Article
Immunology
Marcos S. Cardoso, Rita F. Santos, Sarah Almeida, Monica Sa, Begona Perez-Cabezas, Liliana Oliveira, Joana Tavares, Alexandre M. Carmo
Summary: This study characterizes the biological and functional roles of the circulating human protein SSC4D, a member of the SRCR superfamily, which shows high expression in immune cells and various organs. SSC4D has the ability to physically bind to bacteria and protozoan parasites, highlighting its role as a pattern recognition receptor (PRR) that is unique in its binding capabilities.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Bo Lin, Qiujiao Wang, Kun Liu, Xu Dong, Mingyue Zhu, Mengsen Li
Summary: Alpha-fetoprotein (AFP) entering cancer cells through AFP receptors (AFPRs) has malignant effects, and understanding AFPRs' structure is crucial for cancer treatment. The complex carbohydrate polymer structures of AFP receptors have hindered the identification of universal receptors for AFP over the past three decades. This study focuses on mucin and scavenger receptors as potential AFPRs, providing detailed descriptions of signal transduction and downstream events following AFP binding.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chunyu Tong, Yimin Liang, Xianle Han, Zhelin Zhang, Xiaohui Zheng, Sen Wang, Bocui Song
Summary: Dendritic cells, as the most effective antigen-presenting cells, have many subsets with different surface receptors. Specific receptors targeting different subsets of dendritic cells will cause different immune responses. Currently, targeted research on dendritic cells plays a crucial role in the treatment and prevention of various diseases in the clinic.
Review
Immunology
Dmitry Namgaladze, Bernhard Bruene
Summary: Innate immune responses trigger rapid transcriptional and epigenetic changes, as well as metabolic rewiring, including up-regulation of glycolysis. This mini-review summarizes recent advances in understanding the mechanisms of rapid glycolytic activation in innate immune cells and its impact on inflammatory responses. It also highlights unresolved mechanistic details and future research directions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ana Maria Valencia-Hernandez, Thomas Zillinger, Zhengyu Ge, Peck S. Tan, Anton Cozijnsen, Geoffrey I. McFadden, Mireille H. Lahoud, Irina Caminschi, Winfried Barchet, William R. Heath, Daniel Fernandez-Ruiz
Summary: Tissue resident memory T cells (TRM cells) play a crucial role in tissue surveillance and rapid response to infection. This study explores the potential of various adjuvants targeting different pathogen recognition receptors to induce CD8' TRM formation. CpG oligodeoxynucleotides (ODN) were found to be the most efficient inducers of liver TRM cells among all tested adjuvants. Additionally, combining CpG ODN with cationic liposome DOTAP further enhances their potency. This study provides valuable insights for the development of liver TRM-based vaccines.
Article
Immunology
Nicholas A. Gherardin, Samuel J. Redmond, Hamish E. G. McWilliam, Catarina F. Almeida, Katherine H. A. Gourley, Rebecca Seneviratna, Shihan Li, Robert De Rose, Fiona J. Ross, Catriona Nguyen-Robertson, Shian Su, Matthew E. Ritchie, Jose A. Villadangos, D. Branch Moody, Daniel G. Pellicci, Adam P. Uldrich, Dale Godfrey
Summary: This study identified members of the CD36 family as ligands for CD1c, CD1b, and CD1d proteins, with CD36 being responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Blocking CD36 clarified the identification of CD1c-restricted T cells and enhanced the detection of CD1b- and CD1d-restricted T cells. The technique developed in this study allowed for the characterization of diverse phenotypic features, TCR repertoire, and antigen-specific subsets of CD1c-restricted T cells, facilitating further research in the biology of CD1 and human CD1-restricted T cells.
SCIENCE IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Fabio A. Facchini, Alberto Minotti, Andrea Luraghi, Alessio Romerio, Nicole Gotri, Alejandra Matamoros-Recio, Andrea Iannucci, Charys Palmer, Guanbo Wang, Rebecca Ingram, Sonsoles Martin-Santamaria, Grisha Pirianov, Marco De Andrea, Miguel A. Valvano, Francesco Peri
Summary: Modern adjuvants for vaccine formulations activate pattern recognition receptors to boost immune responses. Research shows that chemically simplified TLR4 agonists can be produced on a large scale and exhibit strong immune-enhancing activity in biological experiments.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Immunology
C. Grasso, C. Pierie, R. E. Mebius, L. G. M. van Baarsen
Summary: Lymph nodes stromal cells are crucial for guiding adaptive immune responses, with recent advancements in single-cell technologies revealing significant heterogeneity among subsets. While most knowledge comes from mouse studies, some similarities with human counterparts suggest their importance.
