Article
Clinical Neurology
Giuseppe Cosentino, Vincenzo Di Stefano, Rosalia Lo Presti, Maria Montana, Massimiliano Todisco, Matteo Gastaldi, Andrea Cortese, Enrico Alfonsi, Cristina Tassorelli, Brigida Fierro, Gregorio Caimi, Filippo Brighina
Summary: This study found that the plasmatic levels of MMPs and TIMPs were significantly altered in patients with CIDP, with higher concentrations of MMP-9, downregulation of TIMP-1, and lower concentration of MMP-2. These new biomarkers may have potential usefulness in the clinical setting and further studies are needed to confirm their utility.
NEUROLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Min-Seob Kim, Se-Eun Ha, Moxin Wu, Hannah Zogg, Charles F. Ronkon, Moon-Young Lee, Seungil Ro
Summary: The composition and changes of the cellular microenvironment play a crucial role in cancer development, with alterations in the ECM significantly impacting the tumor microenvironment. ECM components are important in colorectal cancer and have potential roles as biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Mohd Adnan, Arif Jamal Siddiqui, Walid Sabri Hamadou, Mejdi Snoussi, Riadh Badraoui, Syed Amir Ashraf, Arshad Jamal, Amir Mahgoub Awadelkareem, Manojkumar Sachidanandan, Sibte Hadi, Mushtaq Ahmad Khan, Mitesh Patel
Summary: This study demonstrated that ethanol crude extract of S. repanda inhibited the growth, adhesion, migration, and invasion of human non-small-cell lung and colorectal cancer cells. The anti-metastatic properties of S. repanda may be associated with the inhibition of MMP-2/-9 expression. These findings suggest that S. repanda could be a potential source of anti-metastasis agents in cancer therapy.
Article
Medicine, Research & Experimental
Xiwen Huang, Yongquan Lan, En Li, Jiaquan Li, Qiaoting Deng, Xunwei Deng
Summary: The combined detection of CEA, MMP-7, and TIMP-1 in serum can provide a specific and sensitive biomarker for the diagnosis of CRC.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Oncology
Benjamin Schoeps, Celina Eckfeld, Olga Prokopchuk, Jan Boettcher, Daniel Haeussler, Katja Steiger, Ihsan Ekin Demir, Percy Knolle, Oliver Soehnlein, Dieter E. Jenne, Chris D. Hermann, Achim Krueger
Summary: The study found that TIMP1 is associated with neutrophil activation in PDAC patients and directly triggers the formation of NETs, impacting the progression of PDAC. By combining plasma levels of TIMP1 and NETs, different prognostic subgroups of PDAC patients can be better identified.
Article
Environmental Sciences
Carlos Ramos, Rebeca Canedo-Mondragon, Carina Becerril, Georgina Gonzalez-Avila, Ana Laura Esquivel, Ana Lilia Torres-Machorro, Martha Montano
Summary: Exposure to short-term wood smoke was found to significantly increase total cells, macrophages, neutrophils, and collagen in the respiratory system of guinea pigs, leading to overexpression of pro-inflammatory cytokines, MMPs, and TIMPs in lung tissue.
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Seira Hattori, Tomo Nozawa, Kenichi Nishimura, Ryoki Hara, Ayako Murase, Asami Ohara, Ai Ohnishi, Takashi Ohya, Shuichi Ito
Summary: Arthritis is a common complication of Kawasaki disease, with 20% of patients developing arthritis and 14% experiencing persistent arthritis. Persistent arthritis mainly presents as oligoarthritis in large joints, accompanied by joint pain and fever. Adequate diagnosis and treatment are necessary for patients with Kawasaki disease.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Marley J. Binder, Alister C. Ward
Summary: The metzincin superfamily plays a significant role in the progression of prostate cancer, with members potentially influencing the disease in both positive and negative ways. Further research is needed to understand their mechanisms of action and how they can be utilized as prognostic indicators or molecular targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yuka Ikeda, Kurumi Taniguchi, Haruka Sawamura, Sayuri Yoshikawa, Ai Tsuji, Satoru Matsuda
Summary: In this article, the invasiveness of cancer cells in relation to APRO family proteins is discussed. The role of matrix metalloproteinases (MMPs) and exosomes containing specific microRNAs in regulating cancer invasiveness is highlighted. Understanding these mechanisms can lead to innovative strategies for cancer therapy.
