Article
Public, Environmental & Occupational Health
Tin May Aung, Mang Ngaih Ciin, Atit Silsirivanit, Apinya Jusakul, Worachart Lert-itthiporn, Tanakorn Proungvitaya, Sittiruk Roytrakul, Siriporn Proungvitaya
Summary: In this study, using proteomic analysis and bioinformatics tools, angiopoietin-like protein 4 (ANGPTL4) was identified as a potential biomarker for prognosis of cholangiocarcinoma (CCA) patients. The expression of ANGPTL4 in CCA tissues and serum was found to be associated with lymph node metastasis and vascular invasion. Serum ANGPTL4 levels showed higher predictive efficiency compared with traditional markers CA 19-9 and CEA. In conclusion, serum ANGPTL4 could serve as a novel prognostic biomarker for CCA patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Oncology
Byung Min Lee, Jin-Young Choi, Jinsil Seong
Summary: The study investigated the significance of lymph node metastasis from hepatocellular carcinoma and the efficacy of local treatment. It found that the location of lymph node metastasis significantly affected the survival rate of patients, with the highest survival rate observed in regional metastasis. Local treatment improved overall survival, and its benefits were observed in patients with both lymph node-only metastasis and combined extra-nodal metastasis.
Article
Pharmacology & Pharmacy
Z-Y Guo, Z-T Zhu
Summary: NCAPG upregulation is associated with poor prognosis in hepatocellular carcinoma patients with vascular invasion, and serves as an independent predictor of patient survival outcomes. NCAPG expression levels are related to DNA hypomethylation status, tumor immune cell infiltration, and immune cell-related biomarker expression.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Surgery
Jung Hoon Bae, Ji Hoon Kim, Bong-Hyeon Kye, Abdullah Al-Sawat, Chul Seung Lee, Seung-Rim Han, In Kyu Lee, Sung Hak Lee, Yoon Suk Lee
Summary: In patients with non-metastatic colon cancer, vascular invasion (VI) and lymph node metastasis (LNM) independently impact disease-free survival (DFS). There is a comparable 5-year DFS rate between the VI-/LNM+ and VI+/LNM- groups, but DFS deteriorates in the order of IIIA, II, and IIIB when the VI-/LNM+ group is further subdivided by nodal staging.
FRONTIERS IN SURGERY
(2021)
Article
Oncology
Gang Heng, Benqi Huang, Yanbing Shen, Dan Wang, Zhen Lan, Yuxuan Yao, Jianxin Zhang, Jiankun Jia, Chengcheng Zhang
Summary: The study found that serum CA242 levels were associated with clinical prognosis in HCCA patients, and vascular invasion and lymph node metastasis played significant roles in mediating the impact of CA242 on prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yutaro Higashi, Kodai Nakamura, Ryota Takaoka, Mika Tani, Yusaku Noma, Kazuki Mori, Kota Yamashiro, Seiya Yokoyama, Tomofumi Hamada, Tsuyoshi Sugiura
Summary: Currently, there is a lack of established biomarkers for oral squamous cell carcinoma (OSCC) and imaging studies are relied upon for detecting neck lymph node metastases. This study discovered that serum microRNAs were more accurate at diagnosing primary and late neck lymph node metastases compared to serum squamous cell carcinoma antigens or pathological factors. Detection of microRNAs in OSCC patients using real-time PCR showed high diagnostic and predictive accuracy for neck lymph node metastases. The use of microRNAs can assist in personalized treatment, including follow-up, surgical methods, and postoperative management.
