Article
Oncology
Yahya Madkhali, Araci M. R. Rondon, Sophie Featherby, Anthony Maraveyas, John Greenman, Camille Ettelaie
Summary: Under normal conditions, blood coagulation is suppressed to prevent thrombosis, but TF is released into the bloodstream during inflammatory conditions to modulate cellular fate. Cells regulate the procoagulant and signalling activity of TF by controlling its release levels.
Article
Hematology
Maria Isabel Fleischer, Nadine Roehrig, Verena K. Raker, Juliane Springer, Detlef Becker, Sandra Ritz, Matthias Bros, Henner Stege, Maximilian Haist, Stephan Grabbe, Jessica Haub, Christian Becker, Sabine Reyda, Jennifer Disse, Talkea Schmidt, Karsten Mahnke, Hartmut Weiler, Wolfram Ruf, Kerstin Steinbrink
Summary: The study found increased PAR2(+) infiltrating myeloid cells in ACD patients and CHS mice. Deletion of PAR2 in myeloid cells and PAR2 cleavage insensitivity reduced skin inflammation and Tc1/Th1 cell response.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Kaushik Das, Shiva Keshava, Shabbir A. Ansari, Vijay Kondreddy, Charles T. Esmon, John H. Griffin, Usha R. Pendurthi, L. Vijaya Mohan Rao
Summary: Studies showed that FVIIa induces the release of EVs from endothelial cells through the EPCR-PAR1 signaling pathway, contributing to the hemostatic effect of FVIIa.
Article
Biochemistry & Molecular Biology
Ilaria De Simone, Constance C. F. M. J. Baaten, Martine Jandrot-Perrus, Jonathan M. Gibbins, Hugo ten Cate, Johan W. M. Heemskerk, Chris Jones, Paola E. J. van der Meijden
Summary: Platelet and coagulation activation are reciprocal processes, and factors other than thrombin or fibrin can induce platelet activation via GPVI and PAR receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Grant R. Laskin, Bradley S. Gordon
Summary: Mechanical overload and nutrients can influence the phenotype of skeletal muscles, with mechanical overload primarily affecting mRNA signature and the influence of nutrients on gene programs remaining unclear. This study identified mechanical overload-sensitive gene programs influenced by nutrients and identified potential transcription factors that differentiate mRNA changes in response to mechanical overload and nutrients.
PHYSIOLOGICAL GENOMICS
(2022)
Article
Biology
Min Xie, Ren Hui Chia, Dan Li, Fanny Xueting Teo, Christian Krueger, Kanaga Sabapathy
Summary: The transcription factor c-Jun plays a pro-fibrogenic role in hepatocytes and KCs that functionally interact to regulate liver fibrosis. Deletion of c-Jun in both hepatocytes and KCs reduces fibrosis and cytokine gene expression, but does not affect the resolution phase after fibrotic injury.
LIFE SCIENCE ALLIANCE
(2021)
Article
Chemistry, Multidisciplinary
S. Mallik, R. Prasad, K. Das, P. Sen
Summary: The hydroxyl functionality of cell-surface sphingomyelin plays a role in forming a tight assembly through intermolecular hydrogen bonding and calcium chelation, which limits protein-lipid/protein-protein interactions and thus inhibits the coagulation process.
Article
Multidisciplinary Sciences
Nayan Jain, Zeguo Zhao, Judith Feucht, Richard Koche, Archana Iyer, Anton Dobrin, Jorge Mansilla-Soto, Julie Yang, Yingqian Zhan, Michael Lopez, Gertrude Gunset, Michel Sadelain
Summary: Further advancements in cell engineering are necessary to improve the effectiveness of CAR and other T cell-based therapies. Disrupting TET2 can enhance T cell-mediated tumor rejection, but it also carries the risk of clonal expansions and tissue infiltration by CAR T cells.
Article
Gastroenterology & Hepatology
Ying Xie, Lindsey Fontenot, Andrea Chupina Estrada, Becca Nelson, Jiani Wang, David Q. Shih, Wendy Ho, S. Anjani Mattai, Florian Rieder, Dane D. Jensen, Nigel W. Bunnett, Hon Wai Koon
Summary: The study demonstrates that Elafin can suppress collagen synthesis in intestinal fibroblasts by inhibiting protease-activated receptor 2, which is dependent on cathelin S, leading to a reduction in intestinal fibrosis.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cell Biology
Michael Keith Kullmann, Fragka Pegka, Christian Ploner, Ludger Hengst
Summary: In addition to serving as a CDK inhibitor and tumor suppressor, p57 may also promote tumor growth by activating the proto-oncoprotein c-Jun.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam-Amersdorfer, Patrick M. Brunner, Georg Stary, Latifa Bakiri, Erwin F. Wagner, Herbert Strobl, Maria Sibilia
Summary: This study found that c-Jun/AP-1 protein regulates CCL2 and IL-23 production in DCs following TLR7 activation, affecting psoriasis-like skin inflammation. The expression of CCL2 and IL-23 in human psoriatic skin co-localize with c-Jun in type-2/inflammatory DCs, and inhibition of JNK-AP-1 can reduce the expression of these targets in TLR7/8-stimulated human DCs.
EMBO MOLECULAR MEDICINE
(2021)
Article
Biology
Jiajia Ma, Claire A. Scott, Ying Na Ho, Harsha Mahabaleshwar, Katherine S. Marsay, Changqing Zhang, Christopher Kj Teow, Ser Sue Ng, Weibin Zhang, Vinay Tergaonkar, Lynda J. Partridge, Sudipto Roy, Enrique Amaya, Tom J. Carney
Summary: This study reveals that mutations in the hai1a gene in zebrafish lead to a series of cellular responses, including inflammation and calcium signaling, without inducing epithelial cell motility. Inhibition of the Gq subunit can rescue these abnormal phenotypes, and increased MAPK pathway activity may be the cause of epidermal defects.
Article
Biochemistry & Molecular Biology
Tetsuaki Miyake, John C. McDermott
Summary: This study reveals that the proto-oncogene c-Jun can be targeted to the nucleolus, and its basic domain contains a unique motif that determines nucleolar localization. While partners such as Fra2 do not co-localize with c-Jun in the nucleolus. A point mutation can result in loss of nucleolar targeting for c-Jun, while its nuclear localization remains intact.
Article
Hematology
Jacob Lund, Kasper Jensen, Laurent Burnier, Mirella Ezban
Summary: This study aimed to investigate the response of Mim8 in thrombin generation assays and its combination with other hemostatic proteins. The results showed that Mim8 has a similar mode of action with FVIII and the concomitant use of FVIII and Mim8 for bleed treatment is safe.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Oncology
Hao Li, Taoran Zhou, Yue Zhang, Hengyi Jiang, Jing Zhang, Zichun Hua
Summary: RuvBL1 is identified as a repressor of c-Jun/AP-1 activity leading to TRAIL resistance in lung cancer cells. Silencing RuvBL1 can sensitize resistant cells to TRAIL, while high expression of RuvBL1 inversely related to low c-Jun is associated with a poor overall prognosis in lung cancer patients.
FRONTIERS IN ONCOLOGY
(2021)