Review
Chemistry, Medicinal
Sandip Kumar Baidya, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinases (MMPs) play roles in various pathological and physiological functions, with gelatinases as therapeutic targets against cancer. Although gelatinase inhibitors have shown effectiveness in several diseases, developing them as therapeutic agents is a challenging task. Various studies and patents have been ongoing to expand knowledge and develop better gelatinase inhibitors in recent years.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Obstetrics & Gynecology
Ana C. Palei, Juliana de O. Cruz, Joao Leandro Chaguri, Jose Carlos Peracoli, Mariana Romao-Veiga, Vanessa R. Ribeiro-Vasques, Ricardo C. Cavalli, Priscila R. Nunes, Marcelo R. Luizon, Valeria C. Sandrim
Summary: This study found that circulating tissue inhibitor of metalloproteinase 3 (TIMP-3) concentrations were increased in women with pre-eclampsia compared to healthy pregnant women, and that it was positively correlated with plasma matrix metalloproteinase 2 (MMP-2) and TIMP-1 concentrations in pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Biochemistry & Molecular Biology
Shinji Takai, Denan Jin
Summary: Chymase-activated MMP-9 is closely related to the pathogenesis of various diseases, especially inflammation-related diseases. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of these diseases. Chymase inhibitors attenuate MMP-9 formation and reduce inflammatory cell numbers, thereby ameliorating the development and progression of these disorders.
Article
Oncology
Qing Kay Li, Tung-Shing Mamie Lih, Yuefan Wang, Yingwei Hu, Naseruddin Hoti, Daniel W. Chan, Hui Zhang
Summary: This study evaluated the diagnostic utility of 12 protein markers for assessing the aggressiveness of prostate cancer (PCa). Four proteins were found to be over-expressed in aggressive tumors, while three proteins showed stronger staining patterns in non-aggressive tumors. Combining different protein markers improved the accuracy of diagnosing the aggressiveness of PCa.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Gastroenterology & Hepatology
A. Krishnamoorthy, R. Arasaradnam
Summary: Colorectal cancer is the third most common cancer worldwide, and early stage diagnosis is an important prognostic factor. Diagnostic biomarkers play a crucial role in early detection and prediction of treatment responses.
BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Bocwinska-Kiluk Beata, Jelski Wojciech, Kornhuber Johannes, Lewczuk Piotr, Mroczko Barbara
Summary: There is a lack of empirical research on non-pharmacological interventions for Alzheimer's disease (AD) globally. This paper examines the biochemical, clinical, and social aspects of AD in relation to psychological interventions and their impact on patients' quality of life. Despite limited research, psychological interventions based on biochemical and other studies show potential for improving emotional well-being and slowing disease progression in AD patients. However, no effective methods of AD treatment have been established to date.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Sadowska, Diana Sawicka, Katarzyna Godlewska, Katarzyna Guzinska-Ustymowicz, Ewa Zapora, Emilia Sokolowska, Halina Car
Summary: Fungal extract from Heterobasidion annosum (HA) has been evaluated for its potential anticancer activity in colorectal cancer. In an in vivo model, mice with implanted DLD-1 human cancer cells were treated with HA extract, the drug 5-fluorouracil (5FU), or a combination of both. Results showed that the combination treatment led to the smallest tumor volumes, with increased concentrations of apoptotic proteins caspase-8 and p53, and decreased levels of survivin and Bcl-2. The Ki-67 protein was found to be expressed in all tested groups. These findings provide innovative insights into the antitumor activity of HA extract and its interaction with chemotherapeutic agents.
Article
Medicine, Research & Experimental
Mariusz Gryko, Marta Lukaszewicz-Zajac, Katarzyna Guzinska-Ustymowicz, Mariola Kucharewicz, Barbara Mroczko, Utkus Algirdas
Summary: The aim of this study was to assess the expression of caspase-8 and procaspase-3 proteins in gastric cancer cells and non-cancerous mucosa, and its relationship with clinical and morphological characteristics of the tumor, postoperative survival, and other apoptosis-related proteins. The results showed that procaspase-3 was expressed in all gastric cancer cells, with a significant difference in expression compared to non-cancerous mucosa. Caspase-8 expression was more common in certain types of gastric cancer and was associated with longer survival and better prognosis.
ADVANCES IN MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Elzbieta Pawluczuk, Marta Lukaszewicz-Zajac, Barbara Mroczko
Summary: By 2040, it is predicted that there will be approximately 1.8 million cases of gastric cancer (GC) and 1.3 million GC-caused deaths annually worldwide. Improving the diagnosis of GC patients is crucial since the malignancy is often detected at an advanced stage. Therefore, finding new biomarkers for early GC is essential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Marcin Bazylewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Jan Kochanowicz, Alina Kulakowska
Summary: This review examines the impact of COVID-19 on patients with autoimmunological disorder, specifically those with multiple sclerosis (MS). It found that MS patients have a similar risk, symptoms, and mortality rate compared to the general population when infected with COVID-19. Factors such as comorbidities, male sex, higher disability level, and older age contribute to a more severe course of COVID-19 in MS patients. Additionally, the use of disease-modifying therapies may affect the immune response to SARS-CoV-2 infection and vaccination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Monika Gudowska-Sawczuk, Jacek Kudelski, Michal Olkowicz, Grzegorz Mlynarczyk, Piotr Chlosta, Barbara Mroczko
Summary: This study aimed to assess the clinical usefulness of serum kappa (?) and lambda (?) free light chains (FLCs) in patients with bladder cancer. The concentrations of FLCs, CEA, and CA19-9 were significantly higher in bladder cancer patients compared to the control group. There was also a correlation between FLC and other biomarkers. The findings suggest that FLC measurements may be useful in the diagnosis and prognosis of bladder cancer.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Adam R. Markowski, Konstancja Ustymowicz, Anna J. Markowska, Wiktoria Romanczyk, Katarzyna Guzinska-Ustymowicz
Summary: Different distributions of E-cadherin expression were observed within colorectal cancer, with the highest percentage of positive expression in the invasive front and tumor center. The expression pattern varied depending on cancer progression and other clinical and histopathological features. Low E-cadherin expression appears to be a reliable indicator of higher cancer staging and progression.
