
Nikolaos Skartsis, Yani Peng, Leonardo M. R. Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D. Muller, Flavio Vincenti, Qizhi Tang
Summary: The study shows that human Tregs respond positively to proinflammatory cytokines, enhancing proliferation without affecting their lineage identity or function, providing a potential method for therapeutic Treg manufacturing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Food Science & Technology
M. L. Cuellar-Nunez, E. Gonzalez de Mejia, G. Loarca-Pina
Summary: Moringa oleifera leaves have shown chemopreventive properties against inflammatory response and colon carcinogenesis by modulating gene expression and reducing proinflammatory mediators.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Environmental Sciences
Fallah Hashemi, Farahnaz Soleimani Hamidinejad, Lori Hoepner, Ata Rafiee, Alireza Abbasi, Mohammad Hoseini
Summary: This study investigated the exposure of pregnant women living near the Ilam petrochemical complex to BTEX and its associations with pro-inflammatory cytokines IL-6 and TNF-alpha. Results showed higher levels of BTEX and increased pro-inflammatory cytokine levels in the exposed group, with benzene having the most significant correlation. Long-term residence near petrochemical industries may pose health risks for pregnant women due to exposure to BTEX and elevated cytokine levels.
AIR QUALITY ATMOSPHERE AND HEALTH
(2022)
Review
Integrative & Complementary Medicine
Maryam Teimouri, Masoud Homayouni-Tabrizi, Arezoo Rajabian, Hamed Amiri, Hossein Hosseini
Summary: This study found through systematic review and meta-analysis that resveratrol can significantly decrease serum levels of CRP and TNF-alpha in patients with CVDs.
COMPLEMENTARY THERAPIES IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Wade M. Sanders, Sioban D. Harlow, Kelly R. Ylitalo, Brittney S. Lange-Maia, Aleda M. Leis, Daniel S. McConnell, Carrie A. Karvonen-Gutierrez
Summary: Cardiometabolic factors and inflammation are significantly associated with peripheral neuropathy (PN), independent of diabetes and obesity. C-reactive protein (CRP) mediates the relationship between obesity and MetS with PN.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cell Biology
Mykyta Malkov, Chee Teik Lee, Cormac T. Taylor
Summary: Hypoxia and inflammation frequently co-occur in inflammatory diseases, with pro-inflammatory cytokines such as TNF-alpha and IL-1 beta directly impacting HIF signaling pathways. Multi-level crosstalk between inflammatory and hypoxic signaling pathways plays a crucial role in shaping the degree of inflammation at hypoxic sites.
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gonca Sarac Ozturk, Tulin Ergun, Irem Peker Eyuboglu, Mustafa Akkiprik
Summary: This study evaluated serum levels of proinflammatory cytokines and hs-CRP in HS patients, finding hs-CRP to be an indicator of treatment response and systemic inflammation. However, there is insufficient data to suggest TNF-α, IL-1β, IL-17A, and IL-23 as serum biomarkers in HS.
Article
Clinical Neurology
Sophie Buhelt, Helle Bach Sondergaard, Mie Reith Mahler, Stefan Cobanovic, Lars Bornsen, Cecilie Ammitzboll, Annette Bang Oturai, Finn Sellebjerg
Summary: The soluble interleukin-2 receptor alpha (sIL-2Rα) is associated with tumor necrosis factor-alpha (TNFα) and C-reactive protein (CRP) in healthy subjects, but not in multiple sclerosis (MS) patients. Additionally, the MS-associated SNP rs2104286 does not show significant associations with any of the systemic inflammation biomarkers in healthy subjects or MS patients. Further research is needed to confirm the use of sIL-2Rα as a biomarker of systemic inflammation and to understand the correlation between sIL-2Rα and TNFα levels.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Article
Immunology
Anne Helene Kostner, Anniken Jorlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten
Summary: This study found that the acute phase reactant C-reactive protein (CRP), which can be diagnostically measured by serum levels, is correlated with poor outcomes in different types of cancer. Specifically, high levels of CRP are associated with the pro-inflammatory monomeric isoform of CRP (mCRP) within the tumor microenvironment (TME) in colon cancer patients. These findings shed light on the potential role of CRP in tumor biology.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Review
Physiology
Eco J. C. De Geus
Summary: Twin and family studies have shown that genetic factors play a significant role in determining physical activity levels, as measured by self-report or accelerometers. The heritability of physical activity is estimated to be around 43% throughout a person's lifespan. Genome-wide association studies have identified biological pathways that are related to exercise ability and enjoyment. Developing a polygenic score based on genetic variants that influence physical activity could potentially enhance the effectiveness of intervention programs.
