Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Alexandra Laine, Ossama Labiad, Hector Hernandez-Vargas, Sebastien This, Amelien Sanlaville, Sophie Leon, Stephane Dalle, Dean Sheppard, Mark A. Travis, Helena Paidassi, Julien C. Marie
Summary: The presence of TGF beta in the tumor microenvironment is a significant cancer immune-escape mechanism. This study shows that regulatory T cells work in concert with cancer cells to produce bioactive TGF beta, creating an immunosuppressive micro-environment. The activation of TGF beta by Treg cells through the expression of avb8 integrin’s b8 chain is necessary for tumor growth.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Weiyu Ge, Ming Yue, Ruirong Lin, Tianhao Zhou, Haiyan Xu, Yu Wang, Tiebo Mao, Shumin Li, Xiuqi Wu, Xiaofei Zhang, Yongchao Wang, Jingyu Ma, Yanling Wang, Shengbai Xue, Daiyuan Shentu, Jiujie Cui, Liwei Wang
Summary: Our study identified a novel metabolic cancer associated fibroblasts subset (meCAFs) enriched in pancreatic ductal adenocarcinoma (PDAC) and related to CD8+ T cells accumulation. The abundance of meCAFs was associated with poor prognosis but better immunotherapy responses in PDAC patients. We demonstrated that PLA2G2A+ meCAFs impede the antitumor immune function of CD8+ T cells and facilitate tumor immune escape in PDAC.
Article
Cell Biology
Haiyu Li, Yongyao Tang, Yujing Wang, Yue Li, Yi Yang, Kui Liao, Fangzhou Song, Shixiong Deng, Yaokai Chen
Summary: Immune non-responder after highly active antiretroviral therapy (HAART) is a major problem in AIDS patients, leading to opportunistic infections and high mortality. The underlying mechanism of this immune reconstitution failure is poorly understood. In this study, single-cell sequencing and chromatin accessibility analysis were performed on peripheral blood mononuclear cells (PBMCs) from immune non-responders (INR) and responders (IR) with HIV-1 infection. The results showed that INRs had low expression of mucosal-associated invariant T (MAIT) cells, which were associated with impaired mitochondrial function and apoptosis signaling. Restoring mitochondrial function could potentially improve the immune dysfunction in MAIT cells against bacterial co-infections in INR subjects.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Christopher Tay, Atsushi Tanaka, Shimon Sakaguchi
Summary: Regulatory T cells (Tregs) in tumor tissues can be selectively targeted to enhance anti-tumor immune responses, while maintaining immune homeostasis in healthy organs. Current strategies such as immune checkpoint blockade (ICB) antibodies and differential targeting of surface and intracellular molecules show promise in this regard. Combining Treg targeting with ICB antibodies may enhance the efficacy of cancer immunotherapy.
Review
Oncology
Navid Sobhani, Dana Rae Tardiel-Cyril, Aram Davtyan, Daniele Generali, Raheleh Roudi, Yong Li
Summary: Immunotherapies have shown promise in cancer treatment but face challenges. Understanding the molecular mechanisms of immune checkpoint inhibitors and the role of regulatory T cells is crucial for improving cancer therapies.
Article
Medicine, Research & Experimental
Magdalena Hinterbrandner, Viviana Rubino, Carina Stoll, Stefan Forster, Noah Schnuriger, Ramin Radpour, Gabriela M. Baerlocher, Adrian F. Ochsenbein, Carsten Riether
Summary: The study showed that leukemia stem cells (LSCs) in chronic myeloid leukemia (CML) can be killed by CD8(+) cytotoxic T cells (CTLs) in vitro, but Tregs in CML bone marrow protect LSCs from CTL-mediated elimination in vivo. TNFRSF4 was identified as a potential target to reduce the function of Tregs and enhance antileukemic immunity in CML.
