Article
Biotechnology & Applied Microbiology
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Madeleine Wheatley, Niantao Deng, Sarah Alexandrou, Thomas P. Davis, Maria Kavallaris, C. Elizabeth Caldon, Joshua McCarroll, Katleen De Preter, Pieter Mestdagh, Glenn M. Marshall, Kaylene J. Simpson, Jamie Fletcher, Alexander Swarbrick
Summary: This study discovered that miR-99b-5p, miR-380-3p, and miR-485-3p enhance the chemotherapeutic effects of doxorubicin in high-risk neuroblastoma. These miRNAs are often lost in patients and their low expression predicts poor survival outcomes.
Article
Multidisciplinary Sciences
Jianwei Lin, Yiping Wu, Gaofei Tian, Daqi Yu, Eunjeong Yang, Wai Hei Lam, Zheng Liu, Yihang Jing, Shangyu Dang, Xiucong Bao, Jason Wing Hon Wong, Yuanliang Zhai, Xiang David Li
Summary: H3K79me2 is an important epigenetic mark involved in gene regulation, cellular differentiation, and disease progression. A nucleosome-based photoaffinity probe was used to identify menin as a reader of H3K79me2 in a nucleosomal context. Cryo-electron microscopy showed that menin interacts with the nucleosome through specific domains and recognizes the methylation mark through a p-cation interaction. In cells, menin is selectively associated with H3K79me2 on chromatin, particularly in gene bodies.
Article
Biochemistry & Molecular Biology
Chaima Cherif, Dang Tan Nguyen, Clement Paris, Thi Khanh Le, Thibaud Sefiane, Nadine Carbuccia, Pascal Finetti, Max Chaffanet, Abdessamad El Kaoutari, Julien Vernerey, Ladan Fazli, Martin Gleave, Mohamed Manai, Philippe Barthelemy, Daniel Birnbaum, Francois Bertucci, David Taieb, Palma Rocchi
Summary: Menin (MEN1) protein is highly regulated by HSP27, overexpressed in high-grade PC and CRPC, and high MEN1 mRNA expression is associated with decreased biochemical relapse-free and overall survival. Silencing Menin helps inhibit CRPC cell proliferation, tumor growth, and restore chemotherapeutic sensitivity.
Article
Multidisciplinary Sciences
Mengying Liu, Wenbo Deng, Lu Tang, Meng Liu, Haili Bao, Chuanhui Guo, Changxian Zhang, Jinhua Lu, Haibin Wang, Zhongxian Lu, Shuangbo Kong
Summary: This study reveals that Menin ensures the expression of PTX3 through H3K4me3 modification, balancing the BMP and FGF signals in the decidua for normal pregnancy. Deletion of Men1 disrupts the terminal differentiation of stroma, leading to chaotic decidualization and pregnancy failure.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai, Yoshihiro Kakeji, Vincenzo Alessandro Gennarino, Debashis Sahoo, Piero Dalerba, Yohei Shimono
Summary: In this study, it was found that the coordinated upregulation of miR-200c and miR-203 in colon epithelial cells is associated with terminal differentiation and plays a role in controlling the expansion capacity and stem cell properties of epithelial cells by suppressing BMI1 expression.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Petra Korac, Mariastefania Antica, Maja Matulic
Summary: miR-7 is an ancient miRNA involved in cell signaling pathways, acting primarily as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. It also has additional roles in cell regulation and protection, with potential for use in biotherapeutics.
Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Article
Biochemistry & Molecular Biology
Astrid K. Laut, Carmen Dorneburg, Axel Furstberger, Thomas F. E. Barth, Hans A. Kestler, Klaus-Michael Debatin, Christian Beltinger
Summary: CHD5, a tumor suppressor located at 1p36, is frequently lost or silenced in aggressive neuroblastoma and many adult cancers. Low expression of CHD5 is associated with stage 4 neuroblastoma and its forced expression inhibits key aspects of the metastatic cascade in vitro. Overexpression of CHD5 leads to reduced metastasis-related genes and gene sets, while known metastasis-suppressing genes are upregulated. Additionally, knockdown of PLCL1 and p53 reverses CHD5-induced inhibition of invasion and migration in vitro.