EXERCISE AND SPORT SCIENCES REVIEWS
(2023)
Article
Food Science & Technology
Joshua M. Tybur, Laura W. Wesseldijk, Dorret I. Boomsma, Gonneke Willemsen, Jacqueline M. Vink
Summary: Genetic factors have a significant influence on individuals' food preferences, as well as their decision to abstain from eating meat and fish. In a study conducted on a Dutch twin sample, it was found that genetic factors accounted for a large proportion of variation in pescetarianism and vegetarianism. Different meats and fish were abstained from for different reasons, with health concerns being the main reason for abstaining from pork, dislike for poultry, fish, and shellfish, and beliefs for abstaining from beef.
FOOD QUALITY AND PREFERENCE
(2023)
Article
Psychology, Biological
Denise Johanna van der Mee, Martin J. Gevonden, Joyce H. D. M. Westerink, Eco J. C. de Geus
Summary: This study examined the effects of exercise on physical and psychological stress reactivity through a combined laboratory and daily life study. The results showed that aerobic fitness and physical activity can reduce resting heart rate, but no evidence was found for the cross-stressor adaptation hypothesis.
Article
Clinical Neurology
Mark K. Bakker, Jos P. Kanning, Gad Abraham, Amy E. Martinsen, Bendik S. Winsvold, John-Anker Zwart, Romain Bourcier, Tomonobu Sawada, Masaru Koido, Yoichiro Kamatani, Sandrine Morel, Philippe Amouyel, Stephanie Debette, Philippe Bijlenga, Takiy Berrandou, Santhi K. Ganesh, Nabila Bouatia-Naji, Gregory Jones, Matthew Bown, Gabriel J. E. HUNT All In Stroke, Jan H. CADISP Grp, Ynte M. Int Consortium Blood Pressure, Int Headache Genetics Consortium, ISGC, Intracranial Aneurysm Working Grp, Gabriel J. E. Rinkel, Jan Veldink, Ynte Ruigrok
Summary: Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to have potential for genetic risk prediction. However, a genetic risk score incorporating these factors only showed limited predictive value for IA presence and ASAH incidence, suggesting that it may not be suitable for daily clinical use.
Article
Multidisciplinary Sciences
Lucy Karwatowska, Leonard Frach, Tabea Schoeler, Jorim J. Tielbeek, Joseph Murray, Eco de Geus, Essi Viding, Jean-Baptiste Pingault
Summary: Observational studies have found an association between low resting heart rate (RHR) and higher levels of antisocial behavior (ASB), but it is unclear if this represents a causal relationship. To investigate further, the study conducted various genetic analyses but found no evidence of a causal association between RHR and ASB. The findings suggest that individual differences in autonomic nervous system functioning indexed by RHR are unlikely to directly contribute to the development of ASB.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Biological
Iain Mathieson, Felix R. Day, Nicola Barban, Felix C. Tropf, David M. Brazel, Ahmad Vaez, Natalie van Zuydam, Barbara D. Bitarello, Eugene J. Gardner, Evelina T. Akimova, Ajuna Azad, Sven Bergmann, Lawrence F. Bielak, Dorret Boomsma, Kristina Bosak, Marco Brumat, Julie E. Buring, David Cesarini, Daniel Chasman, Jorge E. Chavarro, Massimiliano Cocca, Maria Pina Concas, George Davey Smith, Gail Davies, Ian J. Deary, Tonu Esko, Jessica D. Faul, Oscar Franco, Andrea Ganna, Audrey J. Gaskins, Andrea Gelemanovic, Eco J. C. de Geus, Christian Gieger, Giorgia Girotto, Bamini Gopinath, Hans Joergen Grabe, Erica P. Gunderson, Caroline Hayward, Chunyan He, Diana van Heemst, W. David Hill, Eva R. Hoffmann, Georg Homuth, Jouke Jan Hottenga, Hongyang Huang, Elina Hyppoenen, M. Arfan Ikram, Rick Jansen, Magnus Johannesson, Zoha Kamali, Sharon L. R. Kardia, Maryam