Article
Immunology
Joseph M. Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Adam Rupert, Jeanette Higgins, Ornella Sortino, Ana M. Ortega-Villa, Virginia Sheikh, Gregg Roby, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti
Summary: Severe mycobacterial IRIS in HIV can cause secondary HLH driven by pathologic IFN gamma production and T-cell activation, leading to worse outcomes. Increased ferritin, anemia, CXCL9, and sCD25 associate with this phenotype and may be used for risk stratification and treatment optimization.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Gerasimos Eleftheriotis, Elias Skopelitis
Summary: This case report presents a patient with tuberculous lymphadenitis who developed IRIS and cat-scratch disease complications following antimicrobial treatment. Early testing for Bartonella infection may be beneficial in patients co-infected with TB and HIV to guide treatment and management.
BMC INFECTIOUS DISEASES
(2022)
Article
Microbiology
Chen Lin, Yuting Tang, Yuchen Wang, Junli Zhang, Yeyu Li, Shuqin Xu, Bin Xia, Qiran Zhai, Yao Li, Lu Zhang, Jun Liu
Summary: WhiB4 plays a critical role in the disease progression and reactivation of Mycobacterium marinum infection. Targeting WhiB4 may be a promising strategy for the development of novel therapeutics to prevent the reactivation of latent tuberculosis infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Dimitrios Basoulis, Nikos Pantazis, Dimitrios Paraskevis, Panos Iliopoulos, Martha Papadopoulou, Karolina Akinosoglou, Angelos Hatzakis, George L. Daikos, Mina Psichogiou
Summary: This study evaluated the effect of pre-cART HIV DNA levels on immune reconstitution and post-cART CD4 count trends. The findings suggest that high HIV RNA and DNA levels are predictors of CD4 cell increase, especially during the first trimester of cART.
Article
Immunology
Elizabeth Christian, Alicia Johnston
Summary: TB-IRIS is an inflammatory response to M. tuberculosis infection that occurs following immune system restoration. Patients treated with inhibitors may face risks of developing IRIS when developing active tuberculosis infection.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Ernest Adankwah, Norman Nausch, Difery Minadzi, Mohammed K. Abass, Kees L. M. C. Franken, Tom H. M. Ottenhoff, Ertan Mayatepek, Richard O. Phillips, Marc Jacobsen
Summary: IL-6 showed the highest sensitivity for detecting tuberculosis patients and asymptomatic contacts. Latency-associated antigens Rv2628 and Rv1733 increased concentrations of IFN gamma, IP-10, and IL-22 in asymptomatic contacts. The combination of IFN gamma induced by Rv2628/Rv1733 and IL-6 induced by IGRA-antigen was optimal for classifying tuberculosis patients and asymptomatic contacts.
JOURNAL OF INFECTION
(2021)
Article
Pharmacology & Pharmacy
Ying Hou, Xin Zhang, Xia Sun, Qiaohong Qin, Di Chen, Min Jia, Yulong Chen
Summary: Genetically modified (GM) rabbits expressing human genes have been widely used as animal models for studying cardiovascular diseases. Current methods for gene modification in rabbits include prokaryotic microinjection and RNA interference, but stable ES cell lines are lacking. However, with the emergence of new genetic technologies such as ZFNs, TALENs, CRISPR, and CRISPR/Cas9, significant progress has been made in rabbit gene targeting.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Microbiology
Polidy Pean, Yoann Madec, Eric Nerrienet, Laurence Borand, Didier Laureillard, Marcelo Fernandez, Olivier Marcy, Daniel Scott-Algara, CAMELIA Study Team
Summary: The aim of this study was to evaluate the reconstitution of NK cells in HIV-infected patients with TB-IRIS compared to those without IRIS. The results showed that NK cell reconstitution appeared to be better in TB-IRIS subjects. However, the development of IRIS does not appear to affect the NK cell reconstitution in HIV and TB-infected individuals.
Review
Biochemistry & Molecular Biology
Daniel G. Sausen, Maimoona S. Bhutta, Elisa S. Gallo, Harel Dahari, Ronen Borenstein
Summary: EBV is often latent in immunocompetent individuals, but perturbations in the host immune system can lead to viral reactivation and various related illnesses. Understanding the interaction between the virus, stress, and the immune system is crucial for effective treatment.