Article
Immunology
Bo-Jin Chen, Jing-Wen Zhao, Da-Hong Zhang, Ai-Hong Zheng, Guo-Qing Wu
Summary: Regulatory T (Treg) cells maintain immune homeostasis and play an important role in immune tolerance, autoimmune diseases, infectious diseases, organ transplantation, and tumor diseases. Targeted elimination of Treg cells can activate tumor-specific effector T cells and improve the efficiency of cancer immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Tej Pratap Singh, Camila Farias Amorim, Victoria M. Lovins, Charles W. Bradley, Lucas P. Carvalho, Edgar M. Carvalho, Elizabeth A. Grice, Phillip Scott
Summary: Cutaneous leishmaniasis leads to changes in the skin microbiota, resulting in immune responses and delayed healing. This study demonstrates that depletion of regulatory T cells contributes to skin inflammation and impaired immunity against Staphylococcus aureus in mice. Similar findings are observed in Leishmania braziliensis-infected mice and patients, suggesting a critical role of these cells in regulating immune balance and disease progression.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Immunology
Yuzhi Lu, Ni Xia, Xiang Cheng
Summary: Regulatory T cells (Tregs) play a crucial role in the development of chronic heart failure, suppressing excessive inflammatory responses and promoting stable scar formation in the early stage of heart injury. However, in chronic heart failure, the functions and phenotypes of Tregs change, transforming into a cell type that is harmful to the heart.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Xiaoyou Liu, Jianmin Hu, Guorong Liao, Ding Liu, Song Zhou, Jie Zhang, Jun Liao, Zefeng Guo, Yuzhu Li, Siqiang Yang, Shichao Li, Hua Chen, Ying Guo, Min Li, Lipei Fan, Liuyang Li, Ming Zhao, Yongguang Liu
Summary: The incidence of acute kidney injury (AKI) is increasing and associated with high mortality, but effective treatments are scarce. The relationship between Tregs and immune microenvironment (IME) in AKI pathogenesis remains unclear. Analysis of immune cells in AKI and Non-AKI groups showed a significant difference in the number of Tregs, and single-cell sequencing data revealed distinct biology of Tregs in patients with chronic kidney rejection and normal kidney tissue.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Immunology
Nicolas Krause, Joerg Mengwasser, Elpida Phithak, Francisca Beato, Marc Appis, Edgar Louis Milford, Johan Pratschke, Igor Sauer, Anja Kuehl, Arndt Vogel, Michael Goodyear, Linda Hammerich, Frank Tacke, Johanna Faith Haas, Tobias Mueller, Nalan Utku
Summary: IR1 cells are a subset of T regulatory cells that have immune suppressive functions and can inhibit proliferation in mixed lymphocyte reactions. They deliver regulatory signals by binding to their ligand, HLA-DR alpha 2, and have the potential to modulate immune dysregulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Article
Cell Biology
Lian Zhang, Yujiao He, Yi Jiang, Qi Wu, Yanchen Liu, Qingqiang Xie, Yuxiu Zou, Jiaqian Wu, Chundong Zhang, Zhongjun Zhou, Xiu-Wu Bian, Guoxiang Jin
Summary: This study reveals the dual role of PRMT1-mediated RIP3 methylation in necroptotic cancer cell death and tumor immune escape. PRMT1 methylates RIP3 and inhibits its interaction with RIP1, thereby suppressing necrosome complex formation and necroptosis activation. The protein levels of PRMT1 and RIP3(ADMA) are positively correlated in cancer tissues and both serve as valuable prognostic markers for colon cancer.
CELL DEATH & DISEASE
(2023)
Review
Oncology
Ion Negura, Mariana Pavel-Tanasa, Mihai Danciu
Summary: Gastric cancer is a highly aggressive malignancy that contributes significantly to cancer-related mortality worldwide. Conventional treatment approaches have limited efficacy, and the clinical benefits of immune checkpoint inhibitors in gastric cancer are limited. Understanding the role of immune cell functions within the tumor microenvironment is crucial for developing targeted therapeutic strategies.
