Article
Biochemistry & Molecular Biology
Barbara Vizio, Ornella Bosco, Ezio David, Gian Paolo Caviglia, Maria Lorena Abate, Martina Schiavello, Angela Pucci, Antonina Smedile, Gianluca Paraluppi, Renato Romagnoli, Enrico Lupia, Graziella Bellone, Giuseppe Montrucchio
Summary: The study revealed that THPO and VEGF-A expression levels were significantly elevated in tumor tissues compared to liver cirrhosis tissues in HCC patients. There was a linear correlation between THPO and VEGF-A transcripts in HCC, indicating a potential interdependent regulation between the two growth factors in promoting cellular growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Kai Zeng, Weiwen Xie, Chunyu Wang, Shengli Wang, Wei Liu, Yingjie Su, Lin Lin, Renlong Zou, Ge Sun, Baosheng Zhou, Manlin Wang, Ruina Luan, Yu Bai, Yunlong Huo, Shigeaki Kato, Xinping Zhong, Yue Zhao
Summary: Hepatocellular carcinoma (HCC) is a common solid tumor with high recurrence and mortality rates. Despite the use of anti-angiogenesis drugs, resistance to these drugs is common in HCC treatment. This study identified a novel VEGFA regulator, USP22, which acts as a co-activator of VEGFA transcription and is involved in maintaining ZEB1 stability. Depletion of USP22 inhibited HCC progression and angiogenesis, and knockdown of USP22 was shown to inhibit HCC growth in mice. These findings suggest that USP22 may serve as a potential therapeutic target for drug resistance in HCC.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Chen Xie, Song-Yang Li, Jian-Hong Fang, Ying Zhu, Jin-E Yang
Summary: Long non-coding RNAs (lncRNAs) have been identified as important regulators in hepatocellular carcinoma (HCC) development, affecting malignant phenotypes and being associated with diseases. Understanding their regulatory network offers new insights into diagnosis and treatment.
Article
Pharmacology & Pharmacy
Qing-Yun Xie, Lu-Ping Huang, Feng-Wei Gao, Da-Qing Liu, Xia Wang, Kang-Yi Jiang, Jie Gong, Xin Zhao, Ben-Jian Gao, Ze-Hua Lei
Summary: This study investigated the therapeutic efficacy of lenvatinib combined with sequential TACE on primary HCC and its effects on serum bFGF and VEGF. The results showed that the combination treatment group had a higher objective response rate, lower serum bFGF and VEGF levels, and better survival rates.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Prashant Jain, Chethan D. Shanthamurthy, Shani Leviatan Ben-Arye, Sharon Yehuda, Sharvani S. Nandikol, Hirekodathakallu Thulasiram, Vered Padler-Karavani, Raghavendra Kikkeri
Summary: A potential heparan sulfate (HS) ligand was discovered to target several growth factors using specific HS tetrasaccharide ligands. One tetrasaccharide ligand showed strong binding with the VEGF(165) growth factor, and in vitro experiments demonstrated the therapeutic potential of these synthetic HS ligands by inhibiting vascular endothelial cell proliferation, migration, and angiogenesis in the presence of VEGF(165) and the specific tetrasaccharides.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Yang Liu, Linyu Long, Fanjun Zhang, Xuefeng Hu, Jieyu Zhang, Cheng Hu, Yunbing Wang, Jianguo Xu
Summary: The study introduced a GelMA microneedle platform for sustained and controlled local delivery of AAV-VEGF, which achieved homogeneous distribution and high transfection efficiency in ischemic brains. Results showed that MNs loaded with AAV-VEGF increased VEGF expression in the brain cortex and enhanced functional angiogenesis and neurogenesis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Clinical Neurology
Carlos Escudero, Jesenia Acurio, Eduardo Lopez, Andres Rodriguez, Antonia Benavente, Evelyn Lara, Steven J. Korzeniewski
Summary: Circulating VEGF levels were found to be elevated 24-48 hours after acute ischemic stroke and were associated with prognosis of moderate to severe disability at 6 months. Combining VEGF with interleukin 6 and C-reactive protein significantly improved predictive performance compared to using VEGF alone.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Oncology
Xin Li, Xinyu Su, Chen Yan, Yuanyuan Ma, Heng Li, Jianhong Xia, Hongliang Li, Qian Jiang, Liqing Zhou, Zhengyun Zou
Summary: This study discusses the role of VEGF in radiotherapy resistance of ESCC. It found that serum VEGF levels were related to clinical response, and knocking down VEGF expression improved the sensitivity of ESCC cells to radiation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mannon Geindreau, Francois Ghiringhelli, Melanie Bruchard
Summary: VEGF plays a crucial role in tumor growth by promoting angiogenesis and modulating the immune response. Clinical approval has been given to therapies targeting VEGF for the treatment of various cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Mechanics
Jyotsana Priyadarshani, Prasoon Awasthi, Pratyaksh Karan, Soumen Das, Suman Chakraborty
Summary: This study presents a simulation mimicking tumor angiogenesis microenvironment on-chip, aiming to establish favorable conditions for gradients of vascular endothelial growth factor. The model platform explores different responses of endothelial cells in a micro-confined fluidic environment, showing potential significance for organ-on-a-chip assays, disease modeling, and optimizing anti-angiogenic therapies.
