Article
Oncology
Olivier Adotevi, Dewi Vernerey, Pascale Jacoulet, Aurelia Meurisse, Caroline Laheurte, Hamadi Almotlak, Marion Jacquin, Vincent Kaulek, Laura Boullerot, Marine Malfroy, Emeline Orillard, Guillaume Eberst, Aurelie Lagrange, Laure Favier, Marie Gainet-Brun, Ludovic Doucet, Luis Teixeira, Zineb Ghrieb, Anne-Laure Clairet, Yves Guillaume, Marie Kroemer, Didier Hocquet, Melanie Moltenis, Samuel Limat, Elisabeth Quoix, Celine Mascaux, Didier Debieuvre, Christine Fagnoni-Legat, Christophe Borg, Virginie Westeel
Summary: The purpose of this study was to test the safety, immunogenicity, and efficacy of UCPVax vaccine in patients with metastatic non-small-cell lung cancer. The results showed that UCPVax vaccine was highly immunogenic and safe, and achieved interesting 1-year survival rate in advanced NSCLC patients.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biology
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn
Summary: Telomeres cap the ends of eukaryotic chromosomes and are essential for genome protection and replication. The maintenance of telomere length is regulated by various factors and dysfunctions in telomere maintenance and telomerase activation are associated with diseases, particularly cancer. Understanding the molecular mechanisms behind telomere length regulation and protection is crucial for future therapeutic opportunities.
Article
Chemistry, Analytical
Haibin Si, Dexin Du, Wenbo Li, Qingling Li, Jingxin Li, Dongbo Zhao, Lu Li, Bo Tang
Summary: The innovative lung cancer diagnosis method proposed in this study uses microfluidic technology for efficient isolation and analysis of exfoliated tumor cells in sputum, providing a practical strategy for non-invasive detection and screening of lung cancer in high-risk groups.
ANALYTICAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Piotr Macek, Mieszko Wieckiewicz, Rafal Poreba, Pawel Gac, Katarzyna Bogunia-Kubik, Marta Dratwa, Anna Wojakowska, Grzegorz Mazur, Helena Martynowicz
Summary: This study investigated the relationship between SNP of the TERT gene and the severity of sleep bruxism, and identified the independent risk factors for sleep bruxism. The results showed that one SNP of TERT was associated with the episode index of phasic bruxism, and the lack of this SNP, male sex, and arterial hypertension were independent risk factors for phasic bruxism.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Hongxia Song, Mei Han, Kun Li, Yingying Zhao, Changqing Xu, Xiaofei Lei
Summary: This meta-analysis found that there was no significant association between TERT rs2736100 polymorphism and digestive cancer susceptibility in both Asian and Caucasian populations. Further research with adequate sample size is needed to confirm the results.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2021)
Review
Oncology
Sara Gandini, Ines Zanna, Simone De Angelis, Domenico Palli, Sara Raimondi, Simone Ribero, Giovanna Masala, Mariano Suppa, Federica Bellerba, Federica Corso, Luigi Nezi, Eduardo Nagore, Saverio Caini
Summary: Somatic mutations of the TERT gene promoter are associated with worse overall survival in melanoma patients, especially in non-acral cutaneous melanomas. Limited evidence suggests a detrimental effect of TERT mutations on various survival measures.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Xiaozheng Wu, Gao Huang, Wen Li, Yunzhi Chen
Summary: The rs2736100 polymorphism of the TERT gene is closely associated with the risk of lung cancer, particularly in the Asian population. Different types of lung cancer show variations in the risk association, and smoking is not the most critical factor in increasing the risk of most lung cancers.
SCIENTIFIC REPORTS
(2023)
Review
Oncology
Miguel Angel Gonzalez-Moles, Eloisa Moya-Gonzalez, Alberto Garcia-Ferrera, Paola Nieto-Casado, Pablo Ramos-Garcia
Summary: TERT protein overexpression in oral cancer is significantly associated with poor survival and has prognostic value. This systematic review and meta-analysis, based on 21 studies and 1698 patients, support the immunohistochemical assessment of TERT overexpression as a new indicator for prognostic evaluation of oral squamous cell carcinoma.