Article
Immunology
Caian L. Vinhaes, Virginia Sheikh, Deivide Oliveira-de-Souza, Jing Wang, Adam Rupert, Gregg Roby, Maria B. Arriaga, Kiyoshi F. Fukutani, Fred Sawe, Doug Shaffer, Jintanat Ananworanich, Nittaya Phanuphak, Bruno B. Andrade, Irini Sereti
Summary: The study found that systemic inflammatory profiles in people with severe immunosuppression can predict the development of immune reconstitution inflammatory syndrome (IRIS). By developing a composite score incorporating various biomarkers, including interleukin-6, IL-10, IL-27, sCD14, interferon-gamma, tumor necrosis factor-alpha, hyaluronic acid, D-dimer, body mass index, and hemoglobin, accurate predictions of IRIS occurrence and death risk can be made.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Julian Friebel, Katina Schinnerling, Anika Geelhaar-Karsch, Kristina Allers, Thomas Schneider, Verena Moos
Summary: This study found that microbial translocation is present in patients with Whipple's disease and immune reconstitution inflammatory syndrome (IRIS). Patients with IRIS showed more pronounced morphological changes in the duodenum before treatment, which improved after therapy. Certain markers in the blood can predict the occurrence of IRIS.
IMMUNITY INFLAMMATION AND DISEASE
(2022)
Review
Immunology
Qingqing Jia, Shihua Li, Xiao-Jiang Li, Peng Yin
Summary: Huntington's disease is a progressive neurodegenerative disorder characterized by loss of neurons in the striatum, leading to motor and cognitive impairments. The cause of the disease is the expansion of a glutamine repeat in the huntingtin protein, but the mechanism underlying neuronal death is still unclear. Inflammation is one of the contributing factors in the pathogenesis of Huntington's disease. This review summarizes the evidence on immune and inflammatory changes in Huntington's disease, providing insights for the development of novel strategies for its treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Joseph M. Rocco, Elizabeth Laidlaw, Frances Galindo, Megan Anderson, Ornella Sortino, Safia Kuriakose, Andrea Lisco, Maura Manion, Irini Sereti
Summary: People with HIV and mycobacterial infections may develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy. The pathophysiology of mycobacterial-IRIS overlaps with primary hemophagocytic lymphohistiocytosis (pHLH). By evaluating protein-altering variants in genes associated with HLH, it was found that 23.2% of IRIS patients had these variants, compared to only 3.8% of those without IRIS. These findings suggest a possible genetic component in the risk of mycobacterial IRIS in people with HIV and mycobacterial infections.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Veterinary Sciences
Laura Hunter, Ines Ruedas-Torres, Irene Agullo-Ros, Emma Rayner, Francisco J. Salguero
Summary: Research on human tuberculosis is limited due to the availability of human tissues, making animal models crucial for understanding the disease's progression and evaluating new therapies. This review examines the pulmonary pathology induced by tuberculosis bacteria in different animal models and compares them to human pulmonary tuberculosis. Although the models share some histopathological features with human tuberculosis, further research is needed to establish the most appropriate model and standard characterization of pulmonary lesions.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Immunology
Syed A. Mian, Fernando Anjos-Afonso, Dominique Bonnet
Summary: Immunotherapy shows promise in cancer treatment, yet challenges remain, including the lack of suitable mouse models. Improved immunodeficient mice offer opportunities for comprehensive evaluation of therapeutic strategies and advancement in human hematopoietic research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Sport Sciences
Karine Naves De Oliveira Goulart, Nathalia Maria Resende, Marcos Daniel Motta Drummond, Luciana Maria Oliveira, Fernando Vitor Lima, Leszek Antoni Szmuchrowski, Ricardo Toshio Fujiwara, Bruno Pena Couto
Summary: This study found that at least 48 hours of recovery interval is needed for the reestablishment of performance, with better perceptual responses evident at 72 hours. First set volume load, countermovement jump, and maximal voluntary isometric contraction were significantly correlated with volume load.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2021)
Article
Immunology
Luisa Mourao Dias Magalhaes, Livia Silva Araujo Passos, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno
Summary: Hookworm infection is a prevalent human soil-transmitted helminth infection with lack of accurate surveillance mechanisms hindering control strategies. Current research sheds light on immunopathology, immunoregulation, and drug therapies for hookworm infection, offering potential for vaccine development and treatments in the future.
PARASITE IMMUNOLOGY
(2021)
Article
Immunology
Joseane C. de Castro, Laila de Almeida, Mariana Santos Cardoso, Fabricio M. Silva Oliveira, Denise S. Nogueira, Joao Luis Reis-Cunha, Luisa M. D. Magalhaes, Bin Zhan, Maria Elena Bottazzi, Peter J. Hotez, Lilian L. Bueno, Daniella Castanheira Bartholomeu, Ricardo T. Fujiwara
Summary: A chimeric protein vaccine designed for protection against Ascaris infection shows promising results in reducing larval load in the lung, enhancing IgG response, and reducing inflammation. The study suggests that chimeric proteins containing multiple B cell epitopes could be a valuable approach for developing vaccines against helminthic infections.