Kavousi, Annette Kifley, Tuomo Kiiskinen, Peter Kraft, Brigitte Kuehnel, Claudia Langenberg, Gerald Liew, Penelope A. Lind, Jian'an Luan, Reedik Magi, Patrik K. E. Magnusson, Anubha Mahajan, Nicholas G. Martin, Hamdi Mbarek, Mark McCarthy, George McMahon, Sarah E. Medland, Thomas Meitinger, Andres Metspalu, Evelin Mihailov, Lili Milani, Stacey A. Missmer, Paul Mitchell, Stine Mollegaard, Dennis O. Mook-Kanamori, Anna Morgan, Peter van der Most, Renee de Mutsert, Matthias Nauck, Ilja M. Nolte, Raymond Noordam, Brenda W. J. H. Penninx, Annette Peters, Patricia A. Peyser, Ozren Polasek, Chris Power, Ajka Pribisalic, Paul Redmond, Janet W. Rich-Edwards, Paul M. Ridker, Cornelius A. Rietveld, Susan M. Ring, Lynda M. Rose, Rico Rueedi, Vallari Shukla, Jennifer A. Smith, Stasa Stankovic, Kari Stefansson, Doris Stoeckl, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Gudmar Thorleifsson, Unnur Thorsteinsdottir, A. Roy Thurik, Nicholas J. Timpson, Constance Turman, Andre G. Uitterlinden, Melanie Waldenberger, Nicholas J. Wareham, David R. Weir, Gonneke Willemsen, Jing Hau Zhao, Wei Zhao, Yajie Zhao, Harold Snieder, Marcel den Hoed, Ken K. Ong, Melinda C. Mills, John R. B. Perry
Summary: Identifying genetic determinants of reproductive success can reveal the mechanisms underlying fertility and identify genes that are currently under natural selection. A genome-wide association study on individuals of European ancestry identified 43 genomic loci associated with the number of children ever born or childlessness. These loci are involved in various aspects of reproductive biology, such as puberty timing, age at first birth, sex hormone regulation, endometriosis, and age at menopause. Additionally, missense variants in ARHGAP27 were found to be associated with higher number of children ever born but shorter reproductive lifespan, suggesting a trade-off at this locus. Other genes, including PIK3IP1, ZFP82, and LRP4, were also implicated by coding variants, and a new role for the melanocortin 1 receptor (MC1R) in reproductive biology was suggested. Furthermore, integration with data from historical selection scans revealed an allele in the FADS1/2 gene locus that has been undergoing selection for thousands of years. These findings highlight the diverse biological mechanisms contributing to reproductive success.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Genetics & Heredity
Veronika V. Odintsova, Jenny van Dongen, Catharina E. M. van Beijsterveldt, Lannie Ligthart, Gonneke Willemsen, Eco J. C. de Geus, Conor V. Dolan, Dorret I. Boomsma
Summary: This study examined the associations between 23 early life characteristics and handedness in a large sample of 37,495 5-year-old twins. The results showed that the prevalence of non-right-handedness was higher in twins compared to previously published data from adults born as singletons. Male sex, lower gestational age, and not being breastfed were associated with non-right-handedness. However, there were no associations between twin-specific characteristics and handedness.
TWIN RESEARCH AND HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Bodine M. A. Gonggrijp, Steve G. A. van de Weijer, Catrien C. J. H. Bijleveld, Jenny van Dongen, Dorret I. Boomsma
Summary: Establishing causal relationships is crucial in research and policy making. The co-twin control design (CTCD) is a powerful approach for investigating causal effects while controlling for confounding factors. This article provides an overview of the CTCD, analysis methods, data simulation tools, and practical guidance for implementing the design in R, SPSS, and Stata.
