Article
Pharmacology & Pharmacy
Guanyu Yu, Mengnan Xu, Leqi Zhou, Kuo Zheng, Xiaoming Zhu, Jinke Sui, Cheng Xin, Wenjun Chang, Wei Zhang, Fuao Cao
Summary: This study investigated the expression of phosphorylated Focal adhesion kinase (p-FAK) in colorectal cancer (CRC) and its association with prognosis. The results showed that high p-FAK expression was associated with poor prognosis and poor chemotherapeutic response in CRC. Therefore, the expression level of p-FAK can serve as an independent prognostic biomarker for CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Wen-Xiang Li, Jia-Jia Zheng, Gang Zhao, Chen-Tao Lyu, Wei-Qi Lu
Summary: The study revealed that reduced expression of DSCR1 is associated with poor clinicopathologic features and shorter overall survival in CRC patients. Overexpression of DSCR1 isoform 4 led to inhibition of cell cycle and proliferation, as well as induction of senescence in CRC cells. Moreover, DSCR1-4 overexpression suppressed tumor growth and angiogenesis in vivo, highlighting its potential as a critical tumor suppressor in CRC progression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Tao Xue, Kejing Yan, Yiqi Cai, Jiancheng Sun, Zhejing Chen, Xiaolei Chen, Wenyi Wu
Summary: Infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients, with high-level infiltration associated with shorter overall survival and disease-free survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Andreas Marx, Lena Koopmann, Doris Haflmayer, Franziska Buescheck, Claudia Hube-Magg, Stefan Steurer, Till Eichenauer, Till S. Clauditz, Waldemar Wilczak, Ronald Simon, Guido Sauter, Jakob R. Izbicki, Hartwig Huland, Hans Heinzer, Markus Graefen, Alexander Haese, Thorsten Schlomm, Christian Bernreuther, Patrick Lebok, Sarah Bonk
Summary: ANO7 protein expression is strongly associated with prostate epithelial cells and its reduced expression is closely linked to adverse tumor features, serving as a strong and independent predictor of poor prognosis in prostate cancer.
CANCER BIOLOGY & MEDICINE
(2021)
Article
Medicine, General & Internal
Tibor Szarvas, Michele J. Hoffmann, Csilla Olah, Eszter Szekely, Andras Kiss, Jochen Hess, Stephan Tschirdewahn, Boris Hadaschik, Vera Grotheer, Peter Nyirady, Anita Csizmarik, Melinda Varadi, Henning Reis
Summary: Chemotherapy resistance is a major issue in bladder cancer treatment. MMP-7 tissue and serum levels are associated with poor prognosis in patients undergoing platinum-based chemotherapy. Analysis of MMP-7 may help in optimizing therapeutic decisions for bladder cancer patients.
Article
Biochemistry & Molecular Biology
Aleksandra Salagacka-Kubiak, Dawid Zawada, Lias Saed, Radzislaw Kordek, Agnieszka Jelen, Ewa Balcerczak
Summary: ABCG2 is a cell membrane pump encoded by the ABCG2 gene, which can protect cells against compounds initiating and/or intensifying neoplasia and is considered a marker of cancer stem cells. Its prognostic significance in colorectal cancer remains unclear. Using publicly available data, ABCG2 was shown to be underexpressed in colon and rectum adenocarcinomas, and this downregulation could result from the methylation level of some sites of the ABCG2 gene. However, no association was found between ABCG2 expression level and survival of colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Soo Hyung Kim, Jung-Soo Pyo, Byoung Kwan Son, Il Hwan Oh, Kyueng-Whan Min
Summary: This study found that the expression of FABP4 in colorectal cancer is closely correlated with clinical pathological characteristics such as patient age, tumor location, tumor stage, lymph node metastasis, and survival rate.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Sara Silva, Ana Cavaco, Bianca Basso, Joana Mota, Raquel Cruz-Duarte, Miguel Costa, Lara Carvalho, Ana Lima, Luis Costa, Ricardo Ferreira, Marta Martins
Summary: This study investigated the role of a protein called deflamin in colorectal cancer treatment. The research found that deflamin can inhibit tumor growth and metastasis, promote tumor cell apoptosis, and impair cancer cell migration and invasion by reducing the activity of MMP-2 and MMP-9. The use of a zebrafish model also revealed deflamin's ability to inhibit collagen degradation and angiogenesis in the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Jacek Kiezun, Marta Kiezun, Bartlomiej Emil Krazinski, Lukasz Paukszto, Anna Koprowicz-Wielguszewska, Zbigniew Kmiec, Janusz Godlewski
Summary: This study found that the expression levels of GALR1 and GALR3 proteins were elevated in colorectal cancer tissue, and higher GALR3 expression was associated with better prognosis. The expression of GALR1 and GALR3 slightly decreased in myenteric plexuses close to the cancer, but showed no correlation with tumor progression. The expression levels of GALRs in submucosal plexuses did not significantly change between distal and close to the tumor. However, elevated GALR1 expression in submucosal plexuses close to the tumor correlated with poor prognosis, higher tumor grading, and shorter overall survival.