Article
Public, Environmental & Occupational Health
Andrew D. Haddow, Tobin E. Rowland, Sarah L. Norris, Thomas R. Sprague, Jorge O. Lopez, Mark C. Carder, Yvonne-Marie Linton, M. Louise M. Pitt
Summary: Following feeding on an artificial blood meal containing rVSV-EBOV, laboratory-reared Phlebotomus papatasi did not show replication or dissemination of the vaccine virus in their bodies or legs at seven or 15 days post-feed. This indicates a low potential for rVSV-EBOV to replicate and disseminate in P. papatasi, a species with geographic distribution ranging from Morocco to southwest Asia and southern Europe.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Pharmacology & Pharmacy
Audrey Silva, Amanda Costa, Sona Jain, Eduardo Coelho, Ricardo Fujiwara, Ricardo Scher, Rogeria Nunes, Silvio Dolabella
Summary: Leishmaniasis, a neglected tropical disease, affects over 1.5 million people annually with a mortality rate of over 20,000. Current drugs for treatment are toxic and expensive with variable efficacy. Studies on nanotechnological strategies suggest that using poloxamers can improve drug solubility, stability, efficacy, and reduce toxicity for the treatment of leishmaniasis.
CURRENT DRUG TARGETS
(2021)
Article
Immunology
Leandro de Freitas Teles, Agostinho Goncalves Viana, Mariana Santos Cardoso, Guilherme Rafael Gomide Pinheiro, Gabriele Ariadine Bento, Jamille Fernandes Lula, Tania de Cassia Moreira Soares, Ricardo Toshio Fujiwara, Silvio Fernando Guimaraes de Carvalho
Summary: The study reveals significant differences in cytokine levels and bone marrow samples between VL patients with varying degrees of severity, with IFN-gamma and IL-10 potentially playing key roles in influencing parasitic load.
PARASITE IMMUNOLOGY
(2021)
Article
Cell Biology
Jun Liu, John C. Trefry, April M. Babka, Christopher W. Schellhase, Kayla M. Coffin, Janice A. Williams, Jo Lynne W. Raymond, Paul R. Facemire, Taylor B. Chance, Neil M. Davis, Jennifer L. Scruggs, Franco D. Rossi, Andrew D. Haddow, Justine M. Zelko, Sandra L. Bixler, Ian Crozier, Patrick L. Iversen, Margaret L. Pitt, Jens H. Kuhn, Gustavo Palacios, Xiankun Zeng
Summary: Persistent Ebola virus infection in the brain ventricular system can occur in macaque survivors after therapeutic treatment, leading to severe tissue damage and inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Virology
Sandra L. Bixler, Christopher P. Stefan, Alexandra N. Jay, Franco D. Rossi, Keersten M. Ricks, Charles J. Shoemaker, Alicia M. Moreau, Xiankun Zeng, Jay W. Hooper, David N. Dyer, Ondraya M. Frick, Jeffrey W. Koehler, Brian J. Kearney, Nina DiPinto, Jun Liu, Samantha D. Tostenson, Tamara L. Clements, Jeffrey M. Smith, Joshua A. Johnson, Kerry L. Berrier, Heather L. Esham, Korey L. Delp, Susan R. Coyne, Holly A. Bloomfield, Paul A. Kuehnert, Kristen Akers, Kathleen M. Gibson, Timothy D. Minogue, Aysegul Nalca, Margaret L. M. Pitt
Summary: This study compares the effects of two different exposure routes in two nonhuman primate species and finds that the aerosol exposure of cynomolgus macaques produces the most severe COVID-19 disease model, which can be used for evaluating therapeutics and vaccines.
Article
Pharmacology & Pharmacy
Guilherme S. Ramos, Virginia M. R. Vallejos, Gabriel S. M. Borges, Raquel M. Almeida, Izabela M. Alves, Marta M. G. Aguiar, Christian Fernandes, Pedro P. G. Guimaraes, Ricardo T. Fujiwara, Philippe M. Loiseau, Lucas A. M. Ferreira, Frederic Frezard
Summary: This study developed a formulation of PEGylated liposomal AmB and compared its efficacy to AmBisome (R) in a murine model of cutaneous leishmaniasis (CL). The results showed that the PEGylated formulation significantly reduced lesion growth and parasite load in the treatment of CL, both through parenteral and oral routes.