Article
Virology
Shu-Xiang Wu, Shuang-Shuang Ye, Yu-Xiang Hong, Yan Chen, Biao Wang, Xin-Jian Lin, Xu Lin
Summary: This study reveals that the HBV protein SHBs enhances angiogenesis in HCC cells by inducing endoplasmic reticulum stress and activating unfolded protein response signaling to increase VEGFA expression and secretion. This finding is of great importance for the prevention and therapeutic intervention of HBV-related HCC.
JOURNAL OF VIROLOGY
(2022)
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuan Lin, Meng-Qi Dong, Zhi-Min Liu, Meng Xu, Zhi-Hao Huang, Hong-Juan Liu, Yi Gao, Wei-Jie Zhou
Summary: There are currently no effective treatments for liver fibrosis, a disease that involves angiogenesis. The role of different microvessels in the liver during fibrogenesis is unclear, and it is difficult to treat liver fibrosis through vascular targeting. This study proposes a combined regulation of multiple different endothelial cell regulatory signaling pathways as a new strategy for liver fibrosis therapy.
Article
Pharmacology & Pharmacy
Yating Pan, Xinyi Liao, Lili Yang, Chunlei Zhang, Jue Wang, Peiyong Zheng, Guanzhen Yu, Haiyan Song
Summary: The extract of Marsdeniatenacissima has shown significant anti-cancer effects on hepatocellular carcinoma (HCC) by inhibiting angiogenesis and suppressing the expression of VEGF, VWF, PDGF, and PDGFRB in HCC cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Aimei Li, Xuanyu Shuai, Zhijun Jia, Hangyu Li, Xiubin Liang, Dongming Su, Wanhua Guo
JOURNAL OF TRANSLATIONAL MEDICINE
(2015)
Article
Oncology
Haiquan Sang, Tingting Li, Hangyu Li, Jingang Liu
Article
Oncology
Yue-Mei Xu, Hong-Jiang Wang, Fang Chen, Wan-Hua Guo, Yan-Yang Wang, Hang-Yu Li, Jin-Hai Tang, Ying Ding, Ya-Chen Shen, Min Li, Wen-Ying Xuan, Lin-Hui Liu, Jia Wang, Xue-Rong Wang, Ze-Jun Gao, Xiu-Bin Liang, Dong-Ming Su
Article
Biochemistry & Molecular Biology
Liang Yang, Xiuwei Zhang, Hangyu Li, Jingang Liu
MOLECULAR BIOSYSTEMS
(2016)
Article
Oncology
Yi Zhe, Yan Li, Dan Liu, Dong-Ming Su, Jin-Gang Liu, Hang-Yu Li
Article
Oncology
Shibo Wei, Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Zhihong Zong, Xiangdong Hua, Dongming Su, Hongzhi Sun, Hangyu Li, Zhen Liu
Review
Oncology
Qing Fan, Liang Yang, Xiaodong Zhang, Xueqiang Peng, Shibo Wei, Dongming Su, Zhenhua Zhai, Xiangdong Hua, Hangyu Li
Article
Oncology
Qing Fan, Liang Yang, Xiaodong Zhang, Yingbo Ma, Yan Li, Lei Dong, Zhihong Zong, Xiangdong Hua, Dongming Su, Hangyu Li, Jingang Liu
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2018)
Article
Oncology
Xiaodong Zhang, Yan Li, Yingbo Ma, Liang Yang, Tao Wang, Xin Meng, Zhihong Zong, Xun Sun, Xiangdong Hua, Hangyu Li
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2018)
Review
Biochemistry & Molecular Biology
Xiaodong Zhang, Haiying Zhao, Yan Li, Di Xia, Liang Yang, Yingbo Ma, Hangyu Li
Article
Multidisciplinary Sciences
Haiquan Sang, Tingting Li, Hangyu Li, Jingang Liu
Article
Oncology
Hangyu Li, Yan Li, Dan Liu, Jingang Liu
Article
Biochemistry & Molecular Biology
Liang Yang, Xueqiang Peng, Yan Li, Xiaodong Zhang, Yingbo Ma, Chunli Wu, Qing Fan, Shibo Wei, Hangyu Li, Jingang Liu
Review
Oncology
Liang Yang, Shuo Yang, Xinyu Li, Bowen Li, Yan Li, Xiaodong Zhang, Yingbo Ma, Xueqiang Peng, Hongyuan Jin, Qing Fan, Shibo Wei, Jingang Liu, Hangyu Li