Article
Oncology
Wenting Peng, Caijin Lin, Shanshan Jing, Guanhua Su, Xi Jin, Genhong Di, Zhiming Shao
Summary: This study established clinical prognostic model, seven-gene signature, and combined model for predicting distant metastasis risk in lymph node-negative TNBC patients. The seven-gene signature showed significant differentiation of distant metastasis risk in both training and validation sets. The composite clinical and gene signature demonstrated improved prognostic accuracy compared to the clinical signature.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jinfeng Wang, Liang Wang, Sha Li, Fei Bai, Hailong Xie, Hanguo Shan, Zhuo Liu, Tiexiang Ma, Xiayu Tang, Haibing Tang, Ang Qin, Sanlin Lei, Chaohui Zuo
Summary: The study of 611 EGC patients identified risk factors for LNM including depth of invasion, tumor diameter, and morphological ulceration. Tumor location in the proximal third of the stomach and morphological ulceration were significantly associated with group 2 LNM. The 5-year survival rate decreased as the number of positive nodes increased, and 15 lymph node dissection and D2 radical operation are recommended for high risk patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hikari Shimoda, Masanori Teshima, Takayuki Murase, Toshitaka Nagao, Kimihide Kusafuka, Masato Nakaguro, Makoto Urano, Ken-ichi Taguchi, Hidetaka Yamamoto, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Daisuke Kawakita, Kazuo Sakurai, Nobuhiro Hanai, Toru Nagao, Ryo Kawata, Naohito Hato, Ken-ichi Nibu, Hiroshi Inagaki
Summary: Adenoid cystic carcinoma (AdCC) of salivary gland grows slowly but can develop distant metastasis. This study investigated prognostic factors in predicting disease free survival (DFS), distant metastasis free survival (DMFS), and overall survival (OS) in surgically treated AdCC patients without cervical lymph node metastasis (LNM). Positive surgical margin, pT3/4 stage, and high-histological grade were identified as significant prognostic factors. The prognostic score (PS) based on the number of positive prognostic factors showed significant differences in 10-year DFS, DMFS, and OS rates.
Article
Cell Biology
Shihua Zhang, Cheng Zhang, Jinke Du, Rui Zhang, Shixiong Yang, Bo Li, Pingping Wang, Wensheng Deng
Summary: Accurate prediction of lymph-node metastasis in cancers is crucial for targeted clinical interventions and favorable prognosis. Different molecular profiles have been used to establish classifiers for cancer prediction, but few studies focus on lymphatic metastasis evaluation. Support vector machine (SVM) classifiers based on different profiles achieved high overall accuracies for predicting lymph-node metastasis in representative cancers with a small set of biomarkers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hye Jin Kim, Gyu-Seog Choi, An Na Seo, Jun Seok Park, Soo Yeun Park, Seung Hyun Cho, Ghilsuk Yoon
Summary: The study demonstrated a considerable increase in venous invasion detection rate with the application of elastin stain in colon cancer. Venous invasion proved to be a valuable predictor of disease recurrence, especially in deciding the use of adjuvant chemotherapy in stage II colon cancer.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Biology
Meiyu Duan, Lei Zhang, Yueying Wang, Yusi Fan, Shuai Liu, Qiong Yu, Lan Huang, Fengfeng Zhou
Summary: This study developed a quantitative transcription regulation model based on regression analysis to analyze dysregulation in regional lymph node metastasis across 18 cancer types. Results revealed a few shared dysregulated models among cancer types, with mRNA genes in these models not showing differential expression during metastasis. The experimental data suggested that the mqTrans technology could complement the evaluation of transcription regulation mechanisms and aid in quantitative investigation of other phenotypes.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Yin-Quan Chen, Chen-Yu Hung, Ming-Tzo Wei, Jean-Cheng Kuo, Muh-Hwa Yang, Han-Ying Cheng, Arthur Chiou
Summary: In this study, the researchers compared the biomolecular and biomechanical properties of lymph node (LN)-metastatic and non-metastatic cells in head and neck squamous cell carcinoma. They found that LN-metastatic cells had a higher level of Snail expression, which promoted cellular invasion capability in confined environments by increasing longitudinal strain of the cell nuclei through stronger cell traction force and softer nuclear stiffness. These biomechanical changes were correlated with a larger amount of focal adhesion and less amount of nuclear lamins. Overall, this study reveals the key process in LN metastasis by examining the biomechanical profiles and corresponding biomolecular expressions of LN-metastatic cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
XiaoXi Ma, Xia Yang, Wentao Yang, Ruohong Shui
Summary: Studies have shown that extranodal extension (ENE) is associated with prognosis in breast cancer. ENE is an independent prognostic factor for DRFS and is linked with OS. ENE in the axillary lymph nodes is related to a higher nodal burden. The size of ENE, divided by 3 mm (CD-ENE) or 2 mm (PD-ENE), did not have significant prognostic value.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
In Hee Lee, Gyeonghwa Kim, Sang Gyu Kwak, Dong Won Baek, Byung Woog Kang, Hye Jin Kim, Su Yeon Park, Jun Seok Park, Gyu-Seog Choi, Keun Hur, Jong Gwang Kim
Summary: The study validated candidate biomarkers for predicting LN metastasis in colon cancer patients using plasma miRNA concentrations, identifying three circulating miRNAs significantly associated with LN metastasis.
