期刊
TUMOR BIOLOGY
卷 35, 期 4, 页码 3891-3897出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-013-1516-2
关键词
CYP1B1; Polymorphism; Head and neck squamous cell carcinoma; Meta-analysis
类别
资金
- National Science Foundation of China [81170993]
- Natural Science Foundation of Taihe Hospital of Hubei University of Medicine [2011QD05]
The associations between CYP1B1 polymorphisms and head and neck squamous cell carcinoma (HNSCC) risk have been conflicting. We therefore performed a meta-analysis to derive a more precise relationship. Six published case-control studies were collected; odds ratios (ORs) with 95 % confidence interval (CI) were used to assess the association between CYP1B1 Leu432Val, Asn453Ser polymorphisms, and HNSCC risk. The Sensitivity analysis and publication bias also were performed to guarantee the statistical power. Overall, the pooled OR with 95 % CIs indicated that CYP1B1 Leu432Val polymorphism was significantly related with HNSCC risk (for Val vs. Leu: OR = 1.13, 95 % CI = 1.03-1.25, P = 0.014, P (heterogeneity) = 0.141; for Val/Val vs. Leu/Leu: OR = 1.30, 95 % CI = 1.06-1.60, P = 0.013, P (heterogeneity) = 0.253; for Val/Val vs. Leu/Leu + Leu/Val: OR = 1.23, 95 % CI = 1.05-1.46, P = 0.013, P (heterogeneity) = 0.456). The similar results were also been found in succeeding analysis of HWE and stratified analysis of Caucasian population. Furthermore, no significant association between CYP1B1 Asn453Ser polymorphism and HNSCC risk was found in this meta-analysis. In conclusion, our meta-analysis demonstrates that CYP1B1 Leu432Val polymorphism may be a risk factor for developing HNSCC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据