Article
Infectious Diseases
Abel Nhama, Lidia Nhamussua, Eusebio Macete, Quique Bassat, Crizolgo Salvador, Sonia Enosse, Baltazar Candrinho, Eva Carvalho, Arsenio Nhacolo, Arlindo Chidimatembue, Abuchahama Saifodine, Rose Zulliger, Naomi Lucchi, Samaly S. Svigel, Leah F. Moriarty, Eric S. Halsey, Alfredo Mayor, Pedro Aide
Summary: An evaluation of artemisinin-based combination therapy (ACT) for malaria treatment in Mozambique showed that both artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) have therapeutic efficacies well above the 90% threshold recommended by WHO, and are well-tolerated.
Article
Public, Environmental & Occupational Health
Mateusz M. Plucinski, Joel L. N. Barratt
Summary: This study introduces a novel method for nonparametric statistical testing of relatedness for P. falciparum parasites. The approach showed high sensitivity and reliability in identifying related genotypes.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Infectious Diseases
Peter Thelma Ngwa Niba, Akindeh Mbuh Nji, Innocent Mbulli Ali, Lawrence Fonyonga Akam, Cedric Hermann Dongmo, Jean Paul Kengne Chedjou, Calvino Tah Fomboh, William Dorian Nana, Ornella Laetitia Ayem Oben, Abdel Aziz Selly-Ngaloumo, Marcel N. Moyeh, Jude Achidi Ngu, Ambassa Jean Ludovic, Pierre Martiniel Aboh, Marie Carine Enyegue Ambani, Pierrette Albertine Mbarga Omgba, Grace Bissohong Kotcholi, Linus Moye Adzemye, Danielle Regine Abenkou Nna, Adele Douanla, Ze Ango, Marie Sophie Ewane, Joel Tewara Ticha, Fritz Mbuh Tatah, Golwa Dinza, Valentine Nchafor Ndikum, Dorothy A. Fosah, Jude D. Bigoga, Michael Alifrangis, Wilfred F. Mbacham
Summary: This study evaluated the effectiveness and safety of AS-AQ and AL for home-based treatment of uncomplicated P. falciparum malaria in Yaounde, Cameroon. The results showed that both AS-AQ and AL were effective and safe for the management of malaria in a home setting.
BMC INFECTIOUS DISEASES
(2022)
Article
Parasitology
Judickaelle Irinantenaina, Gwenaelle Carn, Dina Ny Aina Liantsoa Randriamiarinjatovo, Aina Nirina Harimanana, Seheno Razanatsiorimalala, Nicolas Ralemary, Maurice Randriarison, Celestin Razafinjato, Raphael Hotahiene, Milijaona Randrianarivelojosia
Summary: A study conducted in Madagascar evaluated the efficacy and safety of artemisinin-based combination therapy (ACT) for the treatment of uncomplicated Plasmodium falciparum malaria. The results showed that the combination of artesunate + amodiaquine and artemether + lumefantrine were effective and safe. The study suggests that these therapies can be used for treatment in health facilities, at the community level, and for mass drug administration campaigns. Rating: 8/10.
Article
Infectious Diseases
Youssouf Diarra, Oumar Kone, Lansana Sangare, Lassina Doumbia, Dade Bouye Ben Haidara, Mouctar Diallo, Ababacar Maiga, Hamadoun A. Sango, Halidou Sidibe, Jules Mihigo, Douglas Nace, Dragan Ljolje, Eldin Talundzic, Venkatachalam Udhayakumar, Erin Eckert, Celia J. Woodfill, Leah F. Moriarty, Pharath Lim, Donald J. Krogstad, Eric S. Halsey, Naomi W. Lucchi, Ousmane A. Koita
Summary: The study in Selingue, Mali showed that both artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) remain effective for the treatment of uncomplicated malaria. ASAQ demonstrated significantly better efficacy compared to AL.
Article
Public, Environmental & Occupational Health
Vy Bui, Colleen R. Higgins, Sarah Laing, Sachiko Ozawa
Summary: This study examines the impact of substandard and falsified antimalarials on health and economy in Benin, showing the significant cost and death associated with poor-quality antimalarials. Replacing all antimalarials with quality-assured artemisinin combination therapies has the potential to save costs and prevent deaths.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Plant Sciences
M. S. Nair, Y. Huang, D. A. Fidock, S. J. Polyak, J. Wagoner, M. J. Towler, P. J. Weathers
Summary: Artemisia annua has been traditionally used for treating fever and has shown antiviral activity against SARS-CoV-2, with potential for developing cost-effective therapeutics for infections.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Infectious Diseases
Matilde Riloha Rivas, Marian Warsame, Ramona Mba Andeme, Salomon Nsue Esidang, Policarpo Ricardo Ncogo, Wonder Philip Phiri, Consuelo Oki Eburi, Corona Eyang Edu Maye, Didier Menard, Eric Legrand, Pedro Berzosa, Luz Garcia, Angela Katherine Lao Seoane, Spes Caritas Ntabangana, Pascal Ringwald
Summary: The study confirmed the high efficacy of ASAQ and AL for the treatment of uncomplicated falciparum infections, as well as the absence of delayed parasite clearance and Pfkelch13 mutations associated with artemisinin resistance. Continuous monitoring of the efficacy of these artemisinin-based combinations is essential to inform national malaria treatment policy and detect resistant parasites early.