Article
Biochemistry & Molecular Biology
Li Tao, Wei Zhang, Yaxin Zhang, Mei Zhang, Yueying Zhang, Xing Niu, Qing Zhao, Zhenxing Liu, Yuyin Li, Aipo Diao
Summary: The study showed that caffeine can promote the expression of TERT to extend telomere length and prevent cellular senescence. In animal studies, caffeine also reversed the decline in organ index and improved tissue structure in aging mice. These results suggest that caffeine-containing foods can delay cellular senescence and aging through the expression of TERT.
Article
Biochemistry & Molecular Biology
Jeff Sherman, Grant Verstandig, Yisroel Brumer
Summary: Advancements in biotechnology and machine learning have created a conducive environment for exploring relationships between genomic and epigenetic data with potential therapeutic implications. The study found that CRISPR knockout has strong efficacy in inhibiting growth of tumor cells with varying levels of TERT expression, providing key biomarkers for therapeutic efficacy and potential pathways for drug development. These findings further support the potential of artificial intelligence in oncology.
Article
Endocrinology & Metabolism
Yanxiu Li, Iokfai Cheang, Zhongwen Zhang, Wenming Yao, Yanli Zhou, Haifeng Zhang, Yun Liu, Xiangrong Zuo, Xinli Li, Quan Cao
Summary: This study found that SNPs of TERC and TERT genes are associated with the prognosis of AHF, with mutant alleles being related to long-term mortality. Significant differences were observed in specific haplotypes, with CCAC being a risk factor and GTGT being a protective factor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Jie Xu, Fang-Ping Xu, Zhi-Hua Liu, Qian Cui, Ke-Ping Zhang, Zhi Li
Summary: This study investigated the correlations between mutations in the TERT promoter and IDH1/2 mutations or 1p/19q deletion in human gliomas. The results showed a positive correlation between TERT promoter mutations and 1p/19q deletion, as well as a negative correlation between TERT promoter mutations and IDH gene mutations, except in certain cases. This suggests a complex inter-regulatory relationship between these mutations in human gliomas.
Article
Cell Biology
Shujing Li, Bin Jiang, Haiyang Yu, Dongqing Song
Summary: The study demonstrated that PINX1 and TERT play important roles in lung injury during both acute and convalescent phases, and regulation of PINX1 expression can ameliorate cell senescence and improve lung function.
Review
Biochemistry & Molecular Biology
Tsung-Jang Yeh, Chi-Wen Luo, Jeng-Shiun Du, Chien-Tzu Huang, Min-Hung Wang, Tzer-Ming Chuang, Yuh-Ching Gau, Shih-Feng Cho, Yi-Chang Liu, Hui-Hua Hsiao, Li-Tzong Chen, Mei-Ren Pan, Hui-Ching Wang, Sin-Hua Moi
Summary: Head and neck cancers (HNCs) are a major global malignancy. Telomerase reactivation through TERT promoter mutations has been linked to carcinogenesis. These mutations have high frequencies in HNCs and are associated with poor survival. Therapies targeting telomerase have been developed, but few have reached clinical trials. This review summarizes the current understanding and evidence of TERT promoter mutations in HNC patients.
Article
Plant Sciences
Shoujiang Sun, Wen Ma, Peisheng Mao
Summary: Seed aging is a crucial factor for vigor loss in alfalfa, affecting seed germination and seedling growth. This study investigated the molecular characteristics and expression analysis of the MsTERT gene under abiotic stress and seed aging. The results showed a correlation between telomere length, MsTERT expression, and seed germination percentage, suggesting that they could serve as biomarkers of seed aging.