Article
Gastroenterology & Hepatology
Justyna Wasielica-Berger, Pawel Rogalski, Anna Pryczynicz, Agnieszka Swidnicka-Siergiejko, Andrzej Dabrowski
Summary: Magnification endoscopy and methylene blue chromoendoscopy can effectively detect intestinal metaplasia (IM). Methylene blue staining is more accurate in indicating IM compared to pit pattern and vessel evaluation. Methylene blue chromoendoscopy can serve as a screening method for detecting advanced OLGIM stages.
CLINICAL ENDOSCOPY
(2023)
Article
Medicine, General & Internal
Justyna Dorf, Konrad Zareba, Anna Pryczynicz, Joanna Matowicka-Karna, Boguslaw Kedra, Piotr Zukowski, Anna Zalewska, Mateusz Maciejczyk
Summary: Gastric cancer is associated with redox imbalance and increased oxidative damage to proteins, lipids, and DNA. Histopathological parameters of the tumor are associated with the level of antioxidants and oxidative damage products. Determination of redox parameters may be useful in the assessment of the tumor progression.
ANNALS OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Julia Doroszkiewicz, Jakub Ali Farhan, Jan Mroczko, Izabela Winkel, Maciej Perkowski, Barbara Mroczko
Summary: Trace elements and metals play critical roles in the normal functioning of the central nervous system, and their dysregulation has been implicated in neurodegenerative disorders. Imbalances in copper, zinc, iron, and manganese are associated with Alzheimer's disease and Parkinson's disease, while toxic metals like lead and cadmium impair synaptic transmission and exacerbate neuroinflammation. Understanding the roles of these elements is important for therapeutic interventions against neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Julia Doroszkiewicz, Jan Mroczko, Piotr Rutkowski, Barbara Mroczko
Summary: Alzheimer's disease is the most common cause of dementia worldwide. The lack of established pathology makes it challenging to find suitable approaches for treatment. In addition to the known hallmarks of the disease, such as amyloid β peptides and hyperphosphorylated tau, inflammation and diet also play important roles. Adhering to a beneficial diet high in neuroprotective foods and BDNF-boosting substances may improve memory, cognition, and biomarkers, and even reduce the risk of developing Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Piotr Fiedorczuk, Ewa Olszewska, Agnieszka Polecka, Marzena Walasek, Barbara Mroczko, Agnieszka Kulczynska-Przybik
Summary: In this single-center, case-control study, the concentrations of CRP, S100B, IL-6, TNF-α, and IL-8 were found to be elevated in patients with Obstructive Sleep Apnea (OSA), and positively correlated with disease severity, age, and BMI. These results support the potential role of these biomarkers in diagnosing OSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Grzegorz Mlynarczyk, Monika Gudowska-Sawczuk, Barbara Mroczko, Marta Bruczko-Goralewska, Lech Romanowicz, Anna Tokarzewicz
Summary: Gelatinases A and B, also known as matrix metalloproteinase-2 and matrix metalloproteinase-9 respectively, play a crucial role in breaking down collagen in the extracellular matrix. This study examined the presence, activity, and expression of these gelatinases in human renal cancer. The results showed that MMP-9 had higher content but lower specific activity compared to MMP-2 in renal cancer. The study also revealed changes in the gelatinases in healthy and cancerous tissues of renal cell carcinoma, suggesting the potential of MMPs in the diagnosis and treatment of renal carcinoma.
Article
Medicine, General & Internal
Tadeusz Wasilewski, Jolanta Wasilewska, Marta Lukaszewicz-Zajac, Barbara Mroczko
Summary: Subfertility is a global health issue, and a significant proportion of cases remain unexplained. This study found that unexplained subfertility may be associated with dysregulation of gut microbiota, metabolic abnormalities, and immune dysfunction. One-time laboratory diagnostics including lipid profile, insulin resistance, anti-thyroid peroxidase, and total IgE levels may provide a comprehensive assessment for individuals and couples with unexplained subfertility, allowing for targeted medical and nutritional interventions to optimize patients' health.
JOURNAL OF CLINICAL MEDICINE
(2023)
