Article
Biochemistry & Molecular Biology
Joseph W. Saelens, Mollie I. Sweeney, Gopinath Viswanathan, Ana Maria Xet-Mull, Kristen L. Jurcic Smith, Dana M. Sisk, Daniel D. Hu, Rachel M. Cronin, Erika J. Hughes, W. Jared Brewer, Jorn Coers, Matthew M. Champion, Patricia A. Champion, Craig B. Lowe, Clare M. Smith, Sunhee Lee, Jason E. Stout, David M. Tobin
Summary: The human pathogen Mycobacterium tuberculosis can cause lung disease and disseminate to other tissues. This study identified an outbreak of M. tuberculosis with high rates of extrapulmonary dissemination and bone disease. The causal strain carried a full-length ancestral version of the effector protein EsxM, which exacerbated dissemination through enhancement of macrophage motility and egress from granulomas, as well as alterations in macrophage actin dynamics. Reconstitution of ancestral EsxM in a modern attenuated strain altered the migratory mode of infected macrophages and promoted bone disease in a zebrafish model. The presence of a derived nonsense variant in EsxM in major M. tuberculosis lineages suggests a role for EsxM in regulating dissemination.
Article
Multidisciplinary Sciences
Lihua Qiang, Yong Zhang, Zehui Lei, Zhe Lu, Shasha Tan, Pupu Ge, Qiyao Chai, Mengyuan Zhao, Xinwen Zhang, Bingxi Li, Yu Pang, Lingqiang Zhang, Cui Hua Liu, Jing Wang
Summary: This research discovers that tuberculosis-causing pathogen Mycobacterium tuberculosis (Mtb) activates iron-dependent cell death, called ferroptosis, through a secreted protein called PtpA, promoting Mtb's pathogenicity and dissemination. The mechanism involves PtpA entering the host cell nucleus and enhancing the methylation of histone H3, inhibiting the expression of glutathione peroxidase 4 (GPX4), ultimately inducing ferroptosis. This study provides insights into the molecular mechanisms of pathogen-induced ferroptosis and suggests a potential tuberculosis treatment by targeting Mtb PtpA-host PRMT6 interface to block GPX4-dependent ferroptosis.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Octavio Ramos-Espinosa, Dulce Mata-Espinosa, Alejandro Francisco-Cruz, Manuel Othoniel Lopez-Torres, Sujhey Hernandez-Bazan, Jorge Barrios-Payan, Brenda Marquina-Castillo, Marta Carretero, Marcela del Rio, Rogelio Hernandez-Pando
Summary: This study suggests that adenovirus-delivered antimicrobial peptides can serve as a promising adjuvant therapy for pulmonary tuberculosis by enhancing protective immune response, reducing bacterial load and inflammation, and potentially shortening the duration of antibiotic treatment.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Immunology
Mariana Araujo-Pereira, Charlotte Schutz, Beatriz Barreto-Duarte, David Barr, Klauss Villalva-Serra, Caian L. Vinhaes, Amy Ward, Graeme Meintjes, Bruno B. Andrade
Summary: This study aimed to investigate the relationship between anemia, systemic inflammatory profile, dissemination of tuberculosis (TB), and death. Through the analysis of 496 HIV patients, it was found that severe anemia is associated with increased systemic inflammation, higher TB dissemination score, and greater risk of death.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Morgane Evin, Patrice Sudres, Pascal Weber, Yves Godio-Raboutet, Pierre-Jean Arnoux, Eric Wagnac, Yvan Petit, Yannick Tillier
Summary: This study aims to investigate the mechanical characteristics of swine pia mater and dura and arachnoid complex under bi-axial loading conditions. The results show that the anisotropic Gasser model is the most suitable for modeling the tissue. This research provides reference values for further studies and finite element modeling for physiological applications.
ACTA BIOMATERIALIA
(2022)
Article
Immunology
Yingying Cui, Yangyang Tang, Mingzhu Shao, Xinxin Zang, Yanyan Jiang, Ziyin Cui, Guanghui Dang, Siguo Liu
Summary: The study reveals that Rv3090, a cell wall-associated protease, triggers late cell apoptosis, leads to pathological damage in liver, lung, and spleen, and enhances the survival ability of Mtb in liver and lung.
