期刊
BIOMATERIALS SCIENCE
卷 3, 期 6, 页码 870-878出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5bm00061k
关键词
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资金
- National Natural Science Foundation of China [21474012, 51273037, 50903012, 21174142]
- Jilin Science and Technology Bureau [20130206074GX, 20120729]
- New Century Excellent Talents in University of Jilin Province (Jilin Provincial Education Department) [2013-6]
- Jilin Human Resources and Social Security Bureau [201125020]
- Jilin Environmental Protection Bureau [201127]
Herein, hyperbranched poly(ethylene glycol)-based supramolecular nanoparticles with pH-sensitive properties were designed and used for targeted drug delivery. Via host-guest recognition between benzimidazole anchored poly(ethylene glycol)-hyperbranched polyglycerol (PEG-HPG-BM) and folic acid modified CD (FA-CD), targeted supramolecular nanoparticles (TSNs) were fabricated. At neutral aqueous conditions TSNs could load the model drug DOX. While under intracellular acidic conditions the loaded-drug would be released due to the protonation of BM. This protonation allowed the supramolecular nanoparticles to expand or even disassemble, which showes the pH-dependent property. The introduction of the active targeting FA molecule and the specific interactions with the receptor of HeLa cells means that DOX-loaded TSNs show a significantly improved anticancer efficacy. In vitro drug release assays and intracellular experiments confirmed that TSNs had an obvious pH-sensitive property and remarkably improved anticancer effects, which hold great potential for further biomedical applications such as anticancer drug delivery.
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