Article
Oncology
Liyu Cao, Cong Zhang, Qingqing Wu, Zhenzhen Bai, Jing Chen
Summary: Colorectal cancer (CRC) is the third leading cause of cancer-related death globally. The study found that YAP expression in CRC tissues is associated with histological differentiation, lymph node metastasis, and Duke's stage, promoting cell proliferation and inhibiting apoptosis. Additionally, upregulated YAP expression in CRC tissues correlates with tumor progression and poor prognosis.
Article
Biochemistry & Molecular Biology
Carla Loreto, Alessandro Polizzi, Veronica Filetti, Giuseppe Pannone, Jean Nunes Dos Santos, Pietro Venezia, Rosalia Leonardi, Gaetano Isola
Summary: This study analyzed the immunohistochemical expression of stromal myofibroblasts in odontogenic keratocysts (OKCs) associated with nevoid basal cell carcinoma syndrome (NBCCS). The results showed a significantly increased expression of alpha-smooth muscle actin (alpha SMA), caldesmon, MMP-7, and MMP-9 in NBCCS-OKCs compared to non-syndromic OKCs. However, the expression of desmin did not show a significant difference between the two types of OKCs. NBCCS-OKCs exhibited a greater distribution of myofibroblasts compared to other OKCs subtypes. Further studies are needed to investigate the correlation between the expression of these markers and the clinical behavior of OKCs.
Article
Oncology
Yuanyuan Shang, Yuanyuan Zhang, Jie Liu, Lin Chen, Xudong Yang, Zhe Zhu, Dan Li, Yewei Deng, Zhuqing Zhou, Bing Lu, Chuan-gang Fu
Summary: The study found that the expression of E2F2 is downregulated in colorectal cancer (CRC) and is associated with clinical and pathological features as well as prognosis. Low E2F2 expression is correlated with poor survival and immune cell infiltration in CRC.
Article
Oncology
Il Hwan Oh, Jung-Soo Pyo, Byoung Kwan Son
Summary: This study found that YKL-40 expression in CRC tissues is associated with tumor differentiation and PD-L1 expression. The expression of I-YKL-40 can be useful for prognostic risk stratification in CRC patients.
Article
Pathology
Il Hwan Oh, Jung-Soo Pyo, Kyueng-Whan Min, One Zoong Kim, Byoung Kwan Son
Summary: This study revealed that chemerin expression in colorectal cancer is significantly correlated with distant metastasis and poor survival rates, especially in cases without mucinous component.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Weida Chen, Chengli Miao
Summary: This study found that KRT15 is highly expressed in colorectal cancer cells and its overexpression significantly promotes the migration and invasion of these cells. It was also discovered that MMP-7 plays a crucial role in the KRT15-induced migration and invasion of colorectal cancer cells, and beta-catenin is responsible for the increased expression of MMP-7 induced by KRT15.
Article
Medicine, Research & Experimental
Sanna Viitasalo, Taru Ilmarinen, Leena-Maija Aaltonen, Jaana Hagstrom, Maija Hytonen, Sari Hammaren-Malmi, Petra Pietarinen, Pia Jarvenpaa, Teemu Kinnari, Ahmed Geneid, Markus Lilja
Summary: This retrospective study assessed the epidemiological information of patients treated for sinonasal inverted papilloma (SNIP) at Helsinki University Hospital between 1984 and 2014, and found a very low malignant transformation rate of SNIP. The study also revealed that SNIP patients were not prone to HPV-associated non-sinonasal malignancies. Additionally, endoscopic resection and attachment-oriented surgery have become the predominant approaches in SNIP treatment, with a reduced recurrence rate.