MICROBIAL PATHOGENESIS
(2022)
Review
Microbiology
Pablo Soldevilla, Cristina Vilaplana, Pere-Joan Cardona
Summary: Science has benefited greatly from animal models since ancient Greece and has obtained important findings throughout history. The mouse, especially in research on infectious diseases like tuberculosis, has been one of the most popular models. Research on mice has provided useful information about host and bacterial traits related to susceptibility to tuberculosis, as well as the effects of aging, sexual dimorphisms, route of infection, genetic differences, and immunity imbalances on Mycobacterium tuberculosis infection and tuberculosis development. Despite some discrepancies and gaps in certain areas, these studies will continue to help biomedical researchers in designing new tools for the diagnosis, treatment, and prevention of tuberculosis.
Review
Zoology
Dan Yang, Xiao-Jing Li, De-Zhen Tu, Xiu-Li Li, Bin Wei
Summary: Viral infections, especially neurotropic virus-induced viral encephalitis, have caused major public health crises. Understanding the transmission routes of these viruses and the host immune responses is crucial for controlling the spread and improving antiviral therapy outcomes.
ZOOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Thao K. T. Nguyen, Zainab Niaz, John D'Aigle, Shen-An Hwang, Marian L. Kruzel, Jeffrey K. Actor
Summary: Studies have shown that recombinant human lactoferrin (rHLF) can ameliorate the cohesiveness of granuloma induced by tuberculosis, significantly reduce the size and number of inflammatory foci, and decrease levels of pro-inflammatory cytokines in the lungs. Lactoferrin also facilitates better penetration of fluoroquinolone chemotherapy drugs to pathology sites.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Immunology
Thao K. T. Nguyen, Zainab Niaz, Marian L. Kruzel, Jeffrey K. Actor
Summary: Lactoferrin can reduce inflammation caused by Mtb infection, promote drug penetration, and maintain endothelial cell integrity. In the inflammatory foci, mice treated with rHLF showed an increase in M2-like phenotypic cells.
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
(2022)
Review
Microbiology
Jordi B. Torrelles, Delphi Chatterjee
Summary: This review provides a historical perspective on the discovery and structural characterization of lipoarabinomannan (LAM) in Mycobacterium tuberculosis (Mtb). LAM is not only important for its immunological properties, but also serves as a biomarker for tuberculosis (TB). Despite extensive research, there are still unresolved issues regarding LAM.
Review
Biochemistry & Molecular Biology
Samreen Fatima, Anjna Kumari, Meetu Agarwal, Isha Pahuja, Vinod Yadav, Ved Prakash Dwivedi, Ashima Bhaskar
Summary: Epigenetics plays a crucial role in the survival of TB pathogen and manipulation of the host immune response, with a significant impact on the host genome. By altering the activation status of genes involved in host immune response, the pathogen promotes its survival and subverts antibacterial strategies of the host, which can be utilized to design efficient host-directed therapies.
Article
Biochemistry & Molecular Biology
David M. Hoi, Sabryna Junker, Lukas Junk, Kristin Schwechel, Katharina Fischel, David Podlesainski, Paige M. E. Hawkins, Lasse van Geelen, Farnusch Kaschani, Julia Leodolter, Francesca Ester Morreale, Stefan Kleine, Somraj Guha, Klaus Rumpel, Volker M. Schmiedel, Harald Weinstabl, Anton Meinhart, Richard J. Payne, Markus Kaiser, Markus Harti, Guido Boehmelt, Uli Kazmaier, Rainer Kalscheuer, Tim Clausen
Summary: By using quantitative proteomics, we found that the antibiotics cyclomarin A and ecumicin can cause proteome imbalances and upregulation of two unannotated stress response factors, ClpC2 and ClpC3. These proteins likely protect the Clp protease from excessive misfolded proteins or the damaging effects of cyclomarin A. By developing a BacPROTAC that degrades both ClpC1 and its caretaker ClpC2, we significantly enhanced the potency of killing pathogenic Mycobacterium tuberculosis.