CANCER TREATMENT REVIEWS
(2023)
Article
Materials Science, Multidisciplinary
Svenja Siemer, Dana Westmeier, Cecilia Vallet, Joerg Steinmann, Jan Buer, Roland H. Stauber, Shirley K. Knauer
Article
Chemistry, Medicinal
Jens Bongard, Anna Laura Schmitz, Alex Wolf, Gunther Zischinsky, Michel Pieren, Birgit Schellhorn, Kenny Bravo-Rodriguez, Jasmin Schillinger, Uwe Koch, Peter Nussbaumer, Bert Klebl, Joerg Steinmann, Jan Buer, Elsa Sanchez-Garcia, Michael Ehrmann, Markus Kaiser
Article
Infectious Diseases
B. W. Pelzer, R. Seufert, M. Koldehoff, T. Liebregts, D. Schmidt, J. Buer, P-M Rath, J. Steinmann
Article
Oncology
Carolin Hesse, Sebastian Kollenda, Olga Rotan, Eva Pastille, Alexandra Adamczyk, Christina Wenzek, Wiebke Hansen, Matthias Epple, Jan Buer, Astrid M. Westendorf, Torben Knuschke
MOLECULAR CANCER THERAPEUTICS
(2019)
Article
Immunology
Eva Pastille, Marie-Helene Wasmer, Alexandra Adamczyk, Vivian P. Vu, Lukas F. Mager, Nhi Ngo Thi Phuong, Vittoria Palmieri, Cedric Simillion, Wiebke Hansen, Stefan Kasper, Martin Schuler, Beat Muggli, Kathy D. McCoy, Jan Buer, Inti Zlobec, Astrid M. Westendorf, Philippe Krebs
MUCOSAL IMMUNOLOGY
(2019)
Article
Immunology
Matthias Hose, Anne Guenther, Hanna Abberger, Salina Begum, Marek Korencak, Katrin A. Becker, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Jana Meiners, Vittoria Palmieri, Robert Klopfleisch, Jana-Fabienne Ebel, Lukasz Japtok, Fabian Schumacher, Ayan Mohamud Yusuf, Katrin A. Becker, Julia Zoeller, Matthias Hose, Burkhard Kleuser, Dirk M. Hermann, Richard N. Kolesnick, Jan Buer, Wiebke Hansen, Astrid M. Westendorf
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Jan Kehrmann, Laura Effenberg, Camilla Wilk, Davina Schoemer, Nhi Ngo Thi Phuong, Alexandra Adamczyk, Eva Pastille, Rene Scholtysik, Ludger Klein-Hitpass, Robert Klopfleisch, Astrid M. Westendorf, Jan Buer
Article
Genetics & Heredity
Sascha Beck, Carolin Sehl, Sylvia Voortmann, Hedda Luise Verhasselt, Michael J. Edwards, Jan Buer, Mike Hasenberg, Erich Gulbins, Katrin Anne Becker
JOURNAL OF MOLECULAR MEDICINE-JMM
(2020)
Article
Multidisciplinary Sciences
Lisa Kirchhoff, Diana Arweiler-Harbeck, Judith Arnolds, Timon Hussain, Stefan Hansen, Ralph Bertram, Jan Buer, Stephan Lang, Joerg Steinmann, Benedikt Hoeing
Article
Immunology
Florian Scheffel, Torben Knuschke, Lucas Otto, Sebastian Kollenda, Viktoriya Sokolova, Christine Cosmovici, Jan Buer, Joerg Timm, Matthias Epple, Astrid M. Westendorf
Article
Microbiology
Lisa Kirchhoff, Ann-Kathrin Weisner, Mona Schrepffer, Andrea Hain, Ulrike Scharmann, Jan Buer, Peter-Michael Rath, Joerg Steinmann
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Hanna Abberger, Romy Barthel, Jasmin Bahr, Jacqueline Thiel, Sina Luppus, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: The study found that in activated CD4(+) non-Tregs, Nrp-1 expression has an activating role, while in CD4(+) non-Tregs from naive mice, Nrp-1 expression leads to dysfunction.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biology
Anne Gunther, Matthias Hose, Hanna Abberger, Fabian Schumacher, Ylva Veith, Burkhard Kleuser, Kai Matuschewski, Karl Sebastian Lang, Erich Gulbins, Jan Buer, Astrid M. Westendorf, Wiebke Hansen
Summary: This study demonstrates the involvement of acid ceramidase and ceramide in controlling P. yoelii infection, with a mechanism involving regulation of red blood cell development.
Article
Engineering, Biomedical
V. Sokolova, K. Lozaa, J. F. Ebel, J. Buer, A. M. Westendorf, M. Epple
Summary: The cytotoxicity and cellular uptake of spherical barium sulphate microparticles were investigated in three different cell lines, and it was found that the microparticles were easily taken up by all cell types, mainly through phagocytosis and micropinocytosis. This has important implications in biomaterials science.
ACTA BIOMATERIALIA
(2023)