Article
Gastroenterology & Hepatology
Hanna Belfrage, Emiel Lankinen, Leena Kylanpaa, Johanna Louhimo
Summary: This study aimed to evaluate the current data on acute pancreatitis (AP) in Helsinki. Electronic health care records (EHRs) of AP patients treated at Helsinki University Hospital between 2016 and 2018 were analyzed. The incidence, etiology, potential risk factors, and severity of AP were documented. The study found 1378 AP episodes in 1084 patients during the study period, with a domicile-adjusted incidence of 42.2/100,000. Alcohol etiology accounted for 47% of the cases, while biliary etiology accounted for 23%. The study also identified smoking and anticoagulation medication use as factors associated with AP. Additionally, recurrent AP, female sex, and normal BMI were associated with a milder form of AP.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Multidisciplinary Sciences
Ines Beilmann-Lehtonen, Jussi Kasurinen, Jaana Hagstroem, Tuomas Kaprio, Camilla Boeckelman, Caj Haglund
Summary: This study aimed to investigate the relationship between Toll-like receptor (TLR) immunoexpressions and the infiltration densities of T-lymphocytes in colorectal cancer (CRC). The results showed significant associations between high tissue TLR2, TLR4, and TLR5 immunoexpressions and high densities of CD3- and CD8-positive cells. Combining these markers may improve the prognostic evaluation of CRC patients.
Article
Oncology
Rayan Mroueh, Elli Hirvonen, Janne Pitkaeniemi, Nea Malila, Jaana Hagstrom, Antti Makitie, Anni Virtanen
Summary: This study investigated the burden of head and neck cancer (HNC) among immigrants in Finland. The risk of HNC was not increased among first-generation male immigrants, but significantly elevated for cancer of the pharynx and larynx, and decreased for lip cancer. Female first-generation immigrants had a significantly reduced risk of HNC, while the children of first-generation immigrants did not have an increased risk of HNC.
Article
Oncology
Jussi Kasurinen, Ines Beilmann-Lehtonen, Tuomas Kaprio, Jaana Hagstrom, Caj Haglund, Camilla Bockelman
Summary: A study categorized colorectal cancer patients into four phenotypic subgroups using immunohistochemistry and found associations between these subgroups and patient prognosis and clinicopathological variables. The immune subgroup showed the best 5-year disease-specific survival rate, while the mesenchymal subgroup had the worst prognosis. These subgroups' associations and prognoses resemble the transcriptome-based consensus molecular subtypes (CMS) classification.
Article
Medicine, General & Internal
Karita Nylund, Jaana Helenius-Hietala, Fredrik Aberg, Jaana Hagstrom, Hellevi Ruokonen
Summary: Oral mucosal lesions can persist for years before symptoms or diagnosis of inflammatory bowel disease (IBD) and subsequent primary sclerosing cholangitis (PSC). Since a dental practitioner may be the first clinician to suspect IBD with extraintestinal manifestations (EIMs), early referral and close collaboration with a gastroenterologist are recommended.
CLINICAL CASE REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Piia Huopainen, Sirke Virkkunen, Johanna Snall, Arzu Tezvergil-Mutluay, Jaana Hagstrom, Satu Apajalahti
Summary: This study aimed to compare the detectability of periapical foreign materials in dentoalveolar imaging and histopathology. The results showed that histopathology was more accurate in diagnosing periapical foreign bodies or foreign body reactions. Clinicians should be aware of the limitations of imaging when diagnosing and planning treatment.
ACTA ODONTOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Antti Silvoniemi, Jukka Laine, Katri Aro, Linda Nissi, Leif Back, Jukka Schildt, Jussi Hirvonen, Jaana Hagstrom, Heikki Irjala, Leena-Maija Aaltonen, Marko Seppanen, Heikki Minn
Summary: This study found an association between quantitative parameters in ctDNA and metabolic tumor burden measured with FDG-PET/CT in HNSCC. High maximum VAF correlated positively with TLG. The combination of ctDNA detection and FDG-PET/CT may provide additional value for the prognostic and predictive evaluation of HNSCC.