Article
Oncology
Zhiwei Dong, Kok Siong Yeo, Gonzalo Lopez, Cheng Zhang, Erin N. Dankert Eggum, Jo Lynne Rokita, Choong Yong Ung, Taylor M. Levee, Zuag Paj Her, Cassie J. Howe, Xiaonan Hou, Janine H. van Ree, Shuai Li, Shuning He, Ting Tao, Karen Fritchie, Jorge Torres-Mora, Julia S. Lehman, Alexander Meves, Gina L. Razidlo, Komal S. Rathi, S. John Weroha, A. Thomas Look, Jan M. van Deursen, Hu Li, Jennifer J. Westendorf, John M. Maris, Shizhen Zhu
Summary: Research has shown that GAS7 gene is preferentially deleted in high-risk MYCN-driven neuroblastoma, and its deficiency accelerates metastasis in neuroblastoma models. Loss of GAS7 affects cell-cell interaction and contact among tumor cells, identifying a novel mechanism underlying tumor metastasis in MYCN-driven neuroblastoma.
Review
Oncology
Jennifer Frosch, Ilia Leontari, John Anderson
Summary: Neuroblastoma, a childhood solid cancer, is characterized by resistance to treatment and poor prognosis. Immunotherapeutic approaches targeting myeloid cells show potential, but clinical trials have not replicated preclinical results. Suppressive myeloid cells in the tumor microenvironment play a crucial role in inhibiting antitumor immune responses, correlating with aggressive disease, treatment resistance, and poor prognosis.
Review
Medicine, Research & Experimental
Seyede Fatemeh Hosseini, Setareh Javanshir-giv, Hanieh Soleimani, Homa Mollaei, Farzad Sadri, Zohreh Rezaei
Summary: MicroRNA production in tumorigenesis is dysregulated by various processes, leading to dysfunctional and dysregulated miRNAs. These miRNAs have been identified as potential biomarkers for human cancer, although further evaluation is necessary. The miR-28 family, especially miR-28-5p and miR-28-3p, play essential roles in various cancers and can serve as diagnostic biomarkers for prognosis and early detection of cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Ghayas C. Issa, Farhad Ravandi, Courtney D. DiNardo, Elias Jabbour, Hagop M. Kantarjian, Michael Andreeff
Summary: Menin inhibitors are novel targeted agents currently being developed for the treatment of genetically defined subsets of acute leukemia, showing promising early results in specific leukemia types, such as NPM1 mutations. These inhibitors target various gene regulatory roles of menin in leukemogenesis and are being investigated in clinical studies for relapsed acute leukemias.
Review
Medicine, Research & Experimental
Zhichao Wang, Wenjie Xie, Hongzai Guan
Summary: MicroRNAs are small non-coding RNAs that interact with their target mRNAs to degrade them or inhibit translation. Dysregulation of miRNAs is associated with various human cancers and plays a role in the development of cancer pathology. MiR-328 has been implicated in multiple human cancers and considered a key regulator. It is involved in biological processes such as cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition. This review combines basic and clinical studies to demonstrate that miR-328 promotes tumorigenesis and metastasis in human cancer and discusses its diagnostic, prognostic, and therapeutic value.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xiaomin Liu, Xianyi Wang, Binshu Chai, Zong Wu, Zhitao Gu, Heng Zou, Hui Zhang, Yanli li, Qiangling Sun, Wentao Fang, Zhongliang Ma
Summary: This study found that miR-199a-3p/5p is down-regulated in non-small cell lung cancer (NSCLC), and overexpression of miR-199a-3p/5p can inhibit cell proliferation, migration, and promote apoptosis. Rheb is identified as a common target of miR-199a-3p and miR-199a-5p, participating in the regulation of the mTOR signaling pathway. Additionally, miR-199a significantly inhibits tumor growth and metastasis in NSCLC and enhances the sensitivity of gefitinib in EGFR-T790M mutation. MiR-199a-3p/5p has the potential to serve as an early diagnostic marker or therapeutic target for NSCLC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Rui Peng, Jun Cao, Bing-Bing Su, Xue-song Bai, Xin Jin, Ao-qing Wang, Qian Wang, Ren-jie Liu, Guo-qing Jiang, Sheng-jie Jin, Chi Zhang, Dou-sheng Bai
Summary: In this study, we discovered that circPTTG1IP, a circular RNA, acts as a tumor suppressor in hepatocellular carcinoma (HCC). Low expression of circPTTG1IP is associated with poor prognosis in HCC patients. Mechanistically, circPTTG1IP functions as a competing endogenous RNA (ceRNA) of RNF125 by binding miR-16-5p, thereby increasing the level of E3 ubiquitin ligase RNF125 and promoting the degradation of JAK1 protein. Filgotinib, a JAK1 inhibitor, can restrict HCC progression induced by low circPTTG1IP expression.
