期刊
BIOMATERIALS SCIENCE
卷 3, 期 6, 页码 810-815出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00057b
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [25107707]
- JSPS [25220203]
Silica-containing redox nanoparticles (siRNP) are nanocomposites consisting of silica nanoparticles and amphiphilic block copolymers with nitroxide radicals as reactive oxygen species (ROS) scavengers. Electrostatic interactions between the cationic segment of a polymer in the core and the entrapped silica nanoparticles form a crosslinking structure that provides siRNP stability in vivo, even under harsh conditions in the gastrointestinal tract. Due to the adsorption character of silica nanoparticles in the nano-composite, siRNP can be applied not only for adsorbents of body wastes but also for drug carriers with high loading capacity. The ROS-scavenging character of siRNP significantly improves their performance for medical applications. Here, we describe the development of siRNP and provide two examples of their medical applications as (1) novel nano-sized adsorbents for peritoneal dialysis, and (2) orally administrable drug carriers for the treatment of gastrointestinal inflammation.
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