Article
Multidisciplinary Sciences
Arpita Suri, Vanamail Perumal, Prajwal Ammalli, Varsha Suryan, Sanjiv Kumar Bansal
Summary: The study compared the diagnostic accuracy of ROMA, HE-4, and CA125 in early diagnosis and screening of epithelial ovarian cancer. ROMA was found to be the best marker for differentiating EOC from benign ovarian masses in postmenopausal women, while HE4 showed promise as a diagnostic predictor in premenopausal women. Further research is needed to explore the full potential of HE4 in premenopausal women.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Lingling Gao, Xin Nie, Gou Rui, Yue Qi, Juanjuan Liu, Bei Lin
Summary: The study revealed that CD147 and HE4 co-immunoprecipitated and co-located in ovarian cancer tissues and cells, and were associated with disease progression and poor prognosis. HE4 was identified as an independent risk factor for CD147 in ovarian cancer tissues, and ANXA2 was also confirmed as a interacting protein of CD147 in ovarian cancer. Interaction between CD147 and HE4 can affect the invasion and metastasis of ovarian cancer.
Article
Biochemical Research Methods
Robinson Karunanithy, Suthakaran Ratnasingam, Torrey Holland, Poopalasingam Sivakumar
Summary: Detection of cancer before the appearance of symptoms is crucial for successful treatment. This study developed a user-friendly method using laser-induced breakdown spectroscopy to detect the HE4 biomarker, which is challenging to detect early due to the lack of symptoms. The method improved the sensitivity and selectivity of biomarker detection through cross-linking elemental particles and simultaneous detection of Fe and Si.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Xiuzhu Hou, Shanshan Liu, Jing Liu, Jiansuo Zhou, Yongming Liang, Liyan Cui
Summary: This study examined the blood concentrations of CA125-Tn and AMH in EOC patients and evaluated their potential diagnostic utility together with CA125, HE4, and ROMA. The levels of CA125, HE4, CA125-Tn, and ROMA value were significantly higher in EOC group compared with other control groups, and they had better discriminatory performance compared with AMH. The combination of two positive biomarkers maximizes the diagnostic value for EOC.
CLINICAL BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Syamel Muhammad, Reyhan Julio Azwan, Rauza Sukma Rita, Restu Susanti, Yusrawati
Summary: This study investigates the predictive role of IL6, CA-125, and HE4 in tumor resectability in pre-operative patients with advanced epithelial ovarian cancer and finds a correlation between these markers and tumor resectability.
Article
Multidisciplinary Sciences
Jing Liu, Lili Han, Zhen Jiao
Summary: This study investigated the accuracy of HE4 in diagnosing endometrial cancer and found that the diagnostic value of HE4 for EC is moderate, and the serum HE4 level cannot reflect the stage and type of EC.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ehsan Irajizad, Chae Y. Han, Joseph Celestino, Ranran Wu, Eunice Murage, Rachelle Spencer, Jennifer B. Dennison, Jody Vykoukal, James P. Long, Kim Anh Do, Charles Drescher, Karen Lu, Zhen Lu, Robert C. Bast, Sam Hanash, Johannes F. Fahrmann
Summary: A blood-based metabolite panel, consisting of seven cancer-related metabolites, showed improved predictive ability for early-stage ovarian cancer compared to ROMA alone. Combining the metabolite panel with ROMA model resulted in higher positive predictive value and specificity for early-stage ovarian cancer.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Ruyue Li, Shaohan Ma, Yizheng Zu, Fang Wang, Tingting Gao, Yu'e Yang, Hua Guo, Chunfang Ha
Summary: This study assessed the predictive and diagnostic value of the ROMA index for EOC recurrence. The results showed that the ROMA index was strongly associated with clinical characteristics and had a significant association with recurrence-free survival above the cutoff value. The ROMA index had a higher sensitivity than CA125 and HE4 for recurrence diagnosis.
BIOMARKERS IN MEDICINE
(2022)
Article
Medical Laboratory Technology
Shuidi Yan, Yong Lin, Xuelin Tian
Summary: HE-4 can be used as an alternative biomarker for diagnosing CKD as it is less affected by several preanalytical factors. Nevertheless, in clinical practice, elevated HE-4 requires taking both CKD and ovarian cancer into consideration.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Multidisciplinary Sciences
Shiyun Li, Jiaqi Liu, Yuanhuan Xiong, Peipei Pang, Pinggui Lei, Huachun Zou, Mei Zhang, Bing Fan, Puying Luo
Summary: This study developed a two-dimensional radiomics approach using computed tomography to differentiate between benign and malignant ovarian neoplasms. By extracting texture features, selecting the best features, and building a radiomics model, the method improved the classification and diagnosis of ovarian tumors effectively.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Siew Fei Ngu, Yu Ka Chai, Ka Man Choi, Tsin Wah Leung, Justin Li, Gladys S. T. Kwok, Mandy M. Y. Chu, Ka Yu Tse, Vincent Y. T. Cheung, Hextan Y. S. Ngan, Karen K. L. Chan
Summary: This study evaluated the accuracy of different methods, including IOTA with subjective assessment by expert ultrasound, RMI, and ROMA, in assessing the nature of a pelvic mass. The findings showed that expert ultrasound was more sensitive than ROMA when IOTA was inconclusive, with similar specificity. The assessment methods involving IOTA had similar accuracies and were more accurate than RMI or ROMA alone.
Review
Medicine, General & Internal
Hai-Ying Dai, Fang Hu, Yuan Ding
Summary: This study aims to investigate the general diagnostic significance of HE-4 and CA-125 in patients with ovarian carcinoma, by systematically searching for relevant studies, extracting data, and using appropriate statistical methods for data analysis.
Article
Obstetrics & Gynecology
Makoto Iizuka, Yoshinobu Hamada, Jun Matsushima, Teppei Ichikawa, Taichi Irie, Noriko Yamaguchi, Shuichi Sakamoto, Shinichi Ban, Satoshi Takakura
Summary: This study compares the ability of ROMA and CPH-I to distinguish EOC and MLOT from BeOT in Japanese women, and the results show that they perform comparably well and better than CA125.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Manon Degez, Helene Caillon, Anne Chauvire-Drouard, Maxime Leroy, David Lair, Norbert Winer, Thibault Thubert, Pauline Le Floch, Valerie Desroys du Roure, Melanie Randet, Guillaume Ducarme, Vincent Dochez
Summary: This study aims to explore the sensitivity of the innovative marker HE4 in the diagnosis of endometrial cancer in patients with postmenopausal bleeding, with the ultimate goal of potentially avoiding unnecessary surgeries by distinguishing non-sick individuals.
Article
Immunology
Zhu Wei Lim, Wei Liang Chen
Summary: A study on 2464 female participants revealed that certain serum micronutrients were negatively associated with HE4, potentially impacting the risk of ovarian cancer.
JOURNAL OF INFLAMMATION RESEARCH
(2021)