TWIN RESEARCH AND HUMAN GENETICS
(2023)
Article
Multidisciplinary Sciences
Yordi van de Vegte, Ruben P. Eppinga, M. Yldau van der Ende, Yanick Hagemeijer, Yuvaraj V. Mahendran, Elias Y. Salfati, Albert E. Smith, Vanessa Tan, Dan V. Arking, Ioanna Ntalla, Emil A. Appel, Claudia Schurmann, Jennifer Brody, Rico Rueedi, Ozren Polasek, Gardar Sveinbjornsson, Cecile Lecoeur, Claes Ladenvall, Jing Hua Zhao, Aaron Isaacs, Lihua Wang, Jian'an Luan, Shih-Jen Hwang, Nina U. Mononen, Kirsi F. Auro, Anne Jackson, Lawrence Bielak, Linyao Zeng, Nabi Shah, Maria Nethander, Archie Campbell, Tuomo Rankinen, Sonali Pechlivanis, Lu Qi, Wei Zhao, Federica Rizzi, Toshiko Tanaka, Antonietta Robino, Massimiliano Cocca, Leslie Lange, Martina Mueller-Nurasyid, Carolina E. Roselli, Weihua Zhang, Marcus J. Kleber, Xiuqing Guo, Henry E. Lin, Francesca Pavani, Tessel Galesloot, Raymond E. Noordam, Yuri Milaneschi, Katharina Schraut, Marcel den Hoed, Frauke E. Degenhardt, Stella Trompet, Marten van den Berg, Giorgio Pistis, Yih-Chung S. Tham, Stefan L. Weiss, Xueling J. Sim, Hengtong M. Li, Peter van der Most, Ilja Nolte, Leo-Pekka R. Lyytikaeinen, M. Abdullah Said, Daniel Witte, Carlos M. Iribarren, Lenore S. Launer, Susan Ring, Paul de Vries, Peter P. Sever, Allan Linneberg, Erwin M. Bottinger, Sandosh Padmanabhan, Bruce Psaty, Nona Sotoodehnia, Ivana Kolcic, Delnaz D. Roshandel, Andrew O. Paterson, David F. Arnar, Daniel Gudbjartsson, Hilma Holm, Beverley T. Balkau, Claudia H. Silva, Christopher Newton-Cheh, Kjell Nikus, Perttu L. Salo, Karen A. Mohlke, Patricia Peyser, Heribert Schunkert, Mattias Lorentzon, Jari C. Lahti, Dabeeru C. Rao, Marilyn D. Cornelis, Jessica A. Faul, Jennifer Smith, Katarzyna Stolarz-Skrzypek, Stefania Bandinelli, Maria Pina Concas, Gianfranco Sinagra, Thomas Meitinger, Melanie F. Waldenberger, Moritz Sinner, Konstantin E. Strauch, Graciela D. Delgado, Kent Taylor, Jie Yao, Luisa Foco, Olle Melander, Jacqueline de Graaf, Renee de Mutsert, Eco J. C. de Geus, Asa K. Johansson, Peter K. Joshi, Lars Lind, Andre W. Franke, Peter V. Macfarlane, Kirill Tarasov, Nicholas B. Tan, Stephan Felix, E-Shyong Q. Tai, Debra Quek, Harold Snieder, Johan Ormel, Martin Ingelsson, Cecilia P. Lindgren, Andrew T. Morris, Olli Raitakari, Torben Hansen, Themistocles Assimes, Vilmundur J. Gudnason, Nicholas C. Timpson, Alanna B. Morrison, Patricia P. Munroe, David Strachan, Niels Grarup, Ruth J. F. R. Loos, Susan Heckbert, Peter Vollenweider, Caroline Hayward, Kari Stefansson, Philippe Froguel, Leif J. Groop, Nicholas M. Wareham, Cornelia F. van Duijn, Mary J. Feitosa, Christopher O'Donnell, Mika Kaehoenen, Markus Perola, Michael Boehnke, Sharon L. R. Kardia, Jeanette Erdmann, Colin N. A. Palmer, Claes J. Ohlsson, David G. Porteous, Johan Eriksson, Claude Bouchard, Susanne Moebus, Peter R. Kraft, David Weir, Daniele Cusi, Luigi Ferrucci, Sheila Ulivi, Giorgia Girotto, Adolfo Correa, Stefan Kaeaeb, Annette C. Peters, John S. Chambers, Jaspal Kooner, Winfried I. Maerz, Jerome A. Rotter, Andrew Hicks, J. Gustav Smith, Lambertus A. L. M. O. Kiemeney, Dennis Mook-Kanamori, Brenda W. J. H. Penninx, Ulf F. Gyllensten, James Wilson, Stephen Burgess, Johan Sundstroem, Wolfgang Lieb, J. Wouter Jukema, Mark Eijgelsheim, Edward L. M. Lakatta, Ching-Yu Cheng, Marcus Doerr, Tien-Yin Wong, Charumathi J. Sabanayagam, Albertine Oldehinkel, Harriette Riese, Terho Lehtimaeki, Niek Verweij, Pim van der Harst
Summary: This study identifies new genetic variants associated with resting heart rate (RHR) and demonstrates that higher genetically predicted RHR is associated with a decreased risk of atrial fibrillation and ischemic stroke. Genome-wide analysis reveals multiple genetic variants in cardiomyocyte-related genes and provides insights into their electrocardiogram (ECG) signature. Mendelian randomization analyses indicate that higher genetically predicted RHR increases the risk of dilated cardiomyopathy, but reduces the risk of atrial fibrillation, ischemic stroke, and cardio-embolic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Balewgizie S. Tegegne, M. Abdullah Said, Alireza Ani, Arie M. van Roon, Sonia Shah, Eco J. C. de Geus, Pim van der Harst, Harriette Riese, Ilja M. Nolte, Harold Snieder
Summary: This study identified 17 genetic variants associated with HRV traits, including 8 previously unreported loci. Additionally, lower HRV was associated with increased mortality risk. However, genetically predicted HRV was not associated with mortality.