Article
Immunology
Gao-Yu Liu, Xiao-Hui Deng, Xing Li, Ying-Jiao Cao, Yan-Fang Xing, Pan Zhou, Ai-Hua Lei, Quan Yang, Kai Deng, Hui Zhang, Jie Zhou
JOURNAL OF IMMUNOLOGY
(2020)
Article
Medicine, Research & Experimental
Zhi-Huan Lin, Jun-Rong Jiang, Xiao-Kun Ma, Jie Chen, He-Ping Li, Xing Li, Xiang-Yuan Wu, Ming-Sheng Huang, Qu Lin
Summary: This study investigated the prognostic value of changes in serum HIF-1 alpha levels following TACE treatment in HCC patients. The results suggest that the increment of HIF-1 alpha is a prognostic factor associated with the TACE treatment response, progression-free survival (PFS), and overall survival (OS).
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Min Jia, Bijia Su, Lijun Mo, Wen Qiu, Jiaxu Ying, Peng Lin, Bingxuan Yang, Danying Li, Dongxia Wang, Lili Xu, Hongwei Li, Zhongxin Zhou, Xing Li, Jinlong Li
Summary: Bladder cancer is a common tumor type of the urinary system, and the first-line treatment is cisplatin-based combination chemotherapy, but a significant proportion of patients relapse due to drug resistance. The study found that regulating the circadian protein CRY1 can affect PTX-induced cell senescence, thus preventing the development of cisplatin-resistant bladder cancer cells.
Article
Oncology
Jie Chen, Yi-Dan Qiao, Xing Li, Jian-Liang Xu, Qing-Jian Ye, Nan Jiang, Hui Zhang, Xiang-Yuan Wu
Summary: The study revealed that an accumulation of CD45(+)CD71(+) erythroid cells in HCC tissues could play a superior immunosuppressive role in the tumor microenvironment. They suppress T cells through generation of reactive oxygen species, IL-10, and TGF-beta, and their abundance in tumor tissue may serve as a valuable biomarker to predict HCC recurrence, with a prognostic value better than conventional scoring systems.
Article
Oncology
Jie Chen, Yong-Jian Chen, Nan Jiang, Jian-Liang Xu, Zi-Ming Liang, Ming-Jun Bai, Yan-Fang Xing, Zhuo Liu, Xiang-Yuan Wu, Xing Li
Summary: This study confirmed NAR as an independent predictor for OS among patients with HCC receiving TACE, and highlighted the association of NAR with LOX-1(+) PMN-MDSC level. The integrated NAR-CLIP score showed superior predictive capacity compared to individual CLIP score in predicting survival at different time points.
Article
Pediatrics
Hui-Feng Fan, Chun-Hui He, Gen-Quan Yin, Yi Qin, Nan Jiang, Gen Lu, Xing Li
Summary: During the COVID-19 pandemic, there was no significant difference in the number of asthma exacerbation cases before and during the pandemic in Guangzhou. However, there was a decrease in the frequency of severe asthma exacerbation cases and an increase in mild asthma exacerbation cases. Additionally, the number of hospitalized patients with infectious respiratory diseases decreased during the pandemic.
PEDIATRIC PULMONOLOGY
(2021)
Article
Immunology
Quan Yang, Hongyan Xie, Xing Li, Yuanfa Feng, Shihao Xie, Jiale Qu, Anqi Xie, Yiqiang Zhu, Lu Zhou, Jinxue Yang, Xiaohao Hu, Haixia Wei, Huaina Qiu, Wenjuan Qin, Jun Huang
Summary: This study shows that IRF4 plays a crucial role in the development of PMN-MDSCs, and its deficiency can lead to an increase in PMN-MDSCs and enhanced suppressive activity, promoting tumor growth and metastasis. There is a correlation between the expression levels of IRF4 and c-Myc in clinical cancer patients, which may have predictive value for tumor progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yan-Fang Xing, Jia-Rong Cai, Jun-Jian Qin, Wen-Ying Zhou, Can-Ming Li, Xing Li
Summary: In this study, it was found that monocyte-derived suppressor cells (MDSCs) were elevated in end-stage renal disease (ESRD) patients undergoing hemodialysis, and were strongly associated with increased risk of cardiovascular and cerebrovascular diseases. MDSCs in hemodialysis patients showed enhanced recruitment to atherosclerotic lesions and promoted the migration of endothelial cells through depletion of local L-arginine. Plasma levels of IFN-gamma, TNF-alpha, and IL-6 were elevated in hemodialysis patients compared to healthy controls, with MDSC levels positively correlated with IL-6 levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Xing Li, Jie Chen, Yong-Jian Chen, Yi-Dan Qiao, Li-Yun Zhao, Nan Jiang, Xiang-Yuan Wu, Yan-Fang Xing
Summary: Li et al. demonstrate that dexamethasone and lactoferrin induced polymorphonuclear myeloid-derived suppressor cells relieve inflammatory conditions in mouse models with minimal effect on tumour growth, showing promise for combating inflammatory adverse events during anti-cancer treatments.
