期刊
TUMOR BIOLOGY
卷 33, 期 3, 页码 661-667出版社
SAGE PUBLICATIONS LTD
DOI: 10.1007/s13277-012-0341-3
关键词
Auger; Intercalator; Liposome; Radionuclide; DNA
类别
资金
- Swedish Cancer Society
- Swedish Research Council
- Stiftelsen Olle Engkvist Byggmastare
The Nuclisome concept builds on a novel two-step targeting strategy with the aim to deliver short-range Auger-electron-emitting radionuclides to nuclear DNA of tumor cells. The concept is based on the use of Nuclisome-particles, i.e., tumor-targeted PEG-stabilized liposomes loaded with a unique DNA-intercalating compound that enables specific and effective delivery of radionuclides to DNA. The specific and potent two-step targeting leads to eradication of tumor cells while toxicity to normal organs is reduced to a minimum. Results of in vitro and in vivo studies point towards the Nuclisome concept as a promising strategy for the treatment of small tumor masses and, in particular, for the elimination of spread single cells and micrometastases.
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