COMMUNICATIONS BIOLOGY
(2023)
Article
Hematology
Julie Hahn, Jan Bressler, Arce Domingo-Relloso, Ming-Huei Chen, Daniel L. McCartney, Alexander Teumer, Jenny van Dongen, Marcus E. Kleber, Dylan Aissi, Brenton R. Swenson, Jie Yao, Wei Zhao, Jian Huang, Yujing Xia, Michael R. Brown, Ricardo Costeira, Eco J. C. de Geus, Graciela E. Delgado, Dre'Von A. Dobson, Paul Elliott, Hans J. Grabe, Xiuqing Guo, Sarah E. Harris, Jennifer E. Huffman, Sharon L. R. Kardia, Yongmei Liu, Stefan Lorkowski, Riccardo E. Marioni, Matthias Nauck, Scott M. Ratliff, Maria Sabater-Lleal, Tim D. Spector, Pierre Suchon, Kent D. Taylor, Florian Thibord, David-Alexandre Tregouet, Kerri L. Wiggins, Gonneke Willemsen, Jordana T. Bell, Dorret I. Boomsma, Shelley A. Cole, Simon R. Cox, Abbas Dehghan, Andreas Greinacher, Karin Haack, Winfried Marz, Pierre-Emmanuel Morange, Jerome I. Rotter, Nona Sotoodehnia, Maria Tellez-Plaza, Ana Navas-Acien, Jennifer A. Smith, Andrew D. Johnson, Myriam Fornage, Nicholas L. Smith, Alisa S. Wolberg, Alanna C. Morrison, Paul S. de Vries
Summary: This study examined the association between DNA methylation and circulating fibrinogen levels, and identified 83 CpG sites that are associated with fibrinogen levels. These associations are partially driven by inflammatory pathways shared by both fibrinogen and CRP.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Obstetrics & Gynecology
Hamdi Mbarek, Scott D. Gordon, David L. Duffy, Nikki Hubers, Sally Mortlock, Jeffrey J. Beck, Jouke-Jan Hottenga, Rene Pool, Conor Dolan, Ky'Era Actkins, Zachary F. Gerring, Jenny Van Dongen, Erik A. Ehli, William G. Iacono, Matt Mcgue, Daniel Chasman, C. Scott Gallagher, Samantha L. P. Schilit, Cynthia C. Morton, Guillaume Pare, Gonneke Willemsen, David C. Whiteman, Catherine M. Olsen, Catherine Derom, Robert Vlietinck, Daniel Gudbjartsson, Lisa Cannon-Albright, Eva Krapohl, Robert Plomin, Patrik K. E. Magnusson, Nancy L. Pedersen, Pirro Hysi, Massimo Mangino, Timothy D. Spector, Teemu Palviainen, Yuri Milaneschi, Brenda W. Penninnx, Adrian Campos, Ken K. Ong, John R. B. Perry, Cornelis B. Lambalk, Jaakko Kaprio, Isleifur Olafsson, Karine Duroure, Celine Revenu, Miguel E. Renteria, Loic Yengo, Lea Davis, Eske M. Derks, Sarah E. Medland, Hreinn Stefansson, Kari Stefansson, Filippo Del Bene, Bruno Reversade, Grant W. Montgomery, Dorret Boomsma, Nicholas G. Martin
Summary: This study identified four new loci associated with female propensity for giving birth to spontaneous dizygotic twins. The novel loci, GNRH1 and FSHR, have established roles in female reproduction, while ZFPM1 and IPO8 were not previously linked to female fertility. The study also found significant genetic correlations with multiple aspects of female reproduction and body size, suggesting important roles in human evolution.
HUMAN REPRODUCTION
(2023)
Article
Neurosciences
Camiel M. van der Laan, Steve G. A. van de Weijer, Rene Pool, Jouke-Jan Hottenga, Toos C. E. M. van Beijsterveldt, Gonneke Willemsen, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Summary: Family members resemble each other in their propensity for aggression, with approximately 50% of the variance in aggression explained by genetic influences. This study investigated the importance of PGSs and found significant direct effects on aggression for PGSs based on early-life aggression, educational attainment, and ADHD, though the explained variance was low. Further research on other PGSs related to aggression and related phenotypes is needed to determine the generalizability of these findings to overall genetic influences on aggression.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
