期刊
BIOMATERIALS SCIENCE
卷 3, 期 7, 页码 1147-1156出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00048c
关键词
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资金
- National Natural Scientific Foundation of China (NNSFC) Project [51273188, 81201176]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China (FANEDD) [201224]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20123402120022]
- Fundamental Research Funds for the Central Universities [WK2060200012]
Near-infrared (NIR) light-triggered drug release systems are promising for drug delivery applications in view of the advantages of NIR light, which include high tissue penetration and low damage. In this report, we developed nanogels (NGs) by supramolecular self-assembly from adamantine (AD)-conjugated copolymer, poly[poly(ethylene glycol)monomethyl ether metharcylate]-co-poly(N-(2-hydroxypropyl)methacrylamide)- co-poly(N-adamantan-1-yl-2-methacrylamide) (PPEGMA-co-PHPMA-co-PADMA), and beta-cyclodextrin (beta-CD)-functionalized poly(amidoamine) (PAMAM) dendrimer based on the host-guest interaction of the AD and beta-CD moieties, and they were used to encapsulate indocyanine green (ICG) and doxorubicin (DOX) for combined photothermal-chemotherapy. NGs simultaneously loading ICG and DOX (DINGs) showed significant photothermal effects and stimuli-triggered drug release under NIR laser irradiation by the photothermal-induced relaxation or dissociation of the NGs. In vitro cytotoxicity evaluation of DINGs under NIR irradiation demonstrated the synergistic effects of hyperthermia, photothermal-triggered drug release, and chemotherapy. In vivo investigation revealed their high accumulation in tumor tissue and significant tumor growth suppression under NIR irradiation. These NIR light-triggered drug release NGs represent efficient and promising anticancer drug vectors for the combined photothermal-chemotherapy of cancer to maximize therapeutic efficacy and minimize side effects.
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