Article
Immunology
Sara C. Johnston, Keersten M. Ricks, Ines Lakhal-Naouar, Alexandra Jay, Caroline Subra, Jo Lynne Raymond, Hannah A. D. King, Franco Rossi, Tamara L. Clements, David Fetterer, Samantha Tostenson, Camila Macedo Cincotta, Holly R. Hack, Caitlin Kuklis, Sandrine Soman, Jocelyn King, Kristina K. Peachman, Dohoon Kim, Wei-Hung Chen, Rajeshwer S. Sankhala, Elizabeth J. Martinez, Agnes Hajduczki, William C. Chang, Misook Choe, Paul Thomas, Caroline E. Peterson, Alexander Anderson, Isabella Swafford, Jeffrey R. Currier, Dominic Paquin-Proulx, Linda L. Jagodzinski, Gary R. Matyas, Mangala Rao, Gregory D. Gromowski, Sheila A. Peel, Lauren White, Jeffrey M. Smith, Jay W. Hooper, Nelson L. Michael, Kayvon Modjarrad, M. Gordon Joyce, Aysegul Nalca, Diane L. Bolton, Margaret L. M. Pitt
Summary: This study reported on the immunogenicity and efficacy of a protein-based COVID-19 vaccine in a monkey model, demonstrating strong immune responses and a significant reduction in lung lesions following infection.
Review
Immunology
Anne C. S. Ramos, Luciana M. Oliveira, Yvanna L. D. C. O. Santos, Marlon C. S. Dantas, Cristiani I. B. Walker, Ana M. C. Faria, Lilian L. Bueno, Silvio S. Dolabella, Ricardo T. Fujiwara
Summary: This systematic review aimed to investigate the role of Immunoglobulin-A (IgA) as a mediator of protective immunity against gastrointestinal helminths. The results showed consistent associations between higher IgA levels and lower parasitological parameters in mice, rats, and sheep. However, the role of IgA in other host species remained uncertain, highlighting the need for further research.
IMMUNOLOGY LETTERS
(2022)
Article
Infectious Diseases
Raianna F. Fantin, Claudia Abeijon, Dhelio B. Pereira, Ricardo T. Fujiwara, Lilian L. Bueno, Antonio Campos-Neto
Summary: The article introduces a potential target protein for diagnosing P. vivax malaria, which is unique and unrelated to other species of Plasmodium.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Biology
Danniele L. Vale, Camila S. Freitas, Vivian T. Martins, Gabriel J. L. Moreira, Amanda S. Machado, Fernanda F. Ramos, Isabela A. G. Pereira, Raquel S. Bandeira, Marcelo M. de Jesus, Grasiele S. V. Tavares, Fernanda Ludolf, Miguel A. Chavez-Fumagalli, Alexsandro S. Galdino, Ricardo T. Fujiwara, Lilian L. Bueno, Bruno M. Roatt, Myron Christodoulides, Eduardo A. F. Coelho, Daniela P. Lage
Summary: Our study used an immunotherapeutic approach combining a vaccine and drug to successfully treat mice infected with Leishmania parasites. This approach significantly reduced the parasite load in the animals' internal organs and increased the production of protective antibodies. The inclusion of the vaccine and adjuvant also reduced the toxicity of the drug.
Article
Parasitology
Barbara L. A. Vercosa, Maria Imaculada Muniz-Junqueira, Joilson Ferreira Batista, Teresa Oviedo Socarras, Luisa Mourao Dias Magalhaes, Ricardo T. Fujiwara, Maria N. Melo, Anilton Cesar Vasconcelos
Summary: Hyperactivation of tubular cells contributes to the progression of kidney lesions, and Leishmania-infected dogs showed higher histopathological lesion scores and AgNOR expression, which were associated with clinical signs.
VETERINARY PARASITOLOGY
(2022)
Article
Chemistry, Medicinal
Victor N. dos Santos, Gisele L. de Oliveira, Davyson L. Moreira, Rodrigo G. de Deus, Raquel M. de Almeida, Ricardo T. Fujiwara, Lucia P. S. Pimenta, Sebastiao R. Ferreira
Summary: The study found that the volatile oil of Piper macedoi had leishmanicidal activity against Leishmania infantum amastigotes but exhibited significant cytotoxicity to different cell types. The major components in the volatile oil were apiole, dillapiole, 1,8-cineole, and camphor.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)