Article
Microbiology
Kaleab A. Ribbiso, Laura E. Heller, Abigail Taye, Erin Julian, Andreas Willems, Paul D. Roepe
Summary: Artemisinin-based antimalarial drugs are believed to exert lethal effects on malarial parasites by alkylating a variety of intracellular molecular targets, with recent studies showing that these drugs can inhibit the parasite's detoxification of free heme. The experiments indicate that artemisinins have a strong inhibitory effect on hemozoin crystallization and are more potent inhibitors compared to quinoline-based antimalarial drugs.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Immunology
Christine M. Thomas, William M. Stauffer, Jonathan D. Alpern
Summary: Intravenous artesunate is now available for the treatment of severe malaria in the US. We propose a hospital tier framework to guide the decision of stocking this drug.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Catherine O. Falade, Adebola E. Orimadegun, Fiyinfoluwa I. Olusola, Obaro S. Michael, Oluwafunmibi E. Anjorin, Roland I. Funwei, Aduragbenro D. Adedapo, Abiola L. Olusanya, Bose E. Orimadegun, Olugbenga A. Mokuolu
Summary: In Nigeria, declining responsiveness to artemether-lumefantrine (AL) has been reported, and the efficacy and safety of pyronaridine-artesunate (PA) in the Nigerian pediatric population is unknown. This study compared the efficacy and safety of PA and AL for the treatment of uncomplicated falciparum malaria in Nigeria.
Article
Infectious Diseases
Annarita Botta, Agnese Comelli, Iacopo Vellere, Flavia Chechi, Leila Bianchi, Gardini Giulia, Lina Rachele Tomasoni, Michele Spinicci, Luisa Galli, Francesco Castelli, Alessandro Bartoloni, Lorenzo Zammarchi
Summary: A retrospective cohort study compared the effects of IVA + IVQ and IVA treatment for imported severe malaria and found that IVA + IVQ treatment did not show better outcomes and had more adverse events in adults. Further research is needed to investigate whether IVA + IVQ could be an effective strategy in areas with high artemisinin resistance.
Article
Infectious Diseases
Taiwo Ibinaiye, Olusola Oresanya, Chibuzo Oguoma, Adaeze Aidenagbon, Olabisi Ogunmola, Christian Rassi, Sol Richardson
Summary: In sub-Saharan Africa, malaria is the main cause of morbidity and mortality among infants and young children. Seasonal malaria chemoprevention (SMC) is delivered monthly door-to-door, with children receiving sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) on Day 1 and AQ on Day 2 and Day 3. Non-adherence to AQ administration by caregivers can lead to the emergence of antimalarial resistance.
Article
Public, Environmental & Occupational Health
Irfanul Chakim, Tepanata Pumpaibool, Sayono, Ekha Rifki Fauzi
Summary: Resistance to artemisinin regimen in combating malaria has increased due to low adherence to treatment. A study conducted in Indonesia found that adherence to artemisinin combination therapy (ACT) was less than 80% among participants, highlighting the need for improvement to prevent treatment failure. Additionally, the study identified the metabolite of piperaquine at day 60 as a potential marker for monitoring adherence to the drug in the population.
JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
M. Silva, M. Malmberg, S. D. Otienoburu, A. Bjorkman, B. Ngasala, A. Martensson, J. P. Gil, M. I. Veiga
Summary: The study found significant co-expression patterns of the pfmdr1 and pfcrt genes before and during ACT treatment. This co-expression may play an important role when the parasite is exposed to drug stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Oladapo E. Oyinloye, Ayokulehin M. Kosoko, Benjamin Emikpe, Catherine O. Falade, Olusegun G. Ademowo
AFRICAN HEALTH SCIENCES
(2015)
Article
Microbiology
Olumuyiwa N. Adedeji, Oluseye O. Bolaji, Catherine O. Falade, Odusoga A. Osonuga, Olusegun G. Ademowo
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2015)
Article
Plant Sciences
Abayomi Mayowa Ajayi, Domingos Tabajara de Oliveira Martins, Sikiru Olaitan Balogun, Ruberlei Godinho de Oliveira, Sergio Donizeti Ascencio, Ilsamar Mendes Soares, Robson dos Santos Barbosa, Olusegun George Ademowo
JOURNAL OF ETHNOPHARMACOLOGY
(2017)
Article
Biochemical Research Methods
Jonas Kissenkoetter, Soeren Hansen, Susanne Boehlken-Fascher, Olusegun George Ademowo, Oladapo Elijah Oyinloye, Adeleye Solomon Bakarey, Gerhard Dobler, Dennis Tappe, Pranav Patel, Claus-Peter Czerny, Ahmed Abd El Wahed
ANALYTICAL BIOCHEMISTRY
(2018)
Article
Plant Sciences
Sabitiu A. Oyeleke, Abayomi M. Ajayi, Solomon Umukoro, A. O. Aderibigbe, Olusegun George Ademowo
JOURNAL OF ETHNOPHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Saliu Alao Amolegbe, Yui Hirano, Joseph Oluwatope Adebayo, Olusegun George Ademowo, Elizabeth Abidemi Balogun, Joshua Ayoola Obaleye, Antoniana Ursine Krettli, Chengzhong Yu, Shinya Hayami
SCIENTIFIC REPORTS
(2018)
Article
Public, Environmental & Occupational Health
Meera Venkatesan, Nahla B. Gadalla, Kasia Stepniewska, Prabin Dahal, Christian Nsanzabana, Clarissa Moriera, Ric N. Price, Andreas Martensson, Philip J. Rosenthal, Grant Dorsey, Colin J. Sutherland, Philippe Guerin, Timothy M. E. Davis, Didier Menard, Ishag Adam, George Ademowo, Cesar Arze, Frederick N. Baliraine, Nicole Berens-Riha, Anders Bjorkman, Steffen Borrmann, Francesco Checchi, Meghna Desai, Mehul Dhorda, Abdoulaye A. Djimde, Badria B. El-Sayed, Teferi Eshetu, Frederick Eyase, Catherine Falade, Jean-Francois Faucher, Gabrielle Froberg, Anastasia Grivoyannis, Sally Hamour, Sandrine Houze, Jacob Johnson, Erasmus Kamugisha, Simon Kariuki, Jean-Rene Kiechel, Fred Kironde, Poul-Erik Kofoed, Jacques LeBras, Maja Malmberg, Leah Mwai, Billy Ngasala, Francois Nosten, Samuel L. Nsobya, Alexis Nzila, Mary Oguike, Sabina Dahlstrom Otienoburu, Bernhards Ogutu, Jean-Bosco Ouedraogo, Patrice Piola, Lars Rombo, Birgit Schramm, A. Fabrice Some, Julie Thwing, Johan Ursing, Rina P. M. Wong, Ahmed Zeynudin, Issaka Zongo, Christopher V. Plowe, Carol Hopkins Sibley
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2014)
Article
Plant Sciences
Adewale G. Bakre, Adegbuyi O. Aderibigbe, Olusegun G. Ademowo
JOURNAL OF ETHNOPHARMACOLOGY
(2013)
Article
Infectious Diseases
Patricia N. Okorie, John M. Marshall, Onoja M. Akpa, Olusegun G. Ademowo
Article
Entomology
P. N. Okorie, O. G. Ademowo, H. Irving, L. A. Kelly-Hope, C. S. Wondji
MEDICAL AND VETERINARY ENTOMOLOGY
(2015)
Article
Medicine, General & Internal
C. O. Falade, H. O. Dada-Adegbola, O. O. Ogunkunle, M. C. Oguike, O. Nash, O. G. Ademowo
MEDICAL PRINCIPLES AND PRACTICE
(2014)
Article
Infectious Diseases
Saskia Dede Davi, Jonas Kissenkoetter, Martin Faye, Susanne Boehlken-Fascher, Christiane Stahl-Hennig, Oumar Faye, Ousmane Faye, Amadou A. Sall, Manfred Weidmann, Olusegun George Ademowo, Frank T. Hufert, Claus-Peter Czerny, Ahmed Abd El Wahed
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2019)
Article
Parasitology
Olawunmi R. Rabiu, Hannah Dada-Adegbola, Catherine O. Falade, Olatunbosun G. Arinola, Alexander B. Odaibo, Olusegun G. Ademowo
Summary: Malaria, helminthiasis, and HIV are highly prevalent among pregnant women in developing countries. This study aimed to evaluate the impact of co-infections on peripheral blood cytokines. The results showed significant changes in cytokine levels among those with co-infections compared to single infections, including reductions in IFN-gamma and IL-13 and elevations in IFN-gamma and IL-17.
PARASITOLOGY RESEARCH
(2022)
Article
Chemistry, Medicinal
Abayomi M. Ajayi, Benneth Ben-Azu, Samuel A. Onasanwo, Olusegun Adeoluwa, Anthony Eduviere, Olusegun G. Ademowo
Article
Chemistry, Medicinal
Abayomi M. Ajayi, Solomon Umukoro, Benneth Ben-Azu, Bulus Adzu, Olusegun G. Ademowo
DRUG DEVELOPMENT RESEARCH
(2017)