Multiple, independent, identical IS6110 insertions in Mycobacterium tuberculosis PPE genes

IS6110 is a transposable element found in Mycobacterium tuberculosis complex members. Regions of preferential IS6110 integration occur within the M. tuberculosis genome but the element has not previously been shown to exhibit any sequence-specific integration preferences. Here we provide evidence for multiple independent IS6110 insertions into identical, or near-identical, positions within the highly homologous 50 region of 3 PPE genes. (C) 2009 Elsevier Ltd. All rights reserved.