TRENDS IN IMMUNOLOGY
(2021)
Article
Oncology
Niranjan Kumar, Akanksha Vyas, Saurabh Kumar Agnihotri, Naibedya Chattopadhyay, Monika Sachdev
Summary: Small secretory proteins of immune cells, such as cytokines and chemokines, play a crucial role in modulating immune response and controlling the movement and location of immune cells. They have been extensively studied for their potential in cancer therapy, including gynecological malignancies.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Ananya Ananya, Kaitlyn G. G. Holden, Zhiling Gu, Dan Nettleton, Surya K. K. Mallapragada, Michael J. J. Wannemuehler, Marian L. L. Kohut, Balaji Narasimhan
Summary: Inflammaging, a factor contributing to immunosenescence, reduces vaccine effectiveness. This study demonstrates that combining appropriate adjuvants with nanoparticles and micelles can induce immune responses in older adults while reducing inflammation. These findings have important implications for designing next generation mucosal vaccines for older adults.
Article
Chemistry, Multidisciplinary
Landon J. Edgar, Andrew J. Thompson, Vincent F. Vartabedian, Chika Kikuchi, Jordan L. Woehl, John R. Teijaro, James C. Paulson
Summary: Sialic acid-containing glycans on the surface of T cells and APCs are alternative ligands of CD28 that compete with CD80 for binding, resulting in attenuated costimulation. Removal of sialic acids enhances antigen-mediated activation of naive T cells and increases revival of effector T cells through synergistic mechanism with PD-1 axis antibody blockade. These findings reveal a previously unrecognized role of sialic acid ligands in attenuation of CD28-mediated costimulation of T cells.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Clare S. Hardman, Yi-Ling Chen, Maryam Salimi, Janina Nahler, Daniele Corridoni, Marta Jagielowicz, Chathuranga L. Fonseka, David Johnson, Emmanouela Repapi, David J. Cousins, Jillian L. Barlow, Andrew N. J. McKenzie, Alison Simmons, Graham Ogg
Summary: Cutaneous ILC2 can directly sense skin pathogens through NOD2 and TLR2, leading to cytokine production. NOD2 signaling plays a role in regulating ILC2-derived IL-6 and activating autophagy.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Arash Shahsavari, Prasanna Weeratunga, Dmitry A. Ovchinnikov, Deanne J. Whitworth
Summary: The study found that ciMSCs possess similar immunomodulatory capabilities as harvested cMSCs, expressing a range of pluripotency factors and immunomodulatory factors, supporting further investigation into their potential use for the management of canine immune-mediated and inflammatory disorders.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Luise Mueller, Antje Tunger, Manja Wobus, Malte von Bonin, Russell Towers, Martin Bornhaeuser, Francesco Dazzi, Rebekka Wehner, Marc Schmitz
Summary: Mesenchymal stromal cells (MSCs) have the ability to regulate and inhibit the function of immune cells, playing a crucial role in the pathogenesis of inflammatory disorders and showing promise in the treatment of conditions such as acute graft-versus-host disease, graft rejection, and autoimmune diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Kevin J. Paavola, Julie M. Roda, Vicky Y. Lin, Peirong Chen, Kyle P. O'Hollaren, Richard Ventura, Suzanne C. Crawley, Betty Li, Hung-I H. Chen, Seth Malmersjo, Nikolai A. Sharkov, Geoffrey Horner, Wei Guo, Alan K. Kutach, Kalyani Mondal, Zhen Zhang, Joshua S. Lichtman, Christina Song, Lee B. Rivera, Wenhui Liu, Jian Luo, Yan Wang, Mark J. Solloway, Bernard B. Allan, Avantika Kekatpure, Shelley R. Starck, Raj Haldankar, Bin Fan, Chun Chu, Jie Tang, Martina Molgora, Marco Colonna, Daniel D. Kaplan, Jer-Yuan Hsu
Summary: This study revealed that fibronectin interacting with ILT3 plays a key role in polarizing myeloid cells towards a suppressive phenotype. Blocking this interaction can reprogram tumor-associated myeloid cells towards a stimulatory phenotype and potentially enhance antitumor T-cell responses.
CANCER IMMUNOLOGY RESEARCH
(2021)