期刊
TWIN RESEARCH AND HUMAN GENETICS
卷 15, 期 3, 页码 286-295出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2012.15
关键词
GAB2; imaging genetics; tensor-based morphometry; Alzheimer's disease
资金
- National Institute of Child Health and Human Development [R01 HD050735]
- National Health and Medical Research Council (NHMRC), Australia [486682, 1009064]
- NHMRC [389875]
- NSF GRFP [DGE-0707424]
- UCLA MSTP
- T32 post-doctoral training grant in Neurobehavioral Genetics
- NIH NLM [T15 LM07356]
- NHMRC Fellowship [613667]
- ARC Future Fellowship
The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27-1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.
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