COMMUNICATIONS BIOLOGY
(2021)
Article
Medicine, General & Internal
Qu Lin, Ming-Jun Bai, Hao-Fan Wang, Xiang-Yuan Wu, Ming-Sheng Huang, Xing Li
Summary: In this case study, exclusive mutations of APC in all the Wnt pathway elements were found to be a potential therapeutic target in hepatitis B-related hepatocellular carcinoma (HCC). Aspirin was administered to the patient with these mutations, resulting in four years of disease control.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Public, Environmental & Occupational Health
Jun-Jian Qin, Yan-Fang Xing, Jian-Hua Ren, Yong-Jian Chen, Ying-Fei Gan, Yan-Qiu Jiang, Jie Chen, Xing Li
Summary: The study indicated an association between mandatory mask-wearing and reinforced hand hygiene education and decreased respiratory, catheter-related, and digestive tract infection episodes in the hemodialysis unit during the COVID-19 pandemic.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Gaoyu Liu, Yingying Chen, Ying Wang, Xiaohui Deng, Qiang Xiao, Lijuan Zhang, Haixu Xu, Xu Han, Aihua Lei, Juan He, Xing Li, Yingjiao Cao, Pan Zhou, Chunhui He, Peiqiong Wu, Wenhui Jiang, Meizheng Tan, Chun Chen, Quan Yang, Liwei Lu, Kai Deng, Zhi Yao, Jie Zhou
Summary: This study identifies angiotensin II as a positive regulator of ILC2s and demonstrates its role in driving allergic airway inflammation. Plasma levels of angiotensin II correlate positively with circulating ILC2 abundance and disease severity in asthmatic patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Juan He, Guanmin Jiang, Xing Li, Qiang Xiao, Yingying Chen, Haixu Xu, Gaoyu Liu, Aihua Lei, Pan Zhou, Kun Shi, Quan Yang, Meng Zhao, Zhi Yao, Jie Zhou
Summary: Bilirubin, an end product of heme catabolism, was shown to be a potent negative regulator of ILC2s, suppressing their responses to IL-33 and alleviating airway inflammation. Mechanistic studies revealed that bilirubin exerts its effects on ILC2s through downregulation of ERK phosphorylation and GATA3 expression. Clinical evidence suggested that newborns with hyperbilirubinemia exhibited lower levels of functional ILC2 and suppressed ERK signaling. These findings suggest that bilirubin may have therapeutic potential in the treatment of allergic airway inflammation.
MUCOSAL IMMUNOLOGY
(2022)
Article
Respiratory System
Haiyu Zhou, Lili Lin, Tao Qin, Wei Ren, Yujie Tan, Qiong Yang, Huixin Xu, Xinxin Xie, Yongjian Chen, Shengbo Liu, Xing Li, Zhihua Li, Hai Hu, Yunfang Yu, Herui Yao
Summary: This study aims to investigate the effect of neoadjuvant therapy on stage IIB-III NSCLC patients and establish a multiomics artificial intelligence system for predicting efficacy and assisting decision-making. The research methods involve preoperative treatment with neoadjuvant therapy drugs and evaluation of multiple clinical endpoints.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Oncology
Yong-Jian Chen, Wei-Xin Liao, Shao-Zhuo Huang, Yun-Fang Yu, Jing-Yun Wen, Jie Chen, Da-Gui Lin, Xiang-Yuan Wu, Nan Jiang, Xing Li
Summary: The study identified the expression and prognostic value of CD36 in multiple cancer types. Additionally, CD36 expression was significantly associated with current predictors for the efficacy of immune checkpoint inhibitors (ICIs) with disease-specific patterns.
