Article
Cell Biology
Shuang Wu, Shihai Liu, Yongxian Cao, Geng Chao, Peng Wang, Huazheng Pan
Summary: This study identifies ZC3H13 as a potential tumor suppressor gene in hepatocellular carcinoma (HCC) and reveals the miR-362-3p/miR-425-5p-ZC3H13 axis as a regulatory pathway. The expression of ZC3H13 is closely associated with the prognosis and tumor immune infiltration in HCC.
Article
Oncology
Dan-Dan Zhang, Wen-Er Wang, Yu-Shui Ma, Yi Shi, Jie Yin, Ji-Bin Liu, Xiao-Li Yang, Rui Xin, Da Fu, Wen Jie Zhang
Summary: The study identified the miR-212-3p/SLC6A1 axis as a potential crucial therapeutic target for HCC. Analysis of gene expression and protein levels confirmed the down-regulated expression of SLC6A1 in HCC tissues, as well as the negative correlation between SLC6A1 expression and DNA methylation.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Shuangshuang Li, Jiajia Shao, Guohua Lou, Chao Wu, Yanning Liu, Min Zheng
Summary: The study uncovered the role of EIF4G2 in HCC development through ERK pathway activation. It was also found that EIF4G2 could be negatively regulated by the tumor suppressor miR-144. Investigations suggested that EIF4G2 might be a promising therapeutic target in HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Michele Manganelli, Ilaria Grossi, Manuela Ferracin, Paola Guerriero, Massimo Negrini, Michele Ghidini, Chiara Senti, Margherita Ratti, Claudio Pizzo, Rodolfo Passalacqua, Sarah Molfino, Gianluca Baiocchi, Nazario Portolani, Eleonora Marchina, Giuseppina De Petro, Alessandro Salvi
Summary: The study investigated the longitudinal levels of cell-free long ncRNA GAS5 and microRNAs miR-126-3p and miR-23b-3p in patients with hepatocellular carcinoma (HCC) undergoing sorafenib treatment. The results highlighted the significant downregulation of miR-23b-3p in untreated HCC patients and its diagnostic relevance.
Article
Oncology
Zhongyuan Cui, Jielong Wang, Gang Chen, Dongliang Li, Bianqiao Cheng, Yanhua Lai, Zhixian Wu
Summary: This study aimed to identify potential novel prognostic markers and therapeutic targets for hepatocellular carcinoma (HCC). The upregulation of CLGN in HCC was significantly associated with poor prognosis, especially in advanced stages, and may be regulated by hsa-miR-194-3p. These findings suggest that CLGN may be closely related to the progression of HCC, and is a potential therapeutic target and prognostic indicator for patients with advanced HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Xiao Xiao, Ge Jiang, Shengtao Zhang, Shuo Hu, Yunshan Fan, Gang Li, Haiyang Yu, Shisheng He
Summary: This study identified the expression and function of lncRNA SNHG16 in osteosarcoma, showing that it acts as an oncogene by regulating miR-1285-3p, potentially serving as a novel target for osteosarcoma therapy.
Article
Pharmacology & Pharmacy
Yuan-Yuan Luo, Ke-Gong Tao, Yi-Ting Lu, Bin-Bin Li, Kai-Ming Wu, Chen-Hong Ding, Fang-Zhi Yan, Yue Liu, Yong Lin, Xin Zhang, Xin Zeng
Summary: This study identified hsa_circ_0098181 as a potential therapeutic target for hepatocellular carcinoma (HCC). The downregulation of hsa_circ_0098181 was associated with poor prognosis in HCC patients. Hsa_circ_0098181 sponge miR-18a-3p to regulate PPARA, inhibiting the proliferation, invasion, migration, and colony formation of HCC cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Danlei Chen, Yan Yan, Xinyi Wang, Suzhi Li, Yan Liu, Dandan Yu, Yongjing He, Ruiqing Deng, Yakun Liu, Mei Xu, Jia Luo, Hongjun Gao, Siying Wang
Summary: This study found that chronic alcohol exposure promotes the progression of hepatocellular carcinoma (HCC), with miR-22-3p and TET2 playing important roles in this process, affecting the stemness, tumor growth, and metastasis of HCC cells.β-catenin was identified as an upstream activator of miR-22-3p, indicating the involvement of the beta-catenin/miR-22-3p/TET2 regulatory axis in alcohol-induced HCC malignancy.
Article
Multidisciplinary Sciences
Xuejiao An, Taotao Li, Nana Chen, Huihui Wang, Manchun Su, Huibin Shi, Xinming Duan, Youji Ma
Summary: This study demonstrates that the miR-1285-3p/TPI1 axis regulates glycolysis in Sertoli cells (SCs), providing new insights into the regulation of spermatogenesis in sheep and other mammals.
Article
Oncology
Yue Ma, Jing Liu, Zhuo Yang, Peng Chen, Dan-bo Wang
Summary: The overexpression of circRNA_400029 in cervical cancer promotes cell proliferation, migration, and invasion while inhibiting apoptosis by sponging miR-1285-3p to regulate TLN1. CircRNA_400029 could be a potential onco-circRNA and a promising therapy target for cervical cancer.
Article
Oncology
Ru-nan Zhang, Dong-mei Wu, Li-ping Wu, Guo-wei Gao
Summary: The study shows that the upregulation of LINC00337 in lung adenocarcinoma promotes cell migration, invasion, and proliferation, while enhancing apoptosis. LINC00337 functions as an oncogenic lncRNA by targeting miR-1285-3p and regulating YTHDF1 expression to drive the progression of lung adenocarcinoma.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Weizhi Li, Yingchao Li, Peijie Li, Fuquan Ma, Mengying Liu, Shuzhen Kong, Hui Xue
Summary: The upregulation of HOXB5 in HCC is associated with tumor progression by activating EGFR. miR-200a-3p and miR-181-5p regulate the expression of HOXB5, affecting HCC cell proliferation and migration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yang Ji, Shikun Yang, Xueqi Yan, Li Zhu, Wenjie Yang, Xinchen Yang, Fei Yu, Longqing Shi, Xi Zhu, Yunjie Lu, Chuanyong Zhang, Hao Lu, Feng Zhang
Summary: CircCRIM1 is upregulated in hepatocellular carcinoma (HCC) and is associated with poor prognosis, enhancing cell proliferation and angiogenesis. It promotes HCC progression via the miR-378a-3p/SKP2 axis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
QiGao Yan, BingJie Qi, Pei Zhang, Yao Jin, Kai Cao, Yi Liu
Summary: The purpose of this experiment is to study how miR-1285-3P regulates the NOTCH signaling pathway, thereby affecting the proliferation and differentiation of hair follicle stem cells. The experiment used Inner Mongolia hair follicle stem cells and divided them into different groups for transfection. The results showed that the proliferation ability of cells in the miR-1285-3P transfection group was significantly lower, and they had a higher proportion of cells in the G0-G1 phase.
PREVENTIVE MEDICINE
(2023)
Article
Cell Biology
Shuang-Shuang Dong, Dan-Dan Dong, Zhang-Fu Yang, Gui-Qi Zhu, Dong-Mei Gao, Jie Chen, Yan Zhao, Bin-Bin Liu
Summary: The study demonstrated that exosomal miR-3682-3p derived from HCC cells attenuates angiogenesis by targeting ANGPT1 through RAS-MEK1/2-ERK1/2 signaling, providing novel potential targets for liver cancer therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)