Article
Infectious Diseases
Hongye Ma, Jingjing Sun, Lei Zhang, Yu Liu, Hongjuan Liu, Xiaoling Wu, Litao Guo
Summary: This study analyzed the diagnosis and treatment process of patients with hematogenous disseminated pulmonary tuberculosis after IVF-ET treatment. A patient developed persistent fever and shortness of breath after IVF-ET treatment and was found to have M. tuberculosis infection, leading to her death from multiple organ failure despite anti-tuberculosis treatment. The study highlights the importance of early detection and treatment of M. tuberculosis pulmonary infection in pregnant women, especially those undergoing IVF-ET.
INFECTION AND DRUG RESISTANCE
(2021)
Review
Veterinary Sciences
Laura Hunter, Ines Ruedas-Torres, Irene Agullo-Ros, Emma Rayner, Francisco J. Salguero
Summary: Research on human tuberculosis is limited due to the availability of human tissues, making animal models crucial for understanding the disease's progression and evaluating new therapies. This review examines the pulmonary pathology induced by tuberculosis bacteria in different animal models and compares them to human pulmonary tuberculosis. Although the models share some histopathological features with human tuberculosis, further research is needed to establish the most appropriate model and standard characterization of pulmonary lesions.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Immunology
Cristian Alfredo Segura-Cerda, Michel de Jesus Aceves-Sanchez, Brenda Marquina-Castillo, Dulce Mata-Espinoza, Jorge Barrios-Payan, Perla Jazmin Vega-Dominguez, Cesar Pedroza-Roldan, Jorge Bravo-Madrigal, Alba Adriana Vallejo-Cardona, Rogelio Hernandez-Pando, Mario Alberto Flores-Valdez
Article
Multidisciplinary Sciences
Enrique Becerril-Villanueva, Maria Dolores Ponce-Regalado, Gilberto Perez-Sanchez, Alberto Salazar-Juarez, Rodrigo Arreola, Maria Elizbeth Alvarez-Sanchez, Mario Juarez-Ortega, Ramces Falfan-Valencia, Rogelio Hernandez-Pando, Jorge Morales-Montor, Lenin Pavon, Oscar Rojas-Espinosa
SCIENTIFIC REPORTS
(2018)
Article
Microbiology
Mario A. Flores-Valdez, Cesar Pedroza-Roldan, Michel de Jesus Aceves-Sanchez, Eliza J. R. Peterson, Nitin S. Baliga, Rogelio Hernandez-Pando, JoLynn Troudt, Elizabeth Creissen, Linda Izzo, Helle Bielefeldt-Ohmann, Thomas Bickett, Angelo A. Izzo
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Chemistry, Medicinal
Angelica Flores-Flores, Samuel Estrada-Soto, Cesar Millan-Pacheco, Blanca Bazan-Perkins, Rafael Villalobos-Molina, Leticia Moreno-Fierros, Rogelio Hernandez-Pando, Sara Garcia-Jimenez, Julio Cesar Rivera-Leyva
DRUG DEVELOPMENT RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Omar Emiliano Aparicio-Trejo, Laura Maria Reyes-Fermin, Alfredo Briones-Herrera, Edilia Tapia, Juan Carlos Leon-Contreras, Rogelio Hernandez-Pando, Laura Gabriela Sanchez-Lozada, Jose Pedraza-Chaverri
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Biotechnology & Applied Microbiology
Fernanda Cornejo-Granados, Juan Manuel Hurtado-Ramirez, Rogelio Hernandez-Pando, Adrian Ochoa-Leyva
Article
Immunology
Dulce Adriana Mata-Espinosa, Alejandro Francisco-Cruz, Brenda Marquina-Castillo, Jorge Barrios-Payan, Octavio Ramos-Espinosa, Estela Isabel Bini, Zhou Xing, Rogelio Hernandez-Pando
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Eden M. Rodriguez-Flores, Dulce Mata-Espinosa, Jorge Barrios-Payan, Brenda Marquina-Castillo, Mauricio Castanon-Arreola, Rogelio Hernandez-Pando
Correction
Cell Biology
Thalia Pacheco-Fernandez, Imelda Juarez-Avelar, Oscar Illescas, Luis I. Terrazas, Rogelio Hernandez-Pando, Carlos Perez-Plasencia, Emma B. Gutierrez-Cirlos, Federico avila-Moreno, Yolanda I. Chirino, Jose Luis Reyes, Vilma Maldonado, Miriam Rodriguez-Sosa
MEDIATORS OF INFLAMMATION
(2020)
Article
Immunology