Article
Oncology
Jussi Herman Kasurinen, Jaana Hagstrom, Tuomas Kaprio, Sirpa Jalkanen, Marko Salmi, Camilla Bockelman, Caj Haglund
Summary: In this study, we found that the prognostic value of angiogenic growth factors VEGF, bFGF, and PDGF-bb varies according to the phenotypic subtype of the tumor. Patients were classified into immune, canonical, metabolic, and mesenchymal subgroups, and the serum concentrations and tissue expressions of these factors were determined. High expression and concentration of angiogenic growth factors were associated with improved prognosis in the metabolic subgroup, while a high VEGF serum concentration was associated with worse prognosis in the immune subgroup. Additionally, a high serum concentration of bFGF indicated improved prognosis in the canonical subgroup.
Article
Dentistry, Oral Surgery & Medicine
Orvokki Saraneva, Jussi Furuholm, Jaana Hagstrom, Timo Sorsa, Ville Rita, Taina Tervahartiala, Hannamari Valimaa, Hellevi Ruokonen
Summary: This retrospective study explored the role of oral potentially malignant disorders and the presence of intraepithelial Candida hyphae in the development of oral tongue squamous cell carcinoma. The results showed significant associations between histopathological diagnosis of oral lichen planus/lichenoid reaction and the presence of Candida hyphae with female gender. Patients with oral lichen planus/lichenoid reaction were less likely to be smokers, while Candida hyphae were more frequently observed in patients without alcohol use. Therefore, careful monitoring is necessary for these patients despite the absence of classical risk factors.
Article
Multidisciplinary Sciences
Heini Nieminen, Pirjo Nummela, Tero Satomaa, Annamari Heiskanen, Jukka O. O. Hiltunen, Tuomas Kaprio, Hanna Seppanen, Jaana Hagstrom, Harri Mustonen, Ari Ristimaki, Caj Haglund
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are potentially malignant cystic tumors of the pancreas. Diagnostic methods are needed to recognize IPMNs with malignant potential. Aberrantly expressed glycans offer interesting new options for diagnostics.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Sirke Virkkunen, Jaana Willberg, Caj Haglund, Malin Sund, Timo Sorsa, Jaana Hagstroem
Summary: The aim of this study was to investigate the immunexpression of bacterial lipopolysaccharide (LPS) in periapical lesions. Surprisingly, we found that Rushton bodies (RBs), whose origin has been debated, were positive for LPS. Staining of radicular cyst samples showed that all RBs (N=25) present in the tissue samples were positive for LPS, and calcification in the cyst capsule also showed immunopositivity. This study demonstrates for the first time that LPS is present in RBs, suggesting that the host response to bacteria may be the initial cause of RB formation and cyst capsule calcifications.
HISTOLOGY AND HISTOPATHOLOGY
(2023)
Letter
Oncology
Ella Brandt, Mutlu Keskin, Taina Tervahartiala, Mustafa Yilmaz, Ilknur Harmankaya, Didem Karacetin, Turgut Ipek, Ulvi Kahraman Gursoy, Shipra Gupta, Ismo T. Raisanen, Jaana Hagstrom, Jaana Rautava, Timo Sorsa
Article
Pathology
Anni Sjoblom, Henna Pehkonen, Lauri Jouhi, Outi Monni, Reija Randen-Brady, Piia-Riitta Karhemo, Jussi Tarkkanen, Caj Haglund, Petri Mattila, Antti Makitie, Jaana Hagstrom, Timo Carpen
Summary: Liprin-alpha 1 inhibits the expression of CD82 and its increased expression in tumor-infiltrating lymphocytes is associated with a favorable prognosis in HPV-positive patients with oropharyngeal squamous cell carcinoma.
HEAD & NECK PATHOLOGY
(2023)
Letter
Oncology
Shipra Gupta, Ismo T. Raisanen, Hanna Seppanen, Jaana Hagstrom, Andreas Grigoriadis, Kethe Hermunen, Dimitra Sakellari, Caj Haglund, Timo Sorsa