Albany Resendiz-Mora, Carlos Wong-Baeza, Irene Nevarez-Lechuga, Carla Landa-Saldivar, Erendira Molina-Gomez, Rogelio Hernandez-Pando, Isabel Wong-Baeza, Alejandro Escobar-Gutierrez, Isabel Baeza
Summary: The study evaluated the role of the TH2 response, particularly the cytokine IL-4, in the development of a lupus-like disease in mice induced by NPAs stabilization. The findings indicated that IL-4 plays a central role in this process.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Microbiology
Jacqueline V. Lara-Espinosa, Maria Fernanda Arce-Aceves, Jorge Barrios-Payan, Dulce Mata-Espinosa, Vasti Lozano-Ordaz, Enrique Becerril-Villanueva, Maria Dolores Ponce-Regalado, Rogelio Hernandez-Pando
Summary: This study found that low doses of dexamethasone can reduce the bacilli load and pneumonia in tuberculosis-infected lungs and increase animal survival. Dexamethasone also decreases the inflammatory response and neurological abnormalities in infected animals. Therefore, dexamethasone represents a promising adjuvant treatment for pulmonary tuberculosis.
Article
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Constanza E. Martinez-Olivares, Leonardo Del Valle-Mondragon, Fernando Cortes-Camacho, Oscar R. Zambrano-Vasquez, Rogelio Hernandez-Pando, Fausto Sanchez-Munoz, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: In this study, we evaluated the effects of allicin on vascular remodeling, endothelial function, and oxidative stress in experimental pulmonary arterial hypertension (PAH). Allicin administration improved body weight, survival rate, and prevented wall thickness and right ventricle hypertrophy. Allicin also maintained normal levels of angiotensin II and its receptors, increased nitric oxide and other beneficial molecules, and prevented oxidative stress and hypoxia response. These effects of allicin contribute to preventing endothelial dysfunction, remodeling of the pulmonary arteries, and heart failure in PAH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Belen Cuevas-Lopez, Edgar Ignacio Romero-Ramirez, Fernando E. Garcia-Arroyo, Edilia Tapia, Juan Carlos Leon-Contreras, Alejandro Silva-Palacios, Francisco-Javier Roldan, Omar Noel Medina Campos, Luz Hernandez-Esquivel, Alvaro Marin-Hernandez, Jose Guillermo Gonzaga-Sanchez, Rogelio Hernandez-Pando, Jose Pedraza-Chaverri, Laura Gabriela Sanchez-Lozada, Omar Emiliano Aparicio-Trejo
Summary: The incidence of kidney disease is increasing globally, and acute kidney injury (AKI) can contribute to the development of cardio-renal syndrome (CRS) type 3. However, the mechanism behind CRS development is not fully understood. This study aimed to investigate the molecular mechanisms associated with cardiac mitochondrial impairment and its role in CRS development. The findings suggest that mitochondrial bioenergetics impairment plays a crucial role in heart damage, and the preservation of heart mitochondrial function during AKI could be a valuable strategy to prevent CRS type 3.
Article
Biochemistry & Molecular Biology
Angelica Flores-Flores, Samuel Estrada-Soto, Cesar Millan-Pacheco, Blanca Bazan-Perkins, Rogelio Hernandez-Pando, Maximiliano Ibarra-Barajas, Rafael Villalobos-Molina
Summary: Asthma is a condition where the airways become inflamed and narrowed, causing symptoms such as shortness of breath and wheezing. It was found that 6-aminoflavone (6-NH2F) can effectively relax the airways and has low toxicity in animal models, potentially through calcium channel blockade.
Review
Chemistry, Medicinal
Dulce Mata-Espinosa, Jacqueline V. Lara-Espinosa, Jorge Barrios-Payan, Rogelio Hernandez-Pando
Summary: This study reviews the model strategies for gene therapy and new vaccines in the treatment of tuberculosis, suggesting that it is a potential alternative therapy for active TB, as well as for the prevention and treatment of latent TB reactivation and transmission of Mtb.